HUP9901546A2 - Helicobacter pylori antigének és vakcinakészítmények - Google Patents

Helicobacter pylori antigének és vakcinakészítmények

Info

Publication number
HUP9901546A2
HUP9901546A2 HU9901546A HUP9901546A HUP9901546A2 HU P9901546 A2 HUP9901546 A2 HU P9901546A2 HU 9901546 A HU9901546 A HU 9901546A HU P9901546 A HUP9901546 A HU P9901546A HU P9901546 A2 HUP9901546 A2 HU P9901546A2
Authority
HU
Hungary
Prior art keywords
nucleic acid
subject
helicobacter pylori
acid molecules
vaccine compositions
Prior art date
Application number
HU9901546A
Other languages
English (en)
Inventor
Ingrid Bölin
Ann-Mari Svennerholm
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9502007A external-priority patent/SE9502007D0/xx
Priority claimed from SE9601085A external-priority patent/SE9601085D0/xx
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of HUP9901546A2 publication Critical patent/HUP9901546A2/hu
Publication of HUP9901546A3 publication Critical patent/HUP9901546A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgyát őlyan rekőmbináns pőlipeptidek és előállításűkképezik, amelyek azőnősak vagy lényegében hasőnlóak a Helicőbacterpylőri 29 kD felületen megjelenő fehérjéjével, és tartalmazzák annakimműnőgén epitópját. Ennek megfelelően az emlős szervezetben -beleértve embert is - antigénként viselkednek, és Helicőbacter pylőrielleni antitestek képződését indűkálják. A találmány tárgyát képeziktővábbá a nevezett pőlipeptidet kódőló nűkleinsavmőlekűlák űgyanúgy,mint ilyen nűkleinsavmőlekűlákat tartalmazó vektőrők és gazdasejtek. Anevezet rekőmbináns pőlipeptidek felhasználhatók H. pylőri fertőzésekdiagnősztizálására, és őlyan vakcinakészítmények előállítására,amelyek ilyen fertőzésekkel szembeni prőtektív imműnválaszt váltanakki, nevezett vakcinakészítmények alkalmasak mind terápiás, mindmegelőző felhasználásra. ŕ
HU9901546A 1995-06-01 1996-06-03 Helicobacter pylori antigens and vaccine compositions HUP9901546A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9502007A SE9502007D0 (sv) 1995-06-01 1995-06-01 Novel polypeptides
SE9601085A SE9601085D0 (sv) 1996-03-21 1996-03-21 Novel polypeptides

Publications (2)

Publication Number Publication Date
HUP9901546A2 true HUP9901546A2 (hu) 1999-08-30
HUP9901546A3 HUP9901546A3 (en) 2003-07-28

Family

ID=26662316

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901546A HUP9901546A3 (en) 1995-06-01 1996-06-03 Helicobacter pylori antigens and vaccine compositions

Country Status (22)

Country Link
US (2) US6025164A (hu)
EP (1) EP0828757A1 (hu)
JP (1) JP3380559B2 (hu)
KR (1) KR19990022131A (hu)
CN (1) CN1191544A (hu)
AR (1) AR003125A1 (hu)
BR (1) BR9608627A (hu)
CA (1) CA2222797A1 (hu)
CZ (1) CZ357397A3 (hu)
EE (1) EE9700306A (hu)
HU (1) HUP9901546A3 (hu)
IL (1) IL122340A0 (hu)
IS (1) IS4615A (hu)
MY (1) MY119003A (hu)
NO (1) NO975490L (hu)
NZ (1) NZ303356A (hu)
PL (1) PL323741A1 (hu)
RU (1) RU2195463C2 (hu)
SK (1) SK155297A3 (hu)
TR (1) TR199701471T1 (hu)
TW (1) TW570925B (hu)
WO (1) WO1996038475A1 (hu)

Families Citing this family (33)

