FR2428642A1 - Antitumour 7H-indolo:isoquinoline derivs. prepn. - by heating 2-isocyante-3-phenyl:indene deriv. unsubstituted at 1-posn. - Google Patents

Antitumour 7H-indolo:isoquinoline derivs. prepn. - by heating 2-isocyante-3-phenyl:indene deriv. unsubstituted at 1-posn.

Info

Publication number
FR2428642A1
FR2428642A1 FR7817882A FR7817882A FR2428642A1 FR 2428642 A1 FR2428642 A1 FR 2428642A1 FR 7817882 A FR7817882 A FR 7817882A FR 7817882 A FR7817882 A FR 7817882A FR 2428642 A1 FR2428642 A1 FR 2428642A1
Authority
FR
France
Prior art keywords
derivs
indolo
heating
antitumour
posn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7817882A
Other languages
French (fr)
Other versions
FR2428642B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to FR7817882A priority Critical patent/FR2428642A1/en
Publication of FR2428642A1 publication Critical patent/FR2428642A1/en
Application granted granted Critical
Publication of FR2428642B1 publication Critical patent/FR2428642B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

derivs. of formula (I), nonsubstd. at 7-position, are prepd. by heating 2-isocyanate-3-phenylindene derivs. of formula (II), non-subsubstituted at 1-position, to cause ring closure. In the formulae R1 and R2 are H, F, Cl, Br, I, lower alkyl, esp. (1-4C), lower alkoxy (esp. 1-4C) or nitro. (I) have antitumour activity and are useful as intermediates for the synthesis of 6-substituted indocoisoquinoline derivs. having strong antitumour activity. A specific (I) is 10-chloro-7H-indolo(2,3-c) isoquinoline-s-(6H)one.
FR7817882A 1978-06-15 1978-06-15 Antitumour 7H-indolo:isoquinoline derivs. prepn. - by heating 2-isocyante-3-phenyl:indene deriv. unsubstituted at 1-posn. Granted FR2428642A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7817882A FR2428642A1 (en) 1978-06-15 1978-06-15 Antitumour 7H-indolo:isoquinoline derivs. prepn. - by heating 2-isocyante-3-phenyl:indene deriv. unsubstituted at 1-posn.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7817882A FR2428642A1 (en) 1978-06-15 1978-06-15 Antitumour 7H-indolo:isoquinoline derivs. prepn. - by heating 2-isocyante-3-phenyl:indene deriv. unsubstituted at 1-posn.

Publications (2)

Publication Number Publication Date
FR2428642A1 true FR2428642A1 (en) 1980-01-11
FR2428642B1 FR2428642B1 (en) 1981-05-08

Family

ID=9209545

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7817882A Granted FR2428642A1 (en) 1978-06-15 1978-06-15 Antitumour 7H-indolo:isoquinoline derivs. prepn. - by heating 2-isocyante-3-phenyl:indene deriv. unsubstituted at 1-posn.

Country Status (1)

Country Link
FR (1) FR2428642A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2003999A1 (en) * 1968-03-15 1969-11-14 Glaxo Lab Ltd

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2003999A1 (en) * 1968-03-15 1969-11-14 Glaxo Lab Ltd

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NV134A/75 *

Also Published As

Publication number Publication date
FR2428642B1 (en) 1981-05-08

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