CA1244041A - Procede de preparation du cis, endo-octahydrocyclopenta ¬b|pyrrole-2- carboxylate - Google Patents
Procede de preparation du cis, endo-octahydrocyclopenta ¬b|pyrrole-2- carboxylateInfo
- Publication number
- CA1244041A CA1244041A CA000487583A CA487583A CA1244041A CA 1244041 A CA1244041 A CA 1244041A CA 000487583 A CA000487583 A CA 000487583A CA 487583 A CA487583 A CA 487583A CA 1244041 A CA1244041 A CA 1244041A
- Authority
- CA
- Canada
- Prior art keywords
- compound
- substituted
- lower alkyl
- iiia
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US635,390 | 1984-07-30 | ||
US06/635,390 US4587258A (en) | 1980-10-23 | 1984-07-30 | Angiotensin-converting enzyme inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1244041A true CA1244041A (fr) | 1988-11-01 |
Family
ID=24547612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000487583A Expired CA1244041A (fr) | 1984-07-30 | 1985-07-26 | Procede de preparation du cis, endo-octahydrocyclopenta ¬b|pyrrole-2- carboxylate |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0190224A1 (fr) |
JP (1) | JPS61502818A (fr) |
AU (1) | AU581919B2 (fr) |
CA (1) | CA1244041A (fr) |
DK (1) | DK140886A (fr) |
WO (1) | WO1986000896A1 (fr) |
ZA (1) | ZA855659B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3226768A1 (de) * | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
DE3431541A1 (de) * | 1984-08-28 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung |
DE3518514A1 (de) * | 1985-05-23 | 1986-11-27 | Hoechst Ag, 6230 Frankfurt | Neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
DE3722007A1 (de) * | 1987-07-03 | 1989-01-12 | Hoechst Ag | Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung |
DE3839127A1 (de) * | 1988-11-19 | 1990-05-23 | Hoechst Ag | Pyrrolidon-2-carbonsaeure-derivate mit psychotroper wirkung |
US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
GB9803226D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB0000625D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
WO2005049568A1 (fr) * | 2003-11-24 | 2005-06-02 | Potluri Ramesh Babu | Procede de preparation industriellement viable de (s,s,s) phenylmethyl-2-azabicyclo-[3.3.0]-octane-3-carboxylate tosylate |
PL380887A1 (pl) | 2003-12-29 | 2007-04-02 | Sepracor Inc. | Pirolowe i pirazolowe inhibitory DAAO |
JP5438975B2 (ja) | 2006-01-06 | 2014-03-12 | サノビオン ファーマシューティカルズ インク | テトラロン系モノアミン再取り込み阻害剤 |
ES2594156T3 (es) | 2006-01-06 | 2016-12-16 | Sunovion Pharmaceuticals Inc. | Cicloalquilaminas como inhibidores de la recaptación de monoaminas |
WO2007115185A2 (fr) | 2006-03-31 | 2007-10-11 | Sepracor Inc. | Preparation d'amines et amides chiraux |
WO2008089453A2 (fr) | 2007-01-18 | 2008-07-24 | Sepracor Inc. | Inhibiteurs de la d-amino acide oxydase |
US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
NZ580429A (en) | 2007-05-31 | 2012-04-27 | Sepracor Inc | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU88621I2 (fr) * | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
DE3226768A1 (de) * | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
GR78413B (fr) * | 1981-12-29 | 1984-09-27 | Hoechst Ag | |
IE54551B1 (en) * | 1982-01-22 | 1989-11-22 | Ici Plc | Amide derivatives |
DE3211676A1 (de) * | 1982-03-30 | 1983-10-06 | Hoechst Ag | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
DE3302125A1 (de) * | 1983-01-22 | 1984-07-26 | Boehringer Ingelheim KG, 6507 Ingelheim | Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung |
HU191120B (en) * | 1983-01-31 | 1987-01-28 | Hoechts Ag,De | Process for raceme separation of optically active byciclic imino-alpha-carbonic acid esthers |
DE3315464A1 (de) * | 1983-04-28 | 1984-10-31 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern |
FR2546886B2 (fr) * | 1983-06-06 | 1986-05-16 | Adir | Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant |
US4514391A (en) * | 1983-07-21 | 1985-04-30 | E. R. Squibb & Sons, Inc. | Hydroxy substituted peptide compounds |
DE3333455A1 (de) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung n-alkylierter dipeptide und deren estern |
-
1985
- 1985-07-26 EP EP85903779A patent/EP0190224A1/fr not_active Ceased
- 1985-07-26 ZA ZA855659A patent/ZA855659B/xx unknown
- 1985-07-26 WO PCT/US1985/001406 patent/WO1986000896A1/fr not_active Application Discontinuation
- 1985-07-26 AU AU46718/85A patent/AU581919B2/en not_active Ceased
- 1985-07-26 JP JP60503359A patent/JPS61502818A/ja active Pending
- 1985-07-26 CA CA000487583A patent/CA1244041A/fr not_active Expired
-
1986
- 1986-03-26 DK DK140886A patent/DK140886A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU4671885A (en) | 1986-02-25 |
DK140886D0 (da) | 1986-03-26 |
DK140886A (da) | 1986-03-26 |
ZA855659B (en) | 1987-03-25 |
EP0190224A1 (fr) | 1986-08-13 |
AU581919B2 (en) | 1989-03-09 |
WO1986000896A1 (fr) | 1986-02-13 |
JPS61502818A (ja) | 1986-12-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1244041A (fr) | Procede de preparation du cis, endo-octahydrocyclopenta ¬b|pyrrole-2- carboxylate | |
US5319098A (en) | Process for the stereoselective preparation of L-alanyl-L-proline | |
EP0088341B1 (fr) | Dérivés acylés de l'acide octahydro-1H-indole-2-carboxylique | |
CA1205476A (fr) | Derives de substitution acyles d'acides actahydro-1h-indole-2-carboxyliques | |
KR890003603B1 (ko) | 5-아미노-2,5-이치환된-4-하이드록시펜타노산 잔기를 함유하는 레닌 억제물의 제조방법 | |
US4578480A (en) | Process for preparing 1-(3-bromo-2-alkylpropanoyl)-L-proline derivatives | |
DE2801911A1 (de) | (acyl-)-mercaptoacylaminosaeurederivate, verfahren zu deren herstellung und ihre verwendung bei der bekaempfung von durch angiotensin bedingtem hochdruck | |
Kataoka et al. | Studies of unusual amino acids and their peptides. VI. The synthese and the optical resolutions of. BETA.-methylphenylalanine and its dipeptide present in bottromycin. | |
Kelly et al. | Synthesis of (R)-and (S)-(glu) thz and the corresponding bisthiazole dipeptide of dolastatin 3 | |
Kammermeier et al. | Vanadium (ii)‐and Niobium (iii)‐Induced, Diastereoselective Pinacol Coupling of Peptide Aldehydes to Give a C2‐Symmetrical HIV Protease Inhibitor | |
EP0206090A2 (fr) | Peptides inhibiteurs de rénine | |
KR0143418B1 (ko) | N2-(1-카복시-3-페닐프로필)-l-리신 유도체 및 이를 사용한 리시노프릴의 제조방법 | |
JPS6233198A (ja) | 新規なペプチド誘導体 | |
US4508921A (en) | Process for preparation of alpha-alkyl amino acids | |
DE69322127T2 (de) | Verfahren zur Herstellung von Peptidderivaten und ihrer Salze | |
US4325886A (en) | Optical resolution of acylthiopropionic acid | |
EP0093805A1 (fr) | Acides octahydro-(oméga-mercaptoalcanoyl)-2-isoindole-3-oxo-1H-carboxyliques-1 et leurs esters | |
Mazaleyrat et al. | Practical resolution of an atropoisomeric α, α-disubstituted glycine with l-phenylalanine cyclohexylamide as chiral auxiliary | |
Refouvelet et al. | Synthesis and stereochemical studies of 2‐substituted thiazolidine‐4‐carboxamide derivatives | |
US4503043A (en) | Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids | |
US4442030A (en) | Process for preparing carboxyalkyl dipeptides | |
Katritzky et al. | The Bismuth (III) Chloride Mediated N-Derivatization of L-Proline and Pipecolinic Esters in Aqueous Media | |
US4876383A (en) | Amino acid derivatives, their production and use in preparing carbapenem and carbapenam compounds | |
US5929242A (en) | Manufacture of levobupivacaine and analogues thereof from L-lysine | |
US5204459A (en) | Process for preparing carbapenem compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKEX | Expiry |