IE41386B1 - Aromatic ketones having cardiovascular activity - Google Patents
Aromatic ketones having cardiovascular activityInfo
- Publication number
- IE41386B1 IE41386B1 IE1395/75A IE139575A IE41386B1 IE 41386 B1 IE41386 B1 IE 41386B1 IE 1395/75 A IE1395/75 A IE 1395/75A IE 139575 A IE139575 A IE 139575A IE 41386 B1 IE41386 B1 IE 41386B1
- Authority
- IE
- Ireland
- Prior art keywords
- give
- compound
- june
- alkyl
- treating
- Prior art date
Links
- 230000005792 cardiovascular activity Effects 0.000 title abstract 2
- 150000008365 aromatic ketones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- MUQVVWKGBBDOEF-UHFFFAOYSA-N 4,4-dimethyl-1-phenoxypentan-2-ol Chemical class CC(C)(C)CC(O)COC1=CC=CC=C1 MUQVVWKGBBDOEF-UHFFFAOYSA-N 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000001033 ether group Chemical group 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE676/78A IE41387B1 (en) | 1974-06-28 | 1975-06-24 | 8-aza-4,9-dioxa-2,3-benzobicyclo- (4.2.1)- octanes and method for preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB28925/74A GB1501632A (en) | 1974-06-28 | 1974-06-28 | Aromatic ketones having cardiovascular activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41386L IE41386L (en) | 1975-12-28 |
| IE41386B1 true IE41386B1 (en) | 1979-12-19 |
Family
ID=10283421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1395/75A IE41386B1 (en) | 1974-06-28 | 1975-06-24 | Aromatic ketones having cardiovascular activity |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4252825A (cg-RX-API-DMAC7.html) |
| JP (2) | JPS5826743B2 (cg-RX-API-DMAC7.html) |
| AR (1) | AR205388A1 (cg-RX-API-DMAC7.html) |
| AT (1) | AT343098B (cg-RX-API-DMAC7.html) |
| BE (1) | BE830766A (cg-RX-API-DMAC7.html) |
| CA (1) | CA1052820A (cg-RX-API-DMAC7.html) |
| CS (1) | CS197248B2 (cg-RX-API-DMAC7.html) |
| DE (1) | DE2528147A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK143555C (cg-RX-API-DMAC7.html) |
| ES (1) | ES438931A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2276032A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1501632A (cg-RX-API-DMAC7.html) |
| IE (1) | IE41386B1 (cg-RX-API-DMAC7.html) |
| NL (1) | NL7507703A (cg-RX-API-DMAC7.html) |
| SE (2) | SE416546B (cg-RX-API-DMAC7.html) |
| YU (1) | YU165775A (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA754141B (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1501632A (en) * | 1974-06-28 | 1978-02-22 | Cm Ind | Aromatic ketones having cardiovascular activity |
| JPH0516363Y2 (cg-RX-API-DMAC7.html) * | 1986-08-01 | 1993-04-28 | ||
| OA12905A (en) | 2002-08-19 | 2006-10-13 | Pfizer Prod Inc | Combination therapy for hyperproliferative diseases. |
| RS20050890A (sr) * | 2003-05-30 | 2007-12-31 | Ranbaxy Laboratories Limited, | Supstituisani pirol derivati |
| US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
| GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| WO2007054896A1 (en) * | 2005-11-08 | 2007-05-18 | Ranbaxy Laboratories Limited | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| CL2007000667A1 (es) * | 2006-03-14 | 2008-03-14 | Ranbaxi Lab Ltd | Composicion farmaceutica que comprende al acido 7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]pirrol-1-il]-3,5-dihidroxi-heptanoico o una sal y al menos un agente estabilizante; procedimiento de preparacion, util en e |
| MX2009000439A (es) * | 2006-07-14 | 2009-02-04 | Ranbaxy Lab Ltd | Formas polimorficas de un inhibidor de hmg-coa reductasa y usos de las mismas. |
| CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
| MX2015014666A (es) | 2013-04-17 | 2016-03-01 | Pfizer | Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares. |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| US11248001B2 (en) | 2019-01-18 | 2022-02-15 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL301580A (cg-RX-API-DMAC7.html) * | 1962-12-11 | |||
| US3637852A (en) * | 1963-08-26 | 1972-01-25 | Boehringer Sohn Ingelheim | 1-phenoxy-2-hydroxy-3-isopropylamino-propanes and salts thereof |
| DE1493454C3 (de) * | 1963-08-26 | 1980-04-30 | C.H. Boehringer Sohn, 6507 Ingelheim | 1 -Aryloxy^-hydroxy-S-isopropylaminopropane und deren Salze sowie deren Herstellung und darauf basierende Arzneimittel |
| GB1231783A (en) * | 1967-05-16 | 1971-05-12 | May & Baker Ltd | Benzene derivatives |
| JPS512115B2 (cg-RX-API-DMAC7.html) * | 1971-09-28 | 1976-01-23 | ||
| JPS4911847A (cg-RX-API-DMAC7.html) * | 1972-05-20 | 1974-02-01 | ||
