ATE229510T1 - 2,3,4,5-tetrahydro-1h-3-benzazepinen mit anti- psychotisch wirkung, und synthese von alfa- substituierten-arylacetamiden - Google Patents
2,3,4,5-tetrahydro-1h-3-benzazepinen mit anti- psychotisch wirkung, und synthese von alfa- substituierten-arylacetamidenInfo
- Publication number
- ATE229510T1 ATE229510T1 AT93906034T AT93906034T ATE229510T1 AT E229510 T1 ATE229510 T1 AT E229510T1 AT 93906034 T AT93906034 T AT 93906034T AT 93906034 T AT93906034 T AT 93906034T AT E229510 T1 ATE229510 T1 AT E229510T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- alpha
- pct
- benzazepines
- hydrogen atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/841,603 US5241065A (en) | 1992-02-25 | 1992-02-25 | 2,3,4,5-tetrahydro-1h-3-benzazepines having anti-psychotic activity |
PCT/US1993/001425 WO1993016997A1 (en) | 1992-02-25 | 1993-02-23 | 2,3,4,5-TETRAHYDRO-1H^_-3-BENZAZEPINES HAVING ANTI-PSYCHOTIC ACTIVITY, AND SYNTHESIS OF α-SUBSTITUTED-ARYLACETAMIDES |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE229510T1 true ATE229510T1 (de) | 2002-12-15 |
Family
ID=25285279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93906034T ATE229510T1 (de) | 1992-02-25 | 1993-02-23 | 2,3,4,5-tetrahydro-1h-3-benzazepinen mit anti- psychotisch wirkung, und synthese von alfa- substituierten-arylacetamiden |
Country Status (12)
Country | Link |
---|---|
US (2) | US5241065A (de) |
EP (1) | EP0628030B1 (de) |
JP (1) | JPH07504196A (de) |
AT (1) | ATE229510T1 (de) |
AU (1) | AU3722193A (de) |
CA (1) | CA2130797C (de) |
DE (1) | DE69332559T2 (de) |
ES (1) | ES2183810T3 (de) |
IL (1) | IL104828A (de) |
TW (1) | TW241260B (de) |
WO (1) | WO1993016997A1 (de) |
ZA (1) | ZA931261B (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU666318B2 (en) * | 1991-06-28 | 1996-02-08 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
US6867310B1 (en) | 1997-11-20 | 2005-03-15 | Massachusetts Institute Of Technology | Arylation and vinylation of activated carbons |
ES2209728T3 (es) * | 1999-08-06 | 2004-07-01 | F. Hoffmann-La Roche Ag | Tetrahidro-benzo(d)azepinas y su uso como antagonistas de receptores de glutamato metabotropico. |
EP1274744A2 (de) | 2000-04-13 | 2003-01-15 | E.I. DUPONT DE NEMOURS AND COMPANY, Legal Patent Records Center | Polymerträger-herstellungsverfahren von heteroatom-bidentatliganden und verwendung zur katalyse |
NZ540148A (en) | 2002-12-20 | 2007-11-30 | Glaxo Group Ltd | Benzazepine derivatives for the treatment of neurological disorders |
HUE028976T2 (en) | 2003-06-17 | 2017-02-28 | Arena Pharm Inc | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
ZA200701232B (en) | 2004-07-15 | 2008-08-27 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
ES2600460T3 (es) | 2005-05-10 | 2017-02-09 | Intermune, Inc. | Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés |
JP5199997B2 (ja) | 2006-04-03 | 2013-05-15 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス |
CN101547892B (zh) | 2006-12-05 | 2014-08-20 | 艾尼纳制药公司 | 制备(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的方法和其中间体 |
JP5491421B2 (ja) | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 5−ht2cアゴニストである(r)−8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
WO2010132437A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | (S)−7−([1,2,4]トリアゾロ[1,5−a]ピリジン−6−イル)−4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロイソキノリンの結晶形態およびその使用 |
CA2760837C (en) * | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
WO2010148207A2 (en) | 2009-06-18 | 2010-12-23 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
WO2011153206A1 (en) | 2010-06-02 | 2011-12-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
SG188362A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Modified-release dosage forms of 5-ht2c agonists useful for weight management |
US8999970B2 (en) | 2010-09-01 | 2015-04-07 | Arena Pharmaceuticals, Inc. | Administration of an anti-obesity compound to individuals with renal impairment |
SG10201506870PA (en) | 2010-09-01 | 2015-10-29 | Arena Pharm Inc | Salts of lorcaserin with optically active acids |
EP2611433A2 (de) | 2010-09-01 | 2013-07-10 | Arena Pharmaceuticals, Inc. | Nicht-hygroskopische salze aus 5-ht2c-agonisten |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
KR20150070249A (ko) | 2012-10-09 | 2015-06-24 | 아레나 파마슈티칼스, 인크. | 체중 관리 방법 |
WO2015153683A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
WO2021213353A1 (zh) * | 2020-04-20 | 2021-10-28 | 苏州恩华生物医药科技有限公司 | 酰胺或者磺酰胺类衍生物及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5015639A (en) * | 1987-03-27 | 1991-05-14 | Schering Corporation | Substituted benzazepines, their preparation and pharmaceutical compositions containing them |
ZA882080B (en) * | 1987-03-27 | 1989-04-26 | Schering Corp | Substituted benzazepines,their preparation and pharmaceutical compositions containing them |
DE3936594A1 (de) * | 1989-09-15 | 1991-03-28 | Basf Ag | (gamma)-glutamyl-transferasen zur behandlung von krankheiten |
IL98487A0 (en) * | 1990-06-15 | 1992-07-15 | Schering Corp | 8-lower alkyl-5-cycloalkyl or 5-cycloalkenyl substituted benzazepines and pharmaceutical compositions containing them |
-
1992
- 1992-02-25 US US07/841,603 patent/US5241065A/en not_active Expired - Lifetime
-
1993
- 1993-02-23 TW TW082101289A patent/TW241260B/zh active
- 1993-02-23 JP JP5514943A patent/JPH07504196A/ja not_active Ceased
- 1993-02-23 AT AT93906034T patent/ATE229510T1/de not_active IP Right Cessation
- 1993-02-23 US US08/290,894 patent/US5530125A/en not_active Expired - Fee Related
- 1993-02-23 WO PCT/US1993/001425 patent/WO1993016997A1/en active IP Right Grant
- 1993-02-23 CA CA002130797A patent/CA2130797C/en not_active Expired - Fee Related
- 1993-02-23 AU AU37221/93A patent/AU3722193A/en not_active Abandoned
- 1993-02-23 ES ES93906034T patent/ES2183810T3/es not_active Expired - Lifetime
- 1993-02-23 EP EP93906034A patent/EP0628030B1/de not_active Expired - Lifetime
- 1993-02-23 IL IL10482893A patent/IL104828A/en not_active IP Right Cessation
- 1993-02-23 ZA ZA931261A patent/ZA931261B/xx unknown
- 1993-02-23 DE DE69332559T patent/DE69332559T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU3722193A (en) | 1993-09-13 |
TW241260B (de) | 1995-02-21 |
EP0628030A1 (de) | 1994-12-14 |
WO1993016997A1 (en) | 1993-09-02 |
ES2183810T3 (es) | 2003-04-01 |
CA2130797C (en) | 2006-07-04 |
EP0628030B1 (de) | 2002-12-11 |
JPH07504196A (ja) | 1995-05-11 |
IL104828A0 (en) | 1993-06-10 |
CA2130797A1 (en) | 1993-08-26 |
IL104828A (en) | 1999-08-17 |
DE69332559T2 (de) | 2003-11-20 |
ZA931261B (en) | 1993-08-23 |
US5241065A (en) | 1993-08-31 |
DE69332559D1 (de) | 2003-01-23 |
US5530125A (en) | 1996-06-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |