IL107085A - Substituted pyrimidines and pharmaceutical compositions for inhibiting sorbitol dehydrogenase comprising the same - Google Patents

Substituted pyrimidines and pharmaceutical compositions for inhibiting sorbitol dehydrogenase comprising the same

Info

Publication number
IL107085A
IL107085A IL10708593A IL10708593A IL107085A IL 107085 A IL107085 A IL 107085A IL 10708593 A IL10708593 A IL 10708593A IL 10708593 A IL10708593 A IL 10708593A IL 107085 A IL107085 A IL 107085A
Authority
IL
Israel
Prior art keywords
alkyl
phenyl
heteroaryl
aryl
formula
Prior art date
Application number
IL10708593A
Other languages
English (en)
Other versions
IL107085A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to IL12183793A priority Critical patent/IL121837A/xx
Publication of IL107085A0 publication Critical patent/IL107085A0/xx
Publication of IL107085A publication Critical patent/IL107085A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL10708593A 1992-09-28 1993-09-23 Substituted pyrimidines and pharmaceutical compositions for inhibiting sorbitol dehydrogenase comprising the same IL107085A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL12183793A IL121837A (en) 1993-09-23 1993-09-23 Mutual prodrug conjugate of aldose reductase inhibitors and substituted pyrimidines, pharmaceutical compositions containing them, and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95222292A 1992-09-28 1992-09-28

Publications (2)

Publication Number Publication Date
IL107085A0 IL107085A0 (en) 1993-12-28
IL107085A true IL107085A (en) 2001-01-11

Family

ID=25492671

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10708593A IL107085A (en) 1992-09-28 1993-09-23 Substituted pyrimidines and pharmaceutical compositions for inhibiting sorbitol dehydrogenase comprising the same

Country Status (15)

Country Link
US (2) US5728704A (cs)
EP (1) EP0662962A1 (cs)
JP (1) JP2789134B2 (cs)
KR (1) KR950703539A (cs)
AU (1) AU683620B2 (cs)
CA (1) CA2145640C (cs)
FI (1) FI934224L (cs)
HU (1) HU220669B1 (cs)
IL (1) IL107085A (cs)
MY (1) MY115288A (cs)
NO (1) NO306598B1 (cs)
NZ (1) NZ254550A (cs)
TW (1) TW284759B (cs)
WO (1) WO1994007867A1 (cs)
ZA (1) ZA937142B (cs)

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US6284748B1 (en) 1997-03-07 2001-09-04 Metabasis Therapeutics, Inc. Purine inhibitors of fructose 1,6-bisphosphatase
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IL124236A (en) * 1997-05-05 2003-01-12 Pfizer Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor
CN101125864A (zh) * 1998-09-09 2008-02-20 症变治疗公司 新的果糖1,6-二磷酸酶的杂芳族抑制剂
AU2003242500B2 (en) * 1998-09-09 2006-11-02 Metabasis Therapeutics, Inc. Novel Heteroaromatic Inhibitors of Fructose 1,6-bisphosphatase
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US6756360B1 (en) * 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
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US6380200B1 (en) * 1999-12-07 2002-04-30 Pfizer, Inc. Combination of aldose reductase inhibitors and selective serotonin reuptake inhibitors for the treatment of diabetic complications
CN100595204C (zh) * 1999-12-22 2010-03-24 症变治疗公司 双氨基化膦酸酯前药
RU2002126616A (ru) * 2000-03-08 2004-03-20 Метабэйсис Терапьютикс, Инк. (Us) Новые арильные ингибиторы фруктозо-1, 6-бисфосфатазы
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US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
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IL272246B1 (en) 2017-07-28 2025-09-01 Applied Therapeutics Inc Derivatives of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as aldose reductase inhibitors in treating galactosemia or preventing complications associated with galactosemia
CN108101883B (zh) * 2018-01-31 2018-11-13 佳木斯大学附属第一医院 一种用于防治糖尿病视网膜病变的药物及其制备方法
PL3911648T3 (pl) 2019-01-18 2025-03-10 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluorometoksy)-2- pirymidynylo]amino]cyklopentylo]amino][1(2h),3'-bipirydyn]-2-on jako inhibitor pcsk9 i sposoby jego zastosowania
CN113966396A (zh) 2019-05-07 2022-01-21 迈阿密大学 遗传性神经病和相关障碍的治疗和检测

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Also Published As

Publication number Publication date
HUT65531A (en) 1994-06-28
KR950703539A (ko) 1995-09-20
US5728704A (en) 1998-03-17
IL107085A0 (en) 1993-12-28
WO1994007867A1 (en) 1994-04-14
NZ254550A (en) 1997-08-22
NO306598B1 (no) 1999-11-29
NO951155L (no) 1995-05-26
AU4669793A (en) 1994-04-26
JP2789134B2 (ja) 1998-08-20
FI934224A0 (fi) 1993-09-27
EP0662962A1 (en) 1995-07-19
CA2145640C (en) 2001-01-30
HU9302734D0 (en) 1993-12-28
FI934224A7 (fi) 1994-03-29
NO951155D0 (no) 1995-03-27
AU683620B2 (en) 1997-11-20
HU220669B1 (hu) 2002-04-29
US5866578A (en) 1999-02-02
TW284759B (cs) 1996-09-01
JPH07507072A (ja) 1995-08-03
FI934224L (fi) 1994-03-29
ZA937142B (en) 1995-03-23
CA2145640A1 (en) 1994-04-14
MY115288A (en) 2003-05-31

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