IL104179A - Process for the preparation of solid pharmaceutical dispersions and solid pharmaceutical dispersions with improved solubility characteristics - Google Patents
Process for the preparation of solid pharmaceutical dispersions and solid pharmaceutical dispersions with improved solubility characteristicsInfo
- Publication number
- IL104179A IL104179A IL104179A IL10417992A IL104179A IL 104179 A IL104179 A IL 104179A IL 104179 A IL104179 A IL 104179A IL 10417992 A IL10417992 A IL 10417992A IL 104179 A IL104179 A IL 104179A
- Authority
- IL
- Israel
- Prior art keywords
- solid pharmaceutical
- pharmaceutical dispersions
- preparation
- drug
- improved solubility
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Colloid Chemistry (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Glanulating (AREA)
- Ceramic Products (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80965691A | 1991-12-18 | 1991-12-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL104179A0 IL104179A0 (en) | 1993-05-13 |
IL104179A true IL104179A (en) | 1997-11-20 |
Family
ID=25201894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL104179A IL104179A (en) | 1991-12-18 | 1992-12-18 | Process for the preparation of solid pharmaceutical dispersions and solid pharmaceutical dispersions with improved solubility characteristics |
Country Status (17)
Country | Link |
---|---|
US (3) | US6677362B1 (xx) |
EP (1) | EP0617612B1 (xx) |
JP (1) | JP3722293B2 (xx) |
AT (1) | ATE157864T1 (xx) |
AU (1) | AU671811B2 (xx) |
CA (1) | CA2124821C (xx) |
DE (1) | DE69222182T2 (xx) |
DK (1) | DK0617612T3 (xx) |
ES (1) | ES2109377T3 (xx) |
GR (1) | GR3025501T3 (xx) |
IL (1) | IL104179A (xx) |
MX (1) | MX9207390A (xx) |
NZ (1) | NZ245483A (xx) |
PT (1) | PT101132B (xx) |
SG (1) | SG43179A1 (xx) |
WO (1) | WO1993011749A1 (xx) |
ZA (1) | ZA929789B (xx) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992018106A1 (en) * | 1991-04-16 | 1992-10-29 | Nippon Shinyaku Co., Ltd. | Method of manufacturing solid dispersion |
WO1993011749A1 (en) | 1991-12-18 | 1993-06-24 | Warner-Lambert Company | A process for the preparation of a solid dispersion |
EP0729748B1 (en) * | 1993-11-18 | 2003-02-26 | Nippon Shinyaku Company, Limited | Process for producing stable medicinal composition |
SE9502244D0 (sv) * | 1995-06-20 | 1995-06-20 | Bioglan Ab | A composition and a process for the preparation thereof |
AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
WO1997049384A1 (en) | 1996-06-26 | 1997-12-31 | Board Of Regents, The University Of Texas System | Hot-melt extrudable pharmaceutical formulation |
AU3483497A (en) * | 1996-06-28 | 1998-01-21 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
US20050004049A1 (en) * | 1997-03-11 | 2005-01-06 | Elan Pharma International Limited | Novel griseofulvin compositions |
US5955475A (en) * | 1997-06-30 | 1999-09-21 | Endo Pharmaceuticals Inc. | Process for manufacturing paroxetine solid dispersions |
HN1998000115A (es) * | 1997-08-21 | 1999-06-02 | Warner Lambert Co | Formas de dosificación farmacéuticas sólidas |
CA2214895C (en) * | 1997-09-19 | 1999-04-20 | Bernard Charles Sherman | Improved pharmaceutical composition comprising fenofibrate |
US6376542B1 (en) * | 1997-12-19 | 2002-04-23 | Bissell Homecare, Inc. | Aqueous miticide compositions containing benzyl benzoate |
US6107341A (en) * | 1997-12-19 | 2000-08-22 | Bissell Homecare, Inc. | Aqueous miticide containing benzyl benzoate |
IL136460A0 (en) * | 1997-12-22 | 2001-06-14 | Schering Corp | Molecular dispersion composition with enhanced bioavailability |
US6706283B1 (en) | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
DE19913606A1 (de) * | 1999-03-25 | 2000-09-28 | Basf Ag | Pulverförmige Solubilisationshilfsstoffe für feste pharmazeutische Darreichungsformen |
DE19916383A1 (de) * | 1999-03-31 | 2000-10-05 | Schering Ag | Pharmazeutische Zusammensetzung mit einem Extrusionsstoff |
CA2374117A1 (en) * | 1999-05-28 | 2000-12-07 | Abbott Laboratories | Novel formulations comprising lipid-regulating agents |
DE19929361A1 (de) * | 1999-06-25 | 2001-01-04 | Basf Ag | Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen |
EP1175205B1 (en) * | 1999-11-12 | 2006-06-14 | Abbott Laboratories | Solid dispersion comprising ritonavir, fenofibrate or griseofulvin |
DE10000792A1 (de) * | 2000-01-11 | 2001-07-19 | Bernhard C Lippold | Formulierungen von Wirkstoffen in Form einer festen Dispersion |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
JP2004534812A (ja) | 2001-06-22 | 2004-11-18 | ファイザー・プロダクツ・インク | 薬物および中性ポリマーの分散物の医薬組成物 |
IL158991A0 (en) | 2001-06-22 | 2004-05-12 | Pfizer Prod Inc | Pharmaceutical compositions comprising low-solubility and/or acid sensitive drugs and neutralized acidic polymers |
JP2005523262A (ja) | 2002-02-01 | 2005-08-04 | ファイザー・プロダクツ・インク | 薬物及び親油性ミクロ相形成物質の非晶質分散物の医薬組成物 |
MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
GB0205253D0 (en) * | 2002-03-06 | 2002-04-17 | Univ Gent | Immediate release pharmaceutical granule compositions and a continuous process for making them |
AU2002242339A1 (en) * | 2002-03-14 | 2003-09-29 | Watson Pharmaceuticals, Inc. | Progesterone oral drug delivery system |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
KR20100055542A (ko) * | 2002-06-25 | 2010-05-26 | 애크럭스 디디에스 피티와이 리미티드 | 비정질 약학적 조성물을 이용한 경피전달속도의 제어 |
US20050181032A1 (en) * | 2002-06-25 | 2005-08-18 | Acrux Dds Pty Ltd. | Metastable pharmaceutical compositions |
JP2006518380A (ja) | 2003-01-31 | 2006-08-10 | スミスクライン・ビーチャム・コーポレイション | 固体分散体組成物 |
CA2509958A1 (en) * | 2003-02-03 | 2004-08-19 | Novartis Ag | Pharmaceutical formulation |
US7470791B2 (en) | 2003-03-10 | 2008-12-30 | Nycomed Gmbh | Process for the preparation of roflumilast |
EP1620193B1 (en) * | 2003-04-29 | 2008-09-03 | N.V. Organon | Antisolvent solidification process |
CL2004000983A1 (es) * | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
PE20050150A1 (es) * | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
US8273371B2 (en) | 2003-06-27 | 2012-09-25 | Johan Adriaan Martens | Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs |
GB0315012D0 (en) * | 2003-06-27 | 2003-07-30 | Leuven K U Res & Dev | Zeotiles |
BRPI0413277A (pt) | 2003-08-04 | 2006-10-10 | Pfizer Prod Inc | composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
EP1680091B1 (en) | 2003-10-10 | 2017-05-31 | Veloxis Pharmaceuticals A/S | A solid dosage form comprising a fibrate |
CN1889932A (zh) * | 2003-12-04 | 2007-01-03 | 辉瑞产品公司 | 制备药用多颗粒的方法 |
KR100629771B1 (ko) * | 2004-01-27 | 2006-09-28 | 씨제이 주식회사 | 결정성이 감소되거나 무정형화된 올티프라즈의 제조방법 |
US20050202079A1 (en) * | 2004-03-15 | 2005-09-15 | Mylan Pharmaceuticals Inc. | Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
GB2418854B (en) | 2004-08-31 | 2009-12-23 | Euro Celtique Sa | Multiparticulates |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
ES2421916T3 (es) * | 2005-03-16 | 2013-09-06 | Nycomed Gmbh | Forma farmacéutica de sabor enmascarado que contiene roflumilast |
EP1871346A4 (en) * | 2005-04-20 | 2012-07-18 | Ctc Bio Inc | PHARMACEUTICAL COMPOSITION WITH FREE BASE FROM SIBUTRAMIN AND MANUFACTURING METHOD THEREFOR |
KR100627687B1 (ko) * | 2005-04-20 | 2006-09-25 | 주식회사 씨티씨바이오 | 시부트라민 유리염기 함유 조성물 및 이의 제조방법 |
DE102005023803A1 (de) * | 2005-05-19 | 2006-11-23 | Basf Ag | Verfahren zur Herstellung von festen Blends aus Polyvinylpyrrolidonen und ethoxilierten Fettsäurederivaten |
KR20070025070A (ko) * | 2005-08-31 | 2007-03-08 | 주식회사 대웅제약 | 시부트라민 및 계면활성제를 함유하는 고체분산체 및 그의제조방법 |
GB0612695D0 (en) * | 2006-06-27 | 2006-08-09 | Univ Gent | Process for preparing a solid dosage form |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
US20080132560A1 (en) * | 2006-11-21 | 2008-06-05 | San-Laung Chow | Solid dispersion composition |
WO2008079629A2 (en) * | 2006-12-21 | 2008-07-03 | Boehringer Ingelheim International Gmbh | Formulations with improved bioavailability |
JP2011509283A (ja) * | 2008-01-11 | 2011-03-24 | シプラ・リミテッド | 固体医薬剤形 |
EP2249811A1 (en) | 2008-01-25 | 2010-11-17 | Grünenthal GmbH | Pharmaceutical dosage form |
CA2723438C (en) | 2008-05-09 | 2016-10-11 | Gruenenthal Gmbh | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
WO2011009602A1 (en) | 2009-07-22 | 2011-01-27 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
BR112012001244A2 (pt) | 2009-07-22 | 2020-12-08 | Gruünenthal Gmbh | Forma de dosagem resitente à adulteração, seu processo de produção, e embalagem contendo tal forma |
SG10201501054TA (en) * | 2009-10-27 | 2015-04-29 | Lupin Ltd | Solid dispersion of rifaximin |
AR082862A1 (es) | 2010-09-02 | 2013-01-16 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteracion que comprende un polimero anionico |
RU2604676C2 (ru) | 2010-09-02 | 2016-12-10 | Грюненталь Гмбх | Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль |
JP5999567B2 (ja) | 2010-10-20 | 2016-09-28 | ディーエスエム アイピー アセッツ ビー.ブイ. | ペンダント型親水性物質を有する生分解性組成物および関連デバイス |
KR102095698B1 (ko) * | 2010-10-29 | 2020-04-01 | 애브비 인코포레이티드 | 아폽토시스―유도제를 포함하는 고체 분산체 |
BR112014002022A2 (pt) | 2011-07-29 | 2017-02-21 | Gruenenthal Gmbh | comprimido resistente à violação proporcionando liberação de fármaco imediata |
PT2736497T (pt) | 2011-07-29 | 2017-11-30 | Gruenenthal Gmbh | Comprimido resistente a adulteração proporcionando libertação imediata de fármaco |
WO2013030789A1 (en) | 2011-08-30 | 2013-03-07 | Ranbaxy Laboratories Limited | Pharmaceutical oral solid dosage form containing a poorly water soluble pde - iv inhibitor |
CA2864949A1 (en) | 2012-02-28 | 2013-09-06 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
ES2692944T3 (es) | 2012-04-18 | 2018-12-05 | Grünenthal GmbH | Forma de dosificación farmacéutica resistente a la manipulación y resistente a la descarga rápida de la dosis |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
KR102191562B1 (ko) | 2012-11-07 | 2020-12-15 | 에스케이바이오팜 주식회사 | 난용성 약물의 고체분산체 및 이의 제조방법 |
MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
MX2015016254A (es) | 2013-05-29 | 2016-04-20 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal. |
US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
CN105934241B (zh) | 2013-11-26 | 2020-06-05 | 格吕伦塔尔有限公司 | 通过低温研磨制备粉末状药物组合物 |
WO2015173195A1 (en) | 2014-05-12 | 2015-11-19 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
AU2015266117A1 (en) | 2014-05-26 | 2016-11-24 | Grunenthal Gmbh | Multiparticles safeguarded against ethanolic dose-dumping |
EP3227299B1 (en) | 2014-12-04 | 2021-05-26 | Merck Sharp & Dohme Corp. | Formulation inhibiting effects of low acid environment |
CN107889459A (zh) | 2015-04-24 | 2018-04-06 | 格吕伦塔尔有限公司 | 具有立即释放和对溶剂萃取的抗性的抗篡改剂型 |
US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
CN113616599B (zh) * | 2021-09-10 | 2022-11-18 | 宁夏医科大学 | 一种大黄素固体分散体及其制备方法与应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0083370A1 (en) * | 1981-07-08 | 1983-07-13 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile |
JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
GB8518301D0 (en) * | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
DE3612212A1 (de) | 1986-04-11 | 1987-10-15 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen formen |
US4980378A (en) * | 1988-06-01 | 1990-12-25 | Odontex, Inc. | Biodegradable absorption enhancers |
DE3839825A1 (de) * | 1988-11-25 | 1990-06-13 | Henning Berlin Gmbh | Feststoffdispersionen enthaltend oxipurinol und/oder seine alkali- oder erdalkalisalze |
US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
WO1992018106A1 (en) | 1991-04-16 | 1992-10-29 | Nippon Shinyaku Co., Ltd. | Method of manufacturing solid dispersion |
WO1993011749A1 (en) | 1991-12-18 | 1993-06-24 | Warner-Lambert Company | A process for the preparation of a solid dispersion |
-
1992
- 1992-11-18 WO PCT/US1992/009989 patent/WO1993011749A1/en active IP Right Grant
- 1992-11-18 DK DK92925333.4T patent/DK0617612T3/da active
- 1992-11-18 JP JP51091293A patent/JP3722293B2/ja not_active Expired - Fee Related
- 1992-11-18 SG SG1996004974A patent/SG43179A1/en unknown
- 1992-11-18 AU AU31426/93A patent/AU671811B2/en not_active Ceased
- 1992-11-18 EP EP92925333A patent/EP0617612B1/en not_active Expired - Lifetime
- 1992-11-18 CA CA002124821A patent/CA2124821C/en not_active Expired - Fee Related
- 1992-11-18 ES ES92925333T patent/ES2109377T3/es not_active Expired - Lifetime
- 1992-11-18 DE DE69222182T patent/DE69222182T2/de not_active Expired - Fee Related
- 1992-11-18 AT AT92925333T patent/ATE157864T1/de not_active IP Right Cessation
- 1992-12-16 PT PT101132A patent/PT101132B/pt not_active IP Right Cessation
- 1992-12-16 NZ NZ245483A patent/NZ245483A/en unknown
- 1992-12-17 ZA ZA929789A patent/ZA929789B/xx unknown
- 1992-12-17 MX MX9207390A patent/MX9207390A/es unknown
- 1992-12-18 IL IL104179A patent/IL104179A/xx not_active IP Right Cessation
-
1994
- 1994-03-28 US US08/218,495 patent/US6677362B1/en not_active Expired - Fee Related
-
1997
- 1997-11-26 GR GR970403150T patent/GR3025501T3/el unknown
-
2001
- 2001-06-14 US US09/881,366 patent/US20010044409A1/en not_active Abandoned
-
2003
- 2003-12-03 US US10/726,780 patent/US20040110694A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU3142693A (en) | 1993-07-19 |
PT101132B (pt) | 2000-02-29 |
ATE157864T1 (de) | 1997-09-15 |
ZA929789B (en) | 1993-06-23 |
US20040110694A1 (en) | 2004-06-10 |
NZ245483A (en) | 1995-12-21 |
SG43179A1 (en) | 1997-10-17 |
MX9207390A (es) | 1993-06-01 |
JPH07504162A (ja) | 1995-05-11 |
ES2109377T3 (es) | 1998-01-16 |
WO1993011749A1 (en) | 1993-06-24 |
JP3722293B2 (ja) | 2005-11-30 |
EP0617612B1 (en) | 1997-09-10 |
IL104179A0 (en) | 1993-05-13 |
PT101132A (pt) | 1994-03-31 |
GR3025501T3 (en) | 1998-02-27 |
US6677362B1 (en) | 2004-01-13 |
DE69222182D1 (de) | 1997-10-16 |
DE69222182T2 (de) | 1998-02-26 |
US20010044409A1 (en) | 2001-11-22 |
DK0617612T3 (da) | 1998-04-14 |
CA2124821C (en) | 2003-10-07 |
AU671811B2 (en) | 1996-09-12 |
EP0617612A1 (en) | 1994-10-05 |
CA2124821A1 (en) | 1993-06-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL104179A (en) | Process for the preparation of solid pharmaceutical dispersions and solid pharmaceutical dispersions with improved solubility characteristics | |
CA2039197A1 (en) | Pharmaceutic Formulation for the Treatment of Alcoholism | |
NO178697C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive pyrazolopyridin-forbindelser | |
AU635021B2 (en) | Extended release pharmaceutical formulations | |
ATE122668T1 (de) | Diarylsubstituierte heterocyclische verbindung, ihre herstellung und arzneimittel und kosmetika daraus. | |
ES2067250T3 (es) | Preparado farmaceutico sin disolventes para administracion oral, con liberacion retardada de la sustancia activa y procedimiento para su fabricacion. | |
GR3017411T3 (en) | Production process of microspheres. | |
GR3002601T3 (en) | Microparticles comprising a biodegradable polymer controlling the release of an antimalarial drug, pharmaceutical compositions containing them and process for their preparation | |
EP0548794A3 (en) | Polyaspartamide derivative as adsorbent for bile acids, polyaspartamide loaded with bile acids and preparation and use as a drug | |
KR880009018A (ko) | 3-l-피로글루타밀-l-티아졸리딘-4-카르복실산 및 이의 제법 | |
AU3003189A (en) | 7(2-(2-aminothiazol-4-yl)-2-hydroxyimino-acetamido)-3- methoxymethyl-3-cephem-4-carboxylate ester derivatives | |
EP0394553A3 (en) | Use of fluorine containing pyridone carboxylic acid derivatives for preparing a medicament for the treatment of HIV infections | |
HK65193A (en) | Nicorandil-containing preparation for injection | |
MY114213A (en) | Clavulanic acid salts | |
ATE288269T1 (de) | Arzneizusammensetzungen und herstellungsverfahren von ergotalkaloidhaltigen arzneizusammensetzungen mit verzögerter wirkstoffabgabe und verbesserter bioverfügbarkeit | |
NO160258C (no) | Analogifremgangsmaate for fremstilling av farmakologisk aktive pyridazinonimin-derivater. | |
AU1370895A (en) | 2'-deoxy-5-fluorouridine derivative, pharmaceutically acceptable salt thereof, process for producing the same, and antitumor drug | |
AU6703090A (en) | New substituted benzothiazolinones, process for preparing these and pharmaceutical compositions containing them | |
HUT57781A (en) | Process for producing cytotoxic bicyclo (7.3.1) tridec-4-ene-2,6-diine derivatives and pharmaceutical compositions comprising such ring system | |
DE69325531D1 (de) | Oral anzuwendendes Arzneimittel bestehend aus Ibuprofen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |