HUT64604A - Method for producing endo-bicyclo(2,2,1)-heptane-2-ol derivatives and enzymatical separating the substance obtaine therefrom - Google Patents

Method for producing endo-bicyclo(2,2,1)-heptane-2-ol derivatives and enzymatical separating the substance obtaine therefrom

Info

Publication number
HUT64604A
HUT64604A HU9201587A HU9201587A HUT64604A HU T64604 A HUT64604 A HU T64604A HU 9201587 A HU9201587 A HU 9201587A HU 9201587 A HU9201587 A HU 9201587A HU T64604 A HUT64604 A HU T64604A
Authority
HU
Hungary
Prior art keywords
enzymatical
obtaine
bicyclo
heptane
therefrom
Prior art date
Application number
HU9201587A
Other languages
English (en)
Other versions
HU215441B (hu
Inventor
Nicholas A Saccomano
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HUT64604A publication Critical patent/HUT64604A/hu
Publication of HU215441B publication Critical patent/HU215441B/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
HUP9201587A 1989-11-13 1989-11-13 Eljárás az endo-biciklo [2.2.1]-heptan-2-ol előállítására és az ebből kapott hatóanyagok enzimatikus úton történő elválasztására HU215441B (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/005228 WO1991007501A1 (en) 1989-11-13 1989-11-13 Enzymatic resolution of endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents

Publications (2)

Publication Number Publication Date
HUT64604A true HUT64604A (en) 1994-01-28
HU215441B HU215441B (hu) 1999-04-28

Family

ID=22215375

Family Applications (2)

Application Number Title Priority Date Filing Date
HUP9201587A HU215441B (hu) 1989-11-13 1989-11-13 Eljárás az endo-biciklo [2.2.1]-heptan-2-ol előállítására és az ebből kapott hatóanyagok enzimatikus úton történő elválasztására
HU9802988A HU220962B1 (hu) 1989-11-13 1989-11-13 Optikailag aktív 5-[3-(exo-biciklo[2.2.1]hept-2-il-oxi)-4-metoxi-fenil]-3,4,5,6-tetrahidropirimidin-2(1H)-on, enantiomere, valamint intermedierjeik

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU9802988A HU220962B1 (hu) 1989-11-13 1989-11-13 Optikailag aktív 5-[3-(exo-biciklo[2.2.1]hept-2-il-oxi)-4-metoxi-fenil]-3,4,5,6-tetrahidropirimidin-2(1H)-on, enantiomere, valamint intermedierjeik

Country Status (27)

Country Link
EP (2) EP0428302B1 (hu)
JP (1) JPH06104661B2 (hu)
KR (1) KR930004654B1 (hu)
CN (1) CN1040423C (hu)
AT (1) ATE158577T1 (hu)
AU (3) AU633157B2 (hu)
CA (1) CA2029705C (hu)
CZ (2) CZ280006B6 (hu)
DE (1) DE69031487T2 (hu)
DK (1) DK0428302T3 (hu)
EG (1) EG19860A (hu)
ES (1) ES2107420T3 (hu)
FI (1) FI105106B (hu)
GR (1) GR3025196T3 (hu)
HU (2) HU215441B (hu)
IE (2) IE904059A1 (hu)
IL (5) IL110568A (hu)
MY (1) MY104517A (hu)
NO (1) NO304838B1 (hu)
NZ (1) NZ236037A (hu)
PH (1) PH30255A (hu)
PL (4) PL164176B1 (hu)
PT (1) PT95855B (hu)
RU (1) RU2104306C1 (hu)
WO (1) WO1991007501A1 (hu)
YU (1) YU48413B (hu)
ZA (1) ZA909044B (hu)

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HU215441B (hu) * 1989-11-13 1999-04-28 Pfizer Inc. Eljárás az endo-biciklo [2.2.1]-heptan-2-ol előállítására és az ebből kapott hatóanyagok enzimatikus úton történő elválasztására
US5124455A (en) * 1990-08-08 1992-06-23 American Home Products Corporation Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
IE71647B1 (en) 1991-01-28 1997-02-26 Rhone Poulenc Rorer Ltd Benzamide derivatives
AU655698B2 (en) * 1991-12-06 1995-01-05 Shionogi Seiyaku Kabushiki Kaisha Process for producing optically active norborneol
CA2400368A1 (en) * 1992-12-02 1994-06-09 Allen J. Duplantier Catechol diethers as selective pde iv inhibitors
US5814651A (en) * 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
JP3431204B2 (ja) * 1993-04-22 2003-07-28 塩野義製薬株式会社 ノルボルナン型エステル・ヒドロラーゼ
CN1041436C (zh) * 1993-05-07 1998-12-30 佛山市制药一厂 一种稳定冯了性风湿跌打药酒的方法
US5482944A (en) * 1993-07-13 1996-01-09 Pfizer Inc. Pyrimidones and imidazolinones for treatment of shock
JPH1142095A (ja) * 1997-07-25 1999-02-16 Chisso Corp 新規なオキソジシクロペンタジエンの製造方法
KR100479019B1 (ko) * 1998-05-22 2005-08-29 씨제이 주식회사 캐테콜히드라존유도체,이의제조방법및그를함유한약제학적조성물
HRP20020158B1 (en) 1999-08-21 2007-08-31 Altana Pharma Ag Action of synergistic combination
EP1156120B1 (en) * 2000-05-08 2006-11-22 Pfizer Products Inc. Enzymatic resolution of selective estrogen receptor modulators
US6943195B2 (en) 2001-06-29 2005-09-13 Nikken Chemicals Co., Ltd Cycloalkenone derivative
ES2194588B1 (es) * 2001-07-13 2004-10-16 Astur Pharma S.A. Precursores opticamente puros de paroxetina.
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1624893A2 (en) 2003-04-01 2006-02-15 Applied Research Systems ARS Holding N.V. Inhibitors of phosphodiesterases in infertility
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP3366698A1 (en) 2011-03-01 2018-08-29 Synergy Pharmaceuticals Inc. Guanylate cyclase c agonists
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

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US4261995A (en) * 1979-08-31 1981-04-14 Syntex (U.S.A.) Inc. 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives
US4732853A (en) * 1984-11-21 1988-03-22 President And Fellows Of Harvard College Method of making chiral epoxy alcohols
FI875724L (fi) * 1986-04-29 1987-12-28 Pfizer Av kalcium oberoende camp fosfodiesteras-inhibitordepressant.
HU215441B (hu) * 1989-11-13 1999-04-28 Pfizer Inc. Eljárás az endo-biciklo [2.2.1]-heptan-2-ol előállítására és az ebből kapott hatóanyagok enzimatikus úton történő elválasztására

Also Published As

Publication number Publication date
PL164202B1 (pl) 1994-06-30
PL292070A1 (en) 1992-04-21
YU214290A (sh) 1992-12-21
DK0428302T3 (da) 1997-10-13
DE69031487D1 (de) 1997-10-30
CZ280006B6 (cs) 1995-09-13
IE980174A1 (en) 2000-02-23
IL110564A0 (en) 1994-11-11
PL287727A1 (en) 1992-02-24
CZ560990A3 (en) 1995-04-12
EP0428302B1 (en) 1997-09-24
PL292069A1 (en) 1992-04-21
KR910009622A (ko) 1991-06-28
ATE158577T1 (de) 1997-10-15
IL96261A0 (en) 1991-08-16
AU3292093A (en) 1993-04-22
JPH03173871A (ja) 1991-07-29
IL110564A (en) 1998-03-10
PT95855B (pt) 1998-01-30
EP0428302A2 (en) 1991-05-22
EP0428302A3 (en) 1992-05-13
CA2029705A1 (en) 1991-05-14
ZA909044B (en) 1992-06-24
RU2104306C1 (ru) 1998-02-10
DE69031487T2 (de) 1998-02-05
CZ280011B6 (cs) 1995-09-13
FI922142A0 (fi) 1992-05-12
EG19860A (en) 1996-03-31
IL96261A (en) 1996-12-05
NO304838B1 (no) 1999-02-22
IE904059A1 (en) 1991-05-22
MY104517A (en) 1994-04-30
CN1051905A (zh) 1991-06-05
FI105106B (fi) 2000-06-15
HU215441B (hu) 1999-04-28
AU3197993A (en) 1993-04-22
ES2107420T3 (es) 1997-12-01
PT95855A (pt) 1991-09-13
NO921876D0 (no) 1992-05-12
PL164457B1 (pl) 1994-07-29
EP0801135A1 (en) 1997-10-15
YU48413B (sh) 1998-07-10
JPH06104661B2 (ja) 1994-12-21
NZ236037A (en) 1992-08-26
PH30255A (en) 1997-02-05
PL165132B1 (pl) 1994-11-30
NO921876L (no) 1992-07-10
CN1040423C (zh) 1998-10-28
IL110568A (en) 1995-10-31
AU633157B2 (en) 1993-01-21
AU645449B2 (en) 1994-01-13
GR3025196T3 (en) 1998-02-27
WO1991007501A1 (en) 1991-05-30
HU220962B1 (hu) 2002-07-29
CA2029705C (en) 1998-11-24
AU6653590A (en) 1991-05-16
FI922142L (fi) 1992-05-12
IL110568A0 (en) 1994-11-11
CZ124092A3 (en) 1995-04-12
PL164176B1 (pl) 1994-06-30
KR930004654B1 (ko) 1993-06-02
HU9802988D0 (en) 1999-11-29

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