ID24701A - Komposisi dan metode sintesis analog nukleotida - Google Patents
Komposisi dan metode sintesis analog nukleotidaInfo
- Publication number
- ID24701A ID24701A IDW991548A ID991548A ID24701A ID 24701 A ID24701 A ID 24701A ID W991548 A IDW991548 A ID W991548A ID 991548 A ID991548 A ID 991548A ID 24701 A ID24701 A ID 24701A
- Authority
- ID
- Indonesia
- Prior art keywords
- pmpa
- composition
- diethyl
- useful
- synthesis method
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title 1
- 238000001308 synthesis method Methods 0.000 title 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 2
- -1 diethyl PMPA Chemical compound 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 abstract 2
- MJZYTEBKXLVLMY-UHFFFAOYSA-N 1-(6-aminopurin-9-yl)propan-2-ol Chemical compound N1=CN=C2N(CC(O)C)C=NC2=C1N MJZYTEBKXLVLMY-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZRGHYSBYGWGKOY-UHFFFAOYSA-N diethyl (4-methylphenyl)sulfonylmethyl phosphate Chemical compound CCOP(=O)(OCC)OCS(=O)(=O)C1=CC=C(C)C=C1 ZRGHYSBYGWGKOY-UHFFFAOYSA-N 0.000 abstract 1
- 239000001530 fumaric acid Substances 0.000 abstract 1
- LZWQNOHZMQIFBX-UHFFFAOYSA-N lithium;2-methylpropan-2-olate Chemical compound [Li+].CC(C)(C)[O-] LZWQNOHZMQIFBX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- JFVZFKDSXNQEJW-CQSZACIVSA-N tenofovir disoproxil Chemical compound N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N JFVZFKDSXNQEJW-CQSZACIVSA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5377797P | 1997-07-25 | 1997-07-25 | |
| US08/900,752 US5935946A (en) | 1997-07-25 | 1997-07-25 | Nucleotide analog composition and synthesis method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID24701A true ID24701A (id) | 2000-08-03 |
Family
ID=26732232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW991548A ID24701A (id) | 1997-07-25 | 1998-07-23 | Komposisi dan metode sintesis analog nukleotida |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0998480B1 (ko) |
| JP (7) | JP4173202B2 (ko) |
| KR (3) | KR100617608B1 (ko) |
| CN (2) | CN100383148C (ko) |
| AT (3) | ATE288914T1 (ko) |
| AU (1) | AU756793B2 (ko) |
| BR (1) | BR9811045A (ko) |
| CA (1) | CA2298059C (ko) |
| DE (3) | DE69809750T2 (ko) |
| DK (2) | DK1243593T3 (ko) |
| ES (3) | ES2187989T3 (ko) |
| HK (3) | HK1029793A1 (ko) |
| ID (1) | ID24701A (ko) |
| IN (1) | IN190780B (ko) |
| NZ (1) | NZ501287A (ko) |
| PT (2) | PT1243590E (ko) |
| SG (2) | SG106656A1 (ko) |
| TW (2) | TWI224103B (ko) |
| WO (1) | WO1999005150A1 (ko) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100617608B1 (ko) * | 1997-07-25 | 2006-09-01 | 길리애드 사이언시즈, 인코포레이티드 | (ｒ)-ｐｍｐａ의 키랄 농축을 위한 조성물 및 그의 제조방법 |
| GB0013407D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
| CN100402539C (zh) | 2000-07-21 | 2008-07-16 | 吉里德科学公司 | 核苷酸膦酸酯类似物前药及其筛选和制备方法 |
| UA93354C2 (ru) * | 2004-07-09 | 2011-02-10 | Гилиад Сайенсиз, Инк. | Местный противовирусный препарат |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
| CN100352823C (zh) * | 2005-08-19 | 2007-12-05 | 浙江车头制药有限公司 | 一种腺嘌呤衍生物的制备方法 |
| CN100396689C (zh) * | 2006-03-07 | 2008-06-25 | 中国医学科学院医药生物技术研究所 | 一组具有抑制hiv-1/hbv病毒复制活性的替诺福韦单酯化合物 |
| ES2532502T3 (es) | 2006-07-12 | 2015-03-27 | Mylan Laboratories Limited | Proceso para la preparación de tenofovir |
| WO2008143500A1 (en) | 2007-05-22 | 2008-11-27 | Ultimorphix Technologies B.V. | Tenofovir disoproxil hemi-fumaric acid co-crystal |
| WO2010026603A2 (en) * | 2008-09-05 | 2010-03-11 | Matrix Laboratories Limited | Novel amine salts of tenofovir, process for producing the same and use thereof in production of tenofovir dioproxil |
| CN101906119B (zh) * | 2009-06-03 | 2012-12-26 | 中国人民解放军军事医学科学院毒物药物研究所 | 制备替诺福韦的新方法 |
| EP2389929A1 (en) | 2010-05-30 | 2011-11-30 | Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi | Pharmaceutical formulations of tenofovir |
| WO2012137227A2 (en) | 2011-04-08 | 2012-10-11 | Laurus Labs Private Limited | Solid forms of antiretroviral compounds, process for the preparation and their pharmaceutical composition thereof |
| CN102295660A (zh) * | 2011-07-04 | 2011-12-28 | 常州大学 | 泰诺福韦的合成工艺 |
| UY34262A (es) | 2011-08-16 | 2013-04-05 | Gilead Sciences Inc | Hemifumarato de tenofovir alafenamida, sus composiciones, método de preparación, métodos para tratar infecciones virales y su uso para preparar medi camentos |
| CN103626803B (zh) * | 2012-08-23 | 2017-12-15 | 四川海思科制药有限公司 | 替诺福韦二吡呋酯的固体及其制备方法和用途 |
| CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
| CN103230404A (zh) * | 2013-05-14 | 2013-08-07 | 福建广生堂药业股份有限公司 | 替诺福韦二吡呋酯或其药用盐的新用途 |
| EP2860185A1 (en) | 2013-10-09 | 2015-04-15 | Zentiva, k.s. | An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof |
| PT2860184T (pt) | 2013-10-09 | 2018-11-20 | Zentiva Ks | Sal de di-hidrogenofosfato de tenofovir disoproxil |
| CN103483385B (zh) * | 2013-10-11 | 2015-11-18 | 福建广生堂药业股份有限公司 | 替诺福韦单酯富马酸盐的新晶型及其制备方法 |
| CN104688747B (zh) * | 2013-12-04 | 2019-04-12 | 重庆药友制药有限责任公司 | 包含富马酸替诺福韦二吡呋酯的药物组合物 |
| CN104725423A (zh) * | 2013-12-18 | 2015-06-24 | 山东新时代药业有限公司 | 一种富马酸替诺福韦二吡呋酯的合成方法 |
| CN103705478B (zh) * | 2013-12-23 | 2020-02-07 | 浙江华海药业股份有限公司 | 含有富马酸替诺福韦二吡呋酯的口服片剂 |
| CN104744512B (zh) * | 2013-12-26 | 2017-01-11 | 成都伊诺达博医药科技有限公司 | 一种“一锅法”制备泰诺福韦的新工艺 |
| KR20160003532A (ko) | 2014-07-01 | 2016-01-11 | 한미약품 주식회사 | 테노포비어 디소프록실 인산염과, 비금속염 붕해제 및 비금속염 활택제를 포함하는 약학 조성물 |
| CN104288118A (zh) * | 2014-07-08 | 2015-01-21 | 南京卡文迪许生物工程技术有限公司 | 富马酸替诺福韦二吡呋酯片剂及其制备方法 |
| JP2017535520A (ja) * | 2014-09-30 | 2017-11-30 | ハンミ・ファイン・ケミカル・カンパニー・リミテッドＨａｎｍｉ Ｆｉｎｅ Ｃｈｅｍｉｃａｌ Ｃｏ．， Ｌｔｄ． | 高純度の（ｒ）−９−［２−（ホスホノメトキシ）プロピル］アデニンの製造方法 |
| CN106046055A (zh) * | 2016-05-27 | 2016-10-26 | 湖北丽益医药科技有限公司 | R‑9‑(2‑膦酰甲氧基丙基)‑腺嘌呤一水合物晶体及制备、富马酸替诺福韦二吡呋酯制备 |
| KR101909570B1 (ko) | 2016-12-05 | 2018-10-19 | (주) 성운파마코피아 | 고순도 테노포비어 디소프록실 제조방법 |
| CN108358968B (zh) * | 2018-04-03 | 2020-09-15 | 科兴生物制药股份有限公司 | 一种替诺福韦的制备方法 |
| CN109942634A (zh) * | 2019-01-24 | 2019-06-28 | 深圳科兴药业有限公司 | 一种富马酸替诺福韦二吡呋酯的晶型i及制备方法和应用 |
| CN110507625A (zh) * | 2019-09-19 | 2019-11-29 | 苏州东瑞制药有限公司 | 一种新型富马酸替诺福韦酯片及其制备方法 |
| CN111939134B (zh) * | 2020-08-24 | 2023-02-17 | 山东罗欣药业集团股份有限公司 | 一种抗病毒药物组合物 |
| KR20220141457A (ko) | 2021-04-13 | 2022-10-20 | 경동제약 주식회사 | 신규 결정형의 테노포비어 알라펜아미드 말레산염 및 이를 포함하는 약제학적 조성물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS263951B1 (en) * | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
| US6057305A (en) * | 1992-08-05 | 2000-05-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiretroviral enantiomeric nucleotide analogs |
| CA2126601A1 (en) * | 1993-06-29 | 1994-12-30 | Mitsubishi Chemical Corporation | Phosphonate-nucleotide ester derivatives |
| JP4033494B2 (ja) * | 1996-07-26 | 2008-01-16 | ギリヤド サイエンシーズ， インコーポレイテッド | ヌクレオチドアナログ |
| KR100617608B1 (ko) * | 1997-07-25 | 2006-09-01 | 길리애드 사이언시즈, 인코포레이티드 | (ｒ)-ｐｍｐａ의 키랄 농축을 위한 조성물 및 그의 제조방법 |
-
1998
- 1998-07-23 KR KR1020067001298A patent/KR100617608B1/ko not_active IP Right Cessation
- 1998-07-23 JP JP51006799A patent/JP4173202B2/ja not_active Expired - Lifetime
- 1998-07-23 ID IDW991548A patent/ID24701A/id unknown
- 1998-07-23 CA CA002298059A patent/CA2298059C/en not_active Expired - Lifetime
- 1998-07-23 NZ NZ501287A patent/NZ501287A/en not_active IP Right Cessation
- 1998-07-23 PT PT02010678T patent/PT1243590E/pt unknown
- 1998-07-23 AT AT02010678T patent/ATE288914T1/de active
- 1998-07-23 AT AT98937022T patent/ATE228526T1/de active
- 1998-07-23 BR BR9811045-4A patent/BR9811045A/pt not_active Application Discontinuation
- 1998-07-23 CN CNB988074354A patent/CN100383148C/zh not_active Ceased
- 1998-07-23 KR KR1020007000636A patent/KR100661153B1/ko not_active IP Right Cessation
- 1998-07-23 DK DK02010677T patent/DK1243593T3/da active
- 1998-07-23 DE DE69809750T patent/DE69809750T2/de not_active Expired - Lifetime
- 1998-07-23 DE DE69831694T patent/DE69831694T2/de not_active Expired - Lifetime
- 1998-07-23 SG SG200200438A patent/SG106656A1/en unknown
- 1998-07-23 PT PT98937022T patent/PT998480E/pt unknown
- 1998-07-23 EP EP98937022A patent/EP0998480B1/en not_active Expired - Lifetime
- 1998-07-23 DK DK98937022T patent/DK0998480T3/da active
- 1998-07-23 ES ES98937022T patent/ES2187989T3/es not_active Expired - Lifetime
- 1998-07-23 ES ES02010677T patent/ES2249511T3/es not_active Expired - Lifetime
- 1998-07-23 AT AT02010677T patent/ATE305009T1/de active
- 1998-07-23 KR KR1020067001297A patent/KR100707505B1/ko not_active IP Right Cessation
- 1998-07-23 SG SG200200487A patent/SG106657A1/en unknown
- 1998-07-23 WO PCT/US1998/015254 patent/WO1999005150A1/en not_active Application Discontinuation
- 1998-07-23 AU AU85827/98A patent/AU756793B2/en not_active Expired
- 1998-07-23 ES ES02010678T patent/ES2236389T3/es not_active Expired - Lifetime
- 1998-07-23 DE DE69829010T patent/DE69829010T2/de not_active Expired - Lifetime
- 1998-07-23 CN CNB200410046290XA patent/CN1251679C/zh not_active Expired - Lifetime
- 1998-07-24 IN IN2174DE1998 patent/IN190780B/en unknown
- 1998-07-24 TW TW087112168A patent/TWI224103B/zh not_active IP Right Cessation
- 1998-07-24 TW TW093112403A patent/TWI242561B/zh not_active IP Right Cessation
-
2000
- 2000-11-10 HK HK00107207A patent/HK1029793A1/xx not_active IP Right Cessation
-
2003
- 2003-03-25 HK HK03102167.0A patent/HK1051360B/zh not_active IP Right Cessation
- 2003-03-25 HK HK03102166.1A patent/HK1051373B/zh not_active IP Right Cessation
-
2008
- 2008-03-07 JP JP2008058798A patent/JP4628437B2/ja not_active Expired - Lifetime
-
2010
- 2010-08-04 JP JP2010175808A patent/JP5398662B2/ja not_active Expired - Lifetime
-
2013
- 2013-07-22 JP JP2013151752A patent/JP2013213071A/ja not_active Withdrawn
-
2015
- 2015-07-10 JP JP2015138309A patent/JP2015199773A/ja not_active Withdrawn
-
2017
- 2017-01-06 JP JP2017000870A patent/JP2017057233A/ja not_active Withdrawn
- 2017-10-31 JP JP2017210439A patent/JP2018016645A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ID24701A (id) | Komposisi dan metode sintesis analog nukleotida | |
| ATE61581T1 (de) | Chemische verbindungen. | |
| HU195657B (en) | Process for production of carbocyclic pirin nucleorids and medical compounds containing them | |
| FI893750A0 (fi) | Menetelmä valmistaa terapeuttisesti aktiivista makrosyklistä johdannaista | |
| LU91036I2 (fr) | Adefovir dipivoxil et ses dérivés pharmaceutiquement acceptables (hepsera) | |
| AU1428801A (en) | Novel (1,2,3)-triazolo(4,5-D)pyrimidine compounds | |
| Murakami et al. | Escherichia coli mediated biosynthesis and in vitro anti-HIV activity of lipophilic 6-halo-2', 3'-dideoxypurine nucleosides | |
| HUP0003577A2 (hu) | Tetrahidro-gamma-karbolinok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények | |
| Wojtkowski et al. | . beta.-Thionolactam analogs of cephalosporins and penicillins | |
| MY103569A (en) | Novel 2, 5-disubstituted dithianes having pesticidal activity, methods for their production and for their use | |
| CZ20012352A3 (cs) | Analoga nukleosidů s protivirovou aktivitou | |
| EP0936911B1 (en) | Adenosine deaminase inhibitors | |
| GB2084152A (en) | Antiviral agents their preparation and use | |
| CA2605226A1 (en) | Nucleotide analog composition and synthesis method | |
| AU6826700A (en) | Ceramide analogs, process for their preparation and their use as antitumor agents | |
| ATE34176T1 (de) | 2'-chloropentostatin, eine diese verbindung enthaltende pharmazeutische zusammensetzung und ein mikroorganismus zur herstellung dieser verbindung. | |
| KR890700131A (ko) | 신규 화합물 | |
| Giglio et al. | Synthesis of two 6-N-protected 9-N-vinyladenines as dipolarophiles in the synthesis of modified nucleosides | |
| EP0301834A3 (en) | Derivatives of benzoyloxyacetic acid, and preparation and formulations thereof for therapeutic use | |
| BRPI0409766A (pt) | análogos de fosfonato antiviral |