IL120727A - History of N amidino piperidinyl methylamine - Google Patents

History of N amidino piperidinyl methylamine

Info

Publication number
IL120727A
IL120727A IL12072793A IL12072793A IL120727A IL 120727 A IL120727 A IL 120727A IL 12072793 A IL12072793 A IL 12072793A IL 12072793 A IL12072793 A IL 12072793A IL 120727 A IL120727 A IL 120727A
Authority
IL
Israel
Prior art keywords
methyl
amino
ethyl
butyl
imino
Prior art date
Application number
IL12072793A
Other languages
English (en)
Hebrew (he)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL120727A publication Critical patent/IL120727A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL12072793A 1992-03-06 1993-03-01 History of N amidino piperidinyl methylamine IL120727A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH72892 1992-03-06
CH18093 1993-01-21
IL104893A IL104893A0 (en) 1992-03-06 1993-03-01 Sulphonamido-carboxamides,their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
IL120727A true IL120727A (en) 1998-08-16

Family

ID=25683792

Family Applications (3)

Application Number Title Priority Date Filing Date
IL104893A IL104893A0 (en) 1992-03-06 1993-03-01 Sulphonamido-carboxamides,their preparation and pharmaceutical compositions containing them
IL12072793A IL120727A (en) 1992-03-06 1993-03-01 History of N amidino piperidinyl methylamine
IL12072797A IL120727A0 (en) 1992-03-06 1997-04-25 Guanidine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL104893A IL104893A0 (en) 1992-03-06 1993-03-01 Sulphonamido-carboxamides,their preparation and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL12072797A IL120727A0 (en) 1992-03-06 1997-04-25 Guanidine derivatives

Country Status (24)

Country Link
US (4) US5405854A (zh)
EP (1) EP0559046B1 (zh)
JP (1) JPH0780848B2 (zh)
CN (1) CN1076690A (zh)
AT (1) ATE203013T1 (zh)
AU (1) AU665230B2 (zh)
BG (1) BG61506B1 (zh)
CA (1) CA2089972C (zh)
CZ (1) CZ286926B6 (zh)
DE (1) DE59310186D1 (zh)
DK (1) DK0559046T3 (zh)
ES (1) ES2161217T3 (zh)
FI (1) FI103880B1 (zh)
GR (1) GR3036870T3 (zh)
HU (2) HUT70156A (zh)
IL (3) IL104893A0 (zh)
IS (1) IS3983A (zh)
MY (1) MY131303A (zh)
NO (1) NO302818B1 (zh)
NZ (1) NZ247014A (zh)
PT (1) PT559046E (zh)
RO (1) RO112863B1 (zh)
RU (1) RU2133739C1 (zh)
TW (1) TW223629B (zh)

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TW201303B (zh) * 1990-07-05 1993-03-01 Hoffmann La Roche
TW223629B (zh) * 1992-03-06 1994-05-11 Hoffmann La Roche
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US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
TW394760B (en) * 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
US5536867A (en) * 1994-04-27 1996-07-16 Hoffmann-La Roche Inc. Process for the manufacture of dicarboxamides
EP0684238A3 (en) * 1994-04-27 1997-01-15 Hoffmann La Roche Process for the preparation of dicarboxamides.
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US5610308A (en) * 1995-05-18 1997-03-11 Bristol-Myers Squibb Company Process for preparing intermediates for thrombin inhibitors
WO1997001338A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
WO1997005108A1 (fr) 1995-07-26 1997-02-13 Mitsubishi Chemical Corporation Derives de penicillinamine amide
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JP2000503010A (ja) 1995-12-29 2000-03-14 スリー―ダイメンショナル・ファーマスーティカルス・インコーポレーテッド アミジノプロテアーゼ阻害剤
ZA9756B (en) * 1996-01-16 1997-07-17 Warner Lambert Co Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines
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SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
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US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
US6756389B2 (en) * 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
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US9988421B2 (en) 2014-01-10 2018-06-05 Cornell University Dipeptides as inhibitors of human immunoproteasomes
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Also Published As

Publication number Publication date
EP0559046B1 (de) 2001-07-11
US5578594A (en) 1996-11-26
US5763604A (en) 1998-06-09
DK0559046T3 (da) 2001-11-05
MY131303A (en) 2007-08-30
AU3391693A (en) 1993-09-09
CZ34693A3 (en) 1993-12-15
NZ247014A (en) 1995-11-27
TW223629B (zh) 1994-05-11
IL104893A0 (en) 1993-07-08
IL120727A0 (en) 1997-08-14
US5677448A (en) 1997-10-14
HUT70156A (en) 1995-09-28
JPH0780848B2 (ja) 1995-08-30
CA2089972C (en) 1999-06-08
RU2133739C1 (ru) 1999-07-27
NO930819L (no) 1993-09-07
FI103880B (fi) 1999-10-15
FI930990A (fi) 1993-09-07
FI103880B1 (fi) 1999-10-15
HU211252A9 (en) 1995-11-28
CN1076690A (zh) 1993-09-29
ATE203013T1 (de) 2001-07-15
BG97493A (bg) 1994-03-24
CA2089972A1 (en) 1993-09-07
EP0559046A1 (de) 1993-09-08
GR3036870T3 (en) 2002-01-31
NO930819D0 (no) 1993-03-05
FI930990A0 (fi) 1993-03-05
PT559046E (pt) 2002-01-30
US5405854A (en) 1995-04-11
BG61506B1 (bg) 1997-10-31
ES2161217T3 (es) 2001-12-01
AU665230B2 (en) 1995-12-21
RO112863B1 (ro) 1998-01-30
IS3983A (is) 1993-09-07
CZ286926B6 (en) 2000-08-16
HU9300572D0 (en) 1993-05-28
JPH0625195A (ja) 1994-02-01
NO302818B1 (no) 1998-04-27
DE59310186D1 (de) 2001-08-16

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