IE32705B1 - Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same - Google Patents
Novel alpha-carboline derivatives,the preparation thereof and compositions containing the sameInfo
- Publication number
- IE32705B1 IE32705B1 IE33869A IE33869A IE32705B1 IE 32705 B1 IE32705 B1 IE 32705B1 IE 33869 A IE33869 A IE 33869A IE 33869 A IE33869 A IE 33869A IE 32705 B1 IE32705 B1 IE 32705B1
- Authority
- IE
- Ireland
- Prior art keywords
- compositions
- substituted
- carboline
- araliphatic
- lotions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- BPMFPOGUJAAYHL-UHFFFAOYSA-N 9H-Pyrido[2,3-b]indole Chemical class C1=CC=C2C3=CC=CC=C3NC2=N1 BPMFPOGUJAAYHL-UHFFFAOYSA-N 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000007788 liquid Substances 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 2
- -1 araliphatic Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 239000006210 lotion Substances 0.000 abstract 2
- 239000003973 paint Substances 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 241000919811 Collyria Species 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical group OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- VQODGRNSFPNSQE-DVTGEIKXSA-N betamethasone phosphate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COP(O)(O)=O)(O)[C@@]1(C)C[C@@H]2O VQODGRNSFPNSQE-DVTGEIKXSA-N 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940112822 chewing gum Drugs 0.000 abstract 1
- 235000015218 chewing gum Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000009508 confectionery Nutrition 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 238000010410 dusting Methods 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 230000001804 emulsifying effect Effects 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000007937 lozenge Substances 0.000 abstract 1
- 239000007923 nasal drop Substances 0.000 abstract 1
- 229940100662 nasal drops Drugs 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 230000003019 stabilising effect Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1273068 | 1968-03-15 | ||
| GB1273168A GB1268772A (en) | 1968-03-15 | 1968-03-15 | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE32705L IE32705L (en) | 1969-09-15 |
| IE32705B1 true IE32705B1 (en) | 1973-10-31 |
Family
ID=26249226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE33869A IE32705B1 (en) | 1968-03-15 | 1969-03-14 | Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same |
Country Status (8)
| Country | Link |
|---|---|
| AT (2) | AT310155B (enExample) |
| BE (1) | BE729855A (enExample) |
| CH (2) | CH561206A5 (enExample) |
| DE (1) | DE1913119A1 (enExample) |
| FR (1) | FR2003999A1 (enExample) |
| GB (1) | GB1268772A (enExample) |
| IE (1) | IE32705B1 (enExample) |
| NL (1) | NL6903973A (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7605398L (sv) * | 1975-05-28 | 1976-11-29 | Merck & Co Inc | 3h-1,2,3-trizol(4,5-b)pyridiner |
| US4000286A (en) | 1975-05-28 | 1976-12-28 | Merck & Co., Inc. | 3-Phenyl,3H 1,2,3 triazolo[4,5-b]pyridines |
| JPS5536401A (en) * | 1978-06-09 | 1980-03-14 | Japan Tobacco Inc | Amino-alpha-carboline compound and mutagenic agent containing the same |
| FR2428642A1 (fr) * | 1978-06-15 | 1980-01-11 | Sumitomo Chemical Co | Derives indolo-isoquinoleiniques |
| US4558132A (en) * | 1982-07-02 | 1985-12-10 | A. H. Robins Company, Incorporated | Nitro, amino and aroylamino-N-phenylpyridinamines in a process for preparing pyrido[1,4]benzodiazepines |
| USRE37525E1 (en) | 1991-05-01 | 2002-01-22 | Henry M. Jackson Foundation | Method for treating infectious respiratory diseases |
| PT633886E (pt) * | 1992-04-03 | 2001-03-30 | Upjohn Co | Aminas biciclicas-heterociclicas farmaceuticamente activas |
| US5502187A (en) * | 1992-04-03 | 1996-03-26 | The Upjohn Company | Pharmaceutically active bicyclic-heterocyclic amines |
| US5369086A (en) * | 1993-04-28 | 1994-11-29 | Zeneca Limited | N-benzotriazoles |
| US5783575A (en) * | 1994-03-14 | 1998-07-21 | Novo Nordisk A/S | Antagonists, their preparation and use |
| US5696148A (en) * | 1994-03-14 | 1997-12-09 | Novo Nordisk A/S | Indole compounds and their use in treating diseases of the central nervous system |
| US5945417A (en) * | 1995-07-31 | 1999-08-31 | Novo Nordisk | Heterocyclic compounds, their preparation and use |
| JP2003519693A (ja) | 2000-01-07 | 2003-06-24 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 三環式化合物及びヘルペスウイルスを処置する方法 |
| FR2823975B1 (fr) * | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
| US7064139B2 (en) * | 2001-10-29 | 2006-06-20 | Uniroyal Chemical Company, Inc. | Method for treating retroviral infections |
| FR2846329B1 (fr) | 2002-10-23 | 2004-12-03 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -3 par un phenyle, leur preparation et leur application en therapeutique |
| US7456193B2 (en) | 2002-10-23 | 2008-11-25 | Sanofi-Aventis | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
| FR2869316B1 (fr) * | 2004-04-21 | 2006-06-02 | Sanofi Synthelabo | Derives de pyridoindolone substitues en -6, leur preparation et leur application en therapeutique. |
| FR2892416B1 (fr) | 2005-10-20 | 2008-06-27 | Sanofi Aventis Sa | Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique |
| EP2161271A1 (en) * | 2008-09-08 | 2010-03-10 | Università Degli Studi Di Milano - Bicocca | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl |
| CN113416187B (zh) * | 2013-03-14 | 2024-07-19 | 奥斯菲治疗有限公司 | 促进骨生长的烷基胺骆驼蓬碱衍生物 |
| US10662193B2 (en) | 2014-01-21 | 2020-05-26 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins |
| ES3004565T3 (en) | 2018-08-14 | 2025-03-12 | Ossifi Therapeutics Llc | Pyrrolo - dipyridine compounds for the treatment of bone loss |
| JP7695496B2 (ja) | 2018-08-14 | 2025-06-19 | オシフィ セラピューティクス リミティド ライアビリティ カンパニー | フルオロβ－カルボリン化合物 |
| FR3109534B1 (fr) | 2020-04-22 | 2022-03-25 | Soprema | Installation et procédé de traitement de produits composites à base de matières thermoplastiques |
-
1968
- 1968-03-15 GB GB1273168A patent/GB1268772A/en not_active Expired
-
1969
- 1969-03-14 DE DE19691913119 patent/DE1913119A1/de active Pending
- 1969-03-14 AT AT736471A patent/AT310155B/de not_active IP Right Cessation
- 1969-03-14 NL NL6903973A patent/NL6903973A/xx unknown
- 1969-03-14 CH CH1271771A patent/CH561206A5/xx not_active IP Right Cessation
- 1969-03-14 IE IE33869A patent/IE32705B1/xx unknown
- 1969-03-14 CH CH389969A patent/CH553200A/xx not_active IP Right Cessation
- 1969-03-14 BE BE729855D patent/BE729855A/xx unknown
- 1969-03-14 AT AT253169A patent/AT304533B/de not_active IP Right Cessation
- 1969-03-14 FR FR6907280A patent/FR2003999A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IE32705L (en) | 1969-09-15 |
| CH561206A5 (enExample) | 1975-04-30 |
| BE729855A (enExample) | 1969-09-15 |
| DE1913119A1 (de) | 1970-08-06 |
| NL6903973A (enExample) | 1969-09-17 |
| CH553200A (de) | 1974-08-30 |
| GB1268772A (en) | 1972-03-29 |
| AT310155B (de) | 1973-09-25 |
| AT304533B (de) | 1973-01-10 |
| FR2003999A1 (enExample) | 1969-11-14 |
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