IL115819A - 2,3,3a, 8-Tetrahydrodiebenz[c,f] isoxazolo [2,3-a] azepine-2-alkanamines their preparation and pharmaceutical compositions containing them - Google Patents

2,3,3a, 8-Tetrahydrodiebenz[c,f] isoxazolo [2,3-a] azepine-2-alkanamines their preparation and pharmaceutical compositions containing them

Info

Publication number
IL115819A
IL115819A IL11581995A IL11581995A IL115819A IL 115819 A IL115819 A IL 115819A IL 11581995 A IL11581995 A IL 11581995A IL 11581995 A IL11581995 A IL 11581995A IL 115819 A IL115819 A IL 115819A
Authority
IL
Israel
Prior art keywords
hydrogen
formula
methyl
compound
compounds
Prior art date
Application number
IL11581995A
Other languages
English (en)
Other versions
IL115819A0 (en
Inventor
Jose Ignacio Andresgil
Francisco Javi Fernandezgadea
Pilar Gillopetegui
Theo Frans Meert
Victor Karel Sipido
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL115819A0 publication Critical patent/IL115819A0/xx
Publication of IL115819A publication Critical patent/IL115819A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL11581995A 1994-11-02 1995-10-31 2,3,3a, 8-Tetrahydrodiebenz[c,f] isoxazolo [2,3-a] azepine-2-alkanamines their preparation and pharmaceutical compositions containing them IL115819A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94203178 1994-11-02
US08/457,968 US5552399A (en) 1994-11-02 1995-05-31 Substituted tetracyclic azepine derivatives

Publications (2)

Publication Number Publication Date
IL115819A0 IL115819A0 (en) 1996-01-19
IL115819A true IL115819A (en) 1998-10-30

Family

ID=8217337

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11581995A IL115819A (en) 1994-11-02 1995-10-31 2,3,3a, 8-Tetrahydrodiebenz[c,f] isoxazolo [2,3-a] azepine-2-alkanamines their preparation and pharmaceutical compositions containing them

Country Status (30)

Country Link
US (1) US5552399A (de)
EP (1) EP0789701B1 (de)
JP (1) JP3818541B2 (de)
KR (1) KR100392060B1 (de)
CN (1) CN1085667C (de)
AR (1) AR002238A1 (de)
AT (1) ATE199087T1 (de)
AU (1) AU704285B2 (de)
BR (1) BR9509552A (de)
CA (1) CA2203661A1 (de)
CZ (1) CZ286945B6 (de)
DE (1) DE69520070T2 (de)
DK (1) DK0789701T3 (de)
ES (1) ES2155898T3 (de)
FI (1) FI113050B (de)
GR (1) GR3035680T3 (de)
HR (1) HRP950537A2 (de)
HU (1) HUT77408A (de)
IL (1) IL115819A (de)
MY (1) MY113325A (de)
NO (1) NO308035B1 (de)
NZ (1) NZ295656A (de)
PL (1) PL183686B1 (de)
PT (1) PT789701E (de)
RU (1) RU2163240C2 (de)
SI (1) SI0789701T1 (de)
TR (1) TR199501356A2 (de)
TW (1) TW349950B (de)
WO (1) WO1996014320A1 (de)
ZA (1) ZA959215B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0892804T3 (da) * 1996-04-12 2002-12-02 Janssen Pharmaceutica Nv Isoxazolidin derivater
UA52778C2 (uk) 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
HRP20020305A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
US20110086086A1 (en) * 2005-07-26 2011-04-14 Pfizer Inc Transdermal system for varenicline
US11517557B2 (en) * 2017-07-13 2022-12-06 Tonix Pharmaceuticals Holding Corp. Analogs of cyclobenzaprine and amitriptyline

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT338799B (de) * 1974-03-02 1977-09-12 Boehringer Sohn Ingelheim Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
NL7414038A (nl) * 1974-10-28 1976-05-03 Akzo Nv Nieuwe tetracyclische pyrrolidino derivaten.
DE2647114A1 (de) * 1975-10-21 1977-05-05 Hans Fickler Vorrichtung zur erzeugung einer laengsbewegung
JPS5572177A (en) * 1978-11-27 1980-05-30 Shionogi & Co Ltd 4,1-benzoxazepine or 4,1-benzothiazepine
TW206227B (de) * 1989-10-05 1993-05-21 Sankyo Co
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
MY113325A (en) 2002-01-31
EP0789701A1 (de) 1997-08-20
ATE199087T1 (de) 2001-02-15
ZA959215B (en) 1997-04-30
CN1162313A (zh) 1997-10-15
AR002238A1 (es) 1998-03-11
FI113050B (fi) 2004-02-27
PL183686B1 (pl) 2002-06-28
CZ132397A3 (cs) 1998-01-14
DE69520070D1 (de) 2001-03-15
WO1996014320A1 (en) 1996-05-17
IL115819A0 (en) 1996-01-19
FI971854A7 (fi) 1997-04-30
EP0789701B1 (de) 2001-02-07
MX9703255A (es) 1997-07-31
RU2163240C2 (ru) 2001-02-20
PT789701E (pt) 2001-07-31
CN1085667C (zh) 2002-05-29
CZ286945B6 (en) 2000-08-16
JP3818541B2 (ja) 2006-09-06
HRP950537A2 (en) 1997-08-31
NO972017L (no) 1997-04-30
NO308035B1 (no) 2000-07-10
US5552399A (en) 1996-09-03
JPH10508308A (ja) 1998-08-18
BR9509552A (pt) 1997-09-16
ES2155898T3 (es) 2001-06-01
GR3035680T3 (en) 2001-06-29
CA2203661A1 (en) 1996-05-17
AU3924995A (en) 1996-05-31
AU704285B2 (en) 1999-04-15
KR100392060B1 (ko) 2003-11-28
HUT77408A (hu) 1998-04-28
NZ295656A (en) 1998-10-28
PL319939A1 (en) 1997-09-01
FI971854A0 (fi) 1997-04-30
TW349950B (en) 1999-01-11
SI0789701T1 (en) 2001-08-31
DE69520070T2 (de) 2001-09-13
TR199501356A2 (tr) 1996-06-21
NO972017D0 (no) 1997-04-30
DK0789701T3 (da) 2001-06-18

Similar Documents

Publication Publication Date Title
US6194405B1 (en) Method of using substituted tetracyclic tetrahydrofuran derivatives
AU737334B2 (en) Halogen substituted tetracyclic tetrahydrofuran derivatives
EP0789701B1 (de) Substituierte tetracyclische azepinederivate mit 5-ht2 rezeptoraffinität
US5773433A (en) Substituted tetracyclic oxazepine and thiazepine derivatives
AU716470B2 (en) Isoxazolidine derivatives
CA2232195C (en) Isoxazolidine derivatives
HK1015771B (en) Substituted tetracyclic tetrahydrofuran derivatives

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees