IL102473A - 2-(4-hydroxypiperidino)-1- alkanol derivatives, pharmaceutical compositions containing them and certain intermediates therefor - Google Patents
2-(4-hydroxypiperidino)-1- alkanol derivatives, pharmaceutical compositions containing them and certain intermediates thereforInfo
- Publication number
- IL102473A IL102473A IL102473A IL10247392A IL102473A IL 102473 A IL102473 A IL 102473A IL 102473 A IL102473 A IL 102473A IL 10247392 A IL10247392 A IL 10247392A IL 102473 A IL102473 A IL 102473A
- Authority
- IL
- Israel
- Prior art keywords
- carbons
- alkyl
- group
- alkoxy
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73157791A | 1991-07-17 | 1991-07-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL102473A0 IL102473A0 (en) | 1993-01-14 |
IL102473A true IL102473A (en) | 1997-07-13 |
Family
ID=24940103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL102473A IL102473A (en) | 1991-07-17 | 1992-07-12 | 2-(4-hydroxypiperidino)-1- alkanol derivatives, pharmaceutical compositions containing them and certain intermediates therefor |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0594729A1 (fr) |
JP (1) | JP2571904B2 (fr) |
KR (1) | KR0165003B1 (fr) |
CN (1) | CN1043759C (fr) |
AU (1) | AU655840B2 (fr) |
BR (1) | BR9206272A (fr) |
CA (1) | CA2113568A1 (fr) |
CZ (1) | CZ284133B6 (fr) |
EG (1) | EG20048A (fr) |
FI (2) | FI940192A (fr) |
HU (1) | HUT70528A (fr) |
IE (1) | IE922311A1 (fr) |
IL (1) | IL102473A (fr) |
MX (1) | MX9204190A (fr) |
NO (1) | NO180445C (fr) |
NZ (1) | NZ243580A (fr) |
PL (1) | PL169884B1 (fr) |
PT (1) | PT100689B (fr) |
RU (1) | RU2065859C1 (fr) |
TW (1) | TW201732B (fr) |
WO (1) | WO1993002052A1 (fr) |
ZA (1) | ZA925306B (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5436255A (en) * | 1992-07-23 | 1995-07-25 | Pfizer Inc. | Method of treating diseases susceptable to treatment by blocking NMDA-receptors |
WO1994010166A1 (fr) * | 1992-10-30 | 1994-05-11 | Pfizer Inc. | Composes neuroprotecteurs de 3,4-dihydro-2(1h)-quinolone |
US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
EP1182193A4 (fr) * | 1999-04-09 | 2002-09-11 | Mochida Pharm Co Ltd | Remedes pour douleurs neurogenes |
EP1235572A2 (fr) | 1999-10-29 | 2002-09-04 | MERCK SHARP & DOHME LTD. | Procede de traitement de la douleur a l'aide d'antagonistes nmda/nr2b du benzimidazole |
US6316474B1 (en) | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
US6432976B1 (en) | 1999-10-29 | 2002-08-13 | Merck & Co., Inc. | 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists |
US6291499B1 (en) | 1999-10-29 | 2001-09-18 | Merck & Co., Inc. | 2-cyclohexyl benzimidazole NMDA/NR2B antagonists |
US6380205B1 (en) | 1999-10-29 | 2002-04-30 | Merck & Co., Inc. | 2-cyclohexyl quinazoline NMDA/NR2B antagonists |
US6489477B1 (en) | 1999-10-29 | 2002-12-03 | Merck & Co., Inc. | 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists |
US6476041B1 (en) | 1999-10-29 | 2002-11-05 | Merck & Co., Inc. | 1,4 substituted piperidinyl NMDA/NR2B antagonists |
US6369076B1 (en) | 1999-10-29 | 2002-04-09 | Merck & Co. Inc. | 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists |
US6495561B2 (en) | 1999-10-29 | 2002-12-17 | Merck & Co., Inc. | 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists |
HUP0303258A3 (en) | 2001-02-23 | 2004-06-28 | Merck & Co Inc | N-substituted nonaryl-heterocyclic nmda/nr2b antagonists and pharmaceutical compositions containing them |
CA2443108A1 (fr) | 2001-04-03 | 2002-10-17 | Merck & Co. Inc. | Antagonistes de nmda/nr2b nonaryl-heterocyclo amidyle n-substitues |
WO2004048326A1 (fr) | 2002-11-25 | 2004-06-10 | Mochida Pharmaceutical Co., Ltd. | Agent therapeutique pour maladies respiratoires contenant un derive de 4-hydroxypiperidine en tant qu'ingredient actif |
EP1673367A1 (fr) * | 2003-10-08 | 2006-06-28 | Pfizer, Inc. | Composes de lactame condense |
TWI409289B (zh) | 2010-09-02 | 2013-09-21 | Taiwan Union Technology Corp | 由氮氧雜環化合物所製得之聚合物之穩態溶液及其製法與用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
FR2546166B1 (fr) * | 1983-05-19 | 1985-10-25 | Synthelabo | Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique |
FR2640266B2 (fr) * | 1988-07-12 | 1992-07-10 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique |
ES2098248T3 (es) * | 1989-05-17 | 1997-05-01 | Pfizer | Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos. |
WO1991017156A1 (fr) * | 1990-05-10 | 1991-11-14 | Pfizer Inc | Indolone neuroprotecteur et derives apparentes |
-
1992
- 1992-06-19 AU AU23225/92A patent/AU655840B2/en not_active Ceased
- 1992-06-19 PL PL92302290A patent/PL169884B1/pl unknown
- 1992-06-19 BR BR9206272A patent/BR9206272A/pt not_active Application Discontinuation
- 1992-06-19 CZ CS924008A patent/CZ284133B6/cs not_active IP Right Cessation
- 1992-06-19 EP EP92915510A patent/EP0594729A1/fr not_active Ceased
- 1992-06-19 WO PCT/US1992/004973 patent/WO1993002052A1/fr not_active Application Discontinuation
- 1992-06-19 CA CA002113568A patent/CA2113568A1/fr not_active Abandoned
- 1992-06-19 RU RU9294012366A patent/RU2065859C1/ru active
- 1992-06-19 HU HU9400136A patent/HUT70528A/hu unknown
- 1992-06-19 JP JP5502784A patent/JP2571904B2/ja not_active Expired - Lifetime
- 1992-06-23 TW TW081104921A patent/TW201732B/zh active
- 1992-07-12 IL IL102473A patent/IL102473A/xx not_active IP Right Cessation
- 1992-07-15 PT PT100689A patent/PT100689B/pt not_active IP Right Cessation
- 1992-07-16 ZA ZA925306A patent/ZA925306B/xx unknown
- 1992-07-16 CN CN92105921A patent/CN1043759C/zh not_active Expired - Fee Related
- 1992-07-16 MX MX9204190A patent/MX9204190A/es unknown
- 1992-07-16 IE IE231192A patent/IE922311A1/en not_active Application Discontinuation
- 1992-07-16 EG EG39792A patent/EG20048A/xx active
- 1992-07-16 NZ NZ243580A patent/NZ243580A/en unknown
-
1994
- 1994-01-14 NO NO940144A patent/NO180445C/no not_active IP Right Cessation
- 1994-01-14 FI FI940192A patent/FI940192A/fi unknown
- 1994-01-15 KR KR1019940700124A patent/KR0165003B1/ko not_active IP Right Cessation
-
1998
- 1998-09-11 FI FI981956A patent/FI981956A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
CN1068566A (zh) | 1993-02-03 |
CZ400892A3 (en) | 1994-03-16 |
EP0594729A1 (fr) | 1994-05-04 |
NO940144L (no) | 1994-01-14 |
IL102473A0 (en) | 1993-01-14 |
CA2113568A1 (fr) | 1993-02-04 |
HU9400136D0 (en) | 1994-05-30 |
PT100689A (pt) | 1993-10-29 |
NO180445C (no) | 1997-04-23 |
FI940192A0 (fi) | 1994-01-14 |
NZ243580A (en) | 1994-10-26 |
JP2571904B2 (ja) | 1997-01-16 |
HUT70528A (en) | 1995-10-30 |
PT100689B (pt) | 1999-06-30 |
MX9204190A (es) | 1993-01-01 |
FI981956A0 (fi) | 1998-09-11 |
KR0165003B1 (en) | 1999-01-15 |
IE922311A1 (en) | 1993-01-27 |
EG20048A (en) | 1997-03-27 |
CN1043759C (zh) | 1999-06-23 |
PL169884B1 (pl) | 1996-09-30 |
JPH06504293A (ja) | 1994-05-19 |
RU2065859C1 (ru) | 1996-08-27 |
NO180445B (no) | 1997-01-13 |
NO940144D0 (no) | 1994-01-14 |
TW201732B (fr) | 1993-03-11 |
ZA925306B (en) | 1994-01-17 |
WO1993002052A1 (fr) | 1993-02-04 |
FI940192A (fi) | 1994-01-14 |
AU655840B2 (en) | 1995-01-12 |
CZ284133B6 (cs) | 1998-08-12 |
BR9206272A (pt) | 1995-04-11 |
FI981956A (fi) | 1998-09-11 |
AU2322592A (en) | 1993-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |