IE49267B1 - N-substituted aziridine-2-carboxylic acid derivatives - Google Patents

N-substituted aziridine-2-carboxylic acid derivatives

Info

Publication number
IE49267B1
IE49267B1 IE327/80A IE32780A IE49267B1 IE 49267 B1 IE49267 B1 IE 49267B1 IE 327/80 A IE327/80 A IE 327/80A IE 32780 A IE32780 A IE 32780A IE 49267 B1 IE49267 B1 IE 49267B1
Authority
IE
Ireland
Prior art keywords
radical
general formula
cyano
aziridine
substituted
Prior art date
Application number
IE327/80A
Other languages
English (en)
Other versions
IE800327L (en
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of IE800327L publication Critical patent/IE800327L/xx
Publication of IE49267B1 publication Critical patent/IE49267B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IE327/80A 1979-02-21 1980-02-20 N-substituted aziridine-2-carboxylic acid derivatives IE49267B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792906603 DE2906603A1 (de) 1979-02-21 1979-02-21 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
IE800327L IE800327L (en) 1980-08-21
IE49267B1 true IE49267B1 (en) 1985-09-04

Family

ID=6063481

Family Applications (1)

Application Number Title Priority Date Filing Date
IE327/80A IE49267B1 (en) 1979-02-21 1980-02-20 N-substituted aziridine-2-carboxylic acid derivatives

Country Status (19)

Country Link
US (2) US4397848A (enExample)
EP (1) EP0014976B1 (enExample)
JP (1) JPS55113760A (enExample)
AR (1) AR223863A1 (enExample)
AT (1) ATE818T1 (enExample)
AU (1) AU529982B2 (enExample)
CA (1) CA1148962A (enExample)
CS (1) CS208798B2 (enExample)
DD (1) DD148772A5 (enExample)
DE (2) DE2906603A1 (enExample)
ES (1) ES488656A1 (enExample)
FI (1) FI70702C (enExample)
HU (1) HU182801B (enExample)
IE (1) IE49267B1 (enExample)
IL (1) IL59425A (enExample)
PL (1) PL129707B1 (enExample)
PT (1) PT70847A (enExample)
SU (1) SU1181541A3 (enExample)
ZA (1) ZA80902B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925835A (en) * 1986-05-01 1990-05-15 Sloan-Kettering Institute For Cancer Research Aziridinyl putrescine containing compositions and their uses in treating prostate cancer
JPH07301287A (ja) * 1995-03-23 1995-11-14 Sumitomo Heavy Ind Ltd 制御装置に用いられる内接噛合遊星歯車機構
AU8171498A (en) 1997-06-27 1999-01-19 Arizona Board Of Regents On Behalf Of The University Of Arizona, The Novel cyanoaziridines for treating cancer
WO2002041871A2 (en) * 2000-11-21 2002-05-30 Board Of Regents, The University Of Texas System Composition comprising an imexon or derivatives thereof and lipids
US20030129222A1 (en) * 2000-11-21 2003-07-10 Gabriel Lopez-Berestein Liposomal imexon
ES2294197T3 (es) * 2001-12-21 2008-04-01 Supernus Pharmaceuticals, Inc. Formulacion de capsula oral con estabilidad fisica aumentada.
US20040005339A1 (en) * 2002-06-28 2004-01-08 Shojaei Amir H. Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability
GEP20084540B (en) 2003-01-14 2008-11-25 Arena Pharm Inc 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
MXPA05007614A (es) * 2003-02-24 2006-05-25 Arena Pharm Inc Derivados de fenilo y piridilpiperidina como moduladores del metabolismo de glucosa.
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
EP1756084B1 (en) * 2004-06-04 2008-11-26 Arena Pharmaceuticals, Inc. Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
WO2007035355A2 (en) * 2005-09-16 2007-03-29 Arena Pharmaceuticals, Inc. Modulators of metabolism and the treatment of disorders related thereto
TW200811147A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
US8853419B2 (en) 2010-01-27 2014-10-07 Arena Pharmaceuticals, Inc. Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
JP5941916B2 (ja) 2010-09-22 2016-06-29 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｇｐｒ１１９レセプターのモジュレーターおよびそれに関連する障害の処置
DK3242666T5 (da) 2015-01-06 2025-01-20 Arena Pharm Inc Forbindelsee til anvendelse i behandling af tilstande, der er forbundet med SIP1-receptoren
JP6838744B2 (ja) 2015-06-22 2021-03-03 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩
KR20190116416A (ko) 2017-02-16 2019-10-14 아레나 파마슈티칼스, 인크. 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
ES2987794T3 (es) 2018-06-06 2024-11-18 Arena Pharm Inc Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1
CN113816887A (zh) * 2021-08-31 2021-12-21 华中科技大学 一种氮杂环丙烷类化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2644820A1 (de) * 1976-10-05 1978-04-06 Boehringer Mannheim Gmbh Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben
DE2731264A1 (de) 1977-07-11 1979-02-01 Boehringer Mannheim Gmbh Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen

Also Published As

Publication number Publication date
CA1148962A (en) 1983-06-28
ZA80902B (en) 1981-03-25
SU1181541A3 (ru) 1985-09-23
PL129707B1 (en) 1984-06-30
FI70702B (fi) 1986-06-26
HU182801B (en) 1984-03-28
DE3060268D1 (en) 1982-05-19
IL59425A0 (en) 1980-05-30
IL59425A (en) 1984-05-31
DD148772A5 (de) 1981-06-10
AU529982B2 (en) 1983-06-30
FI70702C (fi) 1986-10-06
JPS55113760A (en) 1980-09-02
EP0014976A1 (de) 1980-09-03
US4397848A (en) 1983-08-09
PT70847A (de) 1980-03-01
CS208798B2 (en) 1981-09-15
ATE818T1 (de) 1982-04-15
DE2906603A1 (de) 1980-09-04
PL222088A1 (enExample) 1980-12-01
EP0014976B1 (de) 1982-04-07
ES488656A1 (es) 1980-09-16
US4517183A (en) 1985-05-14
IE800327L (en) 1980-08-21
FI800510A7 (fi) 1980-08-22
JPH0150700B2 (enExample) 1989-10-31
AR223863A1 (es) 1981-09-30
AU5564980A (en) 1980-08-28

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