ES2131582T3 - Proceso para la produccion de derivados de n-beta-g(b)-hidroxialquil-tri-n-carboxialquil-1,4,7,10-tetraazaciclo-dodecano y de n-beta-g(b)-hidroxialquil-tri-n-carboxialquil-1,4,8,11-tetraazaciclotetradecano y de sus complejos metalicos. - Google Patents

Proceso para la produccion de derivados de n-beta-g(b)-hidroxialquil-tri-n-carboxialquil-1,4,7,10-tetraazaciclo-dodecano y de n-beta-g(b)-hidroxialquil-tri-n-carboxialquil-1,4,8,11-tetraazaciclotetradecano y de sus complejos metalicos.

Info

Publication number
ES2131582T3
ES2131582T3 ES93912835T ES93912835T ES2131582T3 ES 2131582 T3 ES2131582 T3 ES 2131582T3 ES 93912835 T ES93912835 T ES 93912835T ES 93912835 T ES93912835 T ES 93912835T ES 2131582 T3 ES2131582 T3 ES 2131582T3
Authority
ES
Spain
Prior art keywords
tri
beta
hidroxialquil
carboxialquil
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93912835T
Other languages
English (en)
Inventor
Ulf Tilstam
Helmut Borner
Klaus Nickisch
Heinz Gries
Johannes Platzek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2131582T3 publication Critical patent/ES2131582T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCESO PARA LA ELABORACION DE DERIVADOS N ALQUIL ANO Y DERIVADOS N QUIL TALICOS DE LA FORMULA GENERAL (I), DONDE R1 ES UN GRUPO )1 (A), N SIGNIFICA LAS CIFRAS 2 O 3, DONDE SE ENCUENTRA PRESENTE EVENTUALMENTE RESTO HIDROXI O GRUPOS CARBOXI EN FORMA PROTEGIDA, MEDIANTE TRANSFORMACION DE 1,4,7,10 TETRAAZACICLODODECANO O 1,4,8,11 SUS SALES, EN PRESENCIA DE UNA BASE CON UN EPOXI DE LA FORMULA (II), EN UN DISOLVENTE POLAR O SIN DISOLVENTE EN TEMPERATURAS DESDE 0 PRESENCIA DE UNA BASE, CON UN COMPUESTO DE LA FORMULA (III).
ES93912835T 1992-06-04 1993-05-28 Proceso para la produccion de derivados de n-beta-g(b)-hidroxialquil-tri-n-carboxialquil-1,4,7,10-tetraazaciclo-dodecano y de n-beta-g(b)-hidroxialquil-tri-n-carboxialquil-1,4,8,11-tetraazaciclotetradecano y de sus complejos metalicos. Expired - Lifetime ES2131582T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4218744A DE4218744C2 (de) 1992-06-04 1992-06-04 Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe

Publications (1)

Publication Number Publication Date
ES2131582T3 true ES2131582T3 (es) 1999-08-01

Family

ID=6460555

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93912835T Expired - Lifetime ES2131582T3 (es) 1992-06-04 1993-05-28 Proceso para la produccion de derivados de n-beta-g(b)-hidroxialquil-tri-n-carboxialquil-1,4,7,10-tetraazaciclo-dodecano y de n-beta-g(b)-hidroxialquil-tri-n-carboxialquil-1,4,8,11-tetraazaciclotetradecano y de sus complejos metalicos.

Country Status (16)

Country Link
US (1) US5386028A (es)
EP (1) EP0643705B1 (es)
JP (1) JP3565843B2 (es)
KR (1) KR100269081B1 (es)
AT (1) ATE178321T1 (es)
CA (1) CA2137243C (es)
CZ (1) CZ282873B6 (es)
DE (2) DE4218744C2 (es)
DK (1) DK0643705T3 (es)
ES (1) ES2131582T3 (es)
GR (1) GR3030604T3 (es)
HU (1) HU213951B (es)
IL (1) IL105807A (es)
NO (1) NO302232B1 (es)
SK (1) SK281901B6 (es)
WO (1) WO1993024469A1 (es)

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US5608061A (en) * 1995-08-02 1997-03-04 Johnson Matthey Plc Process for preparing 1,4,8,11-tetraazacyclotetradecane
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
DE19652386A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verfahren zur Herstellung von Metallkomplexcarbonsäureamiden
US6045776A (en) * 1996-12-04 2000-04-04 Schering Aktiengesellschaft Process for the production of metal-complex carboxylic acid amides
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
EP1641770A4 (en) * 2003-07-08 2008-12-31 Univ Hong Kong SYNTHESIS OF TRIS-N-ALKYLATED 1,4,7,10-TETRAAZACYCLODODECANES
CA2742954C (en) 2008-11-07 2018-07-10 Massachusetts Institute Of Technology Aminoalcohol lipidoids and uses thereof
DE102009053171B4 (de) * 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
PL2691443T3 (pl) 2011-03-28 2021-08-30 Massachusetts Institute Of Technology Sprzężone lipomery i ich zastosowania
WO2012143355A1 (en) * 2011-04-21 2012-10-26 Bayer Intellectual Property Gmbh Preparation of high-purity gadobutrol
CA3119789A1 (en) 2011-10-27 2013-05-02 Massachusetts Institute Of Technology Amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
EP3102566B1 (en) * 2014-02-06 2018-09-12 T2Pharma GmbH Process for purifying 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
KR101693400B1 (ko) 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
FI3310764T3 (fi) 2015-06-19 2023-07-18 Massachusetts Inst Technology Alkenyylillä substituoidut 2,5-piperatsiinidionit ja niiden käyttö koostumuksissa agenssin kuljettamiseksi subjektille tai soluun
AU2017333698B2 (en) 2016-09-27 2020-12-24 Bayer Pharma Aktiengesellschaft Method for producing the crystalline form of modification a of calcobutrol
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
EP4083026A1 (en) * 2018-07-10 2022-11-02 Biophore India Pharmaceuticals Pvt. Ltd. Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR101979836B1 (ko) * 2019-01-02 2019-05-21 동국생명과학 주식회사 칼코부트롤의 제조방법
WO2024030772A1 (en) * 2022-08-01 2024-02-08 Portland State University High relaxivity contrast agents and stereoselective preparation

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Also Published As

Publication number Publication date
HU213951B (en) 1997-11-28
KR950701918A (ko) 1995-05-17
NO302232B1 (no) 1998-02-09
NO944691L (no) 1994-12-05
GR3030604T3 (en) 1999-10-29
SK281901B6 (sk) 2001-09-11
CZ301594A3 (en) 1995-08-16
CZ282873B6 (cs) 1997-11-12
DE59309488D1 (de) 1999-05-06
WO1993024469A1 (de) 1993-12-09
HUT71263A (en) 1995-11-28
CA2137243C (en) 2005-09-20
DK0643705T3 (da) 1999-10-25
EP0643705B1 (de) 1999-03-31
ATE178321T1 (de) 1999-04-15
IL105807A0 (en) 1993-09-22
JP3565843B2 (ja) 2004-09-15
KR100269081B1 (ko) 2000-10-16
SK148794A3 (en) 1995-07-11
US5386028A (en) 1995-01-31
DE4218744A1 (de) 1993-12-09
IL105807A (en) 1998-12-06
NO944691D0 (no) 1994-12-05
HU9403464D0 (en) 1995-03-28
JPH07507067A (ja) 1995-08-03
EP0643705A1 (de) 1995-03-22
CA2137243A1 (en) 1993-12-09
DE4218744C2 (de) 1997-11-06

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