KR950701821A - 피임 백신(contraceptive vaccine) - Google Patents
피임 백신(contraceptive vaccine)Info
- Publication number
- KR950701821A KR950701821A KR1019940704579A KR19940704579A KR950701821A KR 950701821 A KR950701821 A KR 950701821A KR 1019940704579 A KR1019940704579 A KR 1019940704579A KR 19940704579 A KR19940704579 A KR 19940704579A KR 950701821 A KR950701821 A KR 950701821A
- Authority
- KR
- South Korea
- Prior art keywords
- surface protein
- sperm
- sperm surface
- peptide
- contraception
- Prior art date
Links
- 229940124462 contraceptive vaccine Drugs 0.000 title 2
- 101001076862 Homo sapiens C-Jun-amino-terminal kinase-interacting protein 4 Proteins 0.000 claims abstract 12
- 102100025905 C-Jun-amino-terminal kinase-interacting protein 4 Human genes 0.000 claims abstract 11
- 238000000034 method Methods 0.000 claims abstract 5
- 239000000203 mixture Substances 0.000 claims abstract 4
- 241000124008 Mammalia Species 0.000 claims abstract 3
- 230000004927 fusion Effects 0.000 claims abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 239000003433 contraceptive agent Substances 0.000 claims 3
- 230000002254 contraceptive effect Effects 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 108020004511 Recombinant DNA Proteins 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
본 발명은 피임방법 및 이것에 유용한 조성물에 관한 것이다. 기재된 내용은 하나이상의 정자 표면 단백질이 포유동물에 투여되며, 투여는 면역 반응을 자극하므로써 정자 표면 단백질에 결합하는 항체가 정자-난자 융합을 방지하거나 또는 그 비율을 실질적으로 감소시키게 충분한 양으로 생성되도록 하는 방법이다. 항원성 정자 표면 단백질 펩티드로 또한 이 목적에 유용하다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 생체내에서 정자 표면 단백질과 결합하는 항체의 자극에 효과적인 양의 정자표면 단백질로 부터의 펩티드롤 포유동물에게 투여함으로써, 정자-난자 융합이 방지또는 그 비율이 실제로 감소되는 것으로 이루어지는 피임방법.
- 제1항에 있어서, 정자 표면 단백질이 PH-20인 것을 특징으로하는 방법.
- 제1항에 있어서, 정자 표면 단백질이 PH-30인 것을 특징으로하는 방법.
- 제3항에 있어서, 펩티드가 인티그린 결합 도메인에 상동하는 것을 특징으로하는 방법.
- 약학적으로 허용되는 담체중에, 정자 표면 단백질로 부터 면역원성 에피토프에 상동하는 서열을 갖는 본질적으로 순수한 펩티드를 포함하는 피임 조성물.
- 제5항에 있어서, 정자 표면 단백질이 PH-20 또는 PH-30인 것을 특징으로 하는 피임조성물.
- 제6항에 있어서, 본질적으로 순수한 펩티드가 재조합 DNA 발현 벡터내에서 정자 표면 단백질의 면역원성 에피토프를 코드화하는 DNA를 발현시킴으로써 생성되는 것을 특징으로 하는 피임 조성물.
- 생체내에서 정자 표면 단백질에 결합함으로써 정자-난자 융합을 방지하거나 그 비율을 실제로 감소시키는 항체의 자극에 효과적인, 포유동물에 대한 정자 표면 단백질로부터의 펩티드인 것을 특징으로 하는 피임에 사용하기 위한 펩티드.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89788392A | 1992-06-12 | 1992-06-12 | |
| US07/897,883 | 1992-06-12 | ||
| PCT/US1993/005640 WO1993025233A1 (en) | 1992-06-12 | 1993-06-10 | Contraceptive vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950701821A true KR950701821A (ko) | 1995-05-17 |
Family
ID=25408584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940704579A KR950701821A (ko) | 1992-06-12 | 1993-06-10 | 피임 백신(contraceptive vaccine) |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0646015B1 (ko) |
| JP (1) | JPH08503601A (ko) |
| KR (1) | KR950701821A (ko) |
| AT (1) | ATE175357T1 (ko) |
| AU (1) | AU4534893A (ko) |
| CA (1) | CA2137077A1 (ko) |
| DE (1) | DE69322960T2 (ko) |
| WO (1) | WO1993025233A1 (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693496A (en) * | 1994-06-20 | 1997-12-02 | Merck & Co., Inc. | DNA encoding the mouse and human PH30 beta chain protein |
| WO1996005305A1 (en) * | 1994-08-11 | 1996-02-22 | Duke University | Use of zrk peptide sequences in contraception |
| EP2280723B1 (en) * | 2008-04-07 | 2012-07-25 | Auburn University | Methods for species-specific immunocontraception of animals |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5721348A (en) * | 1990-12-14 | 1998-02-24 | University Of Connecticut | DNA encoding PH-20 proteins |
| WO1993006859A1 (en) * | 1991-10-04 | 1993-04-15 | The Trustees Of Princeton University | Sperm surface protein |
-
1993
- 1993-06-10 AU AU45348/93A patent/AU4534893A/en not_active Abandoned
- 1993-06-10 DE DE69322960T patent/DE69322960T2/de not_active Expired - Fee Related
- 1993-06-10 JP JP6501757A patent/JPH08503601A/ja active Pending
- 1993-06-10 CA CA002137077A patent/CA2137077A1/en not_active Abandoned
- 1993-06-10 EP EP93915326A patent/EP0646015B1/en not_active Expired - Lifetime
- 1993-06-10 KR KR1019940704579A patent/KR950701821A/ko not_active Application Discontinuation
- 1993-06-10 WO PCT/US1993/005640 patent/WO1993025233A1/en active IP Right Grant
- 1993-06-10 AT AT93915326T patent/ATE175357T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08503601A (ja) | 1996-04-23 |
| AU4534893A (en) | 1994-01-04 |
| CA2137077A1 (en) | 1993-12-23 |
| WO1993025233A1 (en) | 1993-12-23 |
| DE69322960D1 (de) | 1999-02-18 |
| EP0646015A1 (en) | 1995-04-05 |
| EP0646015B1 (en) | 1999-01-07 |
| DE69322960T2 (de) | 1999-08-12 |
| ATE175357T1 (de) | 1999-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |