IL103126A - 5-amino-4-hydroxyhexanoic acid derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

5-amino-4-hydroxyhexanoic acid derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL103126A
IL103126A IL103126A IL10312692A IL103126A IL 103126 A IL103126 A IL 103126A IL 103126 A IL103126 A IL 103126A IL 10312692 A IL10312692 A IL 10312692A IL 103126 A IL103126 A IL 103126A
Authority
IL
Israel
Prior art keywords
amino
preparation
pharmaceutical compositions
compositions containing
acid derivatives
Prior art date
Application number
IL103126A
Other languages
English (en)
Other versions
IL103126A0 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IL103126A0 publication Critical patent/IL103126A0/xx
Publication of IL103126A publication Critical patent/IL103126A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL103126A 1991-09-12 1992-09-10 5-amino-4-hydroxyhexanoic acid derivatives, process for their preparation and pharmaceutical compositions containing them IL103126A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH268991 1991-09-12
CH98092 1992-03-27
CH200792 1992-06-25

Publications (2)

Publication Number Publication Date
IL103126A0 IL103126A0 (en) 1993-02-21
IL103126A true IL103126A (en) 1997-09-30

Family

ID=27172572

Family Applications (1)

Application Number Title Priority Date Filing Date
IL103126A IL103126A (en) 1991-09-12 1992-09-10 5-amino-4-hydroxyhexanoic acid derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (15)

Country Link
EP (1) EP0532466A3 (fr)
JP (1) JPH05230095A (fr)
KR (1) KR930006050A (fr)
AU (1) AU661018B2 (fr)
CA (1) CA2077948A1 (fr)
CZ (1) CZ280292A3 (fr)
FI (1) FI924035A (fr)
HU (1) HUT63632A (fr)
IL (1) IL103126A (fr)
MX (1) MX9205208A (fr)
NO (1) NO923533L (fr)
NZ (1) NZ244288A (fr)
PL (1) PL169969B1 (fr)
RU (1) RU2067585C1 (fr)
SK (1) SK280292A3 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
RU2126794C1 (ru) * 1992-03-11 1999-02-27 Нархекс Лимитед Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы
TW217410B (fr) * 1992-04-01 1993-12-11 Ciba Geigy
ATE143004T1 (de) 1992-12-23 1996-10-15 Ciba Geigy Ag Antiretrovirale hydrazinderivate
EP0618222A3 (en) * 1993-03-11 1997-01-02 Ciba Geigy Ag Dipeptid derivatives of 5-amino-4-hydroxy-hexanoic acid.
EP0626178A1 (fr) * 1993-05-17 1994-11-30 Ciba-Geigy Ag Utilisation d'inhibiteurs de la protease du VIH dans le traitement des maladies tumorales
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
IL110752A (en) * 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
US5559158A (en) * 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
IL111991A (en) * 1994-01-28 2000-07-26 Abbott Lab Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
WO1996016980A1 (fr) * 1994-11-29 1996-06-06 Novartis Ag Derives morpholino-ethylamides
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5840835A (en) * 1995-10-30 1998-11-24 Merck & Co., Inc. Inhibitors of peptide binding to MHC class II proteins
US5817757A (en) * 1995-10-30 1998-10-06 Merck & Co., Inc. Inhibitors of peptide binding to MHO class II proteins
AU7475396A (en) * 1995-10-30 1997-05-22 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
EP1149843A4 (fr) * 1999-01-28 2012-06-06 Chugai Pharmaceutical Co Ltd Derives phenethylamine substitues
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
KR100708221B1 (ko) 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
CN100536833C (zh) 2000-01-19 2009-09-09 艾博特公司 改良药物配方
US6506786B2 (en) * 2001-02-13 2003-01-14 Pharmacor Inc. HIV protease inhibitors based on amino acid derivatives
WO2004041201A2 (fr) * 2002-11-01 2004-05-21 Viropharma Incorporated Composes de benzofurane, compositions et methodes utilisees pour le traitement et la prophylaxie des infections virales induites par l'hepatite c et des maladies associees
US7388008B2 (en) 2004-08-02 2008-06-17 Ambrilia Biopharma Inc. Lysine based compounds
ES2452718T3 (es) 2005-11-30 2014-04-02 Taimed Biologics, Inc. Profármacos a base de lisina de inhibidores de la aspartil proteasa y procesos para su preparación
EP2044028B1 (fr) 2006-01-27 2012-05-16 Fibrogen, Inc. Cyanoisoquinolines en tant que stabilisateurs du facteur induit par l' hypoxie
WO2007115315A2 (fr) 2006-04-04 2007-10-11 Fibrogen, Inc. Composés de pyrrolo- et de thiazolopyridine et procédés d'utilisation
JP5401652B2 (ja) 2006-09-21 2014-01-29 タイメッド バイオロジクス インコーポレイテッド プロテアーゼ阻害剤
WO2010056767A1 (fr) 2008-11-14 2010-05-20 Fibrogen, Inc. Dérivés de thiochromène utiles en tant qu'inhibiteurs de l'hydroxylase hif
AU2014209319B2 (en) 2013-01-24 2018-04-19 Fibrogen, Inc. Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126326A (en) * 1989-06-06 1992-06-30 Bio-Mega, Inc. Enzyme inhibiting peptide derivatives

Also Published As

Publication number Publication date
MX9205208A (es) 1993-03-01
KR930006050A (ko) 1993-04-20
JPH05230095A (ja) 1993-09-07
AU661018B2 (en) 1995-07-13
RU2067585C1 (ru) 1996-10-10
HUT63632A (en) 1993-09-28
IL103126A0 (en) 1993-02-21
NO923533D0 (no) 1992-09-11
AU2288992A (en) 1993-03-18
CA2077948A1 (fr) 1993-03-13
SK280292A3 (en) 1995-02-08
PL295905A1 (en) 1993-05-17
EP0532466A2 (fr) 1993-03-17
NZ244288A (en) 1995-03-28
EP0532466A3 (en) 1993-06-16
HU9202925D0 (en) 1992-11-30
FI924035A (fi) 1993-03-13
FI924035A0 (fi) 1992-09-09
NO923533L (no) 1993-03-15
PL169969B1 (pl) 1996-09-30
CZ280292A3 (en) 1994-01-19

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Legal Events

Date Code Title Description
FF Patent granted
RH Patent void