IL104828A - Synthesis of alpha-converted arylacetamides and alpha-converted arylethylamines and some 2,3,4,5 tetrahydro- H3-1 new benzazepines - Google Patents
Synthesis of alpha-converted arylacetamides and alpha-converted arylethylamines and some 2,3,4,5 tetrahydro- H3-1 new benzazepinesInfo
- Publication number
- IL104828A IL104828A IL10482893A IL10482893A IL104828A IL 104828 A IL104828 A IL 104828A IL 10482893 A IL10482893 A IL 10482893A IL 10482893 A IL10482893 A IL 10482893A IL 104828 A IL104828 A IL 104828A
- Authority
- IL
- Israel
- Prior art keywords
- tetrahydro
- methyl
- group
- hydroxy
- chloro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/841,603 US5241065A (en) | 1992-02-25 | 1992-02-25 | 2,3,4,5-tetrahydro-1h-3-benzazepines having anti-psychotic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL104828A0 IL104828A0 (en) | 1993-06-10 |
| IL104828A true IL104828A (en) | 1999-08-17 |
Family
ID=25285279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10482893A IL104828A (en) | 1992-02-25 | 1993-02-23 | Synthesis of alpha-converted arylacetamides and alpha-converted arylethylamines and some 2,3,4,5 tetrahydro- H3-1 new benzazepines |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5241065A (zh) |
| EP (1) | EP0628030B1 (zh) |
| JP (1) | JPH07504196A (zh) |
| AT (1) | ATE229510T1 (zh) |
| AU (1) | AU3722193A (zh) |
| CA (1) | CA2130797C (zh) |
| DE (1) | DE69332559T2 (zh) |
| ES (1) | ES2183810T3 (zh) |
| IL (1) | IL104828A (zh) |
| TW (1) | TW241260B (zh) |
| WO (1) | WO1993016997A1 (zh) |
| ZA (1) | ZA931261B (zh) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU666318B2 (en) * | 1991-06-28 | 1996-02-08 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
| US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
| US6867310B1 (en) | 1997-11-20 | 2005-03-15 | Massachusetts Institute Of Technology | Arylation and vinylation of activated carbons |
| ES2209728T3 (es) * | 1999-08-06 | 2004-07-01 | F. Hoffmann-La Roche Ag | Tetrahidro-benzo(d)azepinas y su uso como antagonistas de receptores de glutamato metabotropico. |
| EP1274744A2 (en) | 2000-04-13 | 2003-01-15 | E.I. DUPONT DE NEMOURS AND COMPANY, Legal Patent Records Center | Polymer-supported synthesis of heteroatom bidentate ligands for catalysis |
| NZ540148A (en) | 2002-12-20 | 2007-11-30 | Glaxo Group Ltd | Benzazepine derivatives for the treatment of neurological disorders |
| HUE028976T2 (en) | 2003-06-17 | 2017-02-28 | Arena Pharm Inc | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
| ZA200701232B (en) | 2004-07-15 | 2008-08-27 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
| ES2600460T3 (es) | 2005-05-10 | 2017-02-09 | Intermune, Inc. | Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés |
| JP5199997B2 (ja) | 2006-04-03 | 2013-05-15 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス |
| CN101547892B (zh) | 2006-12-05 | 2014-08-20 | 艾尼纳制药公司 | 制备(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的方法和其中间体 |
| JP5491421B2 (ja) | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
| CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| WO2010132437A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用 |
| CA2760837C (en) * | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
| WO2010148207A2 (en) | 2009-06-18 | 2010-12-23 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
| WO2011153206A1 (en) | 2010-06-02 | 2011-12-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
| SG188362A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Modified-release dosage forms of 5-ht2c agonists useful for weight management |
| US8999970B2 (en) | 2010-09-01 | 2015-04-07 | Arena Pharmaceuticals, Inc. | Administration of an anti-obesity compound to individuals with renal impairment |
| SG10201506870PA (en) | 2010-09-01 | 2015-10-29 | Arena Pharm Inc | Salts of lorcaserin with optically active acids |
| EP2611433A2 (en) | 2010-09-01 | 2013-07-10 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-ht2c agonists |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| KR20150070249A (ko) | 2012-10-09 | 2015-06-24 | 아레나 파마슈티칼스, 인크. | 체중 관리 방법 |
| WO2015153683A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
| WO2021213353A1 (zh) * | 2020-04-20 | 2021-10-28 | 苏州恩华生物医药科技有限公司 | 酰胺或者磺酰胺类衍生物及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5015639A (en) * | 1987-03-27 | 1991-05-14 | Schering Corporation | Substituted benzazepines, their preparation and pharmaceutical compositions containing them |
| ZA882080B (en) * | 1987-03-27 | 1989-04-26 | Schering Corp | Substituted benzazepines,their preparation and pharmaceutical compositions containing them |
| DE3936594A1 (de) * | 1989-09-15 | 1991-03-28 | Basf Ag | (gamma)-glutamyl-transferasen zur behandlung von krankheiten |
| IL98487A0 (en) * | 1990-06-15 | 1992-07-15 | Schering Corp | 8-lower alkyl-5-cycloalkyl or 5-cycloalkenyl substituted benzazepines and pharmaceutical compositions containing them |
-
1992
- 1992-02-25 US US07/841,603 patent/US5241065A/en not_active Expired - Lifetime
-
1993
- 1993-02-23 TW TW082101289A patent/TW241260B/zh active
- 1993-02-23 JP JP5514943A patent/JPH07504196A/ja not_active Ceased
- 1993-02-23 AT AT93906034T patent/ATE229510T1/de not_active IP Right Cessation
- 1993-02-23 US US08/290,894 patent/US5530125A/en not_active Expired - Fee Related
- 1993-02-23 WO PCT/US1993/001425 patent/WO1993016997A1/en active IP Right Grant
- 1993-02-23 CA CA002130797A patent/CA2130797C/en not_active Expired - Fee Related
- 1993-02-23 AU AU37221/93A patent/AU3722193A/en not_active Abandoned
- 1993-02-23 ES ES93906034T patent/ES2183810T3/es not_active Expired - Lifetime
- 1993-02-23 EP EP93906034A patent/EP0628030B1/en not_active Expired - Lifetime
- 1993-02-23 IL IL10482893A patent/IL104828A/en not_active IP Right Cessation
- 1993-02-23 ZA ZA931261A patent/ZA931261B/xx unknown
- 1993-02-23 DE DE69332559T patent/DE69332559T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU3722193A (en) | 1993-09-13 |
| ATE229510T1 (de) | 2002-12-15 |
| TW241260B (zh) | 1995-02-21 |
| EP0628030A1 (en) | 1994-12-14 |
| WO1993016997A1 (en) | 1993-09-02 |
| ES2183810T3 (es) | 2003-04-01 |
| CA2130797C (en) | 2006-07-04 |
| EP0628030B1 (en) | 2002-12-11 |
| JPH07504196A (ja) | 1995-05-11 |
| IL104828A0 (en) | 1993-06-10 |
| CA2130797A1 (en) | 1993-08-26 |
| DE69332559T2 (de) | 2003-11-20 |
| ZA931261B (en) | 1993-08-23 |
| US5241065A (en) | 1993-08-31 |
| DE69332559D1 (de) | 2003-01-23 |
| US5530125A (en) | 1996-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0628030B1 (en) | 2,3,4,5-TETRAHYDRO-1H --3-BENZAZEPINES HAVING ANTI-PSYCHOTIC ACTIVITY, AND SYNTHESIS OF $g(a)-SUBSTITUTED-ARYLACETAMIDES | |
| US9403776B2 (en) | Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin | |
| US5296482A (en) | (Benzocycloalkyl) alkylamines | |
| CN101023055B (zh) | 环状胺衍生物或其盐 | |
| DD284678A5 (de) | Verfahren zur herstellung von neuen cyclischen aminderivaten | |
| JPH08501559A (ja) | セロトニン受容体剤 | |
| IE912031A1 (en) | 8-lower alkyl-5-cycloalkyl or 5-cycloalkenyl substituted¹benzazepines and pharmaceutical compositions containing them | |
| CA1333485C (en) | Fused benzazepines | |
| JPH03120218A (ja) | 痛みおよび／または中枢神経系障害の新規治療用医薬およびそれに用いる複素環式化合物 | |
| IE58883B1 (en) | Nitrogen containing compounds | |
| EP1828125A1 (fr) | Derives d'arylpiperazine et leur utilization comme ligands selectifs du recepteur d3 de la dopamine | |
| BE898072A (fr) | Derives du pyrrole et leur preparation. | |
| EP1680127B1 (en) | Benzazepine derivatives as mao-b inhibitors | |
| US5258384A (en) | S-11-hydroxy-10-methylaporphine and its biologically active salt forms as 5HT1A inhibitors | |
| JP2002537288A (ja) | ドーパミンｄ１受容体アゴニスト化合物 | |
| KR20010072262A (ko) | 삼환식 카르복스아미드 | |
| EP0299101A1 (en) | Fused benzazepines | |
| AU760373B2 (en) | New spiro imidazoline compounds, a process for their preparation and pharmaceutical compositions containing them | |
| JPH09216879A (ja) | （１ｈ−インドール−４−イル）−ピペリジンまたはテトラヒドロピリジンのエチルアミンおよびエチルカルボキサミド | |
| JP2928307B2 (ja) | ピロリジン誘導体 | |
| JPH11349481A (ja) | シグマ受容体結合剤 | |
| ITMI961861A1 (it) | Derivati tetraciclici spiro-condensati |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |