IL117519A - Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them - Google Patents
Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising themInfo
- Publication number
- IL117519A IL117519A IL11751996A IL11751996A IL117519A IL 117519 A IL117519 A IL 117519A IL 11751996 A IL11751996 A IL 11751996A IL 11751996 A IL11751996 A IL 11751996A IL 117519 A IL117519 A IL 117519A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen
- pharmaceutical compositions
- alkylcarbonyl
- hydroxy
- integer
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- FYKGUURZJVYPQE-UHFFFAOYSA-N 1-(1-benzothiophen-2-yl)piperazine Chemical class C1CNCCN1C1=CC2=CC=CC=C2S1 FYKGUURZJVYPQE-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- -1 benzothienylcarbonyl Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41381895A | 1995-03-17 | 1995-03-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL117519A0 IL117519A0 (en) | 1996-07-23 |
| IL117519A true IL117519A (en) | 2000-08-31 |
Family
ID=23638775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11751996A IL117519A (en) | 1995-03-17 | 1996-03-17 | Substituted benzothienylpiperazines their preparation and pharmaceutical compositions comprising them |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5801176A (cs) |
| EP (1) | EP0732332B1 (cs) |
| JP (1) | JPH093060A (cs) |
| KR (1) | KR100402510B1 (cs) |
| CN (1) | CN1082959C (cs) |
| AT (1) | ATE211137T1 (cs) |
| AU (1) | AU700077B2 (cs) |
| CA (1) | CA2171695A1 (cs) |
| CZ (1) | CZ80496A3 (cs) |
| DE (1) | DE69618050T2 (cs) |
| DK (1) | DK0732332T3 (cs) |
| ES (1) | ES2170177T3 (cs) |
| HU (1) | HUP9600665A3 (cs) |
| IL (1) | IL117519A (cs) |
| NO (1) | NO315652B1 (cs) |
| NZ (1) | NZ286186A (cs) |
| PL (1) | PL182310B1 (cs) |
| PT (1) | PT732332E (cs) |
| RO (1) | RO117453B1 (cs) |
| RU (1) | RU2157371C2 (cs) |
| SG (1) | SG54269A1 (cs) |
| TW (1) | TW328957B (cs) |
| ZA (1) | ZA962075B (cs) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703083A (en) * | 1996-04-15 | 1997-12-30 | Neurogen Corporation | N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands |
| AU5567000A (en) * | 1999-06-24 | 2001-01-09 | Toray Industries, Inc. | Alpha1b-adrenergic receptor antagonists |
| GB0117531D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands |
| EP1392676B1 (en) * | 2001-02-16 | 2006-12-13 | Aventis Pharmaceuticals Inc. | Heterocyclic urea derivatives and their use as dopamine d3 receptor ligands |
| JP4497815B2 (ja) * | 2001-02-16 | 2010-07-07 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 新規な複素環式アミド誘導体およびドーパミンｄ３受容体リガンドとしてのその使用 |
| WO2002078669A1 (fr) * | 2001-03-30 | 2002-10-10 | Takeda Chemical Industries, Ltd. | Solutions medicinales |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| AR055203A1 (es) | 2005-08-31 | 2007-08-08 | Otsuka Pharma Co Ltd | Derivados de benzotiofeno con propiedades antipsicoticas |
| CN105985314A (zh) * | 2015-02-05 | 2016-10-05 | 苏州旺山旺水生物医药有限公司 | 布瑞哌唑类似物的制备方法 |
| KR20220120625A (ko) * | 2019-12-24 | 2022-08-30 | 스미토모 파마 가부시키가이샤 | 지방족 산 아미드 유도체 |
| JP7655885B2 (ja) * | 2021-06-30 | 2025-04-02 | 住友ファーマ株式会社 | 脂肪族酸アミド誘導体を含有する医薬組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU577802B2 (en) * | 1983-10-17 | 1988-10-06 | Duphar International Research B.V. | Blood-pressure lowering piperazine derivatives |
| ATE81123T1 (de) * | 1987-11-20 | 1992-10-15 | Hoechst Roussel Pharma | 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel. |
| US5001130A (en) * | 1988-02-18 | 1991-03-19 | Bristol-Myers Company | Psychotropic heterobicycloalkylpiperazine derivatives |
| US4780466A (en) * | 1988-03-17 | 1988-10-25 | Hoechst-Roussel Pharmaceuticals, Inc. | Arylpiperazinylalkoxy derivatives of cyclic imides |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| US4968792A (en) * | 1989-09-25 | 1990-11-06 | American Home Products Corporation | Psychotropic benzisothiazole derivatives |
| US5143923B1 (en) * | 1991-04-29 | 1993-11-02 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
| RU2024520C1 (ru) * | 1991-10-08 | 1994-12-15 | Институт органической химии Уральского отделения РАН | 10-метокси-5- метил-6- (1',1'- диоксидо-2'- метахлорфенилазо -3'- гидрокси -4'-метоксибензо(в)тиофен- 7-ил) -5h-3,4,6,7- тетрагидрофуро [4.3.2-q] [3]бензазоцин, обладающий антидепрессивным действием |
| GB9202915D0 (en) * | 1992-02-12 | 1992-03-25 | Wellcome Found | Chemical compounds |
| US5240927A (en) * | 1992-05-19 | 1993-08-31 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzo[β]thiophen-3-yl piperazines as antipsychotic agents |
| GB9302622D0 (en) * | 1993-02-10 | 1993-03-24 | Wellcome Found | Heteroaromatic compounds |
| US5395835A (en) * | 1994-03-24 | 1995-03-07 | Warner-Lambert Company | Naphthalamides as central nervous system agents |
| GB9410031D0 (en) * | 1994-05-19 | 1994-07-06 | Merck Sharp & Dohme | Therapeutic agents |
-
1996
- 1996-03-11 EP EP96103772A patent/EP0732332B1/en not_active Expired - Lifetime
- 1996-03-11 PT PT96103772T patent/PT732332E/pt unknown
- 1996-03-11 DE DE69618050T patent/DE69618050T2/de not_active Expired - Fee Related
- 1996-03-11 DK DK96103772T patent/DK0732332T3/da active
- 1996-03-11 ES ES96103772T patent/ES2170177T3/es not_active Expired - Lifetime
- 1996-03-11 AT AT96103772T patent/ATE211137T1/de not_active IP Right Cessation
- 1996-03-12 SG SG1996006846A patent/SG54269A1/en unknown
- 1996-03-13 CA CA002171695A patent/CA2171695A1/en not_active Abandoned
- 1996-03-14 AU AU48113/96A patent/AU700077B2/en not_active Ceased
- 1996-03-14 ZA ZA9602075A patent/ZA962075B/xx unknown
- 1996-03-14 PL PL96313251A patent/PL182310B1/pl unknown
- 1996-03-14 HU HU9600665A patent/HUP9600665A3/hu unknown
- 1996-03-15 RU RU96104547/04A patent/RU2157371C2/ru not_active IP Right Cessation
- 1996-03-15 CZ CZ96804A patent/CZ80496A3/cs unknown
- 1996-03-15 RO RO96-00568A patent/RO117453B1/ro unknown
- 1996-03-15 CN CN96103608A patent/CN1082959C/zh not_active Expired - Fee Related
- 1996-03-15 JP JP8058707A patent/JPH093060A/ja not_active Abandoned
- 1996-03-15 NO NO19961077A patent/NO315652B1/no not_active IP Right Cessation
- 1996-03-15 NZ NZ286186A patent/NZ286186A/en unknown
- 1996-03-16 KR KR1019960007100A patent/KR100402510B1/ko not_active Expired - Fee Related
- 1996-03-17 IL IL11751996A patent/IL117519A/xx not_active IP Right Cessation
- 1996-05-15 TW TW085105712A patent/TW328957B/zh active
-
1997
- 1997-06-06 US US08/870,988 patent/US5801176A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PL182310B1 (pl) | 2001-12-31 |
| ATE211137T1 (de) | 2002-01-15 |
| DK0732332T3 (da) | 2002-04-15 |
| RO117453B1 (ro) | 2002-03-29 |
| IL117519A0 (en) | 1996-07-23 |
| AU700077B2 (en) | 1998-12-17 |
| EP0732332B1 (en) | 2001-12-19 |
| CZ80496A3 (en) | 1996-10-16 |
| CN1082959C (zh) | 2002-04-17 |
| ZA962075B (en) | 1997-12-31 |
| HU9600665D0 (en) | 1996-05-28 |
| PL313251A1 (en) | 1996-09-30 |
| HUP9600665A3 (en) | 1998-08-28 |
| NO961077L (no) | 1996-09-18 |
| JPH093060A (ja) | 1997-01-07 |
| RU2157371C2 (ru) | 2000-10-10 |
| NO961077D0 (no) | 1996-03-15 |
| AU4811396A (en) | 1996-09-26 |
| CN1139108A (zh) | 1997-01-01 |
| EP0732332A1 (en) | 1996-09-18 |
| PT732332E (pt) | 2002-06-28 |
| HUP9600665A2 (en) | 1997-10-28 |
| DE69618050D1 (de) | 2002-01-31 |
| DE69618050T2 (de) | 2002-07-11 |
| ES2170177T3 (es) | 2002-08-01 |
| KR100402510B1 (ko) | 2004-03-18 |
| SG54269A1 (en) | 1998-11-16 |
| TW328957B (en) | 1998-04-01 |
| CA2171695A1 (en) | 1996-09-18 |
| NZ286186A (en) | 1997-07-27 |
| US5801176A (en) | 1998-09-01 |
| KR960034201A (ko) | 1996-10-22 |
| NO315652B1 (no) | 2003-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |