AU2288992A - Further novel 5-amino-4-hydroxyhexanoic acid derivatives as therapeutic agents - Google Patents

Further novel 5-amino-4-hydroxyhexanoic acid derivatives as therapeutic agents

Info

Publication number
AU2288992A
AU2288992A AU22889/92A AU2288992A AU2288992A AU 2288992 A AU2288992 A AU 2288992A AU 22889/92 A AU22889/92 A AU 22889/92A AU 2288992 A AU2288992 A AU 2288992A AU 2288992 A AU2288992 A AU 2288992A
Authority
AU
Australia
Prior art keywords
amino
therapeutic agents
acid derivatives
hydroxyhexanoic acid
further novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU22889/92A
Other versions
AU661018B2 (en
Inventor
Guido Dr. Bold
Alexander Dr. Fassler
Marc Dr. Lang
Peter Dr. Schneider
Peter Dr. Van Hoogevest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2288992A publication Critical patent/AU2288992A/en
Application granted granted Critical
Publication of AU661018B2 publication Critical patent/AU661018B2/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request to Amend Deed and Register Assignors: CIBA-GEIGY AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU22889/92A 1991-09-12 1992-09-10 Further novel 5-amino-4-hydroxyhexanoic acid derivatives as therapeutic agents Ceased AU661018B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH2689/91 1991-09-12
CH268991 1991-09-12
CH980/92 1992-03-27
CH98092 1992-03-27
CH2007/92 1992-06-25
CH200792 1992-06-25

Publications (2)

Publication Number Publication Date
AU2288992A true AU2288992A (en) 1993-03-18
AU661018B2 AU661018B2 (en) 1995-07-13

Family

ID=27172572

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22889/92A Ceased AU661018B2 (en) 1991-09-12 1992-09-10 Further novel 5-amino-4-hydroxyhexanoic acid derivatives as therapeutic agents

Country Status (15)

Country Link
EP (1) EP0532466A3 (en)
JP (1) JPH05230095A (en)
KR (1) KR930006050A (en)
AU (1) AU661018B2 (en)
CA (1) CA2077948A1 (en)
CZ (1) CZ280292A3 (en)
FI (1) FI924035A (en)
HU (1) HUT63632A (en)
IL (1) IL103126A (en)
MX (1) MX9205208A (en)
NO (1) NO923533L (en)
NZ (1) NZ244288A (en)
PL (1) PL169969B1 (en)
RU (1) RU2067585C1 (en)
SK (1) SK280292A3 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007269A1 (en) * 1993-09-10 1995-03-16 Narhex Limited Polar-substituted hydrocarbons
US5679688A (en) * 1992-03-11 1997-10-21 Narhex Limited Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
AU695516B2 (en) * 1993-09-13 1998-08-13 Abbott Laboratories Pharmaceutical composition of HIV-protease inhibitors
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US6258806B1 (en) 1992-03-11 2001-07-10 Narhex Limited Amine derivatives of oxo- and hydroxy- substituted hydrocarbons

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
TW217410B (en) * 1992-04-01 1993-12-11 Ciba Geigy
EP0604368B1 (en) 1992-12-23 1996-09-18 Ciba-Geigy Ag Anti retroviral hydrazine derivatives
EP0618222A3 (en) * 1993-03-11 1997-01-02 Ciba Geigy Ag Dipeptid derivatives of 5-amino-4-hydroxy-hexanoic acid.
EP0626178A1 (en) * 1993-05-17 1994-11-30 Ciba-Geigy Ag Use of inhibitors of HIV-protease for the treatment of tumorous diseases
US5559158A (en) * 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
IL111991A (en) * 1994-01-28 2000-07-26 Abbott Lab Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
WO1996016980A1 (en) * 1994-11-29 1996-06-06 Novartis Ag Morpholinoethylamide derivatives
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5840835A (en) * 1995-10-30 1998-11-24 Merck & Co., Inc. Inhibitors of peptide binding to MHC class II proteins
US5817757A (en) * 1995-10-30 1998-10-06 Merck & Co., Inc. Inhibitors of peptide binding to MHO class II proteins
AU7475396A (en) * 1995-10-30 1997-05-22 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
HUP0105204A3 (en) * 1999-01-28 2002-05-28 Chugai Pharmaceutical Co Ltd Substituted phenethylamine derivatives and pharmaceutical compositions containing them
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
KR100708221B1 (en) 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 Method for producing epoxide crystal
DK1917958T3 (en) 2000-01-19 2012-09-24 Abbott Lab Improved pharmaceutical formulations of HIV protease inhibitors
US6506786B2 (en) 2001-02-13 2003-01-14 Pharmacor Inc. HIV protease inhibitors based on amino acid derivatives
AU2003290584B2 (en) * 2002-11-01 2009-07-16 Viropharma Incorporated Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases
US7388008B2 (en) 2004-08-02 2008-06-17 Ambrilia Biopharma Inc. Lysine based compounds
WO2007062526A1 (en) 2005-11-30 2007-06-07 Ambrilia Biopharma Inc. Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation
BRPI0707302B8 (en) 2006-01-27 2021-05-25 Fibrogen Inc cyanoisoquinoline compounds that act on tissue damage associated with ischemia, hypoxia and anemia, as well as pharmaceutical composition comprising them
RU2461557C2 (en) 2006-04-04 2012-09-20 Файброджен, Инк. Pyrrolo- and thiazolopyridine compounds (versions) and based pharmaceutical composition
CA2664118A1 (en) 2006-09-21 2008-07-03 Ambrilia Biopharma Inc. Protease inhibitors
CN102272117B (en) 2008-11-14 2015-06-17 菲布罗根有限公司 Thiochromene derivatives as hip hydroxylase inhibitors
ES2694297T3 (en) 2013-01-24 2018-12-19 Fibrogen, Inc. Crystalline forms of {[1-cyano-5- (4-chlorophenoxy) -4-hydroxy-isoquinoline-3-carbonyl] -amino} -acetic acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126326A (en) * 1989-06-06 1992-06-30 Bio-Mega, Inc. Enzyme inhibiting peptide derivatives

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679688A (en) * 1992-03-11 1997-10-21 Narhex Limited Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US5942504A (en) * 1992-03-11 1999-08-24 Narhex Limited Amine derivatives of oxo- and hydroxy- substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US6258806B1 (en) 1992-03-11 2001-07-10 Narhex Limited Amine derivatives of oxo- and hydroxy- substituted hydrocarbons
WO1995007269A1 (en) * 1993-09-10 1995-03-16 Narhex Limited Polar-substituted hydrocarbons
AU695516B2 (en) * 1993-09-13 1998-08-13 Abbott Laboratories Pharmaceutical composition of HIV-protease inhibitors

Also Published As

Publication number Publication date
AU661018B2 (en) 1995-07-13
NZ244288A (en) 1995-03-28
EP0532466A3 (en) 1993-06-16
SK280292A3 (en) 1995-02-08
KR930006050A (en) 1993-04-20
IL103126A (en) 1997-09-30
PL169969B1 (en) 1996-09-30
NO923533L (en) 1993-03-15
MX9205208A (en) 1993-03-01
NO923533D0 (en) 1992-09-11
EP0532466A2 (en) 1993-03-17
PL295905A1 (en) 1993-05-17
JPH05230095A (en) 1993-09-07
RU2067585C1 (en) 1996-10-10
CZ280292A3 (en) 1994-01-19
CA2077948A1 (en) 1993-03-13
FI924035A0 (en) 1992-09-09
FI924035A (en) 1993-03-13
IL103126A0 (en) 1993-02-21
HUT63632A (en) 1993-09-28
HU9202925D0 (en) 1992-11-30

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