ES2055036T3 - Antagonistas tetrazolicos de receptores de aminoacidos excitadores. - Google Patents

Antagonistas tetrazolicos de receptores de aminoacidos excitadores.

Info

Publication number
ES2055036T3
ES2055036T3 ES89301337T ES89301337T ES2055036T3 ES 2055036 T3 ES2055036 T3 ES 2055036T3 ES 89301337 T ES89301337 T ES 89301337T ES 89301337 T ES89301337 T ES 89301337T ES 2055036 T3 ES2055036 T3 ES 2055036T3
Authority
ES
Spain
Prior art keywords
amino acid
antagonists
tetrazolic
acid receptors
exciting amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89301337T
Other languages
English (en)
Inventor
Paul Leslie Ornstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2055036T3 publication Critical patent/ES2055036T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS DE TETRAZOLES, UTILES COMO ANTAGONISTA EXITATORIO DE RECEPTORES DE AMINOACIDOS Y EN EL TRATAMIENTO DE UNA VARIEDAD DE DESORDENES ASOCIADOS AL SISTEMA NERVIOSO.
ES89301337T 1988-02-19 1989-02-13 Antagonistas tetrazolicos de receptores de aminoacidos excitadores. Expired - Lifetime ES2055036T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15776088A 1988-02-19 1988-02-19

Publications (1)

Publication Number Publication Date
ES2055036T3 true ES2055036T3 (es) 1994-08-16

Family

ID=22565157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89301337T Expired - Lifetime ES2055036T3 (es) 1988-02-19 1989-02-13 Antagonistas tetrazolicos de receptores de aminoacidos excitadores.

Country Status (18)

Country Link
EP (1) EP0330353B1 (es)
JP (1) JPH01249767A (es)
CN (1) CN1022244C (es)
AT (1) ATE87918T1 (es)
AU (1) AU608692B2 (es)
CA (1) CA1332239C (es)
DE (1) DE68905845T2 (es)
DK (1) DK70289A (es)
ES (1) ES2055036T3 (es)
HU (1) HU202226B (es)
IE (1) IE62645B1 (es)
IL (1) IL89278A (es)
MX (1) MX14957A (es)
NZ (1) NZ227979A (es)
PH (1) PH27562A (es)
PT (1) PT89713B (es)
RU (1) RU2015976C1 (es)
ZA (1) ZA891113B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968678A (en) * 1988-02-19 1990-11-06 Eli Lilly And Company Tetrazole excitatory amino acid receptor antagonists
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5238958A (en) * 1990-02-26 1993-08-24 Warner-Lambert Company Substituted α-amino acids having selected acidic moieties for use as excitatory amino acid antagonists in pharmaceuticals
EP0646115B1 (en) * 1991-03-28 2003-01-22 Eisai Co., Ltd. Heterocyclic-cyclic amine derivatives
US20040208875A1 (en) 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
DE69434571T2 (de) * 1993-03-29 2006-08-03 Queen's University At Kingston, Kingston Propan-1,3-disulphonsäure und deren pharmazeutisch akzeptable Salze zur Behandlung von Amyloidosis
US6022868A (en) * 1995-06-29 2000-02-08 Novo Nordisk Als Substituted azacyclic or azabicyclic compounds
US5880138A (en) * 1996-10-01 1999-03-09 Eli Lilly And Company NMDA receptor selective antagonists
US7056917B2 (en) 2001-04-26 2006-06-06 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
US7244764B2 (en) 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
AU2005326962A1 (en) 2004-12-22 2006-08-17 Bellus Health (International) Limited Methods and compositions for treating amyloid-related diseases
TW200716088A (en) 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
AU2006342958A1 (en) 2005-12-22 2007-11-08 Bellus Health (International) Limited Treatment of renal disorders, diabetic nephropathy and dyslipidemias
ES2533463T3 (es) 2006-10-12 2015-04-10 Bhi Limited Partnership Métodos, compuestos, composiciones y vehículos para suministrar ácido 3-amino-1-propanosulfónico

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
PH23848A (en) * 1985-05-24 1989-11-23 Ciba Geigy Ag Certain phosphonic acids and derivatives
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
US4968678A (en) * 1988-02-19 1990-11-06 Eli Lilly And Company Tetrazole excitatory amino acid receptor antagonists

Also Published As

Publication number Publication date
EP0330353B1 (en) 1993-04-07
IE890518L (en) 1989-08-19
CA1332239C (en) 1994-10-04
DE68905845T2 (de) 1993-08-05
DK70289D0 (da) 1989-02-15
IE62645B1 (en) 1995-02-22
IL89278A0 (en) 1989-09-10
PT89713A (pt) 1989-10-04
AU3009089A (en) 1989-08-24
CN1035114A (zh) 1989-08-30
CN1022244C (zh) 1993-09-29
HU202226B (en) 1991-02-28
ZA891113B (en) 1990-10-31
PH27562A (en) 1993-08-18
ATE87918T1 (de) 1993-04-15
AU608692B2 (en) 1991-04-11
DK70289A (da) 1989-08-21
IL89278A (en) 1993-03-15
JPH01249767A (ja) 1989-10-05
PT89713B (pt) 1994-04-29
DE68905845D1 (de) 1993-05-13
EP0330353A1 (en) 1989-08-30
RU2015976C1 (ru) 1994-07-15
NZ227979A (en) 1991-02-26
HUT49603A (en) 1989-10-30
MX14957A (es) 1993-11-01

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