HUP9902454A2 - Szubsztituált 1,2,3,4-tetrahidronaftalin-származékok, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Szubsztituált 1,2,3,4-tetrahidronaftalin-származékok, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények

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Publication number
HUP9902454A2
HUP9902454A2 HU9902454A HUP9902454A HUP9902454A2 HU P9902454 A2 HUP9902454 A2 HU P9902454A2 HU 9902454 A HU9902454 A HU 9902454A HU P9902454 A HUP9902454 A HU P9902454A HU P9902454 A2 HUP9902454 A2 HU P9902454A2
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Hungary
Prior art keywords
alkyl
powder
compounds
substituted
hydrogen
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HU9902454A
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English (en)
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Stefan Berg
Lennart Florvall
Svante Ross
Seth-Olov Thorberg
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Astra Aktiebolag
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Publication of HUP9902454A2 publication Critical patent/HUP9902454A2/hu
Publication of HUP9902454A3 publication Critical patent/HUP9902454A3/hu

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    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Hydrogenated Pyridines (AREA)
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Abstract

A találmány szerinti piperidinil- vagy piperazinil-szűbsztitűált1,2,3,4-tetrahidrőnaftalin-származékők (I) általánős képletében Xnitrőgénatőm vagy metincsőpőrt (=CH-); Y -NR2CH2-, -CH2-NR2, -NR2-CO-,-CO-NR2- vagy -NR2SO2- általánős képletű csőpőrt; R1 hidrőgénatőm,alkil- vagy ciklőalkilcsőpőrt; R2 hidrőgénatőm vagy alkilcsőpőrt; R3alkil-, ciklőalkilcsőpőrt vagy -(CH2)n-aril általánős képletű csőpőrt,ahől aril- jelentése fenilcsőpőrt vagy a nitrőgén-, őxigén- és kénatőmközül egy vay két hetereőatőmőt tartalmazó heterőarőmás gyűrűscsőpőrt, amely adőtt esetben mőnő- vagy diszűbsztitűált lehet; és n 0,1, 2, 3 vagy 4. A találmány tárgyát képezik a vegyületek (R)- és (S)-enantiőmerei vagy racemátjai, a szabad bázis vagy gyógyászatilagelfőgadható sói vagy hidrát főrmái is. A találmány szerinti vegyületek5-HT1D antagőnista hatásúak, és 5-HT által kiváltőtt különbözőmegbetegedések kezelésére szőlgáló gyógyszerkészítmény hatóanyagaikéntalkalmazhatók. ŕ
HU9902454A 1996-03-22 1997-03-20 Substituted 1,2,3,4-tetrahydronaphthalene derivatives, preparation and use thereof, pharmaceutical compositions containing these compounds HUP9902454A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9601110A SE9601110D0 (sv) 1996-03-22 1996-03-22 Substituted 1,2,3,4-tetrahydronaphthalene derivatives

Publications (2)

Publication Number Publication Date
HUP9902454A2 true HUP9902454A2 (hu) 1999-11-29
HUP9902454A3 HUP9902454A3 (en) 2002-01-28

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HU9902454A HUP9902454A3 (en) 1996-03-22 1997-03-20 Substituted 1,2,3,4-tetrahydronaphthalene derivatives, preparation and use thereof, pharmaceutical compositions containing these compounds

Country Status (27)

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US (2) US6124283A (hu)
EP (1) EP0888319B1 (hu)
JP (1) JP2000506883A (hu)
KR (1) KR20000064751A (hu)
CN (1) CN1073101C (hu)
AR (2) AR006360A1 (hu)
AT (1) ATE231847T1 (hu)
AU (1) AU709856B2 (hu)
BR (1) BR9708093A (hu)
CA (1) CA2247940A1 (hu)
CZ (1) CZ301998A3 (hu)
DE (1) DE69718771T2 (hu)
EE (1) EE9800300A (hu)
HR (1) HRP970166A2 (hu)
HU (1) HUP9902454A3 (hu)
ID (1) ID16298A (hu)
IL (2) IL145681A0 (hu)
IS (1) IS4844A (hu)
NO (1) NO311803B1 (hu)
NZ (1) NZ331613A (hu)
PL (1) PL329121A1 (hu)
SE (1) SE9601110D0 (hu)
SK (1) SK282359B6 (hu)
TR (1) TR199801868T2 (hu)
WO (1) WO1997034883A1 (hu)
YU (1) YU40998A (hu)
ZA (1) ZA972056B (hu)

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SE9702799D0 (sv) 1997-07-25 1997-07-25 Astra Ab New compounds
SE9703376D0 (sv) * 1997-09-18 1997-09-18 Astra Ab A new combination
SE9703374D0 (sv) * 1997-09-18 1997-09-18 Astra Ab A new combination
SE9703375D0 (sv) * 1997-09-18 1997-09-18 Astra Ab A new combination
SE9703379D0 (sv) 1997-09-18 1997-09-18 Astra Ab New compounds
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SE0002729D0 (sv) * 2000-07-20 2000-07-20 Astrazeneca Ab Novel compound form
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KR20080079341A (ko) 2001-01-16 2008-08-29 아스트라제네카 아베 치료용 헤테로시클릭 화합물
EP1408976B3 (en) * 2001-07-20 2010-08-25 Psychogenics Inc. Treatment for attention-deficit hyperactivity disorder
SE0301798D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use IV
SE0301794D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use III
CN101119965B (zh) * 2004-12-21 2012-09-26 弗·哈夫曼-拉罗切有限公司 萘满和茚满衍生物及其用途
US20090054453A1 (en) * 2006-03-17 2009-02-26 Lilian Alcaraz Novel Tetralins as 5-HT6 Modulators
WO2008130322A1 (en) * 2007-04-23 2008-10-30 Astrazeneca Ab Novel 5-heterocyclyl-chromane derivatives for the treatment of pain
WO2008130323A1 (en) * 2007-04-23 2008-10-30 Astrazeneca Ab Novel 8-piperazine-tetrahydronaphtalene derivatives for the treatment of pain
WO2008130321A2 (en) * 2007-04-23 2008-10-30 Astrazeneca Ab Novel n-tetrahydronaphtalene or 5-heterocyclyl-chromane or 8-heterocyclyl-tetrahydronaphtalene derivatives for the treatment of pain
WO2008130319A2 (en) * 2007-04-23 2008-10-30 Astrazeneca Ab Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
EP2098511A1 (en) 2008-03-07 2009-09-09 Solvias AG Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring
BR112017024745A2 (pt) * 2015-05-19 2018-11-13 Univ Northeastern compostos e métodos para modulação de receptores de serotonina na periferia.
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CN118121595A (zh) * 2024-05-06 2024-06-04 广州市朝利良生物科技有限公司 化合物eh-p005j在制备促伤口愈合药物中的用途

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SK118898A3 (en) 1999-03-12
HRP970166A2 (en) 1998-04-30
AU2186597A (en) 1997-10-10
NO311803B1 (no) 2002-01-28
TR199801868T2 (xx) 1998-12-21
ATE231847T1 (de) 2003-02-15
JP2000506883A (ja) 2000-06-06
CZ301998A3 (cs) 1999-05-12
ZA972056B (en) 1997-09-22
CN1219170A (zh) 1999-06-09
SK282359B6 (sk) 2002-01-07
US6124283A (en) 2000-09-26
DE69718771D1 (de) 2003-03-06
IL126070A0 (en) 1999-05-09
CN1073101C (zh) 2001-10-17
IS4844A (is) 1998-09-09
NO984385D0 (no) 1998-09-21
EP0888319A1 (en) 1999-01-07
EE9800300A (et) 1999-02-15
AR006360A1 (es) 1999-08-25
US6410530B1 (en) 2002-06-25
BR9708093A (pt) 1999-07-27
KR20000064751A (ko) 2000-11-06
NZ331613A (en) 2000-03-27
EP0888319B1 (en) 2003-01-29
YU40998A (sh) 1999-09-27
PL329121A1 (en) 1999-03-15
HUP9902454A3 (en) 2002-01-28
DE69718771T2 (de) 2003-10-23
ID16298A (id) 1997-09-18
IL145681A0 (en) 2002-06-30
WO1997034883A1 (en) 1997-09-25
NO984385L (no) 1998-11-23
CA2247940A1 (en) 1997-09-25
SE9601110D0 (sv) 1996-03-22
AU709856B2 (en) 1999-09-09
AR010080A1 (es) 2000-05-17

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