IL105727A - 7-(2-mercapto-acetamido)-octahydro-6-oxopyrido[2,1-a][2]-benzazepine derivatives analogs thereof their preparation and pharmaceutical enkephalinase-inhibiting compositions containing them - Google Patents

7-(2-mercapto-acetamido)-octahydro-6-oxopyrido[2,1-a][2]-benzazepine derivatives analogs thereof their preparation and pharmaceutical enkephalinase-inhibiting compositions containing them

Info

Publication number
IL105727A
IL105727A IL10572793A IL10572793A IL105727A IL 105727 A IL105727 A IL 105727A IL 10572793 A IL10572793 A IL 10572793A IL 10572793 A IL10572793 A IL 10572793A IL 105727 A IL105727 A IL 105727A
Authority
IL
Israel
Prior art keywords
enkephalinase
oxopyrido
octahydro
acetamido
mercapto
Prior art date
Application number
IL10572793A
Other languages
English (en)
Other versions
IL105727A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL105727A0 publication Critical patent/IL105727A0/xx
Publication of IL105727A publication Critical patent/IL105727A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL10572793A 1992-05-20 1993-05-18 7-(2-mercapto-acetamido)-octahydro-6-oxopyrido[2,1-a][2]-benzazepine derivatives analogs thereof their preparation and pharmaceutical enkephalinase-inhibiting compositions containing them IL105727A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/886,029 US5238932A (en) 1992-05-20 1992-05-20 Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

Publications (2)

Publication Number Publication Date
IL105727A0 IL105727A0 (en) 1993-09-22
IL105727A true IL105727A (en) 2000-11-21

Family

ID=25388225

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10572793A IL105727A (en) 1992-05-20 1993-05-18 7-(2-mercapto-acetamido)-octahydro-6-oxopyrido[2,1-a][2]-benzazepine derivatives analogs thereof their preparation and pharmaceutical enkephalinase-inhibiting compositions containing them

Country Status (20)

Country Link
US (1) US5238932A (fr)
EP (1) EP0641343B1 (fr)
JP (1) JP3295848B2 (fr)
KR (1) KR100281608B1 (fr)
AT (1) ATE243694T1 (fr)
AU (1) AU669716B2 (fr)
CA (1) CA2135751C (fr)
DE (1) DE69333062T2 (fr)
DK (1) DK0641343T3 (fr)
ES (1) ES2201058T3 (fr)
FI (1) FI108136B (fr)
HU (1) HUT71107A (fr)
IL (1) IL105727A (fr)
MX (1) MX9302906A (fr)
NO (1) NO302366B1 (fr)
NZ (1) NZ252785A (fr)
PT (1) PT641343E (fr)
TW (1) TW269682B (fr)
WO (1) WO1993023397A1 (fr)
ZA (1) ZA933423B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DE69220744T2 (de) * 1991-09-27 1997-11-13 Merrell Pharma Inc 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
CA2078759C (fr) * 1991-09-27 2003-09-16 Alan M. Warshawsky Derives carboxyalkyliques, utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
AU668707B2 (en) * 1992-02-14 1996-05-16 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
ES2155852T3 (es) * 1992-10-30 2001-06-01 Merrell Pharma Inc Derivados de lactama biciclica de mercaptoacetilamida utiles como inhibidores de encefalinasa y eca.
EP0671172A4 (fr) * 1993-06-11 1998-09-02 Eisai Co Ltd Derive aminoacide.
AU680512B2 (en) * 1993-06-11 1997-07-31 Eisai Co. Ltd. Amino acid derivative
WO1995021840A1 (fr) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Nouveaux derives de bisulfure d'indane-2-mercaptoacetylamide utiles en tant qu'inhibiteurs de l'encephalinase
WO1995021857A1 (fr) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Nouveaux derives bisulfure d'idane-2-mercaptoacetylamides substitues en position 2, utiles comme inhibiteurs de l'encephalinase et de l'enzyme de conversion de l'angiotensine (ace)
AU687507B2 (en) * 1994-02-14 1998-02-26 Merrell Pharmaceuticals Inc. Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
PT750631E (pt) * 1994-02-14 2000-07-31 Merrell Pharma Inc Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
AU688012B2 (en) * 1994-03-24 1998-03-05 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
DK0751783T3 (da) * 1994-03-24 2000-06-26 Merrell Pharma Inc Hypokolesterolæmisk, antiatherosklerotisk og hypotriglyceridæmisk anvendelse af aminoacetylmercaptoderivater
ATE190315T1 (de) * 1994-12-21 2000-03-15 Hoechst Marion Roussel Inc Verfahren zur herstellung von zwischenprodukten von inhibitoren der enkephalinase und des angiotensin konvertierenden enzyms und zwischenprodukte davon
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en) * 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
IT1298268B1 (it) * 1998-02-18 1999-12-20 Zambon Spa Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
AU2502700A (en) * 1999-01-12 2000-08-01 Kenneth Blum Treatment of hypertension with compounds that inhibit the destruction of enkephalins or endorphins
AU2001281464A1 (en) * 2000-03-13 2001-09-24 Monsanto Technology Llc Recombinant proteins containing repeating units
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
CN116535304A (zh) * 2023-03-31 2023-08-04 中国科学院成都生物研究所 毛兰素类似物及其合成方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
NZ204130A (en) * 1982-05-12 1986-03-14 Hoffmann La Roche Bicyclic heterocyclic compounds and pharmaceutical compositions
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
JPH0678531B2 (ja) * 1986-06-11 1994-10-05 株式会社日立製作所 石炭ガス化方法及び装置
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
CA1337654C (fr) * 1986-06-13 1995-11-28 Gary A. Flynn Lactames tricycliques fondus servant d'agents antihypertenseurs
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
AU7168091A (en) * 1989-12-22 1991-07-24 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
CA2053340C (fr) * 1990-10-18 2002-04-02 Timothy P. Burkholder Derives de mercaptoacetylamide utiles comme inhibiteurs de l'encephalinase et de l'ace

