CA2102461A1 - Process for the production of metal complexes of n-.beta- hydroxyalkyl-tri-n-carboxyalkyl-1,4,7,10- tetraazacyclododecane and n-.beta.-hydroxyalkyl-tri-n- carboxyalkyl-1,4,8,11 tetraazacyclotetradecane derivatives - Google Patents

Process for the production of metal complexes of n-.beta- hydroxyalkyl-tri-n-carboxyalkyl-1,4,7,10- tetraazacyclododecane and n-.beta.-hydroxyalkyl-tri-n- carboxyalkyl-1,4,8,11 tetraazacyclotetradecane derivatives

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Publication number
CA2102461A1
CA2102461A1 CA002102461A CA2102461A CA2102461A1 CA 2102461 A1 CA2102461 A1 CA 2102461A1 CA 002102461 A CA002102461 A CA 002102461A CA 2102461 A CA2102461 A CA 2102461A CA 2102461 A1 CA2102461 A1 CA 2102461A1
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CA
Canada
Prior art keywords
carboxyalkyl
hydroxyalkyl
tri
beta
tetraazacyclododecane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002102461A
Other languages
French (fr)
Other versions
CA2102461C (en
Inventor
Johannes Platzek
Heinz Gries
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2102461A1 publication Critical patent/CA2102461A1/en
Application granted granted Critical
Publication of CA2102461C publication Critical patent/CA2102461C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A new process for the production of metal complexes of N-.beta.- hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-.beta.-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11- tetraazacyclotetradecane derivatives is described.
CA002102461A 1992-11-06 1993-11-04 Process for the production of metal complexes of n-.beta- hydroxyalkyl-tri-n-carboxyalkyl-1,4,7,10- tetraazacyclododecane and n-.beta.-hydroxyalkyl-tri-n- carboxyalkyl-1,4,8,11 tetraazacyclotetradecane derivatives Expired - Lifetime CA2102461C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4237943A DE4237943C2 (en) 1992-11-06 1992-11-06 Process for the preparation of metal complexes of N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane Derivatives
DEP4237943.1 1992-11-06

Publications (2)

Publication Number Publication Date
CA2102461A1 true CA2102461A1 (en) 1994-05-07
CA2102461C CA2102461C (en) 2005-01-25

Family

ID=6472539

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002102461A Expired - Lifetime CA2102461C (en) 1992-11-06 1993-11-04 Process for the production of metal complexes of n-.beta- hydroxyalkyl-tri-n-carboxyalkyl-1,4,7,10- tetraazacyclododecane and n-.beta.-hydroxyalkyl-tri-n- carboxyalkyl-1,4,8,11 tetraazacyclotetradecane derivatives

Country Status (13)

Country Link
EP (1) EP0596586B1 (en)
JP (1) JP3727359B2 (en)
AT (1) ATE148110T1 (en)
CA (1) CA2102461C (en)
CZ (1) CZ285411B6 (en)
DE (2) DE4237943C2 (en)
DK (1) DK0596586T3 (en)
ES (1) ES2099900T3 (en)
GR (1) GR3022866T3 (en)
HU (1) HU214014B (en)
IL (1) IL107394A (en)
NO (1) NO302174B1 (en)
SK (1) SK281285B6 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9795695B2 (en) 2009-11-23 2017-10-24 Bracco Imaging S.P.A. Process for the preparation of gadobenate dimeglumine complex in a solid form

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407435D0 (en) * 1994-04-14 1994-06-08 Nycomed Salutar Inc Compounds
DE19724186C2 (en) * 1997-06-02 2002-07-18 Schering Ag Process for the mono- and 1,7-bis-N-ß-hydroxyalkylation of cycles and the corresponding N-ß-hydroxyalkyl-1,4,7,10-tetraazacyclododecane-Li salt complexes
IT1292128B1 (en) * 1997-06-11 1999-01-25 Bracco Spa PROCESS FOR THE PREPARATION OF MACROCYCLIC CHELANTS AND THEIR CHELATES WITH PARAMAGNETIC METALLIC IONS
IT1292130B1 (en) * 1997-06-11 1999-01-25 Bracco Spa PROCESS FOR THE PREPARATION OF 1,4,7,10-TETRAAZACYCLODODECAN -1,4,7-TRIACETIC ACID AND ITS DERIVATIVES
DE102009053171B4 (en) * 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Process for the preparation of the calcium complex of dihydroxy-hydroxy-methylpropyl-tetraazacyclododecane-triacetic acid (Calcobutrol)
DE102009057274B4 (en) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrol preparation using trioxobicyclo-octane
DE102010013833A1 (en) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Producing gadolinium complex of N-(hydroxymethyl-dihydroxypropyl)-triscarboxymethyl-tetraazacyclododecane useful as magnetic resonance imaging contrast agent, comprises e.g. reacting cyclic compound with dimethylformamide dimethylacetal
DE102010023105A1 (en) * 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrol preparation in a one-pot process using DMF-acetal and N-methylimidazole
CN103189057B (en) * 2010-08-26 2015-02-18 崔坤元 Lipomacrocycles and uses thereof
RS60001B1 (en) 2011-04-21 2020-04-30 Bayer Ip Gmbh Preparation of high-purity gadobutrol
KR101653064B1 (en) 2014-12-26 2016-09-09 에스티팜 주식회사 A Method for Gadobutrol
PL3519394T3 (en) 2016-09-27 2020-11-30 Bayer Pharma Aktiengesellschaft Method for producing the crystalline form of modification a of calcobutrol
KR102033964B1 (en) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 Gadoteridol intermediate and method for preparing gadoteridol using the same

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US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (en) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecane derivatives
US5198208A (en) * 1987-07-16 1993-03-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
AU6709390A (en) * 1989-12-22 1991-06-27 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-tris-carboxymethyl -1,4,7,10-tetraazacyclododecane
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
DE4009119A1 (en) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-TETRAAZACYCLODODECANE-BUTYLTRIOLS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
IT1243801B (en) * 1990-08-29 1994-06-28 Bracco Ind Chimica Spa INTERMEDIATES FOR CHELATING AGENTS WITH PRE-FIXED SYMMETRY, AND PROCEDURES FOR THEIR PREPARATION
DE4035760A1 (en) * 1990-11-08 1992-05-14 Schering Ag MONO-N-SUBSTITUTED 1,4,7,10-TETRAAZACYCLODODECAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
DE4115789A1 (en) * 1991-05-10 1992-11-12 Schering Ag MACROCYCLIC POLYMER COMPLEX IMAGERS, THEIR COMPLEXES, METHOD FOR THEIR PRODUCTION AND THE PHARMACEUTICAL AGENTS CONTAINING THEM
DE4140779A1 (en) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De METHOD FOR PRODUCING MONO-N SUBSTITUTED TETRAAZAMACROCYCLES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9795695B2 (en) 2009-11-23 2017-10-24 Bracco Imaging S.P.A. Process for the preparation of gadobenate dimeglumine complex in a solid form

Also Published As

Publication number Publication date
DK0596586T3 (en) 1997-07-28
SK281285B6 (en) 2001-02-12
EP0596586A1 (en) 1994-05-11
DE4237943C2 (en) 1997-10-23
IL107394A0 (en) 1994-01-25
NO934002L (en) 1994-05-09
CZ237493A3 (en) 1994-10-19
CZ285411B6 (en) 1999-08-11
NO302174B1 (en) 1998-02-02
HUT67583A (en) 1995-04-28
JP3727359B2 (en) 2005-12-14
SK124193A3 (en) 1994-12-07
DE59305238D1 (en) 1997-03-06
IL107394A (en) 1998-06-15
NO934002D0 (en) 1993-11-05
ES2099900T3 (en) 1997-06-01
JPH06228115A (en) 1994-08-16
ATE148110T1 (en) 1997-02-15
GR3022866T3 (en) 1997-06-30
HU214014B (en) 1997-12-29
EP0596586B1 (en) 1997-01-22
DE4237943A1 (en) 1994-05-11
CA2102461C (en) 2005-01-25

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