IL109581A - Tetrazole derivatives of bile acids, processes for their preparation and the use of these compounds as medicaments - Google Patents

Tetrazole derivatives of bile acids, processes for their preparation and the use of these compounds as medicaments

Info

Publication number
IL109581A
IL109581A IL109581A IL10958194A IL109581A IL 109581 A IL109581 A IL 109581A IL 109581 A IL109581 A IL 109581A IL 10958194 A IL10958194 A IL 10958194A IL 109581 A IL109581 A IL 109581A
Authority
IL
Israel
Prior art keywords
radical
bile acid
formula
alkyl
branched
Prior art date
Application number
IL109581A
Other languages
English (en)
Other versions
IL109581A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL109581A0 publication Critical patent/IL109581A0/xx
Publication of IL109581A publication Critical patent/IL109581A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL109581A 1993-05-08 1994-05-06 Tetrazole derivatives of bile acids, processes for their preparation and the use of these compounds as medicaments IL109581A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4315368 1993-05-08

Publications (2)

Publication Number Publication Date
IL109581A0 IL109581A0 (en) 1994-08-26
IL109581A true IL109581A (en) 1998-03-10

Family

ID=6487579

Family Applications (1)

Application Number Title Priority Date Filing Date
IL109581A IL109581A (en) 1993-05-08 1994-05-06 Tetrazole derivatives of bile acids, processes for their preparation and the use of these compounds as medicaments

Country Status (19)

Country Link
US (1) US5466815A (cg-RX-API-DMAC7.html)
EP (1) EP0624596B1 (cg-RX-API-DMAC7.html)
JP (1) JP3476157B2 (cg-RX-API-DMAC7.html)
KR (1) KR100333149B1 (cg-RX-API-DMAC7.html)
AT (1) ATE163938T1 (cg-RX-API-DMAC7.html)
AU (1) AU666440B2 (cg-RX-API-DMAC7.html)
CA (1) CA2123048C (cg-RX-API-DMAC7.html)
CY (1) CY2119B1 (cg-RX-API-DMAC7.html)
CZ (1) CZ289515B6 (cg-RX-API-DMAC7.html)
DE (1) DE59405410D1 (cg-RX-API-DMAC7.html)
DK (1) DK0624596T3 (cg-RX-API-DMAC7.html)
ES (1) ES2115096T3 (cg-RX-API-DMAC7.html)
FI (1) FI942075A7 (cg-RX-API-DMAC7.html)
GR (1) GR3026496T3 (cg-RX-API-DMAC7.html)
HU (1) HU217439B (cg-RX-API-DMAC7.html)
IL (1) IL109581A (cg-RX-API-DMAC7.html)
NO (1) NO304795B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ260469A (cg-RX-API-DMAC7.html)
TW (1) TW289757B (cg-RX-API-DMAC7.html)

