ID23666A - Senyawa-senyawa kimia - Google Patents
Senyawa-senyawa kimiaInfo
- Publication number
- ID23666A ID23666A IDW20000172A ID20000172A ID23666A ID 23666 A ID23666 A ID 23666A ID W20000172 A IDW20000172 A ID W20000172A ID 20000172 A ID20000172 A ID 20000172A ID 23666 A ID23666 A ID 23666A
- Authority
- ID
- Indonesia
- Prior art keywords
- sup
- formula
- compound
- compound chemicals
- chemicals
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Mechanical Coupling Of Light Guides (AREA)
- External Artificial Organs (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9716657.3A GB9716657D0 (en) | 1997-08-07 | 1997-08-07 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ID23666A true ID23666A (id) | 2000-05-11 |
Family
ID=10817097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW20000172A ID23666A (id) | 1997-08-07 | 1998-08-04 | Senyawa-senyawa kimia |
Country Status (28)
Country | Link |
---|---|
US (2) | US6441004B1 (fr) |
EP (1) | EP1003504B1 (fr) |
JP (1) | JP3863722B2 (fr) |
KR (1) | KR20010022318A (fr) |
CN (1) | CN1265591A (fr) |
AT (1) | ATE244007T1 (fr) |
AU (1) | AU745907C (fr) |
BR (1) | BR9811818A (fr) |
CA (1) | CA2297290A1 (fr) |
CZ (1) | CZ294600B6 (fr) |
DE (1) | DE69816091T2 (fr) |
DK (1) | DK1003504T3 (fr) |
ES (1) | ES2201517T3 (fr) |
GB (1) | GB9716657D0 (fr) |
HK (1) | HK1027979A1 (fr) |
HR (1) | HRP20000061A2 (fr) |
HU (1) | HUP0004301A3 (fr) |
ID (1) | ID23666A (fr) |
IL (1) | IL133989A0 (fr) |
NO (1) | NO20000573L (fr) |
NZ (1) | NZ502056A (fr) |
PL (1) | PL338948A1 (fr) |
PT (1) | PT1003504E (fr) |
RU (1) | RU2217142C2 (fr) |
SK (1) | SK284408B6 (fr) |
TR (1) | TR200000289T2 (fr) |
WO (1) | WO1999007351A2 (fr) |
ZA (1) | ZA987090B (fr) |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
FR2768146B1 (fr) | 1997-09-05 | 2000-05-05 | Oreal | Nouveaux composes de la famille des indole-carboxyliques et leur utilisation |
GB9902452D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902453D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
FR2796279B1 (fr) * | 1999-07-16 | 2001-09-21 | Oreal | Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour le traitement de la seborrhee |
FR2796274B1 (fr) * | 1999-07-16 | 2001-09-21 | Oreal | Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute |
GB0000625D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
GB0000626D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
IL154981A0 (en) | 2000-10-10 | 2003-10-31 | Smithkline Beecham Corp | Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppay-y-binding agents |
AU2002241724A1 (en) | 2000-12-20 | 2002-07-01 | Bristol-Myers Squibb Company | Diamines as modulators of chemokine receptor activity |
WO2002060859A2 (fr) | 2000-12-20 | 2002-08-08 | Bristol-Myers Squibb Company | Derives cycliques utilises comme modulateurs de l'activite des recepteurs de chimiokines |
BR0207952A (pt) | 2001-03-07 | 2004-07-27 | Pfizer Prod Inc | Moduladores da atividade de receptores de quimiocina |
ES2180436B1 (es) * | 2001-06-04 | 2003-11-01 | Menarini Lab | Nuevos indoles como inhibidores de la ciclooxigenasa- ii |
EP1314733A1 (fr) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides comme inhibiteurs du facteur Xa |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US7157464B2 (en) | 2002-06-12 | 2007-01-02 | Chemocentryx, Inc. | Substituted piperazines |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
US7338975B2 (en) | 2003-02-12 | 2008-03-04 | Bristol-Myers Squibb Co. | Lactams as modulators of chemokine receptor activity |
AU2004220225B2 (en) | 2003-03-14 | 2010-06-17 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient |
JP2006523458A (ja) * | 2003-04-14 | 2006-10-19 | サーフェイス ロジックス,インコーポレイティド | 初代細胞から対象プロフィールを作成するための細胞動態のモニタリング/測定用の装置と測定法 |
EP2364982A1 (fr) | 2003-04-18 | 2011-09-14 | ONO Pharmaceutical Co., Ltd. | Dérivés de spiropipéridine comme antgonistes du recepteur chémokine et leur usage médical |
US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
