FI108136B - Menetelmä terapeuttisesti käyttökelpoisen 6-merkaptoasetyyliamino-5-oksopyrrolo[2,1-a][2]bentsatsepiini- ja 7-merkaptoasetyyli-amino-6-oksopyrido-ja-[1,4]atsatsino-, [1,4]oksatsino- ja tiatsino[3,4-a][2]bentsatsepiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisen 6-merkaptoasetyyliamino-5-oksopyrrolo[2,1-a][2]bentsatsepiini- ja 7-merkaptoasetyyli-amino-6-oksopyrido-ja-[1,4]atsatsino-, [1,4]oksatsino- ja tiatsino[3,4-a][2]bentsatsepiinijohdannaisten valmistamiseksi Download PDF

Info

Publication number
FI108136B
FI108136B FI945434A FI945434A FI108136B FI 108136 B FI108136 B FI 108136B FI 945434 A FI945434 A FI 945434A FI 945434 A FI945434 A FI 945434A FI 108136 B FI108136 B FI 108136B
Authority
FI
Finland
Prior art keywords
mixture
oxo
benzazepine
mmol
formula
Prior art date
Application number
FI945434A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI945434A0 (fi
FI945434A (fi
Inventor
Gary Alan Flynn
Alan M Warshawsky
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI945434A0 publication Critical patent/FI945434A0/fi
Publication of FI945434A publication Critical patent/FI945434A/fi
Application granted granted Critical
Publication of FI108136B publication Critical patent/FI108136B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI945434A 1992-05-20 1994-11-18 Menetelmä terapeuttisesti käyttökelpoisen 6-merkaptoasetyyliamino-5-oksopyrrolo[2,1-a][2]bentsatsepiini- ja 7-merkaptoasetyyli-amino-6-oksopyrido-ja-[1,4]atsatsino-, [1,4]oksatsino- ja tiatsino[3,4-a][2]bentsatsepiinijohdannaisten valmistamiseksi FI108136B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88602992 1992-05-20
US07/886,029 US5238932A (en) 1992-05-20 1992-05-20 Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US9303150 1993-04-06
PCT/US1993/003150 WO1993023397A1 (fr) 1992-05-20 1993-04-06 Derives de 4-mercaptoacetylamino-[2] benzazepinone(3) et leur utilisation en tant qu'inhibiteurs de l'encephalinase

Publications (3)

Publication Number Publication Date
FI945434A0 FI945434A0 (fi) 1994-11-18
FI945434A FI945434A (fi) 1994-11-18
FI108136B true FI108136B (fi) 2001-11-30

Family

ID=25388225

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945434A FI108136B (fi) 1992-05-20 1994-11-18 Menetelmä terapeuttisesti käyttökelpoisen 6-merkaptoasetyyliamino-5-oksopyrrolo[2,1-a][2]bentsatsepiini- ja 7-merkaptoasetyyli-amino-6-oksopyrido-ja-[1,4]atsatsino-, [1,4]oksatsino- ja tiatsino[3,4-a][2]bentsatsepiinijohdannaisten valmistamiseksi

Country Status (20)

Country Link
US (1) US5238932A (fr)
EP (1) EP0641343B1 (fr)
JP (1) JP3295848B2 (fr)
KR (1) KR100281608B1 (fr)
AT (1) ATE243694T1 (fr)
AU (1) AU669716B2 (fr)
CA (1) CA2135751C (fr)
DE (1) DE69333062T2 (fr)
DK (1) DK0641343T3 (fr)
ES (1) ES2201058T3 (fr)
FI (1) FI108136B (fr)
HU (1) HUT71107A (fr)
IL (1) IL105727A (fr)
MX (1) MX9302906A (fr)
NO (1) NO302366B1 (fr)
NZ (1) NZ252785A (fr)
PT (1) PT641343E (fr)
TW (1) TW269682B (fr)
WO (1) WO1993023397A1 (fr)
ZA (1) ZA933423B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
CA2078758C (fr) * 1991-09-27 2003-12-09 Alan M. Warshawsky Derives de substitution en 2 d'indane-2-mercaptoacetylamide, utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2078759C (fr) * 1991-09-27 2003-09-16 Alan M. Warshawsky Derives carboxyalkyliques, utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
ES2155852T3 (es) * 1992-10-30 2001-06-01 Merrell Pharma Inc Derivados de lactama biciclica de mercaptoacetilamida utiles como inhibidores de encefalinasa y eca.
AU680512B2 (en) * 1993-06-11 1997-07-31 Eisai Co. Ltd. Amino acid derivative
NZ267161A (en) * 1993-06-11 1996-12-20 Eisai Co Ltd Dipeptidic benzazepine derivative with ace inhibiting activity
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
WO1995021857A1 (fr) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Nouveaux derives bisulfure d'idane-2-mercaptoacetylamides substitues en position 2, utiles comme inhibiteurs de l'encephalinase et de l'enzyme de conversion de l'angiotensine (ace)
EP0750631B1 (fr) * 1994-02-14 2000-04-05 Merrell Pharmaceuticals Inc. Nouveaux derives bisulfure de mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepine-3-one utiles en tant qu'inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine
CN1046512C (zh) * 1994-02-14 1999-11-17 默里尔药物公司 巯基乙酰胺二硫化物衍生物，其制备方法及含有它们的药物组合物
CN1069317C (zh) * 1994-02-14 2001-08-08 默里尔药物公司 用作脑啡肽酶抑制剂的新的1,2－二氢化茚－2－巯基乙酰胺二硫化物衍生物
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
JPH09510476A (ja) * 1994-03-24 1997-10-21 メリル・フアーマシユウテイカルズ・インコーポレイテツド 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のアミノアセチルメルカプト誘導体
CN1144482A (zh) * 1994-03-24 1997-03-05 默里尔药物公司 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺二硫化物衍生物
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
HU227675B1 (en) * 1994-12-21 2011-11-28 Aventisub Ii Inc Novel processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
IT1298268B1 (it) * 1998-02-18 1999-12-20 Zambon Spa Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
AU2502700A (en) * 1999-01-12 2000-08-01 Kenneth Blum Treatment of hypertension with compounds that inhibit the destruction of enkephalins or endorphins
WO2001068674A2 (fr) * 2000-03-13 2001-09-20 Monsanto Technology Llc Proteines recombinantes contenant des unites recurrentes
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
CN116535304B (zh) * 2023-03-31 2024-07-19 中国科学院成都生物研究所 毛兰素类似物及其合成方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
ZA833214B (en) * 1982-05-12 1983-12-28 Hoffmann La Roche Bicyclic compounds
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
JPH0678531B2 (ja) * 1986-06-11 1994-10-05 株式会社日立製作所 石炭ガス化方法及び装置
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
CA1337654C (fr) * 1986-06-13 1995-11-28 Gary A. Flynn Lactames tricycliques fondus servant d'agents antihypertenseurs
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
US5407960A (en) * 1989-12-22 1995-04-18 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
CA2053340C (fr) * 1990-10-18 2002-04-02 Timothy P. Burkholder Derives de mercaptoacetylamide utiles comme inhibiteurs de l'encephalinase et de l'ace

