IE33933B1 - Quinazolinones - Google Patents
QuinazolinonesInfo
- Publication number
- IE33933B1 IE33933B1 IE1526/69A IE152669A IE33933B1 IE 33933 B1 IE33933 B1 IE 33933B1 IE 1526/69 A IE1526/69 A IE 1526/69A IE 152669 A IE152669 A IE 152669A IE 33933 B1 IE33933 B1 IE 33933B1
- Authority
- IE
- Ireland
- Prior art keywords
- aryl
- methyl
- quinazolinone
- compounds
- halide
- Prior art date
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 methyl halide Chemical class 0.000 abstract 2
- 238000007363 ring formation reaction Methods 0.000 abstract 2
- JQSGYWDRDFLCPD-UHFFFAOYSA-N 1-ethyl-4-phenylquinazolin-2-one Chemical compound N=1C(=O)N(CC)C2=CC=CC=C2C=1C1=CC=CC=C1 JQSGYWDRDFLCPD-UHFFFAOYSA-N 0.000 abstract 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001350 alkyl halides Chemical class 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 229940125716 antipyretic agent Drugs 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00775201A US3723432A (en) | 1968-11-12 | 1968-11-12 | 1-substituted-4-aryl-2(1h)-quinazolinones and their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33933L IE33933L (en) | 1970-05-12 |
| IE33933B1 true IE33933B1 (en) | 1974-12-11 |
Family
ID=25103642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1526/69A IE33933B1 (en) | 1968-11-12 | 1969-11-10 | Quinazolinones |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US3723432A (forum.php) |
| AT (4) | AT310169B (forum.php) |
| BE (1) | BE741529A (forum.php) |
| BG (10) | BG16042A3 (forum.php) |
| BR (1) | BR6914095D0 (forum.php) |
| CH (1) | CH521972A (forum.php) |
| DE (1) | DE1956384C3 (forum.php) |
| DK (1) | DK129347B (forum.php) |
| ES (1) | ES373377A1 (forum.php) |
| FR (1) | FR2024830B1 (forum.php) |
| GB (1) | GB1282612A (forum.php) |
| IE (1) | IE33933B1 (forum.php) |
| IL (1) | IL33348A (forum.php) |
| NL (1) | NL6916514A (forum.php) |
| NO (1) | NO124032B (forum.php) |
| OA (1) | OA03829A (forum.php) |
| PL (1) | PL72695B1 (forum.php) |
| SE (2) | SE376917B (forum.php) |
| ZA (1) | ZA697910B (forum.php) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3923803A (en) * | 1968-07-18 | 1975-12-02 | Sumitomo Chemical Co | 2(1H)-Quinozalinones and process therefor |
| US3642791A (en) * | 1969-08-13 | 1972-02-15 | Sandoz Ag | Morpholino-1-substituted-2(1h)-quinazolinones |
| US4208343A (en) * | 1970-10-30 | 1980-06-17 | Westinghouse Electric Corp. | 2,4 Diamino benzonitrile |
| BE785937A (fr) * | 1971-07-08 | 1973-01-08 | Sandoz Sa | Nouveaux derives de la quinazoline, leur preparation et leur application comme medicaments |
| US3937705A (en) * | 1972-03-09 | 1976-02-10 | Sandoz, Inc. | 1-isopropyl-7-methyl-4-(p-fluorophenyl)-2(1h)-quinazolinone |
| US4064246A (en) * | 1976-10-12 | 1977-12-20 | Sandoz, Inc. | Hydroxymethyl-substituted-2(1H)-quinazolinones |
| US4071516A (en) * | 1976-08-20 | 1978-01-31 | Sandoz, Inc. | 4-(Acyloxyphenyl)-quinazolin-2(1H)-ones |
| US4160092A (en) * | 1977-06-16 | 1979-07-03 | E. I. Du Pont De Nemours And Company | Quinazolinone oxides and their use as intermediates for pharmaceutical agents |
| US4224328A (en) * | 1979-04-11 | 1980-09-23 | Sandoz, Inc. | Methods with 1-substituted-4-aryl-quinazolin-2(1H)-ones and thiones and pyrido[2,3-d]pyrimidin-2-ones as platelet aggregation inhibitors |
| CH645362A5 (de) * | 1979-07-05 | 1984-09-28 | Sandoz Ag | Verfahren zur herstellung von 4-phenyl-2(1h)-chinazolinonen. |
| FR2676042B1 (fr) * | 1991-05-02 | 1993-07-23 | Commissariat Energie Atomique | Procede de preparation d'un borohydrure de metal alcalin tel que le borohydrure de lithium. |
| US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| AR038658A1 (es) * | 2001-06-15 | 2005-01-26 | Novartis Ag | Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento |
| US6753428B2 (en) * | 2001-11-20 | 2004-06-22 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
| AU2003213092A1 (en) * | 2002-02-15 | 2003-09-09 | Smithkline Beecham Corporation | Syntheses of quinazolinones |
| EP1553931A4 (en) | 2002-05-09 | 2006-08-30 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| BR0309892A2 (pt) * | 2002-05-09 | 2011-04-05 | Cytokinetics Inc | composto, composição, métodos para modular a atividade da cinesina de ksp, para inibir a ksp, e para o tratamento de uma doença proliferativa celular, e, uso de um composto |
| US7038048B2 (en) * | 2002-05-23 | 2006-05-02 | Cytokinetics, Inc. | 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use |
| JP2005538062A (ja) * | 2002-06-14 | 2005-12-15 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、および方法 |
| AU2003256805A1 (en) * | 2002-07-23 | 2004-02-09 | Cytokinetics, Inc. | Compounds compositions and methods |
| JP2005536553A (ja) * | 2002-08-21 | 2005-12-02 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| WO2004034972A2 (en) * | 2002-09-30 | 2004-04-29 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| GB0230015D0 (en) * | 2002-12-23 | 2003-01-29 | Novartis Ag | Organic compounds |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US8410102B2 (en) | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
| EP1682534A2 (en) * | 2003-11-03 | 2006-07-26 | Cytokinetics, Inc. | Pyrimidin-4-one compounds, compositions, and methods |
| JP2007510660A (ja) * | 2003-11-07 | 2007-04-26 | サイトキネティクス・インコーポレーテッド | 化合物、組成物及び方法 |
| JP2007513154A (ja) * | 2003-12-08 | 2007-05-24 | サイトキネティクス・インコーポレーテッド | 化合物、組成物及び方法 |
| AU2008268613A1 (en) * | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| US8058469B2 (en) * | 2008-11-03 | 2011-11-15 | Sabic Innovative Plastics Ip B.V. | Method for making carbamates, ureas and isocyanates |
| EP2329849B1 (en) | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
| US8394800B2 (en) | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| EP2552449B1 (en) | 2010-03-26 | 2017-04-19 | Galderma Research & Development | Compositions comprising brimonidine for the treatment of erythema |
| EP2552448B1 (en) | 2010-03-26 | 2019-04-24 | Galderma Research & Development | Improved compositions comprising brimonidine for safe and effective treatment of telangiectasia |
| DK2444068T4 (en) | 2010-10-21 | 2018-03-05 | Galderma Sa | Brimonide sub-composition |
| US8053427B1 (en) | 2010-10-21 | 2011-11-08 | Galderma R&D SNC | Brimonidine gel composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3452041A (en) * | 1965-05-19 | 1969-06-24 | American Home Prod | Hydantoin compounds and methods of preparation |
-
1968
- 1968-11-12 BG BG015055A patent/BG16042A3/bg unknown
- 1968-11-12 US US00775201A patent/US3723432A/en not_active Expired - Lifetime
-
1969
- 1969-10-31 CH CH1624569A patent/CH521972A/de not_active IP Right Cessation
- 1969-10-31 GB GB53620/69A patent/GB1282612A/en not_active Expired
- 1969-11-03 NL NL6916514A patent/NL6916514A/xx not_active Application Discontinuation
- 1969-11-07 FR FR696938404A patent/FR2024830B1/fr not_active Expired
- 1969-11-10 BG BG014694A patent/BG16038A3/bg unknown
- 1969-11-10 DE DE1956384A patent/DE1956384C3/de not_active Expired
- 1969-11-10 IE IE1526/69A patent/IE33933B1/xx unknown
- 1969-11-10 BG BG013325A patent/BG16188A3/bg unknown
- 1969-11-10 AT AT1053269A patent/AT310169B/de not_active IP Right Cessation
- 1969-11-10 AT AT993271A patent/AT319950B/de not_active IP Right Cessation
- 1969-11-10 OA OA53783A patent/OA03829A/xx unknown
- 1969-11-10 AT AT993571A patent/AT310176B/de not_active IP Right Cessation
- 1969-11-10 ES ES373377A patent/ES373377A1/es not_active Expired
- 1969-11-10 NO NO4445/69A patent/NO124032B/no unknown
- 1969-11-10 BG BG014696A patent/BG16040A3/bg unknown
- 1969-11-10 BG BG014692A patent/BG16036A3/bg unknown
- 1969-11-10 AT AT993071A patent/AT319949B/de not_active IP Right Cessation
- 1969-11-10 BE BE741529A patent/BE741529A/xx unknown
- 1969-11-10 BG BG014695A patent/BG16039A3/bg unknown
- 1969-11-10 BG BG014693A patent/BG16037A3/bg unknown
- 1969-11-10 BG BG015469A patent/BG16043A3/bg unknown
- 1969-11-11 IL IL33348A patent/IL33348A/xx unknown
- 1969-11-11 SE SE7213438A patent/SE376917B/xx unknown
- 1969-11-11 DK DK597169AA patent/DK129347B/da unknown
- 1969-11-11 SE SE6915448A patent/SE374920B/xx unknown
- 1969-11-11 BR BR214095/69A patent/BR6914095D0/pt unknown
- 1969-11-12 PL PL1969136872A patent/PL72695B1/pl unknown
- 1969-11-12 ZA ZA697910A patent/ZA697910B/xx unknown
-
1970
- 1970-05-16 BG BG014697A patent/BG16041A3/bg unknown
- 1970-08-13 BG BG015468A patent/BG15573A3/bg unknown
-
1972
- 1972-12-08 US US313531A patent/US3925548A/en not_active Expired - Lifetime
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