IE32705L - Ó-carboline derivatives. - Google Patents

Ó-carboline derivatives.

Info

Publication number
IE32705L
IE32705L IE33869A IE33869A IE32705L IE 32705 L IE32705 L IE 32705L IE 33869 A IE33869 A IE 33869A IE 33869 A IE33869 A IE 33869A IE 32705 L IE32705 L IE 32705L
Authority
IE
Ireland
Prior art keywords
compositions
substituted
carboline
araliphatic
lotions
Prior art date
Application number
IE33869A
Other versions
IE32705B1 (en
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of IE32705L publication Critical patent/IE32705L/en
Publication of IE32705B1 publication Critical patent/IE32705B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

1,268,772. Antiviral compositions. GLAXO LABORATORIES Ltd. 14 March, 1969 [15 March, 1968(2)], Nos. 12730/68 and 12731/68. Heading A5B. [Also in Division C2] Pharmaceutical or veterinary compositions having antiviral activity comprise, as active ingredient, at least one 2-substituted α-carboline of the general formula wherein R is a hydrogen atom or a substituted or unsubstituted aliphatic. araliphatic, aromatic or acyl group, X is a halogen atom or the residue of a nucleophile and wherein the nucleus is optionally additionally substituted by hydroxy, aliphatic, araliphatic, aromatic, carboxy, carboxylic acid ester, acylamino, amino, alkylamino, acyloxy, ether, nitro or sulphonic acid groups or halogen atoms, or physiologically compatible salt thereof, together with one or more pharmaceutical or veterinary carrier or excipient and/or other medicinal agents, e.g. anti-inflammatory agents such as steroids (e.g. betamethasone-21-phosphate) or antibiotics, such as tetracycline. The compositions may be administered orally, topically, rectally, intravaginally or parenterally in the form of tablets, capsules, lozenges, chewing gum, medicated sweets, solutions, suspensions, syrups, elixirs, emulsions, granules for constitution before use, liquid sprays, powder insufflations, nasal drops or ointments, throat paints, gargles, ophthalmic preparations and collyria, skin paints, lotions, creams, dusting powders, medicated dressings, eye drops and lotions, aerosols, suppositories, pessaries or injectable preparations. The compositions may also be formulated with a solid carrier or excipient or a sterile, pyrogen-free liquid or an aqueous oily liquid containing one or more suspending, dispersing, stabilising, preserving, solubilising, emulsifying or buffering agents. The compound 2-chloro-9-(3'-dimethylaminopiopyl) - α - carboline additionally shows neuroleptic activity. [GB1268772A]
IE33869A 1968-03-15 1969-03-14 Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same IE32705B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1273068 1968-03-15
GB1273168A GB1268772A (en) 1968-03-15 1968-03-15 NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME

Publications (2)

Publication Number Publication Date
IE32705L true IE32705L (en) 1969-09-15
IE32705B1 IE32705B1 (en) 1973-10-31

Family

ID=26249226

Family Applications (1)

Application Number Title Priority Date Filing Date
IE33869A IE32705B1 (en) 1968-03-15 1969-03-14 Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same

Country Status (8)

Country Link
AT (2) AT310155B (en)
BE (1) BE729855A (en)
CH (2) CH553200A (en)
DE (1) DE1913119A1 (en)
FR (1) FR2003999A1 (en)
GB (1) GB1268772A (en)
IE (1) IE32705B1 (en)
NL (1) NL6903973A (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000286A (en) 1975-05-28 1976-12-28 Merck & Co., Inc. 3-Phenyl,3H 1,2,3 triazolo[4,5-b]pyridines
DK209976A (en) * 1975-05-28 1976-11-29 Merck & Co Inc PROCEDURE FOR THE PREPARATION OF 3H-1,2,2-TRIAZOLE (4,5-B) PYRIDINES
JPS5536401A (en) * 1978-06-09 1980-03-14 Japan Tobacco Inc Amino-alpha-carboline compound and mutagenic agent containing the same
FR2428642A1 (en) * 1978-06-15 1980-01-11 Sumitomo Chemical Co Antitumour 7H-indolo:isoquinoline derivs. prepn. - by heating 2-isocyante-3-phenyl:indene deriv. unsubstituted at 1-posn.
US4558132A (en) * 1982-07-02 1985-12-10 A. H. Robins Company, Incorporated Nitro, amino and aroylamino-N-phenylpyridinamines in a process for preparing pyrido[1,4]benzodiazepines
USRE37525E1 (en) 1991-05-01 2002-01-22 Henry M. Jackson Foundation Method for treating infectious respiratory diseases
JPH08502721A (en) * 1992-04-03 1996-03-26 ジ・アップジョン・カンパニー Pharmaceutically active bicyclic-heterocyclic amines
US5502187A (en) * 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
US5369086A (en) * 1993-04-28 1994-11-29 Zeneca Limited N-benzotriazoles
US5696148A (en) * 1994-03-14 1997-12-09 Novo Nordisk A/S Indole compounds and their use in treating diseases of the central nervous system
US5783575A (en) * 1994-03-14 1998-07-21 Novo Nordisk A/S Antagonists, their preparation and use
AU6514196A (en) * 1995-07-31 1997-02-26 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
MXPA02005485A (en) 2000-01-07 2002-11-29 Warner Lambert Co Tricyclic compounds with antiviral activity.
FR2823975B1 (en) 2001-04-27 2003-05-30 Sanofi Synthelabo NEW USE OF PYRIDOINDOLONE
US7064139B2 (en) * 2001-10-29 2006-06-20 Uniroyal Chemical Company, Inc. Method for treating retroviral infections
FR2846329B1 (en) 2002-10-23 2004-12-03 Sanofi Synthelabo PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN -3 BY A PHENYL, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US7456193B2 (en) 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2869316B1 (en) * 2004-04-21 2006-06-02 Sanofi Synthelabo PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN -6, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
FR2892416B1 (en) 2005-10-20 2008-06-27 Sanofi Aventis Sa 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
EP2161271A1 (en) 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl
US9540365B2 (en) 2013-03-14 2017-01-10 Osteoqc Inc. Compounds for bone growth
WO2015110263A1 (en) * 2014-01-21 2015-07-30 Ac Immune Sa Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyolid-like proteins
AU2019321434A1 (en) 2018-08-14 2021-03-04 Osteoqc Inc Pyrrolo - dipyridine compounds
WO2020037001A1 (en) 2018-08-14 2020-02-20 Osteoqc Inc. FLUORO β-CARBOLINE COMPOUNDS
FR3109534B1 (en) 2020-04-22 2022-03-25 Soprema Installation and process for processing composite products based on thermoplastic materials

Also Published As

Publication number Publication date
AT310155B (en) 1973-09-25
AT304533B (en) 1973-01-10
CH561206A5 (en) 1975-04-30
CH553200A (en) 1974-08-30
GB1268772A (en) 1972-03-29
DE1913119A1 (en) 1970-08-06
FR2003999A1 (en) 1969-11-14
NL6903973A (en) 1969-09-17
IE32705B1 (en) 1973-10-31
BE729855A (en) 1969-09-15

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