Also Published As

Publication number Publication date
WO1993023397A1 (fr) 1993-11-25
JPH07506827A (ja) 1995-07-27
NZ252785A (en) 1995-11-27
NO944430D0 (no) 1994-11-18
ZA933423B (en) 1993-12-08
ATE243694T1 (de) 2003-07-15
HUT71107A (en) 1995-11-28
HU9403323D0 (en) 1995-02-28
US5238932A (en) 1993-08-24
DE69333062T2 (de) 2004-05-06
ES2201058T3 (es) 2004-03-16
AU4277993A (en) 1993-12-13
IL105727A0 (en) 1993-09-22
KR950701632A (ko) 1995-04-28
FI945434A0 (fi) 1994-11-18
AU669716B2 (en) 1996-06-20
PT641343E (pt) 2003-10-31
NO302366B1 (no) 1998-02-23
CA2135751A1 (fr) 1993-11-25
EP0641343A1 (fr) 1995-03-08
DE69333062D1 (de) 2003-07-31
JP3295848B2 (ja) 2002-06-24
TW269682B (fr) 1996-02-01
CA2135751C (fr) 1999-09-21
IL105727A (en) 2000-11-21
EP0641343B1 (fr) 2003-06-25
MX9302906A (es) 1993-11-01
FI945434A (fi) 1994-11-18
DK0641343T3 (da) 2003-10-13
NO944430L (no) 1995-01-17
KR100281608B1 (ko) 2001-02-15

Similar Documents

Publication Publication Date Title
FI108136B (fi) Menetelmä terapeuttisesti käyttökelpoisen 6-merkaptoasetyyliamino-5-oksopyrrolo[2,1-a][2]bentsatsepiini- ja 7-merkaptoasetyyli-amino-6-oksopyrido-ja-[1,4]atsatsino-, [1,4]oksatsino- ja tiatsino[3,4-a][2]bentsatsepiinijohdannaisten valmistamiseksi
FI101304B (fi) Menetelmä terapeuttisesti käyttökelpoisten trisyklisten karboksialkyyl ijohdannaisten valmistamiseksi
US4477464A (en) Hetero-benzazepine derivatives and their pharmaceutical use
AU691243B2 (en) Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
JP2015524476A5 (fr)
AU758160B2 (en) Novel amide derivatives
BG61448B1 (en) Benzocondensated lactams increasing the release of the growth hormone
NO300848B1 (no) Nye 2-substituerte indan-2-mercaptoacetylamidderivater som er anvendbare som inhibitorer av enkefalinase og ACE
JPH08505145A (ja) 二環式フィブリノゲン拮抗物質
HU220596B1 (hu) 7-Szubsztituált pirido-benzazepin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
HUT71243A (en) Mercaptoacetylamide bicyclic lactam derivatives, process for producing them and pharmaceutical compositions of enkephalinase and ace inhibitor activity containing said compounds
US5420271A (en) 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5491142A (en) 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US4711884A (en) Thiazine and thiazepine containing compounds
EP0187037A2 (fr) Dérivés de pipéridine, leur production et emploi
US5604221A (en) Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
US6211174B1 (en) Naphtho-fused lactams promote release of growth hormone
NZ233811A (en) Amino-substituted heterocycles having renin inhibitory action
CA2183320C (fr) Nouveaux derives bisulfure de mercaptoacetylamides utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine (ace)
CA2183314C (fr) Nouveaux derives bisulfure d'idane-2-mercaptoacetylamides substitues en position 2, utiles comme inhibiteurs de l'encephalinase et de l'enzyme de conversion de l'angiotensine (ace)
NZ278501A (en) Pyridobenzazepines and analogs with dipeptide structure; medicaments
WO1986007064A1 (fr) Derives de piperidine

Legal Events

Date Code Title Description
MA Patent expired