IE921401A1 - Phosphono/biaryl substituted dipeptide derivatives - Google Patents
Phosphono/biaryl substituted dipeptide derivativesInfo
- Publication number
- IE921401A1 IE921401A1 IE140192A IE921401A IE921401A1 IE 921401 A1 IE921401 A1 IE 921401A1 IE 140192 A IE140192 A IE 140192A IE 921401 A IE921401 A IE 921401A IE 921401 A1 IE921401 A1 IE 921401A1
- Authority
- IE
- Ireland
- Prior art keywords
- propionyl
- biphenylyl
- phosphonomethylamino
- aminopropionate
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/694,533 US5155100A (en) | 1991-05-01 | 1991-05-01 | Phosphono/biaryl substituted dipeptide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IE921401A1 true IE921401A1 (en) | 1992-11-04 |
Family
ID=24789228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE140192A IE921401A1 (en) | 1991-05-01 | 1992-07-01 | Phosphono/biaryl substituted dipeptide derivatives |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5155100A (OSRAM) |
| EP (1) | EP0511940A3 (OSRAM) |
| JP (1) | JPH05170792A (OSRAM) |
| KR (1) | KR920021578A (OSRAM) |
| AU (1) | AU655252B2 (OSRAM) |
| CA (1) | CA2067592A1 (OSRAM) |
| FI (1) | FI921884A7 (OSRAM) |
| HU (1) | HUT61032A (OSRAM) |
| IE (1) | IE921401A1 (OSRAM) |
| IL (1) | IL101633A (OSRAM) |
| MX (1) | MX9201953A (OSRAM) |
| NO (1) | NO921719L (OSRAM) |
| NZ (1) | NZ242546A (OSRAM) |
| TW (1) | TW208704B (OSRAM) |
| ZA (1) | ZA923164B (OSRAM) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5177064A (en) * | 1990-07-13 | 1993-01-05 | University Of Florida | Targeted drug delivery via phosphonate derivatives |
| US5294632A (en) * | 1991-05-01 | 1994-03-15 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipetide derivatives |
| JP3130938B2 (ja) * | 1991-10-22 | 2001-01-31 | オーストリア・タバクヴェルケ・アクチエンゲゼルシャフトヴォマー・オーシュターライヒッシェ・タバコレジー | シガレットフィルター |
| US5250522A (en) * | 1992-10-09 | 1993-10-05 | Ciba-Geigy Corporation | Phosphono/biaryl substituted amino acid derivatives |
| US5273990A (en) * | 1992-09-03 | 1993-12-28 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives |
| JPH05148277A (ja) * | 1991-11-05 | 1993-06-15 | Banyu Pharmaceut Co Ltd | アミノホスホン酸誘導体 |
| IT1266570B1 (it) * | 1993-07-30 | 1997-01-09 | Zambon Spa | Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari |
| WO1995013817A1 (en) * | 1993-11-18 | 1995-05-26 | Smithkline Beecham Corporation | Endothelin converting enzyme inhibitors |
| IT1274673B (it) * | 1994-04-14 | 1997-07-24 | Zambon Spa | Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari |
| IT1270260B (it) * | 1994-06-21 | 1997-04-29 | Zambon Spa | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
| US5583123A (en) * | 1994-12-22 | 1996-12-10 | Ciba-Geigy Corporation | Certain tetrazole derivatives |
| US5635103A (en) | 1995-01-20 | 1997-06-03 | The Procter & Gamble Company | Bleaching compositions and additives comprising bleach activators having alpha-modified lactam leaving-groups |
| US5550119A (en) * | 1995-03-02 | 1996-08-27 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives as ECE inhibitors |
| AU7211696A (en) * | 1995-09-27 | 1997-04-17 | Ciba-Geigy Ag | Treatment of chronic progressive renal failure |
| JP3973748B2 (ja) * | 1998-01-14 | 2007-09-12 | 花王株式会社 | 発毛抑制剤 |
| HK1039894A1 (zh) * | 1999-03-29 | 2002-05-17 | Bristol-Myers Squibb Company | 使用血管肽酶抑制物治疗心绞痛 |
| WO2007083774A1 (ja) * | 2006-01-17 | 2007-07-26 | Sumitomo Chemical Company, Limited | ビフェニルメチルヒダントイン化合物、その製造方法、及びそれを用いるビフェニルアラニン化合物の製造方法 |
| JP2007191446A (ja) * | 2006-01-20 | 2007-08-02 | Sumitomo Chemical Co Ltd | ビフェニルメチルヒダントイン化合物、その製造方法、及びそれを用いるビフェニルアラニン化合物の製造方法 |
| TW200838501A (en) | 2007-02-02 | 2008-10-01 | Theravance Inc | Dual-acting antihypertensive agents |
| JP2008260755A (ja) * | 2007-03-20 | 2008-10-30 | Sumitomo Chemical Co Ltd | Ｌ−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法 |
| TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| TWI406850B (zh) * | 2007-06-05 | 2013-09-01 | Theravance Inc | 雙效苯并咪唑抗高血壓劑 |
| JP2010538071A (ja) | 2007-09-07 | 2010-12-09 | セラヴァンス， インコーポレーテッド | 二重作用性降圧剤 |
| US8212052B2 (en) | 2007-12-11 | 2012-07-03 | Theravance, Inc. | Dual-acting benzoimidazole antihypertensive agents |
| JP2011518884A (ja) | 2008-04-29 | 2011-06-30 | セラヴァンス， インコーポレーテッド | 二重活性抗高血圧剤 |
| JP2011529072A (ja) | 2008-07-24 | 2011-12-01 | セラヴァンス， インコーポレーテッド | 二重作用血圧降下薬 |
| JP5833000B2 (ja) | 2009-07-07 | 2015-12-16 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | 二重に作用するピラゾール抗高血圧症薬 |
| EP2456762B1 (en) | 2009-07-22 | 2013-10-16 | Theravance, Inc. | Dual-acting oxazole antihypertensive agents |
| EP2526095A1 (en) | 2010-01-19 | 2012-11-28 | Theravance, Inc. | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents |
| US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
| AU2011343899B2 (en) | 2010-12-15 | 2016-06-30 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| CN103261168B (zh) | 2010-12-15 | 2015-08-05 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| ES2564275T3 (es) | 2011-02-17 | 2016-03-21 | Theravance Biopharma R&D Ip, Llc | Derivados aminobutíricos sustituidos como inhibidores de neprilisina |
| RU2604522C2 (ru) | 2011-02-17 | 2016-12-10 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи,ЭлЭлСи | Замещенные аминомасляные производные в качестве ингибиторов неприлизина |
| JP5959074B2 (ja) | 2011-05-31 | 2016-08-02 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ネプリライシン阻害剤 |
| CN103748070B (zh) | 2011-05-31 | 2015-06-24 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| CA2835220A1 (en) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| CN104350052B (zh) | 2012-05-31 | 2017-05-31 | 施万生物制药研发Ip有限责任公司 | 一氧化氮供体脑啡肽酶抑制剂 |
| US8871792B2 (en) | 2012-06-08 | 2014-10-28 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| SMT201700306T1 (it) | 2012-06-08 | 2017-07-18 | Theravance Biopharma R&D Ip Llc | Inibitori di neprilisina |
| SG11201500845UA (en) | 2012-08-08 | 2015-03-30 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| EP2956464B1 (en) | 2013-02-14 | 2018-03-28 | Novartis AG | Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors |
| LT2964616T (lt) | 2013-03-05 | 2017-07-25 | Theravance Biopharma R&D Ip, Llc | Neprilizino inhibitoriai |
| HK1218298A1 (zh) | 2013-07-25 | 2017-02-10 | Novartis Ag | 用於治疗心力衰竭的环状多肽 |
| UY35671A (es) | 2013-07-25 | 2015-02-27 | Novartis Ag | Bioconjugados de polipéptidos de apelina sintética |
| EP3099668B1 (en) | 2014-01-30 | 2022-05-04 | Theravance Biopharma R&D IP, LLC | 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors |
| CN105992763A (zh) | 2014-01-30 | 2016-10-05 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| CN107406490A (zh) | 2015-01-23 | 2017-11-28 | 诺华股份有限公司 | 具有改善的半衰期的合成apelin脂肪酸缀合物 |
| KR102640906B1 (ko) | 2015-02-11 | 2024-02-27 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 네프릴리신 저해제로서 (2s,4r)-5-(5''-클로로-2''-플루오로비페닐-4-일)-4-(에톡시옥살릴아미노)-2-히드록시메틸-2-메틸펜타노익산 |
| HRP20210040T1 (hr) | 2015-02-19 | 2021-04-02 | Theravance Biopharma R&D Ip, Llc | (2r,4r)-5-(5′-klor-2’-fluorbifenil-4-il)-2-hidroksi-4-[(5-metiloksazol-2-karbonil)amino]pentanska kiselina |
| PL3408260T3 (pl) | 2016-03-08 | 2021-11-08 | Theravance Biopharma R&D Ip, Llc | Krystaliczny kwas (2S,4R)-5-(5'-chloro-2-fluoro-[1,1'-bifenyl]-4-ilo)-2-(etoksymetylo)-4- (3-hydroksyizoksazolo-5-karboksyamido)-2-metylopentanowy i jego zastosowania |
| UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
| EP3887388A1 (en) | 2018-11-27 | 2021-10-06 | Novartis AG | Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders |
| CN113166101A (zh) | 2018-11-27 | 2021-07-23 | 诺华股份有限公司 | 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状五聚体化合物 |
| WO2023084449A1 (en) | 2021-11-12 | 2023-05-19 | Novartis Ag | Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE141930C (OSRAM) * | 1900-01-01 | |||
| US4053505A (en) * | 1976-01-05 | 1977-10-11 | Monsanto Company | Preparation of n-phosphonomethyl glycine |
| EP0054862B1 (en) * | 1980-12-18 | 1985-11-27 | Schering Corporation | Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase |
| US4721726A (en) * | 1980-12-18 | 1988-01-26 | Schering Corporation | Substituted dipeptides as inhibitors of enkephalinases |
| FR2518088B1 (fr) * | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
| DK31784A (da) * | 1983-01-28 | 1984-07-29 | Schering Corp | Phosphorholdige amidforbindelser, farmaceutiske kompositioner indeholdende disse, og fremgangsmaader til forbindelsernes fremstilling |
| US4939261A (en) * | 1984-06-08 | 1990-07-03 | Ciba-Geigy Corporation | N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase |
| EP0225292A3 (en) * | 1985-12-06 | 1988-11-30 | Ciba-Geigy Ag | Certain n-substituted butyramide derivatives |
| US4749688A (en) * | 1986-06-20 | 1988-06-07 | Schering Corporation | Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension |
| CA1337400C (en) * | 1987-06-08 | 1995-10-24 | Norma G. Delaney | Inhibitors of neutral endopeptidase |
| US4963539A (en) * | 1987-09-10 | 1990-10-16 | E. R. Squibb & Sons, Inc. | Phosphonate and phosphonamide endopeptidase inhibitors |
| GB8726714D0 (en) * | 1987-11-14 | 1987-12-16 | Beecham Group Plc | Compounds |
| EP0401963A1 (en) * | 1989-04-13 | 1990-12-12 | Beecham Group p.l.c. | Phosphonopeptides with collagenase inhibiting activity |
| FR2652087B1 (fr) * | 1989-09-15 | 1993-10-15 | Bioprojet Ste Civile | Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques. |
-
1991
- 1991-05-01 US US07/694,533 patent/US5155100A/en not_active Expired - Fee Related
-
1992
- 1992-04-17 IL IL10163392A patent/IL101633A/en not_active IP Right Cessation
- 1992-04-22 EP EP19920810291 patent/EP0511940A3/en not_active Ceased
- 1992-04-23 AU AU15091/92A patent/AU655252B2/en not_active Ceased
- 1992-04-27 FI FI921884A patent/FI921884A7/fi not_active Application Discontinuation
- 1992-04-27 JP JP4107296A patent/JPH05170792A/ja active Pending
- 1992-04-28 MX MX9201953A patent/MX9201953A/es unknown
- 1992-04-29 HU HU9201430A patent/HUT61032A/hu unknown
- 1992-04-29 NZ NZ242546A patent/NZ242546A/en unknown
- 1992-04-29 CA CA002067592A patent/CA2067592A1/en not_active Abandoned
- 1992-04-30 ZA ZA923164A patent/ZA923164B/xx unknown
- 1992-04-30 NO NO92921719A patent/NO921719L/no unknown
- 1992-04-30 KR KR1019920007343A patent/KR920021578A/ko not_active Ceased
- 1992-05-19 TW TW081103890A patent/TW208704B/zh active
- 1992-07-01 IE IE140192A patent/IE921401A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2067592A1 (en) | 1992-11-02 |
| NZ242546A (en) | 1994-08-26 |
| TW208704B (OSRAM) | 1993-07-01 |
| JPH05170792A (ja) | 1993-07-09 |
| US5155100A (en) | 1992-10-13 |
| IL101633A0 (en) | 1992-12-30 |
| NO921719L (no) | 1992-11-02 |
| NO921719D0 (no) | 1992-04-30 |
| AU1509192A (en) | 1992-11-05 |
| HU9201430D0 (en) | 1992-07-28 |
| KR920021578A (ko) | 1992-12-18 |
| ZA923164B (en) | 1992-11-25 |
| FI921884A7 (fi) | 1992-11-02 |
| FI921884A0 (fi) | 1992-04-27 |
| EP0511940A2 (en) | 1992-11-04 |
| EP0511940A3 (en) | 1993-11-03 |
| HUT61032A (en) | 1992-11-30 |
| AU655252B2 (en) | 1994-12-08 |
| IL101633A (en) | 1996-03-31 |
| MX9201953A (es) | 1992-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC9A | Application refused sect. 31(1) |