IL107394A - Process for the preparation of metal complexes of tetraazacycloalkane derivatives - Google Patents
Process for the preparation of metal complexes of tetraazacycloalkane derivativesInfo
- Publication number
- IL107394A IL107394A IL107394A IL10739493A IL107394A IL 107394 A IL107394 A IL 107394A IL 107394 A IL107394 A IL 107394A IL 10739493 A IL10739493 A IL 10739493A IL 107394 A IL107394 A IL 107394A
- Authority
- IL
- Israel
- Prior art keywords
- optionally
- tetraazacyclododecane
- hydroxy
- process according
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4237943A DE4237943C2 (de) | 1992-11-06 | 1992-11-06 | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL107394A0 IL107394A0 (en) | 1994-01-25 |
| IL107394A true IL107394A (en) | 1998-06-15 |
Family
ID=6472539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL107394A IL107394A (en) | 1992-11-06 | 1993-10-25 | Process for the preparation of metal complexes of tetraazacycloalkane derivatives |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0596586B1 (es) |
| JP (1) | JP3727359B2 (es) |
| AT (1) | ATE148110T1 (es) |
| CA (1) | CA2102461C (es) |
| CZ (1) | CZ285411B6 (es) |
| DE (2) | DE4237943C2 (es) |
| DK (1) | DK0596586T3 (es) |
| ES (1) | ES2099900T3 (es) |
| GR (1) | GR3022866T3 (es) |
| HU (1) | HU214014B (es) |
| IL (1) | IL107394A (es) |
| NO (1) | NO302174B1 (es) |
| SK (1) | SK281285B6 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9407435D0 (en) * | 1994-04-14 | 1994-06-08 | Nycomed Salutar Inc | Compounds |
| DE19724186C2 (de) * | 1997-06-02 | 2002-07-18 | Schering Ag | Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe |
| IT1292128B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
| IT1292130B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
| DE102009053171B4 (de) | 2009-11-04 | 2011-07-21 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol) |
| DE102009057274B4 (de) | 2009-12-02 | 2011-09-01 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels Trioxobicyclo-octan |
| EP2327395A1 (en) | 2009-11-23 | 2011-06-01 | Bracco Imaging S.p.A | Process for the preparation of gadobenate dimeglumine complex in a solid form |
| DE102010013833A1 (de) | 2010-03-29 | 2011-09-29 | Bayer Schering Pharma Aktiengesellschaft | Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal |
| DE102010023105A1 (de) | 2010-06-04 | 2011-12-08 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol |
| CN103189057B (zh) * | 2010-08-26 | 2015-02-18 | 崔坤元 | 大环脂类化合物及其应用 |
| PE20141325A1 (es) | 2011-04-21 | 2014-10-08 | Bayer Ip Gmbh | Preparacion de gadobutrol de alta pureza |
| KR101653064B1 (ko) * | 2014-12-26 | 2016-09-09 | 에스티팜 주식회사 | 가도부트롤의 제조방법 |
| IL265536B (en) | 2016-09-27 | 2022-07-01 | Bayer Pharma AG | A method for the production of a crystalline form of the a modification of calcobuterol |
| KR102033964B1 (ko) * | 2018-01-19 | 2019-10-18 | 주식회사 엔지켐생명과학 | 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| DE3625417C2 (de) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
| US5198208A (en) * | 1987-07-16 | 1993-03-30 | Nycomed Imaging As | Aminopolycarboxylic acids and derivatives thereof |
| GB8719042D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
| US4889931A (en) * | 1988-09-27 | 1989-12-26 | Salutar, Inc. | Manganese (II) chelate manufacture |
| AU625529B2 (en) * | 1989-12-22 | 1992-07-16 | E.R. Squibb & Sons, Inc. | 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes |
| NZ236267A (en) * | 1989-12-22 | 1992-12-23 | Squibb & Sons Inc | 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane |
| DE4009119A1 (de) * | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| IT1243801B (it) * | 1990-08-29 | 1994-06-28 | Bracco Ind Chimica Spa | Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione |
| DE4035760A1 (de) * | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4115789A1 (de) * | 1991-05-10 | 1992-11-12 | Schering Ag | Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4140779A1 (de) * | 1991-12-06 | 1993-06-09 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen |
-
1992
- 1992-11-06 DE DE4237943A patent/DE4237943C2/de not_active Expired - Lifetime
-
1993
- 1993-10-25 IL IL107394A patent/IL107394A/en not_active IP Right Cessation
- 1993-11-04 CA CA002102461A patent/CA2102461C/en not_active Expired - Lifetime
- 1993-11-05 DK DK93250304.8T patent/DK0596586T3/da active
- 1993-11-05 JP JP27657793A patent/JP3727359B2/ja not_active Expired - Lifetime
- 1993-11-05 ES ES93250304T patent/ES2099900T3/es not_active Expired - Lifetime
- 1993-11-05 SK SK1241-93A patent/SK281285B6/sk not_active IP Right Cessation
- 1993-11-05 DE DE59305238T patent/DE59305238D1/de not_active Expired - Lifetime
- 1993-11-05 CZ CZ932374A patent/CZ285411B6/cs not_active IP Right Cessation
- 1993-11-05 EP EP93250304A patent/EP0596586B1/de not_active Expired - Lifetime
- 1993-11-05 AT AT93250304T patent/ATE148110T1/de active
- 1993-11-05 HU HU9303153A patent/HU214014B/hu unknown
- 1993-11-05 NO NO19934002A patent/NO302174B1/no not_active IP Right Cessation
-
1997
- 1997-03-18 GR GR970400541T patent/GR3022866T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0596586A1 (de) | 1994-05-11 |
| GR3022866T3 (en) | 1997-06-30 |
| IL107394A0 (en) | 1994-01-25 |
| NO934002L (no) | 1994-05-09 |
| NO934002D0 (no) | 1993-11-05 |
| DK0596586T3 (da) | 1997-07-28 |
| CZ285411B6 (cs) | 1999-08-11 |
| DE59305238D1 (de) | 1997-03-06 |
| CA2102461A1 (en) | 1994-05-07 |
| SK281285B6 (sk) | 2001-02-12 |
| ATE148110T1 (de) | 1997-02-15 |
| EP0596586B1 (de) | 1997-01-22 |
| ES2099900T3 (es) | 1997-06-01 |
| SK124193A3 (en) | 1994-12-07 |
| DE4237943C2 (de) | 1997-10-23 |
| NO302174B1 (no) | 1998-02-02 |
| HUT67583A (en) | 1995-04-28 |
| HU214014B (en) | 1997-12-29 |
| DE4237943A1 (de) | 1994-05-11 |
| CZ237493A3 (en) | 1994-10-19 |
| JP3727359B2 (ja) | 2005-12-14 |
| CA2102461C (en) | 2005-01-25 |
| JPH06228115A (ja) | 1994-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |