PT95855A - Processo para a resolucao enzimatica de endo-biciclo{2.2.1}heptan-2-ol e de agentes farmaceuticos derivados - Google Patents

Processo para a resolucao enzimatica de endo-biciclo{2.2.1}heptan-2-ol e de agentes farmaceuticos derivados

Info

Publication number
PT95855A
PT95855A PT95855A PT9585590A PT95855A PT 95855 A PT95855 A PT 95855A PT 95855 A PT95855 A PT 95855A PT 9585590 A PT9585590 A PT 9585590A PT 95855 A PT95855 A PT 95855A
Authority
PT
Portugal
Prior art keywords
endo
heptan
bicycle
pharmaceutical agents
enzymatic resolution
Prior art date
Application number
PT95855A
Other languages
English (en)
Other versions
PT95855B (pt
Inventor
Nicholas A Saccomano
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT95855A publication Critical patent/PT95855A/pt
Publication of PT95855B publication Critical patent/PT95855B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
PT95855A 1989-11-13 1990-11-12 Processo para a resolucao enzimatica de endo-biciclo{2.2.1}heptan-2-ol e de agentes farmaceuticos derivados PT95855B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/005228 WO1991007501A1 (en) 1989-11-13 1989-11-13 Enzymatic resolution of endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents

Publications (2)

Publication Number Publication Date
PT95855A true PT95855A (pt) 1991-09-13
PT95855B PT95855B (pt) 1998-01-30

Family

ID=22215375

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95855A PT95855B (pt) 1989-11-13 1990-11-12 Processo para a resolucao enzimatica de endo-biciclo{2.2.1}heptan-2-ol e de agentes farmaceuticos derivados

Country Status (27)

Country Link
EP (2) EP0428302B1 (pt)
JP (1) JPH06104661B2 (pt)
KR (1) KR930004654B1 (pt)
CN (1) CN1040423C (pt)
AT (1) ATE158577T1 (pt)
AU (3) AU633157B2 (pt)
CA (1) CA2029705C (pt)
CZ (2) CZ280006B6 (pt)
DE (1) DE69031487T2 (pt)
DK (1) DK0428302T3 (pt)
EG (1) EG19860A (pt)
ES (1) ES2107420T3 (pt)
FI (1) FI105106B (pt)
GR (1) GR3025196T3 (pt)
HU (2) HU220962B1 (pt)
IE (2) IE980174A1 (pt)
IL (5) IL110564A (pt)
MY (1) MY104517A (pt)
NO (1) NO304838B1 (pt)
NZ (1) NZ236037A (pt)
PH (1) PH30255A (pt)
PL (4) PL164176B1 (pt)
PT (1) PT95855B (pt)
RU (1) RU2104306C1 (pt)
WO (1) WO1991007501A1 (pt)
YU (1) YU48413B (pt)
ZA (1) ZA909044B (pt)

Families Citing this family (28)

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HU220962B1 (hu) * 1989-11-13 2002-07-29 Pfizer Inc. Optikailag aktív 5-[3-(exo-biciklo[2.2.1]hept-2-il-oxi)-4-metoxi-fenil]-3,4,5,6-tetrahidropirimidin-2(1H)-on, enantiomere, valamint intermedierjeik
US5124455A (en) * 1990-08-08 1992-06-23 American Home Products Corporation Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
IE71647B1 (en) 1991-01-28 1997-02-26 Rhone Poulenc Rorer Ltd Benzamide derivatives
US5459067A (en) * 1991-12-06 1995-10-17 Shionogi Seiyaku Kabushiki Kaisha Method for producing optically active norborneol by ester hydrolysis
US5814651A (en) * 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
ATE234270T1 (de) * 1992-12-02 2003-03-15 Pfizer Cathecoldiether als selektive pde iv hemmungsmittel
JP3431204B2 (ja) * 1993-04-22 2003-07-28 塩野義製薬株式会社 ノルボルナン型エステル・ヒドロラーゼ
CN1041436C (zh) * 1993-05-07 1998-12-30 佛山市制药一厂 一种稳定冯了性风湿跌打药酒的方法
US5482944A (en) * 1993-07-13 1996-01-09 Pfizer Inc. Pyrimidones and imidazolinones for treatment of shock
JPH1142095A (ja) * 1997-07-25 1999-02-16 Chisso Corp 新規なオキソジシクロペンタジエンの製造方法
KR100479019B1 (ko) * 1998-05-22 2005-08-29 씨제이 주식회사 캐테콜히드라존유도체,이의제조방법및그를함유한약제학적조성물
EP2193808A1 (en) 1999-08-21 2010-06-09 Nycomed GmbH Synergistic combination
EP1405844A4 (en) 2001-06-29 2006-09-20 Nikken Chemicals Co Ltd CYCLOALKENONDERIVAT
ES2194588B1 (es) * 2001-07-13 2004-10-16 Astur Pharma S.A. Precursores opticamente puros de paroxetina.
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
MX2016001714A (es) 2013-08-09 2016-10-03 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

