IL107612A0 - Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid - Google Patents
Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acidInfo
- Publication number
- IL107612A0 IL107612A0 IL10761293A IL10761293A IL107612A0 IL 107612 A0 IL107612 A0 IL 107612A0 IL 10761293 A IL10761293 A IL 10761293A IL 10761293 A IL10761293 A IL 10761293A IL 107612 A0 IL107612 A0 IL 107612A0
- Authority
- IL
- Israel
- Prior art keywords
- pct
- chloro
- thiophenecarboxylic acid
- compound
- regioselective synthesis
- Prior art date
Links
- JWQMRBBWZUKWFJ-UHFFFAOYSA-N 4-chlorothiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC(Cl)=CS1 JWQMRBBWZUKWFJ-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Indole Compounds (AREA)
- Seasonings (AREA)
- Paper (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12046197A IL120461A0 (en) | 1992-11-23 | 1997-03-17 | Process for preparing 5-fluoro-6-chloro-3-(4-chloro-2-thenoyl)-2-oxindole-1-carboxamide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97998392A | 1992-11-23 | 1992-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL107612A0 true IL107612A0 (en) | 1994-02-27 |
Family
ID=25527268
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10761293A IL107612A0 (en) | 1992-11-23 | 1993-11-15 | Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid |
| IL12046197A IL120461A0 (en) | 1992-11-23 | 1997-03-17 | Process for preparing 5-fluoro-6-chloro-3-(4-chloro-2-thenoyl)-2-oxindole-1-carboxamide |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12046197A IL120461A0 (en) | 1992-11-23 | 1997-03-17 | Process for preparing 5-fluoro-6-chloro-3-(4-chloro-2-thenoyl)-2-oxindole-1-carboxamide |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5648502A (pl) |
| EP (1) | EP0669924B1 (pl) |
| JP (2) | JP2706573B2 (pl) |
| KR (1) | KR950704727A (pl) |
| CN (4) | CN1036001C (pl) |
| AT (1) | ATE146181T1 (pl) |
| AU (1) | AU670454B2 (pl) |
| BR (1) | BR9307503A (pl) |
| CA (1) | CA2148616C (pl) |
| CZ (1) | CZ131695A3 (pl) |
| DE (1) | DE69306595T2 (pl) |
| DK (1) | DK0669924T3 (pl) |
| EG (1) | EG20200A (pl) |
| ES (1) | ES2095080T3 (pl) |
| FI (1) | FI935168A (pl) |
| GR (1) | GR3022396T3 (pl) |
| HU (1) | HUT68757A (pl) |
| IL (2) | IL107612A0 (pl) |
| MX (1) | MX9307292A (pl) |
| MY (1) | MY109037A (pl) |
| NO (1) | NO952021L (pl) |
| NZ (1) | NZ256279A (pl) |
| PL (1) | PL174312B1 (pl) |
| RU (1) | RU2114854C1 (pl) |
| WO (1) | WO1994012505A1 (pl) |
| ZA (1) | ZA938705B (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998045282A1 (en) * | 1997-04-04 | 1998-10-15 | Pfizer Inc. | Processes and intermediates for preparing 2-fluorothiophene derivatives |
| US7402608B2 (en) * | 2002-12-10 | 2008-07-22 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
| US7560551B2 (en) | 2006-01-23 | 2009-07-14 | Amgen Inc. | Aurora kinase modulators and method of use |
| US8263641B2 (en) | 2007-09-10 | 2012-09-11 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| ITMI20071971A1 (it) * | 2007-10-10 | 2009-04-11 | Altergon Sa | Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione |
| US8389567B2 (en) | 2007-12-12 | 2013-03-05 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| CN102256969A (zh) | 2008-08-27 | 2011-11-23 | 钙医学公司 | 调节胞内钙的化合物 |
| US8524763B2 (en) | 2008-09-22 | 2013-09-03 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| US8143269B2 (en) | 2008-10-03 | 2012-03-27 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| CN101987842A (zh) * | 2009-07-31 | 2011-03-23 | 上海开拓者医药发展有限公司 | 一种2-甲基噻吩衍生物的制备方法 |
