IL121312A - קומפוננטות מיקראולקטרוניות, ייצורן ורשתות אלקטרוניות המכילות אותן - Google Patents
קומפוננטות מיקראולקטרוניות, ייצורן ורשתות אלקטרוניות המכילות אותןInfo
- Publication number
- IL121312A IL121312A IL12131297A IL12131297A IL121312A IL 121312 A IL121312 A IL 121312A IL 12131297 A IL12131297 A IL 12131297A IL 12131297 A IL12131297 A IL 12131297A IL 121312 A IL121312 A IL 121312A
- Authority
- IL
- Israel
- Prior art keywords
- nucleotide
- network
- fiber
- network according
- bound
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title description 26
- 238000004377 microelectronic Methods 0.000 title description 8
- 239000000835 fiber Substances 0.000 claims abstract description 206
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 135
- 239000002773 nucleotide Substances 0.000 claims abstract description 131
- 239000002245 particle Substances 0.000 claims abstract description 87
- 238000000034 method Methods 0.000 claims abstract description 75
- 239000000126 substance Substances 0.000 claims abstract description 64
- 230000027455 binding Effects 0.000 claims abstract description 60
- 238000000151 deposition Methods 0.000 claims abstract description 22
- 230000000536 complexating effect Effects 0.000 claims abstract description 3
- 150000007523 nucleic acids Chemical group 0.000 claims description 48
- 229910052751 metal Inorganic materials 0.000 claims description 41
- 239000002184 metal Substances 0.000 claims description 41
- 230000003993 interaction Effects 0.000 claims description 25
- 239000004020 conductor Substances 0.000 claims description 22
- 230000000295 complement effect Effects 0.000 claims description 21
- 239000008139 complexing agent Substances 0.000 claims description 21
- 238000009396 hybridization Methods 0.000 claims description 12
- 150000003573 thiols Chemical class 0.000 claims description 10
- 238000001338 self-assembly Methods 0.000 claims description 8
- 230000009870 specific binding Effects 0.000 claims description 8
- 150000001412 amines Chemical group 0.000 claims description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000012546 transfer Methods 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 description 95
- 125000005647 linker group Chemical group 0.000 description 65
- 108091034117 Oligonucleotide Proteins 0.000 description 47
- 229920000642 polymer Polymers 0.000 description 36
- 230000008569 process Effects 0.000 description 36
- 239000000243 solution Substances 0.000 description 35
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 33
- 239000000758 substrate Substances 0.000 description 33
- 229910052737 gold Inorganic materials 0.000 description 32
- 239000010931 gold Substances 0.000 description 32
- 229910052709 silver Inorganic materials 0.000 description 28
- 239000004332 silver Substances 0.000 description 28
- 230000015572 biosynthetic process Effects 0.000 description 26
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 25
- -1 resistor Substances 0.000 description 25
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 24
- 239000000084 colloidal system Substances 0.000 description 24
- 102000039446 nucleic acids Human genes 0.000 description 24
- 108020004707 nucleic acids Proteins 0.000 description 24
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 19
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 16
- 229920000767 polyaniline Polymers 0.000 description 16
- 102000053602 DNA Human genes 0.000 description 15
- 125000004429 atom Chemical group 0.000 description 13
- 229960002685 biotin Drugs 0.000 description 12
- 235000020958 biotin Nutrition 0.000 description 12
- 239000011616 biotin Substances 0.000 description 12
- 230000008021 deposition Effects 0.000 description 12
- 150000002500 ions Chemical class 0.000 description 12
- 239000004065 semiconductor Substances 0.000 description 11
- 239000002585 base Substances 0.000 description 10
- 239000011159 matrix material Substances 0.000 description 10
- 229910021645 metal ion Inorganic materials 0.000 description 10
- 230000006911 nucleation Effects 0.000 description 10
- 238000010899 nucleation Methods 0.000 description 10
- 239000010410 layer Substances 0.000 description 9
- 229920000867 polyelectrolyte Polymers 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 108091028043 Nucleic acid sequence Proteins 0.000 description 8
- 108010090804 Streptavidin Proteins 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000010276 construction Methods 0.000 description 8
- 125000002228 disulfide group Chemical group 0.000 description 8
- 230000004888 barrier function Effects 0.000 description 7
- 229920000547 conjugated polymer Polymers 0.000 description 7
- 239000011521 glass Substances 0.000 description 7
- 239000012212 insulator Substances 0.000 description 7
- 238000005342 ion exchange Methods 0.000 description 7
- 238000001465 metallisation Methods 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- 238000007796 conventional method Methods 0.000 description 6
- 238000007306 functionalization reaction Methods 0.000 description 6
- 229910001868 water Inorganic materials 0.000 description 6
- 239000003638 chemical reducing agent Substances 0.000 description 5
- 239000002322 conducting polymer Substances 0.000 description 5
- 229920001940 conductive polymer Polymers 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 239000002071 nanotube Substances 0.000 description 5
- 238000002161 passivation Methods 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 4
- 108020004511 Recombinant DNA Proteins 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 238000000089 atomic force micrograph Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000007639 printing Methods 0.000 description 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(I) nitrate Inorganic materials [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 230000006820 DNA synthesis Effects 0.000 description 3
- 102000052510 DNA-Binding Proteins Human genes 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 102000001218 Rec A Recombinases Human genes 0.000 description 3
- 108010055016 Rec A Recombinases Proteins 0.000 description 3
- 108020004682 Single-Stranded DNA Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 238000000137 annealing Methods 0.000 description 3
- 238000000429 assembly Methods 0.000 description 3
- 230000000712 assembly Effects 0.000 description 3
- 239000003637 basic solution Substances 0.000 description 3
- 108091008324 binding proteins Proteins 0.000 description 3
- 102000023732 binding proteins Human genes 0.000 description 3
- 239000003990 capacitor Substances 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 238000005234 chemical deposition Methods 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 238000009795 derivation Methods 0.000 description 3
- 239000003623 enhancer Substances 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 230000003100 immobilizing effect Effects 0.000 description 3
- 238000009413 insulation Methods 0.000 description 3
- 238000005304 joining Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 230000000873 masking effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 108700020942 nucleic acid binding protein Proteins 0.000 description 3
- 102000044158 nucleic acid binding protein Human genes 0.000 description 3
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 229910001415 sodium ion Inorganic materials 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- 229930192474 thiophene Natural products 0.000 description 3
- QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
- 108700020911 DNA-Binding Proteins Proteins 0.000 description 2
- 230000004568 DNA-binding Effects 0.000 description 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- 108091093037 Peptide nucleic acid Proteins 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 239000003929 acidic solution Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 108010027090 biotin-streptavidin complex Proteins 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000002041 carbon nanotube Substances 0.000 description 2
- 229910021393 carbon nanotube Inorganic materials 0.000 description 2
- 238000010668 complexation reaction Methods 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000021615 conjugation Effects 0.000 description 2
- 239000005289 controlled pore glass Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000004070 electrodeposition Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 230000005669 field effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 150000002343 gold Chemical class 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
- 239000003504 photosensitizing agent Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000000171 quenching effect Effects 0.000 description 2
- 101150079601 recA gene Proteins 0.000 description 2
- 238000009877 rendering Methods 0.000 description 2
- 230000027756 respiratory electron transport chain Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 125000002652 ribonucleotide group Chemical group 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 description 2
- 150000003577 thiophenes Chemical class 0.000 description 2
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 description 1
- WBIQQQGBSDOWNP-UHFFFAOYSA-N 2-dodecylbenzenesulfonic acid Chemical compound CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O WBIQQQGBSDOWNP-UHFFFAOYSA-N 0.000 description 1
- PPJYSSNKSXAVDB-UHFFFAOYSA-N 3,3',5,5'-tetraiodothyroacetic acid Chemical compound IC1=CC(CC(=O)O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 PPJYSSNKSXAVDB-UHFFFAOYSA-N 0.000 description 1
- FHQKLIHFKVAEEP-UHFFFAOYSA-N 3,3,4,4,5,5-hexafluorocyclopentene Chemical compound FC1(F)C=CC(F)(F)C1(F)F FHQKLIHFKVAEEP-UHFFFAOYSA-N 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 101710184444 Complexin Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 101710096438 DNA-binding protein Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108010054278 Lac Repressors Proteins 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Natural products C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 description 1
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 229910052770 Uranium Inorganic materials 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 238000001015 X-ray lithography Methods 0.000 description 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 1
- 150000000475 acetylene derivatives Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 150000004696 coordination complex Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000006880 cross-coupling reaction Methods 0.000 description 1
- 239000005547 deoxyribonucleotide Substances 0.000 description 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
- 238000005137 deposition process Methods 0.000 description 1
- 230000005595 deprotonation Effects 0.000 description 1
- 238000010537 deprotonation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- WNAHIZMDSQCWRP-UHFFFAOYSA-N dodecane-1-thiol Chemical compound CCCCCCCCCCCCS WNAHIZMDSQCWRP-UHFFFAOYSA-N 0.000 description 1
- 229940060296 dodecylbenzenesulfonic acid Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012776 electronic material Substances 0.000 description 1
- 230000005686 electrostatic field Effects 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000006862 enzymatic digestion Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 230000002687 intercalation Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- QJAOYSPHSNGHNC-UHFFFAOYSA-N octadecane-1-thiol Chemical compound CCCCCCCCCCCCCCCCCCS QJAOYSPHSNGHNC-UHFFFAOYSA-N 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 108010083127 phage repressor proteins Proteins 0.000 description 1
- 125000000843 phenylene group Chemical class C1(=C(C=CC=C1)*)* 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 230000001443 photoexcitation Effects 0.000 description 1
- 238000005289 physical deposition Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 150000003057 platinum Chemical class 0.000 description 1
- 229920000553 poly(phenylenevinylene) Polymers 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920000123 polythiophene Polymers 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 150000003233 pyrroles Chemical class 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- MOOUPSHQAMJMSL-UHFFFAOYSA-N tert-butyl(trichloro)silane Chemical compound CC(C)(C)[Si](Cl)(Cl)Cl MOOUPSHQAMJMSL-UHFFFAOYSA-N 0.000 description 1
- RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical group C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- RCHUVCPBWWSUMC-UHFFFAOYSA-N trichloro(octyl)silane Chemical compound CCCCCCCC[Si](Cl)(Cl)Cl RCHUVCPBWWSUMC-UHFFFAOYSA-N 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000001018 xanthene dye Substances 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K85/00—Organic materials used in the body or electrodes of devices covered by this subclass
- H10K85/761—Biomolecules or bio-macromolecules, e.g. proteins, chlorophyl, lipids or enzymes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N3/00—Computing arrangements based on biological models
- G06N3/12—Computing arrangements based on biological models using genetic models
- G06N3/123—DNA computing
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
- G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
- G11C13/0009—RRAM elements whose operation depends upon chemical change
- G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
- G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
- G11C13/0009—RRAM elements whose operation depends upon chemical change
- G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
- G11C13/0019—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material comprising bio-molecules
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K10/00—Organic devices specially adapted for rectifying, amplifying, oscillating or switching; Organic capacitors or resistors having potential barriers
- H10K10/701—Organic molecular electronic devices
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K71/00—Manufacture or treatment specially adapted for the organic devices covered by this subclass
- H10K71/10—Deposition of organic active material
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K85/00—Organic materials used in the body or electrodes of devices covered by this subclass
- H10K85/10—Organic polymers or oligomers
- H10K85/111—Organic polymers or oligomers comprising aromatic, heteroaromatic, or aryl chains, e.g. polyaniline, polyphenylene or polyphenylene vinylene
- H10K85/113—Heteroaromatic compounds comprising sulfur or selene, e.g. polythiophene
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K85/00—Organic materials used in the body or electrodes of devices covered by this subclass
- H10K85/10—Organic polymers or oligomers
- H10K85/111—Organic polymers or oligomers comprising aromatic, heteroaromatic, or aryl chains, e.g. polyaniline, polyphenylene or polyphenylene vinylene
- H10K85/114—Poly-phenylenevinylene; Derivatives thereof
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K85/00—Organic materials used in the body or electrodes of devices covered by this subclass
- H10K85/60—Organic compounds having low molecular weight
- H10K85/649—Aromatic compounds comprising a hetero atom
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Evolutionary Biology (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Mathematical Physics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Evolutionary Computation (AREA)
- Data Mining & Analysis (AREA)
- Software Systems (AREA)
- Computational Linguistics (AREA)
- Biomedical Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Artificial Intelligence (AREA)
- Genetics & Genomics (AREA)
- Computing Systems (AREA)
- Biochemistry (AREA)
- Manufacturing & Machinery (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Multi Processors (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nonwoven Fabrics (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Battery Electrode And Active Subsutance (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12131297A IL121312A (he) | 1997-07-14 | 1997-07-14 | קומפוננטות מיקראולקטרוניות, ייצורן ורשתות אלקטרוניות המכילות אותן |
| EP98932493A EP0998759A1 (en) | 1997-07-14 | 1998-07-14 | Microelectronic components and electronic networks comprising dna |
| PCT/IL1998/000329 WO1999004440A1 (en) | 1997-07-14 | 1998-07-14 | Microelectronic components and electronic networks comprising dna |
| CNB98807205XA CN1327539C (zh) | 1997-07-14 | 1998-07-14 | 微电子元件和包括dna的电子网络 |
| JP2000503562A JP4611515B2 (ja) | 1997-07-14 | 1998-07-14 | 電気的ネットワークおよびその作製方法 |
| CA002296085A CA2296085C (en) | 1997-07-14 | 1998-07-14 | Microelectronic components and electronic networks comprising dna |
| RU2000103269/28A RU2213393C2 (ru) | 1997-07-14 | 1998-07-14 | Электронная сеть, содержащая нуклеотидные волокна, способ её изготовления и электронная схема, включающая указанную сеть |
| AU82397/98A AU749432B2 (en) | 1997-07-14 | 1998-07-14 | Microelectronic components and electronic networks comprising DNA |
| EP04077478.8A EP1492172B1 (en) | 1997-07-14 | 1998-07-14 | Microelectronic components and electronic networks comprising DNA |
| US09/462,171 US6946675B2 (en) | 1997-07-14 | 1999-01-28 | Microelectronic components and electronic networks comprising DNA |
| US10/985,961 US20050214806A1 (en) | 1997-07-14 | 2004-11-12 | Microelectronic components and electronic networks comprising DNA |
| US14/746,244 US20150372245A1 (en) | 1997-07-14 | 2015-06-22 | Microelectronic components and electronic networks comprising dna |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12131297A IL121312A (he) | 1997-07-14 | 1997-07-14 | קומפוננטות מיקראולקטרוניות, ייצורן ורשתות אלקטרוניות המכילות אותן |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL121312A0 IL121312A0 (en) | 1998-01-04 |
| IL121312A true IL121312A (he) | 2001-09-13 |
Family
ID=11070390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12131297A IL121312A (he) | 1997-07-14 | 1997-07-14 | קומפוננטות מיקראולקטרוניות, ייצורן ורשתות אלקטרוניות המכילות אותן |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6946675B2 (he) |
| EP (2) | EP1492172B1 (he) |
| JP (1) | JP4611515B2 (he) |
| CN (1) | CN1327539C (he) |
| AU (1) | AU749432B2 (he) |
| CA (1) | CA2296085C (he) |
| IL (1) | IL121312A (he) |
| RU (1) | RU2213393C2 (he) |
| WO (1) | WO1999004440A1 (he) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030203394A1 (en) * | 1998-05-04 | 2003-10-30 | Yoav Eichen | Detection of a target in a sample |
| US6664103B2 (en) * | 1998-05-20 | 2003-12-16 | Integrated Nano-Technologies, Llc | Chemically assembled nano-scale circuit elements |
| CA2328593C (en) * | 1998-05-20 | 2011-07-12 | Integrated Nano-Technologies, Llc | Chemically assembled nano-scale devices |
| IL126776A (he) | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | שיטה להשקעת זהב |