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US4261995A (en) * 1979-08-31 1981-04-14 Syntex (U.S.A.) Inc. 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives
US4732853A (en) * 1984-11-21 1988-03-22 President And Fellows Of Harvard College Method of making chiral epoxy alcohols
WO1987006576A1 (en) * 1986-04-29 1987-11-05 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
HU220962B1 (hu) * 1989-11-13 2002-07-29 Pfizer Inc. Optikailag aktív 5-[3-(exo-biciklo[2.2.1]hept-2-il-oxi)-4-metoxi-fenil]-3,4,5,6-tetrahidropirimidin-2(1H)-on, enantiomere, valamint intermedierjeik

Also Published As

Publication number Publication date
ZA909044B (en) 1992-06-24
EP0428302A3 (en) 1992-05-13
HUT64604A (en) 1994-01-28
EP0428302A2 (en) 1991-05-22
PL292070A1 (en) 1992-04-21
ATE158577T1 (de) 1997-10-15
CZ124092A3 (en) 1995-04-12
AU6653590A (en) 1991-05-16
DK0428302T3 (da) 1997-10-13
IE980174A1 (en) 2000-02-23
NZ236037A (en) 1992-08-26
IL110564A0 (en) 1994-11-11
YU48413B (sh) 1998-07-10
CA2029705C (en) 1998-11-24
NO921876D0 (no) 1992-05-12
CA2029705A1 (en) 1991-05-14
IL96261A0 (en) 1991-08-16
AU645449B2 (en) 1994-01-13
KR910009622A (ko) 1991-06-28
MY104517A (en) 1994-04-30
CZ280006B6 (cs) 1995-09-13
PL164202B1 (pl) 1994-06-30
YU214290A (sh) 1992-12-21
IL110564A (en) 1998-03-10
PT95855B (pt) 1998-01-30
FI922142A (fi) 1992-05-12
ES2107420T3 (es) 1997-12-01
HU220962B1 (hu) 2002-07-29
PL287727A1 (en) 1992-02-24
JPH03173871A (ja) 1991-07-29
PL165132B1 (pl) 1994-11-30
GR3025196T3 (en) 1998-02-27
IL110568A0 (en) 1994-11-11
AU3197993A (en) 1993-04-22
HU215441B (hu) 1999-04-28
DE69031487T2 (de) 1998-02-05
CN1051905A (zh) 1991-06-05
PH30255A (en) 1997-02-05
JPH06104661B2 (ja) 1994-12-21
DE69031487D1 (de) 1997-10-30
FI105106B (fi) 2000-06-15
EG19860A (en) 1996-03-31
AU3292093A (en) 1993-04-22
EP0801135A1 (en) 1997-10-15
FI922142A0 (fi) 1992-05-12
PL164176B1 (pl) 1994-06-30
IL96261A (en) 1996-12-05
PL292069A1 (en) 1992-04-21
NO304838B1 (no) 1999-02-22
WO1991007501A1 (en) 1991-05-30
NO921876L (no) 1992-07-10
IE904059A1 (en) 1991-05-22
CN1040423C (zh) 1998-10-28
CZ560990A3 (en) 1995-04-12
PL164457B1 (pl) 1994-07-29
EP0428302B1 (en) 1997-09-24
HU9802988D0 (en) 1999-11-29
CZ280011B6 (cs) 1995-09-13
KR930004654B1 (ko) 1993-06-02
RU2104306C1 (ru) 1998-02-10
AU633157B2 (en) 1993-01-21
IL110568A (en) 1995-10-31

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Effective date: 19910404

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Effective date: 19971008

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