Also Published As

Publication number Publication date
NO944430D0 (no) 1994-11-18
AU4277993A (en) 1993-12-13
JP3295848B2 (ja) 2002-06-24
CA2135751A1 (fr) 1993-11-25
KR100281608B1 (ko) 2001-02-15
HUT71107A (en) 1995-11-28
US5238932A (en) 1993-08-24
KR950701632A (ko) 1995-04-28
EP0641343A1 (fr) 1995-03-08
ES2201058T3 (es) 2004-03-16
DE69333062D1 (de) 2003-07-31
CA2135751C (fr) 1999-09-21
FI945434A (fi) 1994-11-18
NZ252785A (en) 1995-11-27
IL105727A0 (en) 1993-09-22
WO1993023397A1 (fr) 1993-11-25
EP0641343B1 (fr) 2003-06-25
FI108136B (fi) 2001-11-30
DK0641343T3 (da) 2003-10-13
PT641343E (pt) 2003-10-31
AU669716B2 (en) 1996-06-20
ZA933423B (en) 1993-12-08
ATE243694T1 (de) 2003-07-15
NO302366B1 (no) 1998-02-23
JPH07506827A (ja) 1995-07-27
MX9302906A (es) 1993-11-01
FI945434A0 (fi) 1994-11-18
DE69333062T2 (de) 2004-05-06
HU9403323D0 (en) 1995-02-28
NO944430L (no) 1995-01-17
TW269682B (fr) 1996-02-01

Similar Documents

Publication Publication Date Title
IL105727A (en) 7-(2-mercapto-acetamido)-octahydro-6-oxopyrido[2,1-a][2]-benzazepine derivatives analogs thereof their preparation and pharmaceutical enkephalinase-inhibiting compositions containing them
NZ240230A (en) Mercaptoacetylamide derivatives; preparation, use and pharmaceutical compositions thereof
NZ236589A (en) A-nor-steroid-3-carboxylic acid derivatives and pharmaceutical compositions
HUT65192A (en) Process for producing pyrido-, pyrrolo-, thiazino-, oxazino- and pyrazino benzazepine derivatives and pharmaceutical preparations containing
HUT67691A (en) 7-(substituted)-8-(substituted)-9-[(substituted-glycyl)amido]6-demethyl-6-deoxytetracyclines, pharmaceutical compositions containing them and process to prepare them
HUT65278A (en) Process for producing pyrido-, pyrrolo-, thiazino-, oxazino- and pyrazino-benzazepine derivatives and pharmaceutical preparations containing them
OA09772A (en) "mometasone furoate monohydrate, process for making same and pharmaceutical compositions".
IL102759A0 (en) Hydantoin derivatives,their preparation and pharmaceutical compositions containing them
PT84860A (en) Process for the preparation of novel tetrahydronaphtalene derivatives and of pharmaceutical compositions containing the same
HU896444D0 (en) Process for the preparation of pharmaceutical compositions
IL103510A0 (en) Pharmaceutical compositions containing antibodies for causing immunosuppression
GR850472B (fr)
HU902693D0 (en) Process for the preparation of n-heteroaryl-4-quinolin-amine compounds and pharmaceutical compositions containing them
IT1150213B (it) Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche
HUT67014A (en) Benzofuran derivatives, pharmaceutical compositions containing them and process for the preparation of thereof
NZ234501A (en) Hemoregulatory peptides and pharmaceutical compositions containing them
CA2141563A1 (fr) Nouveaux derives tricycliques de indane-2-mercaptoacetylamise subsitues en position 2 utilises comme inhibiteurs de l'encephalinase
PT87535A (pt) Process for the preparation of novel anf peptide derivatives and of pharmaceutical compositions containing the same
SG81198A1 (en) Purified form of streptogramins, its preparation and pharmaceutical compositions containing it
IL94645A0 (en) Preparation of n-oxo-tetrahydro-beta-carbolines,certain such novel compounds and pharmaceutical compositions containing them
PL286188A1 (en) Method of obtaining renine retarding aminooligohydroxy derivatives
GR3015706T3 (en) Benzylselenobenzamides of aminopyridines and picolylamines.
GB2275269B (en) Purified form of streptogramins,its preparation and pharmaceutical compositions containing it
PT82145A (en) Process for the preparation of tricyclic dibenzo condensed derivatives of pharmaceutical compositions containing the same
HU9402237D0 (en) Use of benzene-sulfonyl-indol derivatives for producing pharmaceutical compositions

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.

MM9K Patent not in force due to non-payment of renewal fees