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FR2682122B1 (fr) * 1991-10-03 1995-06-09 Pasteur Institut Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
US5843460A (en) * 1993-05-19 1998-12-01 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides
WO1995014093A1 (en) 1993-05-19 1995-05-26 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions and nucleic acid sequences encoding said polypeptides
US6406703B1 (en) 1993-07-27 2002-06-18 Csl Limited Treatment of H. pylori associated gastroduodenal disease
NZ269124A (en) * 1993-07-27 1997-06-24 Csl Ltd Vaccine comprising helicobacter antigens and its use in treating such infections
AUPM612494A0 (en) * 1994-06-08 1994-06-30 Csl Limited Treatment or prevention of helicobacter infection
RU98100081A (ru) * 1995-06-07 2005-11-27 Астра Актиеболаг (SE) Нуклеиново-кислотные и аминокислотные последовательности helicobacter pylory для диагностики и терапии
AU6584298A (en) * 1997-03-26 1998-10-20 Avant Immunotherapeutics, Inc. Carbohydrate antigens which immunoreact with polyclonal antisera against (h. pylori)
KR20010020366A (ko) * 1997-04-30 2001-03-15 메리오 오라벡 횡경막하 전신 경로용 항-헬리코박터 백신 조성물 및 복합 점막/경구 면역법
SE9702241D0 (sv) * 1997-06-12 1997-06-12 Astra Ab Vaccine compositions IV
SE9702242D0 (sv) * 1997-06-12 1997-06-12 Astra Ab Vaccine compositions V
US7393529B2 (en) * 1998-04-09 2008-07-01 Idexx Laboratories, Inc. Methods and compositions for inhibiting binding of IgE to a high affinity receptor
SE9801288D0 (sv) * 1998-04-14 1998-04-14 Astra Ab Vaccine delivery system and metod of production
US6841155B1 (en) * 1998-04-30 2005-01-11 Chiron S.R.L. Immunization against and treatment for infection by H. pylori
WO2000049044A1 (en) * 1999-02-19 2000-08-24 Astrazeneca Ab Expression of helicobacter polypeptides in pichia pastoris
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
ATE345354T1 (de) * 2000-04-27 2006-12-15 Max Planck Gesellschaft Methode zur identifizierung von helicobacter antigenen
GB0010371D0 (en) * 2000-04-29 2000-06-14 Astrazeneca Ab Helicobacter pylori antigens
US20020107368A1 (en) * 2000-12-07 2002-08-08 Jing-Hui Tian Helicobacter proteins, gene sequences and uses thereof
WO2005019249A2 (en) 2003-08-15 2005-03-03 University Of Florida Identification of porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases
US7381547B2 (en) * 2004-04-28 2008-06-03 Tzam Diagnostics, Llc Methods and compositions to detect bacteria using multiplex PCR
KR100613924B1 (ko) * 2004-06-23 2006-08-21 현대자동차주식회사 자동차 연료 시스템
US20090269362A1 (en) * 2005-07-25 2009-10-29 Sant Andrea J Method for Controlling Immunodominance
EP2139993A2 (en) * 2007-04-27 2010-01-06 Dow Global Technologies Inc. Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles
CN101496898B (zh) * 2009-02-16 2011-06-15 中国人民解放军军事医学科学院生物工程研究所 一种预防和/或治疗幽门螺杆菌感染的疫苗
RU2449805C1 (ru) 2011-01-27 2012-05-10 Общество С Ограниченной Ответственностью "Гармония" Пептидная фармацевтическая композиция, средство на ее основе для лечения гастродуоденальных заболеваний, вызываемых helicobacter pylori, и способ его использования
JP6959937B2 (ja) 2015-12-14 2021-11-05 テクニシェ ユニバーシタット ミュンヘン ヘリコバクターピロリワクチン
US10577409B2 (en) * 2016-05-26 2020-03-03 Sagabio Co., Ltd. Monoclonal antibody inhibiting immunosuppressive functions of pathogens, antigen-binding fragment thereof, and hybridomas producing such antibody
CN107456578A (zh) * 2016-06-03 2017-12-12 硕英生医股份有限公司 一种关闭病原体的免疫抑制功能的方法及其用途
EP3272354A1 (en) 2016-07-20 2018-01-24 Technische Universität München Agents and methods for the prevention or treatment of h. pylori infections
CN111467368B (zh) * 2020-04-13 2021-05-28 江南大学 含庚糖链的寡糖化合物在制备幽门螺旋杆菌疫苗中的应用
CN113144182B (zh) * 2021-04-22 2023-03-10 成都欧林生物科技股份有限公司 一种幽门螺杆菌口服缓释疫苗及其制备与应用
CN113896775A (zh) * 2021-08-25 2022-01-07 河北医科大学第四医院 幽门螺杆菌特异性免疫原性肽段

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100188323B1 (ko) * 1989-03-09 1999-06-01 이곤 이이 버어그 비타입성 헤모필루스 인플렌자에 대한 백신
US5721349A (en) * 1992-02-26 1998-02-24 Vanderbilt University Vacuolating toxin-deficient H. pylori
MX9301706A (es) * 1992-04-13 1994-05-31 Oravax Inc Composicion de vacuna para el tratamiento de la infeccion por helicobacter.
US5420014A (en) * 1992-04-30 1995-05-30 Auspharm International Ltd. Rapid in vitro test for helicobacter pylori using saliva

Also Published As

Publication number Publication date
IS4615A (is) 1997-11-17
US6025164A (en) 2000-02-15
SK155297A3 (en) 1998-08-05
AR003125A1 (es) 1998-07-08
EP0828757A1 (en) 1998-03-18
US20020168726A1 (en) 2002-11-14
NZ303356A (en) 1999-05-28
KR19990022131A (ko) 1999-03-25
IL122340A0 (en) 1998-04-05
WO1996038475A1 (en) 1996-12-05
JP3380559B2 (ja) 2003-02-24
RU2195463C2 (ru) 2002-12-27
EE9700306A (xx) 1998-06-15
TW570925B (en) 2004-01-11
JPH11507210A (ja) 1999-06-29
CZ357397A3 (cs) 1998-05-13
AU6020596A (en) 1996-12-18
CA2222797A1 (en) 1996-12-05
MY119003A (en) 2005-03-31
MX9709194A (es) 1998-07-31
HUP9901546A3 (en) 2003-07-28
PL323741A1 (en) 1998-04-14
BR9608627A (pt) 1999-06-15
NO975490D0 (no) 1997-11-28
TR199701471T1 (xx) 1998-02-21
CN1191544A (zh) 1998-08-26
AU703331B2 (en) 1999-03-25
NO975490L (no) 1998-01-07

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