IE48476B1 - Method and apparatus for discriminating platelets from red blood cells in a blood sample - Google Patents
Method and apparatus for discriminating platelets from red blood cells in a blood sampleInfo
- Publication number
- IE48476B1 IE48476B1 IE1685/79A IE168579A IE48476B1 IE 48476 B1 IE48476 B1 IE 48476B1 IE 1685/79 A IE1685/79 A IE 1685/79A IE 168579 A IE168579 A IE 168579A IE 48476 B1 IE48476 B1 IE 48476B1
- Authority
- IE
- Ireland
- Prior art keywords
- light
- cells
- platelets
- zone
- sample
- Prior art date
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 21
- 239000008280 blood Substances 0.000 title claims abstract description 21
- 210000003743 erythrocyte Anatomy 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims description 16
- 210000004027 cell Anatomy 0.000 claims abstract description 88
- 239000012530 fluid Substances 0.000 claims description 11
- 238000005286 illumination Methods 0.000 claims description 11
- 230000003287 optical effect Effects 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 238000001446 dark-field microscopy Methods 0.000 abstract description 4
- 238000004458 analytical method Methods 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 238000011835 investigation Methods 0.000 description 6
- 230000000875 corresponding effect Effects 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000013459 approach Methods 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000001575 pathological effect Effects 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 238000009652 hydrodynamic focusing Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000010287 polarization Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- CPBQJMYROZQQJC-UHFFFAOYSA-N helium neon Chemical compound [He].[Ne] CPBQJMYROZQQJC-UHFFFAOYSA-N 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000012538 light obscuration Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Microscoopes, Condenser (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/939,943 US4577964A (en) | 1978-09-06 | 1978-09-06 | Apparatus and method for detecting platelets in whole blood |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE791685L IE791685L (en) | 1980-03-06 |
| IE48476B1 true IE48476B1 (en) | 1985-02-06 |
Family
ID=25473975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1685/79A IE48476B1 (en) | 1978-09-06 | 1979-09-05 | Method and apparatus for discriminating platelets from red blood cells in a blood sample |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4577964A (enExample) |
| EP (1) | EP0009307B1 (enExample) |
| JP (1) | JPS5537998A (enExample) |
| AU (1) | AU524291B2 (enExample) |
| CA (1) | CA1125050A (enExample) |
| DE (1) | DE2966186D1 (enExample) |
| IE (1) | IE48476B1 (enExample) |
| NO (1) | NO792876L (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5994037A (ja) * | 1982-11-19 | 1984-05-30 | Shimadzu Corp | 血球計数装置 |
| EP0138591A3 (en) * | 1983-10-14 | 1986-02-12 | Ortho Diagnostic Systems Inc. | Screening method for red blood cell abnormality |
| US4735504A (en) * | 1983-10-31 | 1988-04-05 | Technicon Instruments Corporation | Method and apparatus for determining the volume & index of refraction of particles |
| US4989977A (en) * | 1985-07-29 | 1991-02-05 | Becton, Dickinson And Company | Flow cytometry apparatus with improved light beam adjustment |
| DE3534973C2 (de) * | 1985-10-01 | 1995-02-09 | Eppendorf Geraetebau Netheler | Durchflußimpulsphotometer zur Partikelmessung |
| GB8603391D0 (en) * | 1986-02-12 | 1986-03-19 | British Aerospace | Position sensor |
| US4989978A (en) * | 1986-04-04 | 1991-02-05 | Technicon Instruments Corporation | Method and apparatus for determining the count per unit volume of particles |
| RU2122831C1 (ru) * | 1986-07-07 | 1998-12-10 | Дальневосточный зональный научно-исследовательский ветеринарный институт | Способ диагностики европейского гнильца пчел |
| US5104526A (en) * | 1987-01-30 | 1992-04-14 | Baxter International Inc. | Centrifugation system having an interface detection system |
| US5076911A (en) * | 1987-01-30 | 1991-12-31 | Baxter International Inc. | Centrifugation chamber having an interface detection surface |
| US6780333B1 (en) | 1987-01-30 | 2004-08-24 | Baxter International Inc. | Centrifugation pheresis method |
| JPS63191043A (ja) * | 1987-02-03 | 1988-08-08 | Omron Tateisi Electronics Co | 細胞分析装置 |
| KR970007077B1 (ko) * | 1987-03-13 | 1997-05-02 | 코울터 일렉트로닉스 인커퍼레이티드 | 광산란 기술을 이용한 다중-부분식별 분석 방법 |
| US4810090A (en) * | 1987-08-24 | 1989-03-07 | Cobe Laboratories, Inc. | Method and apparatus for monitoring blood components |
| JPH01132932A (ja) * | 1987-11-18 | 1989-05-25 | Omron Tateisi Electron Co | 流れ式粒子分析装置の信号光検出光学系 |
| US5071247A (en) * | 1988-04-20 | 1991-12-10 | Ruben A Markosian | Method for analysis of blood platelet aggregations and apparatus therefor |
| US5061070A (en) * | 1988-04-22 | 1991-10-29 | International Business Machines Corporation | Particulate inspection of fluids using interferometric light measurements |
| US4920275A (en) * | 1988-12-30 | 1990-04-24 | Canon Kabushiki Kaisha | Particle measuring device with elliptically-shaped scanning beam |
| CA2016699C (en) * | 1989-05-15 | 2003-11-18 | Paul N. Marshall | Lytic agents and uses thereof |
| JPH03181384A (ja) * | 1989-12-12 | 1991-08-07 | Tonen Corp | 純水製造装置の樹脂再生システム |
| US5133602A (en) * | 1991-04-08 | 1992-07-28 | International Business Machines Corporation | Particle path determination system |
| US5534999A (en) * | 1993-03-05 | 1996-07-09 | Shinmikuni Kikai Ltd. | Monitoring sub-micron particles |
| US6215587B1 (en) * | 1994-02-14 | 2001-04-10 | Robert R. Alfano | Microscope imaging inside highly scattering media |
| US5891734A (en) * | 1994-08-01 | 1999-04-06 | Abbott Laboratories | Method for performing automated analysis |
| US5656499A (en) * | 1994-08-01 | 1997-08-12 | Abbott Laboratories | Method for performing automated hematology and cytometry analysis |
| US5631165A (en) * | 1994-08-01 | 1997-05-20 | Abbott Laboratories | Method for performing automated hematology and cytometry analysis |
| CA2200455A1 (en) * | 1994-09-20 | 1996-03-28 | Louis R. Piloco | Apparatus for illumination stabilization and homogenization |
| US5817519A (en) * | 1995-12-28 | 1998-10-06 | Bayer Corporation | Automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
| US6025201A (en) * | 1995-12-28 | 2000-02-15 | Bayer Corporation | Highly sensitive, accurate, and precise automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
| US5734464A (en) * | 1996-11-06 | 1998-03-31 | Cobe Laboratories, Inc. | Red blood cell spillover detection technique |
| US5831730A (en) * | 1996-12-06 | 1998-11-03 | United Sciences, Inc. | Method for monitoring particulates using beam-steered solid-state light source |
| US5751423A (en) * | 1996-12-06 | 1998-05-12 | United Sciences, Inc. | Opacity and forward scattering monitor using beam-steered solid-state light source |
| US7390662B2 (en) * | 2005-11-09 | 2008-06-24 | Beckman Coulter, Inc. | Method and apparatus for performing platelet measurement |
| EP2278383A1 (en) * | 2004-11-24 | 2011-01-26 | Battelle Memorial Institute | A test tube handling apparatus |
| CN101438143B (zh) * | 2005-04-29 | 2013-06-12 | 霍尼韦尔国际公司 | 血细胞计数器细胞计数和尺寸测量方法 |
| US7344890B2 (en) * | 2005-11-09 | 2008-03-18 | Beckman Coulter, Inc. | Method for discriminating platelets from red blood cells |
| JP4817442B2 (ja) * | 2006-07-31 | 2011-11-16 | シスメックス株式会社 | 粒子分析装置用光学系、及びそれを用いた粒子分析装置 |
| CN101153868B (zh) * | 2006-09-30 | 2012-05-30 | 深圳迈瑞生物医疗电子股份有限公司 | 流式细胞分析仪 |
| CN101498646B (zh) * | 2008-02-03 | 2014-06-11 | 深圳迈瑞生物医疗电子股份有限公司 | 前向散射光信号探测装置与方法及细胞或粒子分析仪 |
| JP4850873B2 (ja) * | 2008-06-16 | 2012-01-11 | 日之出水道機器株式会社 | 地下構造物用ブロック |
| GB0814297D0 (en) * | 2008-08-05 | 2008-09-10 | Ge Healthcare Uk Ltd | Microscopy |
| JP6352713B2 (ja) * | 2014-07-22 | 2018-07-04 | シスメックス株式会社 | フローサイトメータ、粒子分析装置およびフローサイトメトリー法 |
| JP6617775B2 (ja) * | 2016-01-21 | 2019-12-11 | 東京エレクトロン株式会社 | 異物検出装置及び異物検出方法 |
| CN109477837B (zh) * | 2016-09-28 | 2022-09-16 | 泰尔茂株式会社 | 用于检测血液样品中的分析对象物的方法、组合物和芯片 |
| DE102019008685B4 (de) * | 2019-12-16 | 2025-08-07 | Baumer Electric Ag | Optische Messanordnung und Verfahren zur Präsenzerkennung kleiner Objekte in einem Strahlengang |
| CN115049721B (zh) * | 2022-05-30 | 2024-08-16 | 上海交通大学 | 微米级生物组织的体积测量方法、体积测量装置、细胞数量测量方法及计算机设备 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1292877B (de) * | 1961-06-23 | 1969-04-17 | Cap Ges Fuer Entwicklung Von M | Verfahren und Vorrichtung zum selbsttaetigen photoelektrischen Zaehlen, Registrierenund Differenzieren von Teilchen |
| US3315229A (en) * | 1963-12-31 | 1967-04-18 | Ibm | Blood cell recognizer |
| US3703641A (en) * | 1969-08-18 | 1972-11-21 | North American Rockwell | Particle-size measuring apparatus |
| US3790760A (en) * | 1971-09-27 | 1974-02-05 | Cornell Aeronautical Labor Inc | Apparatus for counting, differentiating and sorting particles according to their microstructure variations |
| BE793185A (fr) * | 1971-12-23 | 1973-04-16 | Atomic Energy Commission | Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques |
| US3785735A (en) * | 1972-01-19 | 1974-01-15 | Bio Physics Systems Inc | Photoanalysis method |
| FR2195907A5 (enExample) * | 1972-08-10 | 1974-03-08 | Meric Jean Paul | |
| US3819270A (en) * | 1972-10-02 | 1974-06-25 | Block Engineering | Blood cell analyzer |
| US3871770A (en) * | 1973-06-04 | 1975-03-18 | Nuclear Data Inc | Hydrodynamic focusing method and apparatus |
| US3824402A (en) * | 1973-06-04 | 1974-07-16 | Energy Commission | Dual parameter flow photometric apparatus and method |
| US3947123A (en) * | 1974-05-13 | 1976-03-30 | The Board Of Regents Of The University Of Washington | Coherent optical analyzer |
| US3960449A (en) * | 1975-06-05 | 1976-06-01 | The Board Of Trustees Of Leland Stanford Junior University | Measurement of angular dependence of scattered light in a flowing stream |
| JPS5842637B2 (ja) * | 1975-07-04 | 1983-09-21 | 株式会社東芝 | レ−ザシユツリヨクアンテイカソウチ |
| JPS5267595A (en) * | 1975-12-02 | 1977-06-04 | Nec Corp | Laser output stabilizing device |
| JPS5949529B2 (ja) * | 1976-06-25 | 1984-12-03 | 東亜医用電子株式会社 | 血小板計測装置 |
| US4110604A (en) * | 1976-11-04 | 1978-08-29 | Becton, Dickinson And Company | Particle density measuring system |
| US4202625A (en) * | 1978-08-18 | 1980-05-13 | Ortho Diagnostics, Inc. | Method and apparatus for discriminating red blood cells from platelets |
-
1978
- 1978-09-06 US US05/939,943 patent/US4577964A/en not_active Expired - Lifetime
-
1979
- 1979-07-23 AU AU49128/79A patent/AU524291B2/en not_active Expired
- 1979-08-01 DE DE7979301538T patent/DE2966186D1/de not_active Expired
- 1979-08-01 EP EP79301538A patent/EP0009307B1/en not_active Expired
- 1979-09-04 CA CA334,999A patent/CA1125050A/en not_active Expired
- 1979-09-05 NO NO792876A patent/NO792876L/no unknown
- 1979-09-05 JP JP11304079A patent/JPS5537998A/ja active Granted
- 1979-09-05 IE IE1685/79A patent/IE48476B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU4912879A (en) | 1980-03-13 |
| DE2966186D1 (en) | 1983-10-27 |
| JPS6351268B2 (enExample) | 1988-10-13 |
| US4577964A (en) | 1986-03-25 |
| JPS5537998A (en) | 1980-03-17 |
| EP0009307B1 (en) | 1983-09-21 |
| EP0009307A1 (en) | 1980-04-02 |
| CA1125050A (en) | 1982-06-08 |
| AU524291B2 (en) | 1982-09-09 |
| NO792876L (no) | 1980-03-07 |
| IE791685L (en) | 1980-03-06 |
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