ID20717A - Proses yang diperbaiki untuk memperoleh prekursor-prekursor insulin yang mempunyai jembatan-jembatan sistin yang terikat dengan tepat - Google Patents

Proses yang diperbaiki untuk memperoleh prekursor-prekursor insulin yang mempunyai jembatan-jembatan sistin yang terikat dengan tepat

Info

Publication number
ID20717A
ID20717A IDP981136A ID981136A ID20717A ID 20717 A ID20717 A ID 20717A ID P981136 A IDP981136 A ID P981136A ID 981136 A ID981136 A ID 981136A ID 20717 A ID20717 A ID 20717A
Authority
ID
Indonesia
Prior art keywords
improved process
right bridge
insulin precursors
bridge systems
obtain insulin
Prior art date
Application number
IDP981136A
Other languages
English (en)
Indonesian (id)
Inventor
Franz-Josef Rubroder
Reinhold Keller
Original Assignee
Hoechst Marion Roussel De Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel De Gmbh filed Critical Hoechst Marion Roussel De Gmbh
Publication of ID20717A publication Critical patent/ID20717A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IDP981136A 1997-08-18 1998-08-14 Proses yang diperbaiki untuk memperoleh prekursor-prekursor insulin yang mempunyai jembatan-jembatan sistin yang terikat dengan tepat ID20717A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19735711A DE19735711C2 (de) 1997-08-18 1997-08-18 Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken

Publications (1)

Publication Number Publication Date
ID20717A true ID20717A (id) 1999-02-18

Family

ID=7839275

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP981136A ID20717A (id) 1997-08-18 1998-08-14 Proses yang diperbaiki untuk memperoleh prekursor-prekursor insulin yang mempunyai jembatan-jembatan sistin yang terikat dengan tepat

Country Status (21)

Country Link
US (3) US5986048A (ru)
EP (2) EP0980874B1 (ru)
JP (1) JP4291900B2 (ru)
KR (2) KR100537842B1 (ru)
CN (3) CN1132845C (ru)
AR (1) AR016821A1 (ru)
AT (2) ATE217636T1 (ru)
AU (1) AU744824B2 (ru)
BR (2) BRPI9816233B8 (ru)
CA (1) CA2245151C (ru)
CZ (1) CZ295679B6 (ru)
DE (3) DE19735711C2 (ru)
DK (2) DK0906918T3 (ru)
ES (2) ES2177178T3 (ru)
HK (3) HK1018464A1 (ru)
HU (2) HU228203B1 (ru)
ID (1) ID20717A (ru)
PL (1) PL191901B1 (ru)
PT (2) PT906918E (ru)
RU (2) RU2205836C2 (ru)
TR (1) TR199801587A3 (ru)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19735711C2 (de) 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
JP2003530316A (ja) 1999-12-22 2003-10-14 ノボ ノルディスク アクティーゼルスカブ スクランブルした一本鎖ポリペプチドの抽出的再生法
AU2001280436A1 (en) * 2000-07-12 2002-01-21 Eli Lilly And Company Process to increase protein stability
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
DE102004015965A1 (de) * 2004-04-01 2005-10-20 Aventis Pharma Gmbh Verfahren zur Gewinnung von Insulinen durch verbesserte Luftbegasung der Faltung
US20080032343A1 (en) 2005-12-22 2008-02-07 Genentech, Inc. Recombinant Production of Heparin Binding Proteins
RU2439076C2 (ru) 2006-07-14 2012-01-10 Дженентек, Инк. Способ выделения повторно свернутого рекомбинантного белка из культуры прокариотических клеток (варианты)
JP5244175B2 (ja) * 2007-07-03 2013-07-24 アムジエン・インコーポレーテツド 封入体乾燥重量を用いたタンパク質の測定
RU2451750C2 (ru) * 2007-09-24 2012-05-27 Общество С Ограниченной Ответственностью "Герофарм" Способ получения рекомбинантного с-пептида проинсулина человека
KR20100111682A (ko) 2008-01-09 2010-10-15 사노피-아벤티스 도이칠란트 게엠베하 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체
EP2274318B1 (en) * 2008-04-30 2014-08-13 Wockhardt Limited Processes for refolding of insulin
KR101820024B1 (ko) 2008-10-17 2018-01-18 사노피-아벤티스 도이칠란트 게엠베하 인슐린과 ｇｌｐ－1 효능제의 병용물
HUE037735T2 (hu) 2009-11-13 2018-09-28 Sanofi Aventis Deutschland DesPro36exendin-4(1-39)-Lys6-NH2-t és metionint tartalmazó gyógyszerkészítmény
ES2534191T3 (es) 2009-11-13 2015-04-20 Sanofi-Aventis Deutschland Gmbh Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
BR112013004756B1 (pt) 2010-08-30 2020-04-28 Sanofi Aventis Deutschland uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US20180282405A1 (en) * 2012-08-05 2018-10-04 Absci, Llc Cytoplasmic expression system
US10421795B2 (en) 2012-12-17 2019-09-24 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
WO2014133324A1 (ko) * 2013-02-26 2014-09-04 한미약품 주식회사 신규한 인슐린 아날로그 및 이의 용도
CN103694339B (zh) * 2013-12-04 2017-10-13 珠海联邦制药股份有限公司 一种甘精胰岛素前体的复性方法
WO2015138548A1 (en) 2014-03-14 2015-09-17 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
JP6970615B2 (ja) 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリングラルギン／リキシセナチド固定比処方
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN104911203A (zh) * 2015-06-30 2015-09-16 成都易胜科生物科技有限公司 一种重组人胰岛素的工业制备方法
EP3344651B1 (en) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds
US10689430B2 (en) 2016-05-25 2020-06-23 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
WO2018018613A1 (zh) 2016-07-29 2018-02-01 广东东阳光药业有限公司 一种提高抗体纯度的细胞培养基和培养方法
CN113773391B (zh) * 2020-06-09 2023-10-20 宁波鲲鹏生物科技有限公司 一种门冬胰岛素的制备方法
CN113773400B (zh) * 2020-06-09 2023-08-18 宁波鲲鹏生物科技有限公司 一种门冬胰岛素衍生物及其应用
CN113773396A (zh) * 2020-06-10 2021-12-10 宁波鲲鹏生物科技有限公司 一种地特胰岛素衍生物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
GR1005153B (el) * 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.
EP0600372B1 (de) * 1992-12-02 1997-02-05 Hoechst Aktiengesellschaft Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
JP4624495B2 (ja) * 1994-12-29 2011-02-02 フェリング・インターナショナル・センター・エス．・エー． ヒト・インスリンの生成
DE19735711C2 (de) * 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken

Also Published As

Publication number Publication date
PL191901B1 (pl) 2006-07-31
US5986048A (en) 1999-11-16
HK1018464A1 (en) 1999-12-24
KR19990023651A (ko) 1999-03-25
ATE217012T1 (de) 2002-05-15
DE19735711A1 (de) 1999-02-25
RU2205836C2 (ru) 2003-06-10
ES2176870T3 (es) 2002-12-01
EP0906918B1 (de) 2002-05-15
ES2177178T3 (es) 2002-12-01
CZ295679B6 (cs) 2005-09-14
CN1209437A (zh) 1999-03-03
HU9801886D0 (en) 1998-10-28
AR016821A1 (es) 2001-08-01
CA2245151A1 (en) 1999-02-18
ATE217636T1 (de) 2002-06-15
CN1132845C (zh) 2003-12-31
CN1483831B (zh) 2012-06-13
KR100537842B1 (ko) 2006-03-23
US6727346B2 (en) 2004-04-27
BR9803755A (pt) 2000-03-28
KR20050067371A (ko) 2005-07-01
CZ259898A3 (cs) 1999-03-17
CA2245151C (en) 2009-10-06
EP0906918A2 (de) 1999-04-07
HU228161B1 (en) 2013-01-28
AU8076398A (en) 1999-02-25
HK1061870A1 (en) 2004-10-08
PT906918E (pt) 2002-10-31
US20020156234A1 (en) 2002-10-24
DK0906918T3 (da) 2002-09-09
DE59804121D1 (de) 2002-06-20
EP0980874B1 (de) 2002-05-02
KR100574580B1 (ko) 2006-04-28
BRPI9816233B8 (pt) 2021-05-25
PT980874E (pt) 2002-10-31
CN1483831A (zh) 2004-03-24
DE19735711C2 (de) 2001-04-26
CN101186940B (zh) 2012-02-08
JPH11130798A (ja) 1999-05-18
EP0980874A1 (de) 2000-02-23
HK1119449A1 (en) 2009-03-06
EP0906918A3 (de) 1999-08-11
DK0980874T3 (da) 2002-08-19
HUP9801886A2 (hu) 1999-01-28
TR199801587A2 (xx) 1999-03-22
JP4291900B2 (ja) 2009-07-08
HUP9801886A3 (en) 1999-06-28
CN101186940A (zh) 2008-05-28
HU228203B1 (en) 2013-01-28
PL328108A1 (en) 1999-03-01
US6380355B1 (en) 2002-04-30
TR199801587A3 (tr) 1999-03-22
DE59803985D1 (de) 2002-06-06
RU2302882C2 (ru) 2007-07-20
AU744824B2 (en) 2002-03-07
BRPI9816233B1 (pt) 2016-09-27
HU0600287D0 (en) 2006-05-29

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