| US8618307B2 (en) | 2009-09-16 | 2013-12-31 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| CA2809830C (en) | 2010-08-27 | 2019-09-10 | Calcimedica, Inc. | Compounds comprising n-acyl-2-amino-1,3-thiazole for modulating intracellular calcium |
| US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| CN109096245A (zh) * | 2018-09-27 | 2018-12-28 | 上海雅本化学有限公司 | 一种5-氯噻吩-2-甲酸的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4432974A (en) * | 1982-03-04 | 1984-02-21 | E. I. Du Pont De Nemours And Company | Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes |
| DE3534286A1 (de) * | 1985-09-26 | 1987-04-02 | Hoechst Ag | Verfahren zur herstellung von halogenthiophen-2-carbonsaeuren |
| WO1990004393A1 (en) * | 1988-10-18 | 1990-05-03 | Pfizer Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| FR2655655A1 (fr) * | 1989-12-07 | 1991-06-14 | Rhone Poulenc Chimie | Procede de preparation de polysilthiophenediyle et polymeres obtenus a l'issue de ce procede. |
| CA2119155C (en) * | 1991-10-18 | 1999-06-15 | Dennis Paul Phillion | Fungicides for the control of take-all disease of plants |
-
1993
- 1993-09-17 WO PCT/US1993/008613 patent/WO1994012505A1/en not_active Application Discontinuation
- 1993-09-17 AU AU48587/93A patent/AU670454B2/en not_active Ceased
- 1993-09-17 PL PL93309048A patent/PL174312B1/pl unknown
- 1993-09-17 JP JP6513105A patent/JP2706573B2/ja not_active Expired - Lifetime
- 1993-09-17 CZ CZ951316A patent/CZ131695A3/cs unknown
- 1993-09-17 EP EP93921527A patent/EP0669924B1/en not_active Expired - Lifetime
- 1993-09-17 KR KR1019950702059A patent/KR950704727A/ko active IP Right Grant
- 1993-09-17 DK DK93921527.3T patent/DK0669924T3/da active
- 1993-09-17 BR BR9307503A patent/BR9307503A/pt not_active Application Discontinuation
- 1993-09-17 DE DE69306595T patent/DE69306595T2/de not_active Expired - Fee Related
- 1993-09-17 US US08/436,415 patent/US5648502A/en not_active Expired - Fee Related
- 1993-09-17 ES ES93921527T patent/ES2095080T3/es not_active Expired - Lifetime
- 1993-09-17 NZ NZ256279A patent/NZ256279A/en unknown
- 1993-09-17 RU RU95112836A patent/RU2114854C1/ru active
- 1993-09-17 AT AT93921527T patent/ATE146181T1/de not_active IP Right Cessation
- 1993-09-17 CA CA002148616A patent/CA2148616C/en not_active Expired - Fee Related
- 1993-11-15 IL IL10761293A patent/IL107612A0/xx unknown
- 1993-11-19 MY MYPI93002430A patent/MY109037A/en unknown
- 1993-11-21 EG EG73493A patent/EG20200A/xx active
- 1993-11-21 ZA ZA938705A patent/ZA938705B/xx unknown
- 1993-11-22 FI FI935168A patent/FI935168A/fi not_active Application Discontinuation
- 1993-11-22 CN CN93114714A patent/CN1036001C/zh not_active Expired - Fee Related
- 1993-11-22 HU HU9303311A patent/HUT68757A/hu unknown
- 1993-11-22 MX MX9307292A patent/MX9307292A/es not_active IP Right Cessation
-
1995
- 1995-05-22 NO NO952021A patent/NO952021L/no unknown
-
1996
- 1996-11-08 CN CN96114450A patent/CN1156725A/zh active Pending
- 1996-11-08 CN CN96114451A patent/CN1158851A/zh active Pending
- 1996-11-08 CN CN96114452A patent/CN1158853A/zh active Pending
-
1997
- 1997-01-29 GR GR960403453T patent/GR3022396T3/el unknown
- 1997-03-17 IL IL12046197A patent/IL120461A0/xx unknown
- 1997-07-02 JP JP9176977A patent/JP2795642B2/ja not_active Expired - Lifetime
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