GR3030604T3 - PROCESS FOR PRODUCING N--g(b)-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,7,10-TETRAAZACYCLODODECANE AND N--g(b)-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AND THEIR METAL COMPLEXES. - Google Patents

PROCESS FOR PRODUCING N--g(b)-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,7,10-TETRAAZACYCLODODECANE AND N--g(b)-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AND THEIR METAL COMPLEXES.

Info

Publication number
GR3030604T3
GR3030604T3 GR990401687T GR990401687T GR3030604T3 GR 3030604 T3 GR3030604 T3 GR 3030604T3 GR 990401687 T GR990401687 T GR 990401687T GR 990401687 T GR990401687 T GR 990401687T GR 3030604 T3 GR3030604 T3 GR 3030604T3
Authority
GR
Greece
Prior art keywords
carboxyalkyl
hydroxyalkyl
tri
tetraazacyclododecane
metal complexes
Prior art date
Application number
GR990401687T
Other languages
English (en)
Inventor
Ulf Tilstam
Helmut Boerner
Klaus Nickisch
Heinz Gries
Johannes Platzek
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of GR3030604T3 publication Critical patent/GR3030604T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GR990401687T 1992-06-04 1999-06-23 PROCESS FOR PRODUCING N--g(b)-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,7,10-TETRAAZACYCLODODECANE AND N--g(b)-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AND THEIR METAL COMPLEXES. GR3030604T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4218744A DE4218744C2 (de) 1992-06-04 1992-06-04 Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
PCT/EP1993/001362 WO1993024469A1 (de) 1992-06-04 1993-05-28 VERFAHREN ZUR HERSTELLUNG VON N-β-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,7,10-TETRAAZACYCLODODECAN- UND N-β-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,8,11-TETRAAZACYCLOTETRADECAN-DERIVATEN UND DEREN METALLKOMPLEXE

Publications (1)

Publication Number Publication Date
GR3030604T3 true GR3030604T3 (en) 1999-10-29

Family

ID=6460555

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990401687T GR3030604T3 (en) 1992-06-04 1999-06-23 PROCESS FOR PRODUCING N--g(b)-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,7,10-TETRAAZACYCLODODECANE AND N--g(b)-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES AND THEIR METAL COMPLEXES.

Country Status (16)

Country Link
US (1) US5386028A (el)
EP (1) EP0643705B1 (el)
JP (1) JP3565843B2 (el)
KR (1) KR100269081B1 (el)
AT (1) ATE178321T1 (el)
CA (1) CA2137243C (el)
CZ (1) CZ282873B6 (el)
DE (2) DE4218744C2 (el)
DK (1) DK0643705T3 (el)
ES (1) ES2131582T3 (el)
GR (1) GR3030604T3 (el)
HU (1) HU213951B (el)
IL (1) IL105807A (el)
NO (1) NO302232B1 (el)
SK (1) SK281901B6 (el)
WO (1) WO1993024469A1 (el)

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DE19652386A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verfahren zur Herstellung von Metallkomplexcarbonsäureamiden
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
CN100418957C (zh) * 2003-07-08 2008-09-17 香港大学 三-n-烷基化的1,4,7,10-四氮杂环十二烷的合成
US8969353B2 (en) 2008-11-07 2015-03-03 Massachusetts Institute Of Technology Aminoalcohol lipidoids and uses thereof
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
CA2831392C (en) * 2011-03-28 2020-04-28 Massachusetts Institute Of Technology Conjugated lipomers and uses thereof
PT2896405T (pt) * 2011-04-21 2020-03-31 Bayer Ip Gmbh Preparação de gadobutrol de pureza elevada
JP6151707B2 (ja) 2011-10-27 2017-06-21 マサチューセッツ インスティテュート オブ テクノロジー 薬物内包微小球の形成が可能なｎ−末端で官能基化されたアミノ酸誘導体
EP3102566B1 (en) * 2014-02-06 2018-09-12 T2Pharma GmbH Process for purifying 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
KR101693400B1 (ko) * 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
HRP20230494T1 (hr) 2015-06-19 2023-08-04 Massachusetts Institute Of Technology Alkenil supstituirani 2,5-piperazindioni i njihova upotreba u pripravcima za isporuku sredstva subjektu ili stanici
WO2018059914A1 (en) 2016-09-27 2018-04-05 Bayer Pharma Aktiengesellschaft Method for producing the crystalline form of modification a of calcobutrol
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
WO2020012372A1 (en) * 2018-07-10 2020-01-16 Biophore India Pharmaceuticals Pvt. Ltd Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR101979836B1 (ko) * 2019-01-02 2019-05-21 동국생명과학 주식회사 칼코부트롤의 제조방법
WO2024030772A1 (en) * 2022-08-01 2024-02-08 Portland State University High relaxivity contrast agents and stereoselective preparation

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Also Published As

Publication number Publication date
CA2137243A1 (en) 1993-12-09
NO944691D0 (no) 1994-12-05
CA2137243C (en) 2005-09-20
DK0643705T3 (da) 1999-10-25
IL105807A (en) 1998-12-06
EP0643705A1 (de) 1995-03-22
HUT71263A (en) 1995-11-28
KR950701918A (ko) 1995-05-17
WO1993024469A1 (de) 1993-12-09
JPH07507067A (ja) 1995-08-03
DE4218744A1 (de) 1993-12-09
SK148794A3 (en) 1995-07-11
NO944691L (no) 1994-12-05
IL105807A0 (en) 1993-09-22
NO302232B1 (no) 1998-02-09
HU9403464D0 (en) 1995-03-28
EP0643705B1 (de) 1999-03-31
CZ301594A3 (en) 1995-08-16
ES2131582T3 (es) 1999-08-01
SK281901B6 (sk) 2001-09-11
KR100269081B1 (ko) 2000-10-16
DE59309488D1 (de) 1999-05-06
US5386028A (en) 1995-01-31
DE4218744C2 (de) 1997-11-06
ATE178321T1 (de) 1999-04-15
JP3565843B2 (ja) 2004-09-15
HU213951B (en) 1997-11-28
CZ282873B6 (cs) 1997-11-12

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