CA1148962A - N-substituted aziridine-2-carboxylic acid derivatives - Google Patents

N-substituted aziridine-2-carboxylic acid derivatives

Info

Publication number
CA1148962A
CA1148962A CA000345886A CA345886A CA1148962A CA 1148962 A CA1148962 A CA 1148962A CA 000345886 A CA000345886 A CA 000345886A CA 345886 A CA345886 A CA 345886A CA 1148962 A CA1148962 A CA 1148962A
Authority
CA
Canada
Prior art keywords
cyano
formula
radical
process according
aziridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000345886A
Other languages
English (en)
French (fr)
Inventor
Elmar Bosies
Wolfgang Kampe
Max Thiel
Uwe Bicker
Dietmar Boerner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of CA1148962A publication Critical patent/CA1148962A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA000345886A 1979-02-21 1980-02-18 N-substituted aziridine-2-carboxylic acid derivatives Expired CA1148962A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP2906603.3 1979-02-21
DE19792906603 DE2906603A1 (de) 1979-02-21 1979-02-21 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
CA1148962A true CA1148962A (en) 1983-06-28

Family

ID=6063481

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000345886A Expired CA1148962A (en) 1979-02-21 1980-02-18 N-substituted aziridine-2-carboxylic acid derivatives

Country Status (19)

Country Link
US (2) US4397848A (enExample)
EP (1) EP0014976B1 (enExample)
JP (1) JPS55113760A (enExample)
AR (1) AR223863A1 (enExample)
AT (1) ATE818T1 (enExample)
AU (1) AU529982B2 (enExample)
CA (1) CA1148962A (enExample)
CS (1) CS208798B2 (enExample)
DD (1) DD148772A5 (enExample)
DE (2) DE2906603A1 (enExample)
ES (1) ES488656A1 (enExample)
FI (1) FI70702C (enExample)
HU (1) HU182801B (enExample)
IE (1) IE49267B1 (enExample)
IL (1) IL59425A (enExample)
PL (1) PL129707B1 (enExample)
PT (1) PT70847A (enExample)
SU (1) SU1181541A3 (enExample)
ZA (1) ZA80902B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925835A (en) * 1986-05-01 1990-05-15 Sloan-Kettering Institute For Cancer Research Aziridinyl putrescine containing compositions and their uses in treating prostate cancer
JPH07301287A (ja) * 1995-03-23 1995-11-14 Sumitomo Heavy Ind Ltd 制御装置に用いられる内接噛合遊星歯車機構
DE69819192T2 (de) * 1997-06-27 2004-06-09 Amplimed, Inc., Tucson Neue cyanoaziridine zur behandlung von krebs
WO2002041871A2 (en) * 2000-11-21 2002-05-30 Board Of Regents, The University Of Texas System Composition comprising an imexon or derivatives thereof and lipids
US20030129222A1 (en) * 2000-11-21 2003-07-10 Gabriel Lopez-Berestein Liposomal imexon
ATE374602T1 (de) * 2001-12-21 2007-10-15 Supernus Pharmaceuticals Inc Orale kapselformulierung mit verbesserter physikalischer stabilität
US20040005339A1 (en) * 2002-06-28 2004-01-08 Shojaei Amir H. Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability
CN102558155A (zh) 2003-01-14 2012-07-11 阿伦纳药品公司 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
WO2004076413A2 (en) * 2003-02-24 2004-09-10 Arena Pharmaceuticals, Inc. Phenyl- and pyridylpiperidine-derivatives as modulators of glucose metabolism
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
HRP20090093T3 (en) * 2004-06-04 2009-03-31 Arena Pharmaceuticals Inc. Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
GEP20104966B (en) * 2005-09-16 2010-04-26 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811147A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
CA2786994C (en) 2010-01-27 2018-01-16 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
MX2013003184A (es) 2010-09-22 2013-06-07 Arena Pharm Inc Moduladores del receptor gpr119 y el tratamiento de transtornos relacionados con el mismo.
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
PL3310760T3 (pl) 2015-06-22 2023-03-06 Arena Pharmaceuticals, Inc. Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
KR20190116416A (ko) 2017-02-16 2019-10-14 아레나 파마슈티칼스, 인크. 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
AU2019280822A1 (en) 2018-06-06 2021-01-07 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
CN113816887A (zh) * 2021-08-31 2021-12-21 华中科技大学 一种氮杂环丙烷类化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2644820A1 (de) * 1976-10-05 1978-04-06 Boehringer Mannheim Gmbh Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben
DE2731264A1 (de) 1977-07-11 1979-02-01 Boehringer Mannheim Gmbh Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen

Also Published As

Publication number Publication date
IE800327L (en) 1980-08-21
JPH0150700B2 (enExample) 1989-10-31
FI800510A7 (fi) 1980-08-22
AU529982B2 (en) 1983-06-30
FI70702C (fi) 1986-10-06
ES488656A1 (es) 1980-09-16
IE49267B1 (en) 1985-09-04
ATE818T1 (de) 1982-04-15
US4397848A (en) 1983-08-09
AR223863A1 (es) 1981-09-30
ZA80902B (en) 1981-03-25
DE2906603A1 (de) 1980-09-04
HU182801B (en) 1984-03-28
FI70702B (fi) 1986-06-26
SU1181541A3 (ru) 1985-09-23
JPS55113760A (en) 1980-09-02
CS208798B2 (en) 1981-09-15
DE3060268D1 (en) 1982-05-19
PL129707B1 (en) 1984-06-30
PT70847A (de) 1980-03-01
DD148772A5 (de) 1981-06-10
EP0014976B1 (de) 1982-04-07
IL59425A0 (en) 1980-05-30
AU5564980A (en) 1980-08-28
EP0014976A1 (de) 1980-09-03
PL222088A1 (enExample) 1980-12-01
US4517183A (en) 1985-05-14
IL59425A (en) 1984-05-31

Similar Documents

Publication Publication Date Title
US4517183A (en) N-Substituted aziridine-2-carboxylic acid derivatives
US3862139A (en) Heterocyclic benzamide compounds
US3950418A (en) Vitamin A acid amides
US3288795A (en) 1, 4-bis-(diphenylacetyl) piperazines
US4410532A (en) N-Substituted aziridine-2-carboxylic acid derivatives and their immuno-stimulation compositions and methods
EP0350878B1 (en) Conjugated gamma-oxybutenolide compounds for treating ulcer
DE3854981T2 (de) 1-Pyrrolidinacetamid-Derivate und ihre Verwendung
US4158062A (en) Cyclopentane derivatives
JPH0615533B2 (ja) ピラジン誘導体およびこれを含有する血小板凝集抑制剤
US3920691A (en) 5-(3-substituted amino-2-hydroxypropoxy)-1,3-disubstituted pyrazoles and method of preparation
US3968224A (en) 3-(4'-Chlorophenyl)-5-methyl-4,5-dihydro-1,2,4-oxadiazole, its use as an anti-inflammatory agent
US4478838A (en) 1-(3,4,5-Trimethoxycinnamoyl)-4-alkylaminocarbonylethyl piperazines
US4464379A (en) Indol acetic acid derivatives and anti-inflamatory and related uses thereof
JPS63170366A (ja) イミダゾール誘導体、その製造方法及びこれを含有する抗菌剤
DE69018741T2 (de) Konjugierte gamma-Hydroxybutenolid-Derivate und sie als aktiver Wirkstoff enthaltende Mittel gegen Magengeschwüre.
CA1164862A (en) Indol acetic derivates, process for producing the same and pharmaceutical compositions comprising the same
JP2835545B2 (ja) 白内障予防及び治療剤
US4005073A (en) 6-Acyl derivatives of aminopenicillanic acid
SU816402A3 (ru) Способ получени аминопроизводных2-МЕТил-5-(2-ОКСиСТиРил)-1,3,4-ТиА-диАзОлА или иХ СОлЕй
US4185021A (en) 5-(p-Nitrophenyl)-2-furaldehyde 2-(2-hydroxyethyl)hydrazone
KR840001967B1 (ko) 1,1,3,5-치환 뷰렛 화합물의 제조방법
US4088774A (en) 2-Phenyl-3-(4-hydroxycoumarin-3-yl)phthalimidine
US3069318A (en) 2-lower alkyl-4, 5-dihydro-3-pyridazinone-6-carboxamides and antitussive compositions
US4341773A (en) 2,4-Diamino-5-sulfamoylbenzene sulfonic acids and process for their manufacture
US4097609A (en) 2,4-Disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrenes

Legal Events

Date Code Title Description
MKEX Expiry