DK0596586T3 - Process for the preparation of metal complexes of N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives. - Google Patents

Process for the preparation of metal complexes of N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives.

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Publication number
DK0596586T3
DK0596586T3 DK93250304.8T DK93250304T DK0596586T3 DK 0596586 T3 DK0596586 T3 DK 0596586T3 DK 93250304 T DK93250304 T DK 93250304T DK 0596586 T3 DK0596586 T3 DK 0596586T3
Authority
DK
Denmark
Prior art keywords
carboxyalkyl
hydroxyalkyl
tri
beta
preparation
Prior art date
Application number
DK93250304.8T
Other languages
Danish (da)
Inventor
Heinz Dr Gries
Johannes Dr Platzek
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0596586T3 publication Critical patent/DK0596586T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A novel process is described for the preparation of metal complexes of N- beta -hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclo-dodecane and N- beta -hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraaza-cyclotetradecane derivatives.
DK93250304.8T 1992-11-06 1993-11-05 Process for the preparation of metal complexes of N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives. DK0596586T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4237943A DE4237943C2 (en) 1992-11-06 1992-11-06 Process for the preparation of metal complexes of N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane Derivatives

Publications (1)

Publication Number Publication Date
DK0596586T3 true DK0596586T3 (en) 1997-07-28

Family

ID=6472539

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93250304.8T DK0596586T3 (en) 1992-11-06 1993-11-05 Process for the preparation of metal complexes of N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivatives.

Country Status (13)

Country Link
EP (1) EP0596586B1 (en)
JP (1) JP3727359B2 (en)
AT (1) ATE148110T1 (en)
CA (1) CA2102461C (en)
CZ (1) CZ285411B6 (en)
DE (2) DE4237943C2 (en)
DK (1) DK0596586T3 (en)
ES (1) ES2099900T3 (en)
GR (1) GR3022866T3 (en)
HU (1) HU214014B (en)
IL (1) IL107394A (en)
NO (1) NO302174B1 (en)
SK (1) SK281285B6 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407435D0 (en) * 1994-04-14 1994-06-08 Nycomed Salutar Inc Compounds
DE19724186C2 (en) * 1997-06-02 2002-07-18 Schering Ag Process for the mono- and 1,7-bis-N-ß-hydroxyalkylation of cycles and the corresponding N-ß-hydroxyalkyl-1,4,7,10-tetraazacyclododecane-Li salt complexes
IT1292130B1 (en) * 1997-06-11 1999-01-25 Bracco Spa PROCESS FOR THE PREPARATION OF 1,4,7,10-TETRAAZACYCLODODECAN -1,4,7-TRIACETIC ACID AND ITS DERIVATIVES
IT1292128B1 (en) * 1997-06-11 1999-01-25 Bracco Spa PROCESS FOR THE PREPARATION OF MACROCYCLIC CHELANTS AND THEIR CHELATES WITH PARAMAGNETIC METALLIC IONS
DE102009053171B4 (en) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Process for the preparation of the calcium complex of dihydroxy-hydroxy-methylpropyl-tetraazacyclododecane-triacetic acid (Calcobutrol)
DE102009057274B4 (en) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrol preparation using trioxobicyclo-octane
EP2327395A1 (en) 2009-11-23 2011-06-01 Bracco Imaging S.p.A Process for the preparation of gadobenate dimeglumine complex in a solid form
DE102010013833A1 (en) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Producing gadolinium complex of N-(hydroxymethyl-dihydroxypropyl)-triscarboxymethyl-tetraazacyclododecane useful as magnetic resonance imaging contrast agent, comprises e.g. reacting cyclic compound with dimethylformamide dimethylacetal
DE102010023105A1 (en) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrol preparation in a one-pot process using DMF-acetal and N-methylimidazole
JP6124078B2 (en) * 2010-08-26 2017-05-10 ツイ，クンユァン Macrocyclic aliphatic compounds and their applications
PE20141325A1 (en) 2011-04-21 2014-10-08 Bayer Ip Gmbh HIGH PURITY GADOBUTROL PREPARATION
KR101653064B1 (en) * 2014-12-26 2016-09-09 에스티팜 주식회사 A Method for Gadobutrol
HUE050553T2 (en) 2016-09-27 2020-12-28 Bayer Pharma AG Method for producing the crystalline form of modification a of calcobutrol
KR102033964B1 (en) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 Gadoteridol intermediate and method for preparing gadoteridol using the same

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (en) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecane derivatives
ES2033433T3 (en) * 1987-07-16 1993-03-16 Nycomed As PROCEDURE TO PREPARE AMINOPOLICARBOXILIC ACIDS AND THEIR DERIVATIVES.
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
AU6709390A (en) * 1989-12-22 1991-06-27 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-tris-carboxymethyl -1,4,7,10-tetraazacyclododecane
DE4009119A1 (en) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-TETRAAZACYCLODODECANE-BUTYLTRIOLS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
IT1243801B (en) * 1990-08-29 1994-06-28 Bracco Ind Chimica Spa INTERMEDIATES FOR CHELATING AGENTS WITH PRE-FIXED SYMMETRY, AND PROCEDURES FOR THEIR PREPARATION
DE4035760A1 (en) * 1990-11-08 1992-05-14 Schering Ag MONO-N-SUBSTITUTED 1,4,7,10-TETRAAZACYCLODODECAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
DE4115789A1 (en) * 1991-05-10 1992-11-12 Schering Ag MACROCYCLIC POLYMER COMPLEX IMAGERS, THEIR COMPLEXES, METHOD FOR THEIR PRODUCTION AND THE PHARMACEUTICAL AGENTS CONTAINING THEM
DE4140779A1 (en) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De METHOD FOR PRODUCING MONO-N SUBSTITUTED TETRAAZAMACROCYCLES

Also Published As

Publication number Publication date
GR3022866T3 (en) 1997-06-30
EP0596586B1 (en) 1997-01-22
NO934002D0 (en) 1993-11-05
DE4237943C2 (en) 1997-10-23
ES2099900T3 (en) 1997-06-01
CA2102461C (en) 2005-01-25
JPH06228115A (en) 1994-08-16
ATE148110T1 (en) 1997-02-15
SK124193A3 (en) 1994-12-07
HU214014B (en) 1997-12-29
NO302174B1 (en) 1998-02-02
CA2102461A1 (en) 1994-05-07
NO934002L (en) 1994-05-09
IL107394A0 (en) 1994-01-25
CZ237493A3 (en) 1994-10-19
DE4237943A1 (en) 1994-05-11
IL107394A (en) 1998-06-15
CZ285411B6 (en) 1999-08-11
JP3727359B2 (en) 2005-12-14
SK281285B6 (en) 2001-02-12
DE59305238D1 (en) 1997-03-06
EP0596586A1 (en) 1994-05-11
HUT67583A (en) 1995-04-28

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