WO2004108671A1 (fr) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant |
SE0302035D0 (sv) * | 2003-07-09 | 2003-07-09 | Biolipox Ab | New compound |
US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
US7435830B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
WO2005101002A1 (fr) * | 2004-04-13 | 2005-10-27 | Bayer Healthcare Ag | Agents diagnostiques et therapeutiques de maladies associees au recepteur 2 de c-c chimiokine (ccr2) |
US8481035B2 (en) | 2004-04-27 | 2013-07-09 | Northwestern University | Methods for treating chronic pelvic pain syndrome with antibodies that binds MCP-1 or MIP-1A |
MXPA06014536A (es) * | 2004-06-18 | 2007-06-05 | Biolipox Ab | Indoles utiles en el tratamiento de inflamacion. |
DE602005009209D1 (de) | 2004-06-18 | 2008-10-02 | Biolipox Ab | Zur behandlung von entzündungen geeignete indole |
WO2005123675A1 (fr) * | 2004-06-18 | 2005-12-29 | Biolipox Ab | Indoles utiles dans le traitement de l'inflammation |
US7795295B2 (en) * | 2004-07-01 | 2010-09-14 | The Regents Of The University Of California | Small molecule inhibition of PDZ-domain interaction |
AU2005283326B2 (en) | 2004-09-13 | 2011-07-21 | Ono Pharmaceutical Co., Ltd. | Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient |
GB0428173D0 (en) * | 2004-12-23 | 2005-01-26 | Astrazeneca Ab | Compounds |
EP1676834A1 (fr) * | 2004-12-30 | 2006-07-05 | Sanofi-Aventis Deutschland GmbH | Dérivés de carboxamide bicycliqués et fusionnés utiles comme des inhibiteurs de CXCR2 pour traiter l'inflammation |
US20090069384A1 (en) * | 2005-01-19 | 2009-03-12 | Biolipox Ab | Thienopyrroles useful in the treatment of inflammation |
JP2008527029A (ja) | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
JP2008527027A (ja) * | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
EP1841736A1 (fr) * | 2005-01-19 | 2007-10-10 | Biolipox AB | Indoles utiles dans le traitement de l'inflammation |
CA2594773A1 (fr) * | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles utiles dans le traitement de l'inflammation |
WO2006077401A1 (fr) * | 2005-01-19 | 2006-07-27 | Biolipox Ab | Pyrrolopyridines utiles dans le traitement de l'inflammation |
US20110052612A1 (en) | 2005-05-31 | 2011-03-03 | Ono Pharmaceutical Co., Ltd. | Spiropiperidine compound and medicinal use thereof |
PT1942108E (pt) | 2005-10-28 | 2013-10-24 | Ono Pharmaceutical Co | Composto com um grupo básico e a sua utilização |
GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
US8168783B2 (en) | 2005-11-18 | 2012-05-01 | Ono Pharmaceutical Co., Ltd. | Chemokine receptor antagonists and use thereof |
UA95788C2 (en) | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
US8003642B2 (en) | 2006-03-10 | 2011-08-23 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
US7732287B2 (en) * | 2006-05-02 | 2010-06-08 | Honeywell International Inc. | Method of forming a body-tie |
JP5257068B2 (ja) | 2006-05-16 | 2013-08-07 | 小野薬品工業株式会社 | 保護されていてもよい酸性基を含有する化合物およびその用途 |
WO2008000407A1 (fr) | 2006-06-28 | 2008-01-03 | Sanofi-Aventis | Inhibiteurs de cxcr2 |
JP5237938B2 (ja) | 2006-06-28 | 2013-07-17 | サノフイ | 新規なcxcr2阻害剤 |
WO2008000408A1 (fr) | 2006-06-28 | 2008-01-03 | Sanofi-Aventis | Antagonistes de cxcr2 |
WO2008000410A1 (fr) | 2006-06-30 | 2008-01-03 | Sanofi-Aventis | Inhibiteurs de cxcr2 |
WO2008016006A1 (fr) | 2006-07-31 | 2008-02-07 | Ono Pharmaceutical Co., Ltd. | Composé auquel un groupe cyclique est lié par une liaison spiro et son utilisation |
WO2008042571A2 (fr) | 2006-09-29 | 2008-04-10 | Smithkline Beecham Corporation | Composés chimiques |
EA200970350A1 (ru) * | 2006-10-05 | 2009-12-30 | Сентокор Орто Байотек, Инк. | Антагонисты ccr2 для лечения фиброза |
WO2008055945A1 (fr) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | Dérivés 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one utiles en tant qu' inhibiteurs de la glutaminyl-cyclase dans le traitement des ulcères, du cancer et d'autres maladies |
DK2091948T3 (da) | 2006-11-30 | 2012-07-23 | Probiodrug Ag | Nye inhibitorer af glutaminylcyclase |
KR20090115951A (ko) | 2007-03-01 | 2009-11-10 | 프로비오드룩 아게 | 글루타미닐 사이클라제 저해제의 신규 용도 |
US7981888B2 (en) | 2007-04-16 | 2011-07-19 | Abbott Laboratories | 1-oxyalkyl-2-carboxyl-7-nonsubstituted indole derivatives |
ES2643164T3 (es) | 2007-04-16 | 2017-11-21 | Abbvie Inc. | Indol 7-sustituido como inhibidores de Mcl-1 |
EP2865670B1 (fr) | 2007-04-18 | 2017-01-11 | Probiodrug AG | Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase |
EP2164850B1 (fr) * | 2007-06-12 | 2016-01-13 | Genentech, Inc. | Azaindoles n-substitués et procédés d'utilisation |
US9855370B2 (en) * | 2008-01-08 | 2018-01-02 | Yale University | Compositions and methods for promoting patency of vascular grafts |
US7964897B2 (en) | 2008-07-22 | 2011-06-21 | Honeywell International Inc. | Direct contact to area efficient body tie process flow |
CA2772488C (fr) | 2009-09-11 | 2018-04-17 | Probiodrug Ag | Derives heterocycliques en tant qu'inhibiteurs de glutaminyle cyclase |
ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
DK2545047T3 (da) | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
EP2560953B1 (fr) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibiteurs de glutaminyl cyclase |
DK2686313T3 (en) | 2011-03-16 | 2016-05-02 | Probiodrug Ag | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
WO2013009582A1 (fr) * | 2011-07-12 | 2013-01-17 | Merck Sharp & Dohme Corp. | Inhibiteurs de la kinase trka, compositions en contenant et méthodes associées |
US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
EP3203840B1 (fr) | 2014-10-06 | 2020-08-05 | Vertex Pharmaceuticals Incorporated | Modulateurs du régulateur de conductance transmembranaire de la mucoviscidose |
JP6957468B2 (ja) | 2015-12-11 | 2021-11-02 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | 最適化された患者特異的組織操作血管移植片のためのシステムおよび方法 |
AU2017240685B2 (en) | 2016-03-31 | 2021-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
CN109803962B (zh) | 2016-09-30 | 2022-04-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调控蛋白的调节剂、以及药物组合物 |
EP3551046B1 (fr) | 2016-12-07 | 2023-07-19 | Biora Therapeutics, Inc. | Procédés, dispositifs et systèmes de détection du tractus gastro-intestinal |
WO2018107100A1 (fr) | 2016-12-09 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Modulateur de régulateur de conductance transmembranaire de fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur |
CA3045310A1 (fr) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Traitement d'une maladie du tractus gastro-intestinal avec une chimoikine/un inhibiteur du recepteur de chimiokine |
US11339144B2 (en) * | 2017-04-10 | 2022-05-24 | Navitor Pharmaceuticals, Inc. | Heteroaryl Rheb inhibitors and uses thereof |
BR112019025801A2 (pt) | 2017-06-08 | 2020-07-07 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
AU2018304168B2 (en) | 2017-07-17 | 2023-05-04 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
KR102606188B1 (ko) | 2017-08-02 | 2023-11-23 | 버텍스 파마슈티칼스 인코포레이티드 | 피롤리딘 화합물을 제조하기 위한 공정 |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
AU2018351533B2 (en) | 2017-10-19 | 2023-02-02 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of CFTR modulators |
KR20200097293A (ko) | 2017-12-08 | 2020-08-18 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법 |
TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
US11414439B2 (en) | 2018-04-13 | 2022-08-16 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
EP3883634A1 (fr) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Méthodes et dispositifs pour traiter une maladie à l'aide d'agents biothérapeutiques |
CN115666704A (zh) | 2019-12-13 | 2023-01-31 | 比奥拉治疗股份有限公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3557142A (en) | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
US3776923A (en) | 1970-01-06 | 1973-12-04 | American Cyanamid Co | 2-nitro-4-oxo-4,5,6,7-tetrahydroindole |
US3997557A (en) | 1974-04-23 | 1976-12-14 | American Hoechst Corporation | Substituted N-aminoalkylpyrroles |
US4384994A (en) | 1981-10-08 | 1983-05-24 | Merck & Co., Inc. | Renin inhibitory peptides |
US4496742A (en) | 1981-10-13 | 1985-01-29 | The Upjohn Company | Analogs of 5,6-dihydro PGI2 |
FR2537974A1 (fr) | 1982-12-16 | 1984-06-22 | Adir | Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
US4529724A (en) | 1983-10-11 | 1985-07-16 | Mcneilab, Inc. | 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives |
DE3342688A1 (de) | 1983-11-25 | 1985-06-05 | Siemens AG, 1000 Berlin und 8000 München | Roentgenroehre |
FR2565981B1 (fr) | 1984-06-15 | 1986-09-19 | Adir | Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
CA1244041A (fr) | 1984-07-30 | 1988-11-01 | Elijah H. Gold | Procede de preparation du cis, endo-octahydrocyclopenta ¬b|pyrrole-2- carboxylate |
US4675332A (en) | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
EP0189690B1 (fr) | 1984-12-12 | 1989-03-01 | Merck & Co. Inc. | Sulfonamides aromatiques substitués, leur préparation et compositions ophtalmiques les contenant |
US4721725A (en) | 1986-01-27 | 1988-01-26 | E. R. Squibb & Sons, Inc. | Aryl-cycloalkyl[b]pyrrole derivatives |
IL84796A (en) | 1986-12-17 | 1992-03-29 | Merck Frosst Canada Inc | Substituted n-benzyl-indoles and pharmaceutical compositions containing them |
US4751231A (en) | 1987-09-16 | 1988-06-14 | Merck & Co., Inc. | Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents |
DE3907388A1 (de) | 1989-03-08 | 1990-09-13 | Kali Chemie Pharma Gmbh | Verfahren zur herstellung von indolcarbonsaeurederivaten |
US5272145A (en) | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
NZ234883A (en) | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof |
DE3943225A1 (de) | 1989-12-23 | 1991-06-27 | Schering Ag | Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
US5081145A (en) | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
CA2079374C (fr) | 1991-09-30 | 2003-08-05 | Merck Frosst Canada Incorporated | Indol (azaarylmethoxy bicyclique) comme inhibiteur de leucotriene biosynthetique |
US5290798A (en) | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5308850A (en) | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5389650A (en) | 1991-09-30 | 1995-02-14 | Merck Frosst Canada, Inc. | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5190968A (en) | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
US5273980A (en) | 1991-09-30 | 1993-12-28 | Merck Frosst Canada Inc. | Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
US5318985A (en) | 1991-12-20 | 1994-06-07 | Merrell Dow Pharmaceuticals Inc. | Potentiation of NMDA antagonists |
CA2129429A1 (fr) | 1992-02-13 | 1993-08-14 | Richard Frenette | (azaaromaticalkoxy) indoles utilises comme inhibiteurs de la biosynthese de la leucotriene |
PL175327B1 (pl) | 1992-04-03 | 1998-12-31 | Upjohn Co | Dwupierścieniowe heterocykliczne aminy |
US5334719A (en) | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
US5288743A (en) | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
ZA939516B (en) | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
EP0639573A1 (fr) * | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Hétérocycles à cinq chaînons benzocondensés, procédé pour leur préparation, leur utilisation comme médicament et comme diagnostique aussi bien que les produits pharmaceutiques le contenant |
US5852046A (en) | 1993-08-03 | 1998-12-22 | Hoechst Aktiengesellschaft | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them |
US5401287A (en) | 1993-08-19 | 1995-03-28 | Ppg Industries, Inc. | Reduction of nickel sulfide stones in a glass melting operation |
US5399699A (en) | 1994-01-24 | 1995-03-21 | Abbott Laboratories | Indole iminooxy derivatives which inhibit leukotriene biosynthesis |
CN1166169A (zh) | 1994-07-27 | 1997-11-26 | 三共株式会社 | 用作毒蕈碱性受体别构效应物的杂环化合物 |
US5482960A (en) | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
US5684032A (en) | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
EP0800389A4 (fr) * | 1994-12-13 | 1998-04-29 | Smithkline Beecham Corp | Nouveaux composes |
ES2201181T3 (es) | 1995-04-04 | 2004-03-16 | Encysive Pharmaceuticals Inc. | Tienil-, furil-, pirrolil- y bifenilsulfonamidas y derivados de los mismos que modulan la actividad de endotelina. |
IT1282797B1 (it) | 1995-04-21 | 1998-03-31 | Colla Paolo | Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids |
US5639780A (en) | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
US5604253A (en) | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
WO1997012613A1 (fr) * | 1995-10-05 | 1997-04-10 | Warner-Lambert Company | Procede de traitement et de prevention des inflammations et de l'atherosclerose |
JP4392481B2 (ja) | 1996-02-26 | 2010-01-06 | アドヴァンスド リサーチ アンド テクノロジー インスティトゥート | 斑水腫の治療 |
JP3540495B2 (ja) * | 1996-03-18 | 2004-07-07 | 三菱重工業株式会社 | 水素分離膜 |
JP2000507556A (ja) | 1996-03-28 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | ケモカインのカルボン酸インドール阻害剤 |
EP0822185A1 (fr) | 1996-07-31 | 1998-02-04 | Pfizer Inc. | Agonistes bèta-3-adrénergiques en tant qu'agents antidiabète et anti-obésité |
US6184235B1 (en) | 1996-08-14 | 2001-02-06 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as MCP-1 antagonists |
GB9716656D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
PT1042287E (pt) | 1997-12-24 | 2005-08-31 | Aventis Pharma Gmbh | Derivados de indole como inibidores do factor xa |
GB9803228D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
GB9803226D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB0000625D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
GB0000626D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
-
1997
- 1997-08-07 GB GBGB9716657.3A patent/GB9716657D0/en active Pending
-
1998
- 1998-08-04 TR TR2000/00289T patent/TR200000289T2/xx unknown
- 1998-08-04 ID IDW20000172A patent/ID23666A/id unknown
- 1998-08-04 IL IL13398998A patent/IL133989A0/xx unknown
- 1998-08-04 AT AT98937659T patent/ATE244007T1/de not_active IP Right Cessation
- 1998-08-04 DK DK98937659T patent/DK1003504T3/da active
- 1998-08-04 PL PL98338948A patent/PL338948A1/xx unknown
- 1998-08-04 HU HU0004301A patent/HUP0004301A3/hu unknown
- 1998-08-04 CA CA002297290A patent/CA2297290A1/fr not_active Abandoned
- 1998-08-04 AU AU86381/98A patent/AU745907C/en not_active Ceased
- 1998-08-04 NZ NZ502056A patent/NZ502056A/en unknown
- 1998-08-04 EP EP98937659A patent/EP1003504B1/fr not_active Expired - Lifetime
- 1998-08-04 CN CN98807795A patent/CN1265591A/zh active Pending
- 1998-08-04 WO PCT/GB1998/002341 patent/WO1999007351A2/fr not_active Application Discontinuation
- 1998-08-04 SK SK167-2000A patent/SK284408B6/sk unknown
- 1998-08-04 KR KR1020007000897A patent/KR20010022318A/ko not_active Application Discontinuation
- 1998-08-04 JP JP2000506944A patent/JP3863722B2/ja not_active Expired - Fee Related
- 1998-08-04 CZ CZ2000431A patent/CZ294600B6/cs not_active IP Right Cessation
- 1998-08-04 DE DE69816091T patent/DE69816091T2/de not_active Expired - Fee Related
- 1998-08-04 PT PT98937659T patent/PT1003504E/pt unknown
- 1998-08-04 US US09/485,061 patent/US6441004B1/en not_active Expired - Fee Related
- 1998-08-04 BR BR9811818-8A patent/BR9811818A/pt not_active IP Right Cessation
- 1998-08-04 RU RU2000105901/15A patent/RU2217142C2/ru not_active IP Right Cessation
- 1998-08-04 ES ES98937659T patent/ES2201517T3/es not_active Expired - Lifetime
- 1998-08-06 ZA ZA987090A patent/ZA987090B/xx unknown
-
2000
- 2000-02-03 HR HR20000061A patent/HRP20000061A2/hr not_active Application Discontinuation
- 2000-02-04 NO NO20000573A patent/NO20000573L/no not_active Application Discontinuation
- 2000-11-21 HK HK00107435A patent/HK1027979A1/xx not_active IP Right Cessation
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2002
- 2002-07-15 US US10/194,969 patent/US6953809B2/en not_active Expired - Fee Related
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