IE60572B1 - Substituted thienoimidazole derivatives, a process for their preparation, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion - Google Patents

Substituted thienoimidazole derivatives, a process for their preparation, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion

Info

Publication number
IE60572B1
IE60572B1 IE42187A IE42187A IE60572B1 IE 60572 B1 IE60572 B1 IE 60572B1 IE 42187 A IE42187 A IE 42187A IE 42187 A IE42187 A IE 42187A IE 60572 B1 IE60572 B1 IE 60572B1
Authority
IE
Ireland
Prior art keywords
ome
ohe
compound
formula
oet
Prior art date
Application number
IE42187A
Other languages
English (en)
Other versions
IE870421L (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863605395 external-priority patent/DE3605395A1/de
Priority claimed from DE19863623683 external-priority patent/DE3623683A1/de
Priority claimed from DE19873700436 external-priority patent/DE3700436A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IE870421L publication Critical patent/IE870421L/en
Publication of IE60572B1 publication Critical patent/IE60572B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
IE42187A 1986-02-20 1987-02-19 Substituted thienoimidazole derivatives, a process for their preparation, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion IE60572B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19863605395 DE3605395A1 (de) 1986-02-20 1986-02-20 Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DE19863623683 DE3623683A1 (de) 1986-07-12 1986-07-12 Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DE19873700436 DE3700436A1 (de) 1987-01-09 1987-01-09 Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer

Publications (2)

Publication Number Publication Date
IE870421L IE870421L (en) 1987-08-20
IE60572B1 true IE60572B1 (en) 1994-07-27

Family

ID=27194035

Family Applications (1)

Application Number Title Priority Date Filing Date
IE42187A IE60572B1 (en) 1986-02-20 1987-02-19 Substituted thienoimidazole derivatives, a process for their preparation, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion

Country Status (22)

Country Link
US (1) US4845118A (instruction)
EP (1) EP0234485B1 (instruction)
JP (1) JPH0633275B2 (instruction)
KR (2) KR950001025B1 (instruction)
CN (1) CN1021911C (instruction)
AR (1) AR246739A1 (instruction)
AU (1) AU590390B2 (instruction)
CA (1) CA1337197C (instruction)
DE (1) DE3777855D1 (instruction)
DK (1) DK85087A (instruction)
EG (1) EG18128A (instruction)
ES (1) ES2032394T3 (instruction)
FI (1) FI870672A7 (instruction)
GR (1) GR3004765T3 (instruction)
HU (1) HU197330B (instruction)
IE (1) IE60572B1 (instruction)
IL (1) IL81609A (instruction)
MA (1) MA20880A1 (instruction)
NO (1) NO170155C (instruction)
NZ (1) NZ219320A (instruction)
PT (1) PT84319B (instruction)
TN (1) TNSN87024A1 (instruction)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI861772L (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
CA1256109A (en) * 1986-09-10 1989-06-20 Franz Rovenszky Process for the preparation of derivatives of 4, 5-dihydrooxazoles
US4912101A (en) * 1987-03-13 1990-03-27 Fujirebio Kabushiki Kaisha 4-aminomethyl-pyridyl-2-oxy derivatives having anti-ulcer activity
DE3723327A1 (de) * 1987-07-15 1989-02-02 Hoechst Ag Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer, magenschutzmittel sowie als medikament gegen intestinale entzuendungen
AU622866B2 (en) * 1987-07-21 1992-04-30 Hoechst Aktiengesellschaft Substituted thienoimidazole derivatives, processes for their preparation, pharmaceutical formulations containing them and their use as gastric acid secretion inhibitors
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
FI89602C (fi) * 1987-08-15 1993-10-25 Hoechst Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara substituerade tienoimidazolderivat
ES2060672T3 (es) * 1987-11-13 1994-12-01 Hoechst Ag Derivados de tienoimidazol sustituidos, procedimiento para su preparacion, preparados farmaceuticos que los contienen y su utilizacion como inhibidores de la secrecion de acidos gastricos.
FI885878L (fi) * 1987-12-22 1989-06-23 Hoechst Ag Substituerade tienoimidazolderivat, foerfarande foer deras framstaellning, dessa innehaollande farmaceutiska kompositioner och deras anvaendning som inhibitorer vid avsoendring av magsyra.
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
CZ20014405A3 (cs) 1999-06-07 2002-04-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Léková forma
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
WO2004012659A2 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
EP2112920B1 (en) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
PL1746980T3 (pl) * 2004-05-07 2012-03-30 Nycomed Gmbh Farmaceutyczna postać dawkowania zawierająca peletki i sposób jej wytwarzania
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CN104825397A (zh) 2006-04-03 2015-08-12 伊萨·奥迪迪 含有机溶胶涂层的受控释放递送物件
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
CA2667682A1 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
US8247440B2 (en) 2008-02-20 2012-08-21 Curators Of The University Of Missouri Composition comprising omeprazole, lansoprazole and at least one buffering agent

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3132167A1 (de) 1981-08-14 1983-03-03 Hoechst Ag, 6000 Frankfurt "5(6)-phenylsulfonyloxy-benzimidazolderivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung gegen leberegel"
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4472409A (en) 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
GB8417171D0 (en) * 1984-07-05 1984-08-08 Beecham Group Plc Compounds
AU568441B2 (en) 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
FI861772L (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
WO1987005296A1 (en) * 1986-03-07 1987-09-11 Pfizer Inc. 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles and related compounds as antiulcer agents

Also Published As

Publication number Publication date
HU197330B (en) 1989-03-28
NZ219320A (en) 1990-06-26
CN87100719A (zh) 1987-09-09
EG18128A (en) 1992-08-30
US4845118A (en) 1989-07-04
EP0234485B1 (de) 1992-04-01
PT84319B (pt) 1989-09-14
DK85087D0 (da) 1987-02-19
FI870672A0 (fi) 1987-02-18
IL81609A0 (en) 1987-09-16
DE3777855D1 (de) 1992-05-07
KR890009937A (ko) 1989-08-05
NO170155B (no) 1992-06-09
AU590390B2 (en) 1989-11-02
HUT44255A (en) 1988-02-29
FI870672A7 (fi) 1987-08-21
NO870666D0 (no) 1987-02-19
KR950001025B1 (ko) 1995-02-07
TNSN87024A1 (fr) 1990-01-01
GR3004765T3 (instruction) 1993-04-28
MA20880A1 (fr) 1987-10-01
CN1021911C (zh) 1993-08-25
AR246739A1 (es) 1994-09-30
IE870421L (en) 1987-08-20
AU6906687A (en) 1987-08-27
CA1337197C (en) 1995-10-03
EP0234485A1 (de) 1987-09-02
JPH0633275B2 (ja) 1994-05-02
KR870007934A (ko) 1987-09-23
ES2032394T3 (es) 1993-02-16
JPS62198683A (ja) 1987-09-02
NO870666L (no) 1987-08-21
IL81609A (en) 1994-10-21
NO170155C (no) 1992-09-16
DK85087A (da) 1987-08-21
PT84319A (de) 1987-03-01

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MM4A Patent lapsed