ES2099900T3 - Procedimiento para la preparacion de complejos con metales de derivados de n-beta-hidroxialquil-tri-n-carboxialquil-1,4,7,10-tetraaza-ciclododecanos y de n-beta-hidroxialquil-tri-n-carboxialquil-1,4,8,11-tetraaza-ciclotetradecanos. - Google Patents

Procedimiento para la preparacion de complejos con metales de derivados de n-beta-hidroxialquil-tri-n-carboxialquil-1,4,7,10-tetraaza-ciclododecanos y de n-beta-hidroxialquil-tri-n-carboxialquil-1,4,8,11-tetraaza-ciclotetradecanos.

Info

Publication number
ES2099900T3
ES2099900T3 ES93250304T ES93250304T ES2099900T3 ES 2099900 T3 ES2099900 T3 ES 2099900T3 ES 93250304 T ES93250304 T ES 93250304T ES 93250304 T ES93250304 T ES 93250304T ES 2099900 T3 ES2099900 T3 ES 2099900T3
Authority
ES
Spain
Prior art keywords
tri
beta
tetraaza
hidroxialquil
carboxialquil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93250304T
Other languages
English (en)
Inventor
Johannes Dr Platzek
Heinz Dr Gries
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2099900T3 publication Critical patent/ES2099900T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA OBTENER COMPLEJOS METALICOS DEL DERIVADO DE N-BETA-HIDROXI-ALQUILO-TRI-N-CARBOXIALQUILO-1, 4, 7,10 UILO-TRI-NCARBOXIALQUILO-1, 4, 8, 11 -TETRAAZACICLOTETRADECANO
ES93250304T 1992-11-06 1993-11-05 Procedimiento para la preparacion de complejos con metales de derivados de n-beta-hidroxialquil-tri-n-carboxialquil-1,4,7,10-tetraaza-ciclododecanos y de n-beta-hidroxialquil-tri-n-carboxialquil-1,4,8,11-tetraaza-ciclotetradecanos. Expired - Lifetime ES2099900T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4237943A DE4237943C2 (de) 1992-11-06 1992-11-06 Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate

Publications (1)

Publication Number Publication Date
ES2099900T3 true ES2099900T3 (es) 1997-06-01

Family

ID=6472539

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93250304T Expired - Lifetime ES2099900T3 (es) 1992-11-06 1993-11-05 Procedimiento para la preparacion de complejos con metales de derivados de n-beta-hidroxialquil-tri-n-carboxialquil-1,4,7,10-tetraaza-ciclododecanos y de n-beta-hidroxialquil-tri-n-carboxialquil-1,4,8,11-tetraaza-ciclotetradecanos.

Country Status (13)

Country Link
EP (1) EP0596586B1 (es)
JP (1) JP3727359B2 (es)
AT (1) ATE148110T1 (es)
CA (1) CA2102461C (es)
CZ (1) CZ285411B6 (es)
DE (2) DE4237943C2 (es)
DK (1) DK0596586T3 (es)
ES (1) ES2099900T3 (es)
GR (1) GR3022866T3 (es)
HU (1) HU214014B (es)
IL (1) IL107394A (es)
NO (1) NO302174B1 (es)
SK (1) SK281285B6 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407435D0 (en) * 1994-04-14 1994-06-08 Nycomed Salutar Inc Compounds
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
EP2327395A1 (en) * 2009-11-23 2011-06-01 Bracco Imaging S.p.A Process for the preparation of gadobenate dimeglumine complex in a solid form
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
JP6124078B2 (ja) * 2010-08-26 2017-05-10 ツイ，クンユァン 巨大環状脂肪族化合物及びその応用
RS60001B1 (sr) 2011-04-21 2020-04-30 Bayer Ip Gmbh Pripremanje gadobutrola visoke čistoće
KR101653064B1 (ko) 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
ES2809736T3 (es) 2016-09-27 2021-03-05 Bayer Pharma AG Método para producir la forma cristalina de modificación a de calcobutrol
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
EP0466200B1 (en) * 1987-07-16 1996-04-24 Nycomed Imaging As Aminocarboxylic acids and derivatives thereof
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
AU6709390A (en) * 1989-12-22 1991-06-27 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-tris-carboxymethyl -1,4,7,10-tetraazacyclododecane
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
IT1243801B (it) * 1990-08-29 1994-06-28 Bracco Ind Chimica Spa Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen

Also Published As

Publication number Publication date
CA2102461A1 (en) 1994-05-07
HUT67583A (en) 1995-04-28
DK0596586T3 (da) 1997-07-28
SK124193A3 (en) 1994-12-07
SK281285B6 (sk) 2001-02-12
CA2102461C (en) 2005-01-25
DE4237943A1 (de) 1994-05-11
HU214014B (en) 1997-12-29
JPH06228115A (ja) 1994-08-16
NO934002D0 (no) 1993-11-05
EP0596586B1 (de) 1997-01-22
IL107394A0 (en) 1994-01-25
DE59305238D1 (de) 1997-03-06
NO934002L (no) 1994-05-09
EP0596586A1 (de) 1994-05-11
GR3022866T3 (en) 1997-06-30
NO302174B1 (no) 1998-02-02
CZ285411B6 (cs) 1999-08-11
IL107394A (en) 1998-06-15
JP3727359B2 (ja) 2005-12-14
DE4237943C2 (de) 1997-10-23
CZ237493A3 (en) 1994-10-19
ATE148110T1 (de) 1997-02-15

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