| GB1501632A (en) * | 1974-06-28 | 1978-02-22 | Cm Ind | Aromatic ketones having cardiovascular activity |
-
1974
- 1974-06-28 GB GB28925/74A patent/GB1501632A/en not_active Expired
-
1975
- 1975-01-01 AR AR259407A patent/AR205388A1/es active
- 1975-06-20 FR FR7519386A patent/FR2276032A1/fr active Granted
- 1975-06-24 DE DE19752528147 patent/DE2528147A1/de not_active Withdrawn
- 1975-06-24 IE IE1395/75A patent/IE41386B1/xx unknown
- 1975-06-24 CS CS754483A patent/CS197248B2/cs unknown
- 1975-06-26 SE SE7507359A patent/SE416546B/xx unknown
- 1975-06-27 YU YU01657/75A patent/YU165775A/xx unknown
- 1975-06-27 ES ES438931A patent/ES438931A1/es not_active Expired
- 1975-06-27 ZA ZA00754141A patent/ZA754141B/xx unknown
- 1975-06-27 BE BE157788A patent/BE830766A/xx not_active IP Right Cessation
- 1975-06-27 DK DK292475A patent/DK143555C/da not_active IP Right Cessation
- 1975-06-27 NL NL7507703A patent/NL7507703A/xx not_active Application Discontinuation
- 1975-06-27 AT AT497275A patent/AT343098B/de not_active IP Right Cessation
- 1975-06-27 CA CA230,291A patent/CA1052820A/en not_active Expired
- 1975-06-28 JP JP50080469A patent/JPS5826743B2/ja not_active Expired
-
1978
- 1978-12-08 SE SE7812646A patent/SE417087B/sv unknown
-
1979
- 1979-01-05 US US06/001,314 patent/US4252825A/en not_active Expired - Lifetime
-
1980
- 1980-03-12 US US06/129,730 patent/US4302601A/en not_active Expired - Lifetime
-
1983
- 1983-01-07 JP JP58001033A patent/JPS5929574B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATA497275A (de) | 1977-09-15 |
| JPS5929574B2 (ja) | 1984-07-21 |
| SE7812646L (sv) | 1978-12-08 |
| GB1501632A (en) | 1978-02-22 |
| SE417087B (sv) | 1981-02-23 |
| AU8256675A (en) | 1977-01-06 |
| AT343098B (de) | 1978-05-10 |
| FR2276032B1 (cg-RX-API-DMAC7.html) | 1979-08-10 |
| AR205388A1 (es) | 1976-04-30 |
| DE2528147A1 (de) | 1976-01-15 |
| CS197248B2 (en) | 1980-04-30 |
| JPS5123233A (en) | 1976-02-24 |
| DK143555C (da) | 1982-02-01 |
| SE416546B (sv) | 1981-01-19 |
| CA1052820A (en) | 1979-04-17 |
| ZA754141B (en) | 1976-06-30 |
| JPS5826743B2 (ja) | 1983-06-04 |
| JPS58140050A (ja) | 1983-08-19 |
| US4252825A (en) | 1981-02-24 |
| US4302601A (en) | 1981-11-24 |
| BE830766A (fr) | 1975-12-29 |
| FR2276032A1 (fr) | 1976-01-23 |
| NL7507703A (nl) | 1975-12-30 |
| DK143555B (da) | 1981-09-07 |
| SE7507359L (sv) | 1975-12-29 |
| DK292475A (da) | 1975-12-29 |
| YU165775A (en) | 1982-02-28 |
| IE41386L (en) | 1975-12-28 |
| ES438931A1 (es) | 1977-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE41386B1 (en) | Aromatic ketones having cardiovascular activity | |
| GB1356087A (en) | Alpha-cyanobenzyl cyclopropanecarboxylates | |
| DK153782C (da) | Fremgangsmaade til fremstilling af beta-hydroxysmoersyre. | |
| GB1423330A (en) | Preparation of diketone derivatives | |
| GB1288436A (cg-RX-API-DMAC7.html) | ||
| JPS5735597A (en) | 25,26-epoxy-3beta,24-dihydroxycholest-5-ene or its hydroxyl- protected derivative and their preparation | |
| GB1374402A (en) | Production of 2- cyclohex-1-enyl- cyclohexanone | |
| ATE47709T1 (de) | Verfahren zur herstellung von aldehyden. | |
| GB1474260A (en) | Perfluorinated amino compounds process for their manufacture and their use | |
| GB1350883A (en) | Bis-stilbene compounds | |
| GB1499480A (en) | Process for the manufacture of pure substituted 2,5-diarylaminoterephthalates and the corresponding free acids | |
| GB1394619A (en) | Imides | |
| ATE32706T1 (de) | Verfahren zur herstellung von 4hydroxybenzophenonen. | |
| IE41342B1 (en) | 2,3-methylene prostaglawandins and their preparation | |
| DK129969B (da) | Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin. | |
| GB1450969A (en) | Hexamethyltetracosane-diol derivatives and process for preparing them | |
| GB1297402A (cg-RX-API-DMAC7.html) | ||
| GB1310382A (en) | Process for the preparation of glucofuranosides | |
| ES446187A1 (es) | Un metodo de preparar nuevos compuestos de oxima-eter. | |
| GB1419141A (en) | Halocyanoalkyl eopoxy ehters and polymers thereof | |
| GB1442250A (en) | Preparation of 4-hydroxybenzonitrile derivatives | |
| GB1416943A (en) | Alkyl-alkenyl ketones and their use in pest control | |
| IE34367L (en) | P-biphenylylacetic acid esters | |
| ATE5772T1 (de) | Verfahren zur herstellung von 1-isopropylamino-3(4-(2-methoxy-ethyl)-phenoxy)-2-propanol. | |
| GB1469959A (en) | Perfluoro-alkylethanediols process for their manufacture and their use |