| DE19964220C2 (de) | 1998-11-23 | 2003-07-03 | Friz Biochem Gmbh | Verfahren zur Herstellung einer modifizierten leitfähigen Oberfläche |
| DE19901761A1 (de) * | 1999-01-18 | 1999-07-01 | Gerhard Dr Hartwich | Verfahren zur elektrochemischen Detektion von Nukleinsäure-Oligomer-Hybridisierungsereignissen |
| EP1196629A2 (en) * | 1999-04-07 | 2002-04-17 | Dennis Michael Connolly | High resolution dna detection methods and devices |
| US7364920B2 (en) | 1999-10-27 | 2008-04-29 | Technion Research And Development Foundation Ltd. | Method for gold deposition |
| IL134295A0 (en) * | 2000-01-31 | 2001-04-30 | Yeda Res & Dev | A hybrid organic-inorganic semiconductor device and a method of its fabrication |
| AU2001275420A1 (en) * | 2000-06-09 | 2001-12-17 | Purdue Research Foundation | Bio-mediated assembly of micrometer-scale and nanometer-scale structures |
| WO2002003482A1 (de) * | 2000-07-04 | 2002-01-10 | Infineon Technologies Ag | Feldeffekttransistor |
| AU2001275984A1 (en) * | 2000-07-20 | 2002-02-05 | President And Fellows Of Harvard College | Self-assembled electrical networks |
| DE60014678T2 (de) | 2000-11-24 | 2005-10-13 | Sony International (Europe) Gmbh | Verfahren zur selektiven Metallisierung von Nukleinsäuren durch in-situ hergestellter metallischen Nanopartikeln |
| US7176482B1 (en) | 2000-11-28 | 2007-02-13 | Ramot At Tel-Aviv University | DNA-based electronics |
| US7250147B2 (en) | 2001-01-29 | 2007-07-31 | Tour James M | Process for derivatizing carbon nanotubes with diazonium species |
| GB2412370B (en) * | 2001-01-29 | 2005-11-09 | Univ Rice William M | Process for derivatizing carbon nanotubes with diazonium species and compositions thereof |
| DE10113550A1 (de) * | 2001-03-20 | 2002-10-02 | Infineon Technologies Ag | Verfahren zum Erfassen von makromolekularen Biopolymeren mittels einer Elektrodenanordnung |
| WO2002082544A2 (en) * | 2001-04-03 | 2002-10-17 | Carnegie Mellon University | Electronic circuit device, system and method |
| JP4886160B2 (ja) | 2001-05-07 | 2012-02-29 | アドバンスト・マイクロ・ディバイシズ・インコーポレイテッド | セルフアセンブリによるポリマーフィルムを用いた記憶装置およびその製造方法 |
| EP1390984B1 (en) | 2001-05-07 | 2009-08-26 | Advanced Micro Devices, Inc. | Floating gate memory device using composite molecular material |
| AU2002340795A1 (en) | 2001-05-07 | 2002-11-18 | Advanced Micro Devices, Inc. | Reversible field-programmable electric interconnects |
| US6873540B2 (en) | 2001-05-07 | 2005-03-29 | Advanced Micro Devices, Inc. | Molecular memory cell |
| AU2002340793A1 (en) * | 2001-05-07 | 2002-11-18 | Coatue Corporation | Molecular memory device |
| KR100895901B1 (ko) | 2001-05-07 | 2009-05-04 | 어드밴스드 마이크로 디바이시즈, 인코포레이티드 | 메모리 효과를 갖는 스위치 요소 |
| EP1389350A1 (en) * | 2001-05-24 | 2004-02-18 | University of Saskatchewan Technologies Inc. | Nucleic acid circuit elements and methods |
| US20030018179A1 (en) * | 2001-06-22 | 2003-01-23 | Technische Universitat Dresden | Method for generating nucleation centers for selective heterogeneous growth of metal clusters on DNA molecules |
| EP1283526B1 (en) | 2001-08-03 | 2004-10-13 | Sony International (Europe) GmbH | Metallisation of nucleic acids via metal nanoparticles produced ex-situ |
| US20030040000A1 (en) * | 2001-08-08 | 2003-02-27 | Connolly Dennis M. | Methods for attaching nucleic acid molecules to electrically conductive surfaces |
| WO2003017282A1 (fr) | 2001-08-13 | 2003-02-27 | Advanced Micro Devices, Inc. | Cellule de memoire |
| US6806526B2 (en) | 2001-08-13 | 2004-10-19 | Advanced Micro Devices, Inc. | Memory device |
| US6768157B2 (en) | 2001-08-13 | 2004-07-27 | Advanced Micro Devices, Inc. | Memory device |
| US6838720B2 (en) | 2001-08-13 | 2005-01-04 | Advanced Micro Devices, Inc. | Memory device with active passive layers |
| US6858481B2 (en) | 2001-08-13 | 2005-02-22 | Advanced Micro Devices, Inc. | Memory device with active and passive layers |
| DE10155054C2 (de) * | 2001-11-09 | 2003-10-23 | Friz Biochem Gmbh | Molekulares elektronisches Bauelement zum Aufbau nanoelektronischer Schaltungen, molekulare elektronische Baugruppe, elektronische Schaltung und Herstellungsverfahren |
| ES2191553B2 (es) * | 2002-01-22 | 2005-02-01 | Universitat Rovira I Virgili | Metodo para la fabricacion de chips para la deteccion de analitos. |
| JP4862950B2 (ja) * | 2002-07-02 | 2012-01-25 | ソニー株式会社 | 半導体装置及びその製造方法 |
| JP4635410B2 (ja) | 2002-07-02 | 2011-02-23 | ソニー株式会社 | 半導体装置及びその製造方法 |
| US6848092B2 (en) * | 2002-08-03 | 2005-01-25 | Texas Instruments Incorporated | Layout of networks using parallel and series elements |
| US7012276B2 (en) | 2002-09-17 | 2006-03-14 | Advanced Micro Devices, Inc. | Organic thin film Zener diodes |
| DE60312892T2 (de) * | 2002-12-23 | 2007-12-06 | University Of Saskatchewan, Saskatoon | Chemische schaltung von nukleinsäureschaltungselementen |
