FI921884A7 - Fosfono/biarylsubstituerade dipeptidderivat - Google Patents
Fosfono/biarylsubstituerade dipeptidderivat Download PDFInfo
- Publication number
- FI921884A7 FI921884A7 FI921884A FI921884A FI921884A7 FI 921884 A7 FI921884 A7 FI 921884A7 FI 921884 A FI921884 A FI 921884A FI 921884 A FI921884 A FI 921884A FI 921884 A7 FI921884 A7 FI 921884A7
- Authority
- FI
- Finland
- Prior art keywords
- biarylsubstituerade
- phosphono
- dipeptide derivatives
- dipeptide
- derivatives
- Prior art date
Links
- 108010016626 Dipeptides Proteins 0.000 title 1
- -1 PHOSPHONO Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/694,533 US5155100A (en) | 1991-05-01 | 1991-05-01 | Phosphono/biaryl substituted dipeptide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI921884A0 FI921884A0 (fi) | 1992-04-27 |
| FI921884A7 true FI921884A7 (fi) | 1992-11-02 |
Family
ID=24789228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI921884A FI921884A7 (fi) | 1991-05-01 | 1992-04-27 | Fosfono/biarylsubstituerade dipeptidderivat |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5155100A (OSRAM) |
| EP (1) | EP0511940A3 (OSRAM) |
| JP (1) | JPH05170792A (OSRAM) |
| KR (1) | KR920021578A (OSRAM) |
| AU (1) | AU655252B2 (OSRAM) |
| CA (1) | CA2067592A1 (OSRAM) |
| FI (1) | FI921884A7 (OSRAM) |
| HU (1) | HUT61032A (OSRAM) |
| IE (1) | IE921401A1 (OSRAM) |
| IL (1) | IL101633A (OSRAM) |
| MX (1) | MX9201953A (OSRAM) |
| NO (1) | NO921719L (OSRAM) |
| NZ (1) | NZ242546A (OSRAM) |
| TW (1) | TW208704B (OSRAM) |
| ZA (1) | ZA923164B (OSRAM) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5177064A (en) * | 1990-07-13 | 1993-01-05 | University Of Florida | Targeted drug delivery via phosphonate derivatives |
| US5294632A (en) * | 1991-05-01 | 1994-03-15 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipetide derivatives |
| US5273990A (en) * | 1992-09-03 | 1993-12-28 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives |
| JP3130938B2 (ja) * | 1991-10-22 | 2001-01-31 | オーストリア・タバクヴェルケ・アクチエンゲゼルシャフトヴォマー・オーシュターライヒッシェ・タバコレジー | シガレットフィルター |
| US5250522A (en) * | 1992-10-09 | 1993-10-05 | Ciba-Geigy Corporation | Phosphono/biaryl substituted amino acid derivatives |
| JPH05148277A (ja) * | 1991-11-05 | 1993-06-15 | Banyu Pharmaceut Co Ltd | アミノホスホン酸誘導体 |
| IT1266570B1 (it) * | 1993-07-30 | 1997-01-09 | Zambon Spa | Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari |
| WO1995013817A1 (en) * | 1993-11-18 | 1995-05-26 | Smithkline Beecham Corporation | Endothelin converting enzyme inhibitors |
| IT1274673B (it) * | 1994-04-14 | 1997-07-24 | Zambon Spa | Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari |
| IT1270260B (it) * | 1994-06-21 | 1997-04-29 | Zambon Spa | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
| US5583123A (en) * | 1994-12-22 | 1996-12-10 | Ciba-Geigy Corporation | Certain tetrazole derivatives |
| US5635103A (en) | 1995-01-20 | 1997-06-03 | The Procter & Gamble Company | Bleaching compositions and additives comprising bleach activators having alpha-modified lactam leaving-groups |
| US5550119A (en) * | 1995-03-02 | 1996-08-27 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives as ECE inhibitors |
| WO1997011717A1 (en) * | 1995-09-27 | 1997-04-03 | Novartis Ag | Treatment of chronic progressive renal failure |
| JP3973748B2 (ja) * | 1998-01-14 | 2007-09-12 | 花王株式会社 | 発毛抑制剤 |
| CA2368616A1 (en) * | 1999-03-29 | 2000-10-05 | James R. Powell | Use of vasopeptidase inhibitors to treat angina pectoris |
| WO2007083774A1 (ja) * | 2006-01-17 | 2007-07-26 | Sumitomo Chemical Company, Limited | ビフェニルメチルヒダントイン化合物、その製造方法、及びそれを用いるビフェニルアラニン化合物の製造方法 |
| JP2007191446A (ja) * | 2006-01-20 | 2007-08-02 | Sumitomo Chemical Co Ltd | ビフェニルメチルヒダントイン化合物、その製造方法、及びそれを用いるビフェニルアラニン化合物の製造方法 |
| TW200838501A (en) | 2007-02-02 | 2008-10-01 | Theravance Inc | Dual-acting antihypertensive agents |
| JP2008260755A (ja) * | 2007-03-20 | 2008-10-30 | Sumitomo Chemical Co Ltd | Ｌ−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法 |
| TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| TWI406850B (zh) * | 2007-06-05 | 2013-09-01 | Theravance Inc | 雙效苯并咪唑抗高血壓劑 |
| EP2200975A1 (en) * | 2007-09-07 | 2010-06-30 | Theravance, Inc. | Dual-acting antihypertensive agents |
| CN101896470B (zh) | 2007-12-11 | 2013-04-10 | 施万制药 | 双重作用的苯并咪唑衍生物和其作为抗高血压药剂的用途 |
| JP2011518884A (ja) | 2008-04-29 | 2011-06-30 | セラヴァンス， インコーポレーテッド | 二重活性抗高血圧剤 |
| EP2334651A2 (en) | 2008-07-24 | 2011-06-22 | Theravance, Inc. | Dual-acting antihypertensive agents |
| US7956054B2 (en) | 2009-07-07 | 2011-06-07 | Theravance, Inc. | Dual-acting pyrazole antihypertensive agents |
| ES2441419T3 (es) | 2009-07-22 | 2014-02-04 | Theravance, Inc. | Agentes antihipertensivos de doble acción basados en oxazol |
| WO2011090929A1 (en) | 2010-01-19 | 2011-07-28 | Theravance, Inc. | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents |
| US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
| HRP20151115T1 (en) | 2010-12-15 | 2015-11-20 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| BR112013014952A2 (pt) | 2010-12-15 | 2017-05-30 | Theravance Inc | inibidores de neprilisina |
| WO2012154249A1 (en) | 2011-02-17 | 2012-11-15 | Theravance, Inc. | Substituted aminobutyric derivatives as neprilysin inhibitors |
| EP2675795B1 (en) | 2011-02-17 | 2016-04-20 | Theravance Biopharma R&D IP, LLC | Substituted aminobutyric derivatives as neprilysin inhibitors |
| JP5959074B2 (ja) | 2011-05-31 | 2016-08-02 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ネプリライシン阻害剤 |
| CN103748070B (zh) | 2011-05-31 | 2015-06-24 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| EP2714660B1 (en) | 2011-05-31 | 2018-09-26 | Theravance Biopharma R&D IP, LLC | Neprilysin inhibitors |
| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| CN104350052B (zh) | 2012-05-31 | 2017-05-31 | 施万生物制药研发Ip有限责任公司 | 一氧化氮供体脑啡肽酶抑制剂 |
| CA2873328A1 (en) | 2012-06-08 | 2013-12-12 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| RS55967B1 (sr) | 2012-06-08 | 2017-09-29 | Theravance Biopharma R&D Ip Llc | Inhibitori neprilizina |
| SMT201700134T1 (it) | 2012-08-08 | 2017-05-08 | Theravance Biopharma R&D Ip Llc | Inibitori della neprilisina |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| CN105073762B (zh) | 2013-02-14 | 2017-03-08 | 诺华股份有限公司 | 作为nep(中性内肽酶)抑制剂的取代的联苯丁酰膦酸衍生物 |
| WO2014138053A1 (en) | 2013-03-05 | 2014-09-12 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| MX2016001021A (es) | 2013-07-25 | 2016-08-03 | Novartis Ag | Bioconjugados de polipeptidos de apelina sinteticos. |
| AU2014293386B2 (en) | 2013-07-25 | 2016-11-17 | Novartis Ag | Cyclic polypeptides for the treatment of heart failure |
| CN105992763A (zh) | 2014-01-30 | 2016-10-05 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
| SG11201606057PA (en) | 2014-01-30 | 2016-08-30 | Theravance Biopharma R&D Ip Llc | 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors |
| PE20171328A1 (es) | 2015-01-23 | 2017-09-12 | Novartis Ag | Conjugados de acidos grasos y apelina sintetica con mayor vida media |
| RU2726623C2 (ru) | 2015-02-11 | 2020-07-15 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | (2s,4r)-5-(5'-хлор-2'-фторбифенил-4-ил)-4-(этоксиоксалиламино)-2-гидроксиметил-2-метилпентановая кислота |
| RU2715241C2 (ru) | 2015-02-19 | 2020-02-26 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | (2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота |
| US10100021B2 (en) | 2016-03-08 | 2018-10-16 | Theravance Biopharma R&D Ip, Llc | Crystalline(2S,4R)-5-(5′-chloro-2′-fluoro-[1,1′-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof |
| CN113166204B (zh) | 2018-11-27 | 2025-01-28 | 诺华股份有限公司 | 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状肽 |
| WO2020110008A1 (en) | 2018-11-27 | 2020-06-04 | Novartis Ag | Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder |
| UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
| TW202333563A (zh) | 2021-11-12 | 2023-09-01 | 瑞士商諾華公司 | 用於治療疾病或障礙之二胺基環戊基吡啶衍生物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE141930C (OSRAM) * | 1900-01-01 | |||
| US4053505A (en) * | 1976-01-05 | 1977-10-11 | Monsanto Company | Preparation of n-phosphonomethyl glycine |
| CY1406A (en) * | 1980-12-18 | 1988-04-22 | Schering Corp | Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase |
| US4721726A (en) * | 1980-12-18 | 1988-01-26 | Schering Corporation | Substituted dipeptides as inhibitors of enkephalinases |
| FR2518088B1 (fr) * | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
| NZ206920A (en) * | 1983-01-28 | 1986-10-08 | Schering Corp | Phosphorus-containing amide,urea or carbamate derivatives and pharmaceutical compositions |
| US4939261A (en) * | 1984-06-08 | 1990-07-03 | Ciba-Geigy Corporation | N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase |
| EP0225292A3 (en) * | 1985-12-06 | 1988-11-30 | Ciba-Geigy Ag | Certain n-substituted butyramide derivatives |
| US4749688A (en) * | 1986-06-20 | 1988-06-07 | Schering Corporation | Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension |
| CA1337400C (en) * | 1987-06-08 | 1995-10-24 | Norma G. Delaney | Inhibitors of neutral endopeptidase |
| US4963539A (en) * | 1987-09-10 | 1990-10-16 | E. R. Squibb & Sons, Inc. | Phosphonate and phosphonamide endopeptidase inhibitors |
| GB8726714D0 (en) * | 1987-11-14 | 1987-12-16 | Beecham Group Plc | Compounds |
| EP0401963A1 (en) * | 1989-04-13 | 1990-12-12 | Beecham Group p.l.c. | Phosphonopeptides with collagenase inhibiting activity |
| FR2652087B1 (fr) * | 1989-09-15 | 1993-10-15 | Bioprojet Ste Civile | Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques. |
-
1991
- 1991-05-01 US US07/694,533 patent/US5155100A/en not_active Expired - Fee Related
-
1992
- 1992-04-17 IL IL10163392A patent/IL101633A/en not_active IP Right Cessation
- 1992-04-22 EP EP19920810291 patent/EP0511940A3/en not_active Ceased
- 1992-04-23 AU AU15091/92A patent/AU655252B2/en not_active Ceased
- 1992-04-27 JP JP4107296A patent/JPH05170792A/ja active Pending
- 1992-04-27 FI FI921884A patent/FI921884A7/fi not_active Application Discontinuation
- 1992-04-28 MX MX9201953A patent/MX9201953A/es unknown
- 1992-04-29 CA CA002067592A patent/CA2067592A1/en not_active Abandoned
- 1992-04-29 NZ NZ242546A patent/NZ242546A/en unknown
- 1992-04-29 HU HU9201430A patent/HUT61032A/hu unknown
- 1992-04-30 NO NO92921719A patent/NO921719L/no unknown
- 1992-04-30 KR KR1019920007343A patent/KR920021578A/ko not_active Ceased
- 1992-04-30 ZA ZA923164A patent/ZA923164B/xx unknown
- 1992-05-19 TW TW081103890A patent/TW208704B/zh active
- 1992-07-01 IE IE140192A patent/IE921401A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0511940A3 (en) | 1993-11-03 |
| IE921401A1 (en) | 1992-11-04 |
| HUT61032A (en) | 1992-11-30 |
| US5155100A (en) | 1992-10-13 |
| NZ242546A (en) | 1994-08-26 |
| IL101633A0 (en) | 1992-12-30 |
| MX9201953A (es) | 1992-11-01 |
| CA2067592A1 (en) | 1992-11-02 |
| FI921884A0 (fi) | 1992-04-27 |
| JPH05170792A (ja) | 1993-07-09 |
| NO921719D0 (no) | 1992-04-30 |
| HU9201430D0 (en) | 1992-07-28 |
| AU1509192A (en) | 1992-11-05 |
| IL101633A (en) | 1996-03-31 |
| ZA923164B (en) | 1992-11-25 |
| TW208704B (OSRAM) | 1993-07-01 |
| NO921719L (no) | 1992-11-02 |
| EP0511940A2 (en) | 1992-11-04 |
| KR920021578A (ko) | 1992-12-18 |
| AU655252B2 (en) | 1994-12-08 |
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