ID19718A - Formulasi peptida aprotik polar tidak berair - Google Patents

Formulasi peptida aprotik polar tidak berair

Info

Publication number
ID19718A
ID19718A IDP972314A ID972314A ID19718A ID 19718 A ID19718 A ID 19718A ID P972314 A IDP972314 A ID P972314A ID 972314 A ID972314 A ID 972314A ID 19718 A ID19718 A ID 19718A
Authority
ID
Indonesia
Prior art keywords
peptid
formulation
water
polar aprotic
aprotic
Prior art date
Application number
IDP972314A
Other languages
English (en)
Indonesian (id)
Inventor
Cynthia L Stevenson
Steven J Prestrelski
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21810971&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ID19718(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Publication of ID19718A publication Critical patent/ID19718A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
IDP972314A 1996-07-03 1997-07-03 Formulasi peptida aprotik polar tidak berair ID19718A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2269996P 1996-07-03 1996-07-03

Publications (1)

Publication Number Publication Date
ID19718A true ID19718A (id) 1998-07-30

Family

ID=21810971

Family Applications (2)

Application Number Title Priority Date Filing Date
IDP20010116A ID28822A (id) 1996-07-03 1997-07-03 FORMULASI PEPTIDA APROTIK POLAR TIDAK-BERAIR (Pecahan dari no. P972314)
IDP972314A ID19718A (id) 1996-07-03 1997-07-03 Formulasi peptida aprotik polar tidak berair

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IDP20010116A ID28822A (id) 1996-07-03 1997-07-03 FORMULASI PEPTIDA APROTIK POLAR TIDAK-BERAIR (Pecahan dari no. P972314)

Country Status (29)

Country Link
US (3) US5932547A (fr)
EP (2) EP0921808B1 (fr)
JP (2) JP2000515131A (fr)
CN (4) CN101239179A (fr)
AR (1) AR007714A1 (fr)
AT (2) ATE224199T1 (fr)
AU (1) AU739169B2 (fr)
BR (1) BR9710132A (fr)
CA (1) CA2259557A1 (fr)
CO (1) CO4870762A1 (fr)
CY (1) CY2486B1 (fr)
CZ (2) CZ299464B6 (fr)
DE (2) DE69728582T2 (fr)
DK (2) DK1208846T3 (fr)
ES (2) ES2215967T3 (fr)
HU (1) HUP9904270A3 (fr)
ID (2) ID28822A (fr)
IL (3) IL127771A0 (fr)
MY (1) MY128850A (fr)
NO (2) NO322514B1 (fr)
NZ (1) NZ333294A (fr)
PL (1) PL189015B1 (fr)
PT (2) PT1208846E (fr)
RO (1) RO119863B1 (fr)
RU (1) RU2203084C2 (fr)
SK (1) SK283926B6 (fr)
TW (1) TW584562B (fr)
WO (1) WO1998000158A1 (fr)
ZA (1) ZA975941B (fr)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
GB2344287A (en) * 1998-12-03 2000-06-07 Ferring Bv Controlled release pharmaceutical formulation
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
CA2406790C (fr) 2000-04-19 2009-07-07 Genentech, Inc. Formulations a liberation lente
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
AU2002242231B2 (en) * 2001-02-23 2007-09-06 Genentech, Inc. Erodible polymers for injection
ES2554106T3 (es) * 2001-06-21 2015-12-16 Genentech, Inc. Formulación de liberación sostenida
EP2261250B1 (fr) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. Protéines de fusion d'albumine et GCSF
JP2006514914A (ja) * 2002-02-14 2006-05-18 バイエル・フアーマシユーチカルズ・コーポレーシヨン 有機溶媒中および乾燥状態のペプチドの安定化における製剤の戦略
DE60315474T2 (de) * 2002-06-17 2008-04-24 Alza Corp., Mountain View Osmotische abgabesysteme mit osmotischen antrieb und verfahren zur herstellung sowohl des osmotischen antriebs als auch des osmotischen abgabesystems
WO2004056338A2 (fr) * 2002-12-19 2004-07-08 Alza Corporation Gels stables non aqueux a phase unique et formulations, destines a etre administres a partir d'un dispositif implantable
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
JP5591434B2 (ja) 2002-12-20 2014-09-17 ゼリス ファーマシューティカルズ インコーポレイテッド 皮内注射方法
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004089334A2 (fr) * 2003-03-31 2004-10-21 Alza Corporation Systeme de liberation osmotique et procede de reduction des temps de demarrage de systemes de liberation osmotique
KR20060017749A (ko) * 2003-03-31 2006-02-27 알자 코포레이션 내압 소멸 수단을 갖는 삼투성 펌프
ATE494885T1 (de) * 2003-04-25 2011-01-15 Boston Scient Scimed Inc Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe
EP1631308B1 (fr) * 2003-05-30 2013-07-31 Amylin Pharmaceuticals, LLC Nouveaux procedes et nouvelles compositions pour une administration amelioree par voie muqueuse de peptides et de proteines
US7407499B2 (en) * 2003-10-31 2008-08-05 Intarcia Therapeutics, Inc. Osmotic pump with self-retaining, fast-start membrane plug
AU2004289218A1 (en) * 2003-11-06 2005-05-26 Alza Corporation Modular imbibition rate reducer for use with implantable osmotic pump
FI116942B (fi) * 2004-05-10 2006-04-13 Biohit Oyj Proteiini- ja peptidistabilointi
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
US20060045902A1 (en) * 2004-09-01 2006-03-02 Serbousek Jon C Polymeric wrap for in vivo delivery of osteoinductive formulations
US20060057184A1 (en) * 2004-09-16 2006-03-16 Nycz Jeffrey H Process to treat avascular necrosis (AVN) with osteoinductive materials
US8137664B2 (en) * 2005-02-02 2012-03-20 Sdgi Holdings, Inc. Method and kit for repairing a defect in bone
WO2006083761A2 (fr) 2005-02-03 2006-08-10 Alza Corporation Solutions de solvant/polymere utilisees comme vehicules de suspension
US20060263433A1 (en) * 2005-02-03 2006-11-23 Ayer Rupal A Suspension formulation of interferon
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US7959938B2 (en) 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
CN101193652B (zh) * 2005-04-08 2011-11-02 安米林药品公司 包含肠降血糖素肽和非质子极性溶剂的药物制剂
US20070015689A1 (en) * 2005-06-23 2007-01-18 Alza Corporation Complexation of metal ions with polypeptides
AU2006330526B2 (en) * 2005-12-22 2012-09-27 Oakwood Laboratories, Llc Sublimable sustained release delivery system and method of making same
EP2526950A1 (fr) 2006-04-07 2012-11-28 Merrion Research III Limited Forme pharmaceutique solide par voie orale contenant un activateur
CA2651855C (fr) * 2006-05-30 2011-08-02 Intarcia Therapeutics, Inc. Modulateur de flux pour un systeme d'administration osmotique presentant deux pieces et conduite interne
US20070292512A1 (en) * 2006-06-09 2007-12-20 Merrion Research Ii Limited Solid Oral Dosage Form Containing an Enhancer
ES2422864T3 (es) * 2006-08-09 2013-09-16 Intarcia Therapeutics, Inc Sistemas de liberación osmótica y unidades de pistón
PT2157967E (pt) 2007-04-23 2013-04-03 Intarcia Therapeutics Inc Formulações de suspensões de péptidos insulinotrópicos e suas utilizações
DK2170283T3 (en) 2007-06-22 2019-04-15 Univ Texas CREATION OF STABLE SUBMICRON Peptide OR PROTEIN PARTICLES BY THIN FILM FREEZING
US20100210562A1 (en) * 2007-09-11 2010-08-19 Dorian Bevec Use of il-1 receptor peptide, alone or in combination with d-ala-gln-octadecyl ester, as a therapeutic agent
EP2240155B1 (fr) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Dispositifs, formulations et méthodes d administration de plusieurs agents bénéfiques
KR20110007614A (ko) * 2008-05-07 2011-01-24 메리온 리서치 Ⅲ 리미티드 ＧｎＲＨ 관련 화합물의 조성물 및 제조 방법
CA2730760A1 (fr) * 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Procede pour preparer des microparticules contenant des peptides bioactifs
PL2328601T3 (pl) 2008-08-15 2020-07-13 Ironwood Pharmaceuticals, Inc. Formulacje zawierające linaklotyd do podawania doustnego
EP2161030A1 (fr) * 2008-09-09 2010-03-10 Rijksuniversiteit te Groningen Formulations d'oxytocine et leurs utilisations
CA2738715C (fr) * 2008-10-15 2013-07-16 Intarcia Therapeutics, Inc. Particules medicamenteuses hautement concentrees, formes pharmaceutiques, suspensions et leurs utilisations
JP5711138B2 (ja) 2008-11-16 2015-04-30 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 高濃度の低粘度懸濁液
TWI480286B (zh) * 2009-02-25 2015-04-11 Merrion Res Iii Ltd 雙膦酸鹽類組合物及藥物遞送
WO2011017502A2 (fr) 2009-08-06 2011-02-10 Ironwood Pharmaceuticals, Inc. Formulations comprenant du linaclotide
KR101823699B1 (ko) 2009-09-28 2018-01-30 인타르시아 세라퓨틱스 인코포레이티드 실질 항정상태 약물 전달의 신속 확립 및/또는 종결
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
UA108636C2 (xx) 2010-02-17 2015-05-25 Пептид
WO2011120033A1 (fr) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Compositions pharmaceutiques d'inhibiteurs de facteur xa sélectifs destinées à une administration orale
US20120046225A1 (en) 2010-07-19 2012-02-23 The Regents Of The University Of Colorado, A Body Corporate Stable glucagon formulations for the treatment of hypoglycemia
SI2603232T1 (sl) 2010-08-11 2020-03-31 Ironwood Pharmaceuticals, Inc. Stabilne formulacije linaklotida
CN103476419A (zh) 2011-01-07 2013-12-25 梅里翁第三研究有限公司 口服投药的含铁药物组合物
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
BR112013023062B1 (pt) 2011-03-10 2022-01-18 Xeris Pharmaceuticals, Inc Solução estável para a injeção parenteral e método de fabricação da mesma
JP6312592B2 (ja) 2011-08-17 2018-04-18 アイアンウッド ファーマシューティカルズ インコーポレイテッド 消化器疾患の治療
KR102007057B1 (ko) * 2011-10-31 2019-08-02 엑스에리스 파머수티클스, 인크. 당뇨병 치료를 위한 제형물
WO2013154779A1 (fr) * 2012-04-10 2013-10-17 The Regents Of The University Of California Dispositif électrochimique nanocomposite nanocristallin-polymère
US9125805B2 (en) 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
US9018162B2 (en) 2013-02-06 2015-04-28 Xeris Pharmaceuticals, Inc. Methods for rapidly treating severe hypoglycemia
KR102327754B1 (ko) * 2014-02-06 2021-11-17 엑스에리스 파머수티클스, 인크. 안정한 펩티드 제형물 및 제조 방법
AU2015300944B2 (en) 2014-08-06 2019-07-11 Xeris Pharmaceuticals, Inc. Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP3250191B1 (fr) 2015-01-29 2024-01-17 Novo Nordisk A/S Comprimés contenant un agoniste de glp-1 et revêtement gastro-résistant
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
US9649364B2 (en) 2015-09-25 2017-05-16 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic formulations in aprotic polar solvents
US11590205B2 (en) 2015-09-25 2023-02-28 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents
KR102574993B1 (ko) 2016-05-16 2023-09-06 인타르시아 세라퓨틱스 인코포레이티드 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
KR20190104039A (ko) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법
CN110709061B (zh) 2017-06-02 2023-09-08 Xeris药物公司 抗沉淀的小分子药物制剂
AR112480A1 (es) 2017-08-24 2019-10-30 Novo Nordisk As Composiciones de glp-1 y sus usos
AU2021208601A1 (en) 2020-02-18 2022-07-28 Novo Nordisk A/S Glp-1 compositions and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL22493A (en) * 1963-12-09 1968-10-24 Crown Zellerbach Corp Membrane penetrant composition containing a dialkyl sulfoxide
US3914412A (en) * 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
GB2008403B (en) * 1977-11-04 1982-07-28 Christie R B Parsons J A Pharmaceutical compositions
GB2119248A (en) * 1982-04-28 1983-11-16 John Kenneth Mcmullen Insulin formulations and method of producing them
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4661472A (en) * 1985-05-09 1987-04-28 The Salk Institute For Biological Studies GnRH antagonists IX
US4897256A (en) * 1986-11-25 1990-01-30 Abbott Laboratories LHRH analog formulations
US4851385A (en) * 1987-07-15 1989-07-25 Indiana University Foundation LHRH antagonist analogs having low histamine-release activity
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
CA1336401C (fr) * 1987-10-15 1995-07-25 Brian H. Vickery Administration intranasale de polypeptides sous forme de poudre
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5110596A (en) * 1988-12-13 1992-05-05 Alza Corporation Delivery system comprising means for delivering agent to livestock
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
DE4117507A1 (de) * 1991-05-24 1992-11-26 Schering Ag Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
DK0661989T3 (da) * 1992-09-21 1998-03-02 Upjohn Co Proteinsammensætninger med vedvarende frigivelse
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US5589167A (en) * 1993-02-23 1996-12-31 Genentech, Inc. Excipient stabilization of polypeptides treated with organic solvents
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
NZ331186A (en) * 1996-02-02 2000-04-28 Alza Corp Osmotically driven sustained delivery drug delivery capsule
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations

Also Published As

Publication number Publication date
ZA975941B (en) 1998-04-16
AU3587997A (en) 1998-01-21
NO20063870L (no) 1999-03-03
RU2203084C2 (ru) 2003-04-27
ATE224199T1 (de) 2002-10-15
CY2486B1 (en) 2005-06-03
NZ333294A (en) 2000-05-26
PT921808E (pt) 2003-01-31
JP2009073852A (ja) 2009-04-09
SK179798A3 (en) 1999-05-07
IL170958A (en) 2009-11-18
IL178824A (en) 2011-08-31
CO4870762A1 (es) 1999-12-27
JP2000515131A (ja) 2000-11-14
DK1208846T3 (da) 2004-08-02
PL189015B1 (pl) 2005-06-30
EP0921808B1 (fr) 2002-09-18
CZ434098A3 (cs) 1999-04-14
CN101239179A (zh) 2008-08-13
CZ300378B6 (cs) 2009-05-06
NO986207D0 (no) 1998-12-30
BR9710132A (pt) 1999-08-10
PT1208846E (pt) 2004-06-30
AU739169B2 (en) 2001-10-04
PL330927A1 (en) 1999-06-07
ES2181010T3 (es) 2003-02-16
EP1208846A3 (fr) 2003-04-16
DE69728582T2 (de) 2004-08-19
NO986207L (no) 1999-03-03
TW584562B (en) 2004-04-21
WO1998000158A1 (fr) 1998-01-08
US6235712B1 (en) 2001-05-22
SK283926B6 (sk) 2004-05-04
CN102512658A (zh) 2012-06-27
CN101116742A (zh) 2008-02-06
US6124261A (en) 2000-09-26
HUP9904270A3 (en) 2001-08-28
ID28822A (id) 1998-01-08
CZ299464B6 (cs) 2008-08-06
EP1208846B1 (fr) 2004-04-07
HUP9904270A2 (hu) 2000-05-28
RO119863B1 (ro) 2005-05-30
CA2259557A1 (fr) 1998-01-08
DE69728582D1 (de) 2004-05-13
DE69715639D1 (de) 2002-10-24
EP1208846A2 (fr) 2002-05-29
US5932547A (en) 1999-08-03
AR007714A1 (es) 1999-11-10
NO322514B1 (no) 2006-10-16
IL178824A0 (en) 2007-03-08
CN1636589A (zh) 2005-07-13
DK0921808T3 (da) 2003-01-27
ES2215967T3 (es) 2004-10-16
IL127771A0 (en) 1999-10-28
MY128850A (en) 2007-02-28
EP0921808A1 (fr) 1999-06-16
ATE263570T1 (de) 2004-04-15
DE69715639T2 (de) 2003-02-06

Similar Documents

Publication Publication Date Title
ID19718A (id) Formulasi peptida aprotik polar tidak berair
ID19305A (id) Formulasi peptida berair
DK0830818T3 (da) Glasursæt
ID19165A (id) Formulasi-formulasi protik tidak-berair
DE59703559D1 (de) Schnellanschlusskupplung
DE69730237D1 (de) Verbindungsaufbauverfahren
FR2759143B1 (fr) Raccord rapide etanche perfectionne
ID17708A (id) Komposisi bahan tahan air
DE59710258D1 (de) Verbindungsbeschlag
MX206802B (es) Dispersiones acuosas
ID22436A (id) Komposisi pembersih yang kesat
DE69721846D1 (de) Hosenträger
DE59700996D1 (de) Leitungsverbindung
ATA185096A (de) Badeteichanlage
DE59701838D1 (de) Anschlussarmatur
KR980000073U (ko) 물분사기
BR9605313A (pt) Roley water
ATA155696A (de) Wasserheizer
KR970050042U (ko) 수도 직결형 가습기
DE69702407D1 (de) Wasserdichte Kamera
KR970056452U (ko) 물꼬
BR7603168U (pt) Vedágua
KR970056771U (ko) 물컵
AT406415B8 (de) Wasserheizer
ATA155496A (de) Wasserheizer