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EP0624593A3 (de) * 1993-05-08 1995-06-07 Hoechst Ag Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel.
TW289020B (cg-RX-API-DMAC7.html) * 1993-05-08 1996-10-21 Hoechst Sktiengesellschaft
US6323190B1 (en) * 1998-07-31 2001-11-27 The Univeristy Of Georgia Research Foundation, Inc. Estrogen mimetics lacking reproductive tract effects
BR0010197A (pt) 1999-04-30 2002-07-16 Arch Dev Corp Derivados de esteróides
US7086134B2 (en) * 2000-08-07 2006-08-08 Shipley Company, L.L.C. Alignment apparatus and method for aligning stacked devices
WO2002062302A2 (en) * 2001-02-08 2002-08-15 The University Of Chicago Steroidal derivatives
US20070197484A1 (en) * 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
US7078396B2 (en) * 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
CN100360550C (zh) * 2001-05-03 2008-01-09 芝加哥大学 肝脏x受体激动剂
US6816317B2 (en) * 2002-01-31 2004-11-09 Lightel Technologies Inc. Collimator for ready fitting to an optical device with precise optical alignment without need for adjusting positions or angles to compensate for offsets or deviations during optical device assembly and method of making same
CA2482195A1 (en) * 2002-04-12 2003-10-23 The University Of Chicago Farnesoid x-activated receptor agonists
AU2005261740A1 (en) * 2004-07-08 2006-01-19 Novo Nordisk A/S Polypeptide protracting tags comprising a tetrazole moiety
US20070032464A1 (en) * 2004-10-08 2007-02-08 Shutsung Liao Methods of treating cancers
US7960439B1 (en) 2006-06-12 2011-06-14 Iowa State University Research Foundation, Inc. Environmentally sensitive foldable oligomers
CN102482315A (zh) * 2009-07-29 2012-05-30 芝加哥大学 肝x受体激动剂
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ES2586956T3 (es) 2010-11-08 2016-10-19 Albireo Ab Combinación farmacéutica que comprende un inhibidor de IBAT y un aglutinante de ácidos biliares
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JP6751020B2 (ja) 2014-06-25 2020-09-02 Ｅａファーマ株式会社 固形製剤及びその着色防止又は着色低減方法
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CA2966885A1 (en) 2014-11-06 2016-05-12 Enanta Pharmaceuticals, Inc. Bile acid analogs an fxr/tgr5 agonists and methods of use thereof
US10519191B2 (en) * 2014-11-26 2019-12-31 Enanta Pharmaceuticals, Inc. Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
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US20180148470A1 (en) * 2015-04-28 2018-05-31 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Cholic acid derivative, and preparation method and medical use thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
CA3011565C (en) 2016-02-09 2024-01-02 Albireo Ab Oral cholestyramine formulation and use thereof
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
ES2874546T3 (es) 2016-02-09 2021-11-05 Albireo Ab Formulación oral de colestiramina y uso de la misma
US10323061B2 (en) 2016-02-23 2019-06-18 Enanta Pharmaceuticals, Inc. Heteroaryl containing bile acid analogs as FXR/TGR5 agonists and methods of use thereof
WO2017147137A1 (en) 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof
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CN115418389A (zh) * 2019-03-19 2022-12-02 美国西门子医学诊断股份有限公司 减轻疏水分析物的体外诊断测定中的脂蛋白干扰的组合物、装置和方法
CN114761018B (zh) 2019-12-04 2025-12-02 阿尔比里奥公司 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
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TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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WO2025119319A1 (zh) * 2023-12-08 2025-06-12 山东绿叶制药有限公司 一种gabaa受体调节剂的晶型及其制备方法和应用
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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
ATE144988T1 (de) * 1990-12-06 1996-11-15 Hoechst Ag Gallensäurederivate, verfahren zu ihrer herstellung und verwendung dieser verbindung als arzneimittel

Also Published As

Publication number Publication date
NO304795B1 (no) 1999-02-15
NZ260469A (en) 1995-03-28
DK0624596T3 (da) 1998-10-07
CZ113594A3 (en) 1994-12-15
DE59405410D1 (de) 1998-04-16
US5466815A (en) 1995-11-14
ES2115096T3 (es) 1998-06-16
JPH06329695A (ja) 1994-11-29
CA2123048C (en) 2005-11-29
KR100333149B1 (ko) 2002-09-19
HUT67390A (en) 1995-04-28
AU6194794A (en) 1994-11-10
EP0624596B1 (de) 1998-03-11
NO941677D0 (no) 1994-05-06
IL109581A0 (en) 1994-08-26
CA2123048A1 (en) 1994-11-09
FI942075L (fi) 1994-11-09
HU217439B (hu) 2000-01-28
ATE163938T1 (de) 1998-03-15
EP0624596A3 (de) 1995-06-07
FI942075A7 (fi) 1994-11-09
NO941677L (no) 1994-11-09
GR3026496T3 (en) 1998-07-31
CY2119B1 (en) 2002-04-26
TW289757B (cg-RX-API-DMAC7.html) 1996-11-01
JP3476157B2 (ja) 2003-12-10
FI942075A0 (fi) 1994-05-05
HU9401443D0 (en) 1994-08-29
CZ289515B6 (cs) 2002-02-13
AU666440B2 (en) 1996-02-08
EP0624596A2 (de) 1994-11-17

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