| JP2004235618A (ja) * | 2003-01-10 | 2004-08-19 | Sanyo Electric Co Ltd | カーボンナノチューブを用いた配線、単一電子トランジスタおよびキャパシタ |
| US20050164371A1 (en) * | 2003-03-28 | 2005-07-28 | Fujitsu Limited | Cavity electrode structure, and sensor and protein detection device using the same |
| WO2005065290A2 (en) * | 2003-12-30 | 2005-07-21 | Integrated Nano-Technologies, Llc | Metallization of nucleic acids by metal sols, and uses thereof |
| JP2005335054A (ja) * | 2004-04-27 | 2005-12-08 | Japan Science & Technology Agency | 金属ナノワイヤー及びその製造方法 |
| US20060019273A1 (en) * | 2004-05-12 | 2006-01-26 | Connolly Dennis M | Detection card for analyzing a sample for a target nucleic acid molecule, and uses thereof |
| EP1630882B1 (en) | 2004-08-31 | 2012-05-02 | STMicroelectronics S.r.l. | Nanometric structure and corresponding manufacturing method |
| DE602004016496D1 (de) | 2004-08-31 | 2008-10-23 | St Microelectronics Srl | Verfahren zur Herstellung einer Wirtsstruktur für nanometergroße Elemente |
| EP1630881B1 (en) | 2004-08-31 | 2011-11-16 | STMicroelectronics Srl | Hosting structure of nanometric elements and corresponding manufacturing method |
| EP1922419A4 (en) | 2005-06-10 | 2010-11-17 | Life Technologies Corp | METHOD AND SYSTEM FOR GENETIC MULTIPLEX ANALYSIS |
| KR101195612B1 (ko) * | 2006-04-10 | 2012-10-29 | 삼성전자주식회사 | 금층을 포함하는 전계 효과 트랜지스터, 상기 전계 효과 트랜지스터를 포함하는 미세유동장치, 및 상기 전계 효과 트랜지스터 및 미세유동장치를 이용하여 티올기를 포함하는 분석물을 검출하는 방법 |
| US8951473B2 (en) | 2008-03-04 | 2015-02-10 | Massachusetts Institute Of Technology | Devices and methods for determination of species including chemical warfare agents |
| KR101062416B1 (ko) * | 2008-10-09 | 2011-09-06 | 성균관대학교산학협력단 | 나노 소자의 형성방법 |
| WO2010123482A2 (en) * | 2008-12-12 | 2010-10-28 | Massachusetts Institute Of Technology | High charge density structures, including carbon-based nanostructures and applications thereof |
| WO2011056936A2 (en) * | 2009-11-04 | 2011-05-12 | Massachusetts Institute Of Technology | Nanostructured devices including analyte detectors, and related methods |
| EP2635525A2 (en) | 2010-11-03 | 2013-09-11 | Massachusetts Institute Of Technology | Compositions comprising functionalized carbon-based nanostructures and related methods |
| WO2013040190A1 (en) | 2011-09-16 | 2013-03-21 | The Research Foundation Of State University Of New York | Low concentration ammonia nanosensor |
| RU2509157C2 (ru) * | 2011-10-26 | 2014-03-10 | Закрытое акционерное общество "КАРСИ" (ЗАО "КАРСИ") | Способ детекции специфических последовательностей нуклеиновых кислот (варианты) и устройство для его осуществления |
| EP2831915A4 (en) * | 2012-03-28 | 2016-08-17 | David Bobbak Zakariaie | DNA COMPUTING |
| RU2491631C1 (ru) * | 2012-04-02 | 2013-08-27 | Максим Петрович Никитин | Комплекс логического элемента на основе биомолекул (варианты) |
| TWI514566B (zh) * | 2012-09-19 | 2015-12-21 | Univ Nat Chiao Tung | 半導體生物奈米線裝置及其製作方法 |
| US20150004599A1 (en) * | 2013-06-27 | 2015-01-01 | Verizon Patent And Licensing Inc. | Real-time dna-based identity solution |
| US9275871B2 (en) | 2014-01-09 | 2016-03-01 | Micron Technology, Inc. | Nanostructures having low defect density and methods of forming thereof |
| US9881786B2 (en) * | 2015-04-02 | 2018-01-30 | Micron Technology, Inc. | Methods of forming nanostructures using self-assembled nucleic acids, and nanostructures thereof |
| US9761806B1 (en) * | 2016-09-23 | 2017-09-12 | International Business Machines Corporation | Sensors with integrated data processing circuitry |
| US11505467B2 (en) | 2017-11-06 | 2022-11-22 | Massachusetts Institute Of Technology | High functionalization density graphene |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3833894A (en) * | 1973-06-20 | 1974-09-03 | Ibm | Organic memory device |
| US4314821A (en) * | 1979-04-09 | 1982-02-09 | Minnesota Mining And Manufacturing Company | Sandwich immunoassay using piezoelectric oscillator |
| US4822566A (en) * | 1985-11-19 | 1989-04-18 | The Johns Hopkins University | Optimized capacitive sensor for chemical analysis and measurement |
| US5137827A (en) * | 1986-03-25 | 1992-08-11 | Midwest Research Technologies, Inc. | Diagnostic element for electrical detection of a binding reaction |
| US4703016A (en) * | 1986-05-05 | 1987-10-27 | The United States Of America As Represented By The Department Of Health And Human Services | Silver stain for rapid, quantitative detection of polypeptides and nucleic acids |
| US4826784A (en) * | 1987-11-13 | 1989-05-02 | Kopin Corporation | Selective OMCVD growth of compound semiconductor materials on silicon substrates |
| US5063417A (en) * | 1988-07-18 | 1991-11-05 | California Institute Of Technology | Molecular shift register based on electron transfer |
| US4995402A (en) | 1988-10-12 | 1991-02-26 | Thorne, Smith, Astill Technologies, Inc. | Medical droplet whole blood and like monitoring |
| CA2002660A1 (en) | 1988-11-10 | 1990-05-10 | Susan J. Mroczkowski | Method for electrical detection of a binding reaction |
| US5089545A (en) * | 1989-02-12 | 1992-02-18 | Biotech International, Inc. | Switching and memory elements from polyamino acids and the method of their assembly |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5156810A (en) * | 1989-06-15 | 1992-10-20 | Biocircuits Corporation | Biosensors employing electrical, optical and mechanical signals |
| DE3924454A1 (de) * | 1989-07-24 | 1991-02-07 | Cornelis P Prof Dr Hollenberg | Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips) |
| CA2034266A1 (en) | 1990-02-27 | 1991-08-28 | Paul A. D'orazio | Thick film reagent spreading and reagent immobilization layer |
| JPH04222599A (ja) * | 1990-04-20 | 1992-08-12 | Syntex Usa Inc | 二重受容体ポリヌクレオチド検定方法 |
| HU218095B (hu) * | 1990-05-01 | 2000-05-28 | Amgen Inc. | Eljárás átvitt szennyeződések csökkentésére, amplifikációs eljárásokban |
| JP3064001B2 (ja) | 1990-10-09 | 2000-07-12 | 株式会社アドバンス | 分子固定装置 |
| US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
| JP2778304B2 (ja) * | 1991-09-17 | 1998-07-23 | 三菱電機株式会社 | 有機電子素子材料 |
| US6051380A (en) | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
| US5787032A (en) * | 1991-11-07 | 1998-07-28 | Nanogen | Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group |
| US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| ATE251361T1 (de) * | 1992-06-01 | 2003-10-15 | Univ Yale | Elektronischer schaltkreis im nanobereich und verfahren zu dessen herstellung |
| US5331183A (en) * | 1992-08-17 | 1994-07-19 | The Regents Of The University Of California | Conjugated polymer - acceptor heterojunctions; diodes, photodiodes, and photovoltaic cells |
| US5312527A (en) * | 1992-10-06 | 1994-05-17 | Concordia University | Voltammetric sequence-selective sensor for target polynucleotide sequences |
| AU684748B2 (en) * | 1993-01-21 | 1998-01-08 | Hybridon, Inc. | Foldback triplex-forming oligonucleotides |
| US5858659A (en) * | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| US5837546A (en) * | 1993-08-24 | 1998-11-17 | Metrika, Inc. | Electronic assay device and method |
| US5591578A (en) * | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5952172A (en) * | 1993-12-10 | 1999-09-14 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5824473A (en) * | 1993-12-10 | 1998-10-20 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US6071699A (en) * | 1996-06-07 | 2000-06-06 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5561043A (en) | 1994-01-31 | 1996-10-01 | Trustees Of Boston University | Self-assembling multimeric nucleic acid constructs |
| US5563424A (en) * | 1994-03-24 | 1996-10-08 | Uniax Corporation | Polymer grid triodes |
| WO1996030508A1 (en) | 1995-03-24 | 1996-10-03 | Ely Michael Rabani | Assembly of complex molecular and supramolecular objects and devices and uses thereof |
| JPH0973780A (ja) * | 1995-09-01 | 1997-03-18 | Toshiba Corp | 半導体集積回路 |
| US5888370A (en) * | 1996-02-23 | 1999-03-30 | Board Of Regents, The University Of Texas System | Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation |
| EP0990149A4 (en) | 1996-05-22 | 2003-02-26 | Au Membrane & Biotech Res Inst | NUCLEIC ACID SENSOR |
| US5948897A (en) * | 1996-06-14 | 1999-09-07 | Simon Fraser University | Method of binding two or more DNA double helices and products formed |
| US5787332A (en) * | 1996-09-26 | 1998-07-28 | Fansteel Inc. | Process for recovering tantalum and/or niobium compounds from composites containing a variety of metal compounds |
| US5874046A (en) * | 1996-10-30 | 1999-02-23 | Raytheon Company | Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences |
| US6306584B1 (en) | 1997-01-21 | 2001-10-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
| US5946550A (en) * | 1997-03-14 | 1999-08-31 | University Of Connecticut | Self-assembled semiconductor and method of making same |
| US6210880B1 (en) * | 1997-09-19 | 2001-04-03 | Third Wave Technologies, Inc. | Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides |
| WO1998053841A1 (en) | 1997-05-27 | 1998-12-03 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Scaffold-organized metal, alloy, semiconductor and/or magnetic clusters and electronic devices made using such clusters |
| US6013459A (en) * | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| US20020025552A1 (en) | 1998-01-06 | 2002-02-28 | Institut Pasteur | Screening interactor molecules with whole genome oligonucleotide or polynucleotide arrays |
| AU2559599A (en) | 1998-01-20 | 1999-08-02 | Bruce Parkinson | Detection of genetic information |
| US6060023A (en) * | 1998-03-31 | 2000-05-09 | Motorola, Inc. | Molecular sensing apparatus |
| IL124322A (en) | 1998-05-04 | 2002-05-23 | Technion Res & Dev Foundation | Detection of an entity in a sample |
| CA2328593C (en) | 1998-05-20 | 2011-07-12 | Integrated Nano-Technologies, Llc | Chemically assembled nano-scale devices |
| US6093370A (en) * | 1998-06-11 | 2000-07-25 | Hitachi, Ltd. | Polynucleotide separation method and apparatus therefor |
| IL126776A (he) | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | שיטה להשקעת זהב |
| EP1196629A2 (en) * | 1999-04-07 | 2002-04-17 | Dennis Michael Connolly | High resolution dna detection methods and devices |
-
1997
- 1997-07-14 IL IL12131297A patent/IL121312A/he not_active IP Right Cessation
-
1998
- 1998-07-14 CN CNB98807205XA patent/CN1327539C/zh not_active Expired - Fee Related
- 1998-07-14 RU RU2000103269/28A patent/RU2213393C2/ru not_active IP Right Cessation
- 1998-07-14 WO PCT/IL1998/000329 patent/WO1999004440A1/en active IP Right Grant
- 1998-07-14 CA CA002296085A patent/CA2296085C/en not_active Expired - Fee Related
- 1998-07-14 EP EP04077478.8A patent/EP1492172B1/en not_active Expired - Lifetime
- 1998-07-14 EP EP98932493A patent/EP0998759A1/en not_active Withdrawn
- 1998-07-14 JP JP2000503562A patent/JP4611515B2/ja not_active Expired - Fee Related
- 1998-07-14 AU AU82397/98A patent/AU749432B2/en not_active Ceased
-
1999
- 1999-01-28 US US09/462,171 patent/US6946675B2/en not_active Expired - Lifetime
-
2004
- 2004-11-12 US US10/985,961 patent/US20050214806A1/en not_active Abandoned
-
2015
- 2015-06-22 US US14/746,244 patent/US20150372245A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150372245A1 (en) | 2015-12-24 |
| AU749432B2 (en) | 2002-06-27 |
| JP4611515B2 (ja) | 2011-01-12 |
| US20050214806A1 (en) | 2005-09-29 |
| CA2296085A1 (en) | 1999-01-28 |
| CA2296085C (en) | 2008-10-07 |
| CN1264498A (zh) | 2000-08-23 |
| US20020171079A1 (en) | 2002-11-21 |
| EP0998759A1 (en) | 2000-05-10 |
| IL121312A0 (en) | 1998-01-04 |
| EP1492172A1 (en) | 2004-12-29 |
| JP2001510922A (ja) | 2001-08-07 |
| WO1999004440A1 (en) | 1999-01-28 |
| EP1492172B1 (en) | 2016-04-27 |
| US6946675B2 (en) | 2005-09-20 |
| AU8239798A (en) | 1999-02-10 |
| RU2213393C2 (ru) | 2003-09-27 |
| CN1327539C (zh) | 2007-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6946675B2 (en) | Microelectronic components and electronic networks comprising DNA | |
| Kwon et al. | Materials science of DNA | |
| Cai et al. | Nanowire-based molecular monolayer junctions: synthesis, assembly, and electrical characterization | |
| Jiang et al. | Nanoscaled surface patterning of conducting polymers | |
| Dai et al. | DNA-based fabrication for nanoelectronics | |
| Hui et al. | DNA‐based nanofabrication for nanoelectronics | |
| EP0987653A2 (en) | Self assembled nano-devices using DNA | |
| Weiss et al. | The study of charge transport through organic thin films: mechanism, tools and applications | |
| US20050041458A1 (en) | Molecular electronic component used to construct nanoelectronic circuits, molecular electronic component, electronic circuit and method for producing the same | |
| Shao et al. | DNA-templated assembly and electropolymerization of aniline on gold surface | |
| Ghosh et al. | Metal‐Complex/DNA Conjugates: A Versatile Building Block for DNA Nanoarrays | |
| Björk et al. | Soft lithographic printing of patterns of stretched DNA and DNA/electronic polymer wires by surface‐energy modification and transfer | |
| Hu et al. | Polymer Light‐Emitting Electrochemical Cells with Bipolar Electrode‐Dynamic Doping and Wireless Electroluminescence | |
| Wu et al. | Rotaxane nanomachines in future molecular electronics | |
| Nakao et al. | Fabricating and aligning π-conjugated polymer-functionalized DNA nanowires: atomic force microscopic and scanning near-field optical microscopic studies | |
| CN102067350B (zh) | 功能性分子元件、其制造方法以及功能性分子装置 | |
| US6989290B2 (en) | Electrical contacts for molecular electronic transistors | |
| WO2002021576A2 (en) | Organic nanoelectric conductors | |
| Björk et al. | Biomolecular nanowires decorated by organic electronic polymers | |
| Li et al. | Intrinsically conducting polymers (ICPs) | |
| Wibowo | DNA molecular wire-based nanoelectronics: new insight and high frequency AC electrical characterization | |
| Keren et al. | Sequence‐Specific Molecular Lithography Towards DNA‐Templated Electronics | |
| Szymonik et al. | DNA self-assembly-driven positioning of molecular components on nanopatterned surfaces | |
| Wang et al. | DNA‐Based Conductors: From Materials Design to Ultra‐Scaled Electronics | |
| Bilby et al. | Self‐Assembly of Conjugated Polymers and their Application to Biosensors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |