IL101327A - HISTORY OF TROCCYLIC-CYCLE AMINES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM - Google Patents

HISTORY OF TROCCYLIC-CYCLE AMINES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Info

Publication number
IL101327A
IL101327A IL101327A IL10132792A IL101327A IL 101327 A IL101327 A IL 101327A IL 101327 A IL101327 A IL 101327A IL 10132792 A IL10132792 A IL 10132792A IL 101327 A IL101327 A IL 101327A
Authority
IL
Israel
Prior art keywords
ethyl
phenylmethyl
piperidinyl
benzisoxazole
mmol
Prior art date
Application number
IL101327A
Other languages
English (en)
Hebrew (he)
Other versions
IL101327A0 (en
Inventor
Anabella Villalobos
Arthur Adam Nagel
Yuhpyng Liang Chen
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to IL11612292A priority Critical patent/IL116122A/en
Publication of IL101327A0 publication Critical patent/IL101327A0/xx
Publication of IL101327A publication Critical patent/IL101327A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
IL101327A 1991-03-28 1992-03-22 HISTORY OF TROCCYLIC-CYCLE AMINES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM IL101327A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL11612292A IL116122A (en) 1991-03-28 1992-03-22 Intermediates for the history of 0-cyclic heterocyclic amines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67691891A 1991-03-28 1991-03-28

Publications (2)

Publication Number Publication Date
IL101327A0 IL101327A0 (en) 1992-11-15
IL101327A true IL101327A (en) 1998-06-15

Family

ID=24716559

Family Applications (3)

Application Number Title Priority Date Filing Date
IL11612292A IL116122A (en) 1991-03-28 1992-03-22 Intermediates for the history of 0-cyclic heterocyclic amines
IL11612295A IL116122A0 (en) 1991-03-28 1992-03-22 Intermediates to heterocyclic-cyclic amine derivatives
IL101327A IL101327A (en) 1991-03-28 1992-03-22 HISTORY OF TROCCYLIC-CYCLE AMINES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL11612292A IL116122A (en) 1991-03-28 1992-03-22 Intermediates for the history of 0-cyclic heterocyclic amines
IL11612295A IL116122A0 (en) 1991-03-28 1992-03-22 Intermediates to heterocyclic-cyclic amine derivatives

Country Status (29)

Country Link
EP (1) EP0646115B1 (fi)
JP (3) JP2659107B2 (fi)
KR (1) KR0179054B1 (fi)
CN (1) CN1044242C (fi)
AT (1) ATE231505T1 (fi)
AU (2) AU658194B2 (fi)
BR (1) BR9205811A (fi)
CA (2) CA2195129C (fi)
CZ (1) CZ289756B6 (fi)
DE (1) DE69232907T2 (fi)
DK (1) DK0646115T3 (fi)
EG (1) EG20281A (fi)
ES (1) ES2188584T3 (fi)
FI (1) FI934223A (fi)
HU (1) HU225047B1 (fi)
IE (1) IE920980A1 (fi)
IL (3) IL116122A (fi)
MX (1) MX9201419A (fi)
MY (1) MY108885A (fi)
NO (1) NO304071B1 (fi)
NZ (3) NZ242151A (fi)
PL (3) PL170567B1 (fi)
PT (1) PT100300B (fi)
RU (1) RU2119920C1 (fi)
SG (1) SG49055A1 (fi)
UA (1) UA45944C2 (fi)
WO (1) WO1992017475A1 (fi)
YU (1) YU31392A (fi)
ZA (1) ZA922239B (fi)

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NZ258747A (en) * 1992-11-23 1997-02-24 Hoechst Marion Roussel Inc Sub 3-heterocyclyalkylamino benzisoxazole derivatives; medicaments
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
CA2200607C (en) * 1994-10-26 2003-03-18 Pfizer Inc. Processes and intermediates for preparing 5,7-dihydro-3-[2-{1-benzylpiperidin-4-yl}ethyl]-6h-pyrrolo-[4,5-f]-1,2-benzisoxazol-6-one
JPH11500123A (ja) * 1995-02-15 1999-01-06 ファルマシア・アンド・アップジョン・カンパニー ＣＮＳおよび心臓病の治療のためのイミダゾ［１，２−ａ］ピリジン類
KR19980703192A (ko) * 1995-03-22 1998-10-15 우에하라아끼라 티아졸 유도체
AU697953B2 (en) * 1995-06-06 1998-10-22 Hoechst Marion Roussel, Inc. Benzisoxazole and indazole derivatives as antipsychotic agents
JPH09124643A (ja) * 1995-08-14 1997-05-13 Bristol Myers Squibb Co 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
US5916902A (en) * 1995-09-13 1999-06-29 Pfizer Inc. Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one
WO1997016446A1 (en) * 1995-11-02 1997-05-09 Merck Sharp & Dohme Limited Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation and their use as selective agonists of 5-ht1-like receptors
FR2751412B3 (fr) * 1996-07-17 1998-09-25 Valbiofrance Methodes de diagnostic in vitro de maladies neurodegeneratives et trousses pour la mise en oeuvre de ces methodes
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
EP0976404A3 (en) * 1998-07-30 2001-06-27 Pfizer Products Inc. A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal
NZ510685A (en) 1998-09-30 2003-10-31 Takeda Chemical Industries Ltd Drugs for improving vesical excretory strength
US6951873B1 (en) 1999-04-27 2005-10-04 Pfizer Inc. Methods for treating age-related behavioral disorders in companion animals
EP1050303A3 (en) * 1999-04-27 2003-01-15 Pfizer Products Inc. Methods and compositions for treating age-related behavioral disorders in companion animals
EP1048302A3 (en) * 1999-04-30 2002-07-17 Pfizer Products Inc. Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
ATE360612T1 (de) 1999-09-01 2007-05-15 Eisai R&D Man Co Ltd In 4-stellung substituierte piperidinderivate
WO2001098271A1 (fr) 2000-06-21 2001-12-27 Eisai Co., Ltd. Compose piperidine 4-substitue
EP1609783A1 (en) * 2004-06-17 2005-12-28 Neuropharma S.A.U. Marine compounds with calcium channel blocking properties for Alzheimer's disease treatment
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
US20090221644A1 (en) * 2005-06-30 2009-09-03 Stuart Edward Bradley Gpcr Agonists
GB0519879D0 (en) 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
US20090318690A1 (en) 2006-04-28 2009-12-24 Eisai R&D Management Co., Ltd. Benzisoxazole Compound
MX2009013130A (es) 2007-06-01 2010-01-15 Schering Corp Moduladores de gamma secretasa.
CA2722923C (en) 2008-04-29 2016-08-02 Boehringer Ingelheim International Gmbh Indazole compounds as ccr1 receptor antagonists
CA2722811C (en) 2008-05-06 2016-07-05 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
PE20110854A1 (es) 2008-09-26 2011-12-23 Boehringer Ingelheim Int DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1
JP4955835B2 (ja) * 2008-12-12 2012-06-20 アクテリオン ファーマシューティカルズ リミテッド ５−アミノ−２−（１−ヒドロキシ−エチル）−テトラヒドロピラン誘導体
EA021015B1 (ru) 2009-10-21 2015-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Индазолы и пиразолопиридины в качестве антагонистов рецептора ccr1
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
US20110212928A1 (en) 2010-02-09 2011-09-01 The Johns Hopkins University Methods and compositions for improving cognitive function
WO2011137109A1 (en) 2010-04-30 2011-11-03 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as ccr1 receptor antagonists
WO2012087782A1 (en) 2010-12-23 2012-06-28 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as ccr1 receptor antagonists
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA
JP5903681B2 (ja) * 2012-11-21 2016-04-13 ラクオリア創薬株式会社 多形形態
ES2881081T3 (es) 2013-03-15 2021-11-26 Agenebio Inc Procedimientos y composiciones para mejorar la función cognitiva
US10806717B2 (en) 2013-03-15 2020-10-20 The Johns Hopkins University Methods and compositions for improving cognitive function
JP6899043B2 (ja) 2015-05-22 2021-07-07 エージンバイオ， インコーポレイテッド レベチラセタムの持続放出性医薬組成物
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JPS63234065A (ja) * 1987-03-23 1988-09-29 Mitsubishi Rayon Co Ltd 包接能を有する高分子組成物
JPH0657707B2 (ja) * 1987-05-25 1994-08-03 吉富製薬株式会社 ピペリジン化合物
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
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FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
ES2157204T3 (es) * 1991-04-17 2001-08-16 Upjohn Co Derivados de (s)-3-fenilpiperidina sustituidos, su preparacion y uso como antagonistas de autorreceptores de dopamina.

Also Published As

Publication number Publication date
IL101327A0 (en) 1992-11-15
JP2000154185A (ja) 2000-06-06
MX9201419A (es) 1992-10-01
JP3051076B2 (ja) 2000-06-12
IE920980A1 (en) 1992-10-07
CN1044242C (zh) 1999-07-21
IL116122A0 (en) 1996-01-31
AU1878292A (en) 1992-11-02
HU9302733D0 (en) 1993-12-28
KR0179054B1 (en) 1999-03-20
CA2195129C (en) 2002-09-10
DK0646115T3 (da) 2003-04-22
ES2188584T3 (es) 2003-07-01
AU658194B2 (en) 1995-04-06
PL171914B1 (pl) 1997-06-30
ZA922239B (en) 1993-09-27
YU31392A (sh) 1994-12-28
EP0646115B1 (en) 2003-01-22
AU2178895A (en) 1995-09-07
CA2107105C (en) 2003-10-07
CZ289756B6 (cs) 2002-04-17
HU225047B1 (en) 2006-05-29
RU2119920C1 (ru) 1998-10-10
JP2659107B2 (ja) 1997-09-30
MY108885A (en) 1996-11-30
NO933445D0 (no) 1993-09-27
IL116122A (en) 1998-10-30
FI934223A0 (fi) 1993-09-27
ATE231505T1 (de) 2003-02-15
AU674477B2 (en) 1996-12-19
CN1065267A (zh) 1992-10-14
NO933445L (no) 1993-09-27
NZ242151A (en) 1994-10-26
DE69232907D1 (de) 2003-02-27
WO1992017475A1 (en) 1992-10-15
EP0646115A1 (en) 1995-04-05
JPH06500794A (ja) 1994-01-27
EG20281A (en) 1998-07-30
NZ250987A (en) 1997-06-24
NO304071B1 (no) 1998-10-19
PT100300A (pt) 1993-08-31
DE69232907T2 (de) 2003-05-15
PL171915B1 (pl) 1997-06-30
HUT68357A (en) 1995-06-28
FI934223A (fi) 1993-09-27
UA45944C2 (uk) 2002-05-15
CZ395892A3 (en) 1994-04-13
CA2195129A1 (en) 1992-09-29
BR9205811A (pt) 1994-06-28
PT100300B (pt) 1999-09-30
SG49055A1 (en) 1998-05-18
PL170567B1 (pl) 1997-01-31
CA2107105A1 (en) 1992-09-29
JPH10158264A (ja) 1998-06-16
NZ248946A (en) 1995-04-27

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