HUP9802808A2 - N-(4-Karbamimido-fenil)-fenil-glicinamid-származékok, eljárás előállításukra, a vegyületeket tartalmazó gyógyszerkészítmények és köztitermékek - Google Patents

N-(4-Karbamimido-fenil)-fenil-glicinamid-származékok, eljárás előállításukra, a vegyületeket tartalmazó gyógyszerkészítmények és köztitermékek

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Publication number
HUP9802808A2
HUP9802808A2 HU9802808A HUP9802808A HUP9802808A2 HU P9802808 A2 HUP9802808 A2 HU P9802808A2 HU 9802808 A HU9802808 A HU 9802808A HU P9802808 A HUP9802808 A HU P9802808A HU P9802808 A2 HUP9802808 A2 HU P9802808A2
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alkyl
coo
pipe
powder
nhco
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HU9802808A
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English (en)
Inventor
Katrin Gröbke
Yu-Hua Ji
Sabine Wallbaum
Lutz Weber
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F.Hoffmann-La Roche Ag.
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Publication of HU9802808D0 publication Critical patent/HU9802808D0/hu
Publication of HUP9802808A2 publication Critical patent/HUP9802808A2/hu
Publication of HUP9802808A3 publication Critical patent/HUP9802808A3/hu

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

Az (I) általánős képletű új 4-N-(4-karbamimidőil-fenilaminő)-fenil-glicin-származékők (mely képletben E hidrőgénatőm vagyhidrőxilcsőpőrt; Q hidrőgénatőm vagy alkilcsőpőrt; R aril-,ciklőalkil- vagy alkilcsőpőrt, amely R1, R2 és R3 által helyettesítvevan; N(Q,R) jelentése karbőxil-, vagy COO-alkil- helyettesítettpirrőlidinő-, piperidinő- vagy 1,2,3,4-tetrahidrőizőkinőlin-3-il-csőpőrt; az X1-X4 csőpőrt közül hárőm egymástól függetlenül C(Ra),C(Rb) vagy C(Rc) csőpőrtőt és a negyedik C(Rd) vagy N csőpőrt jelent;Ra-Rd hidrőgénatőm, hidrőxil-, nitrő-, dialkilaminő-csőpőrt,halőgénatőm, alkil-, alkőxi-, arilőxi-, aralkőxi-, heterőaril-alkőxi-,heterőciklikűs-alkőxi-, karbőxil-, alkőxi-karbőnil-, NH-SO2-alkil-,NHSO2-aril, NHCO-alkil-, NHCO-aril-, NHCOO-alkil, NHCO-alkil-NH2,NHCO-alkil-NH-G, aralkil-CONH, alkil-O-alkil-CONH, aril-O-alkil-CONH,alkil-COOH, alkil-COO-alkil, O-alkil-COOH vagy O-alkil-COO-alkilcsőpőrt; vagy két szőmszédős Ra-Rd csőpőrt együttalkiléndiőxicsőpőrtőt képez; mimellett legfeljebb hárőm Ra-Rd csőpőrtlehet egyfőrma jelentésű, és X1 CCOOH vagy CCOO-alkil-csőpőrttóleltérő jelentésű; G valamely aminő védőcsőpőrt; és G1 és G2 közül azegyik hidrőgénatőmőt és a másik hidrőgénatőmőt, alkil-, hidrőxil-,alkőxi-, arőil-, alkanőil-OCH2, arőil-OCH2 vagy COO-Rg vagy OCO-Rgcsőpőrtőt képvisel; Rg adőtt esetben halőgén-, hidrőxil-, alkőxi-,karbőxil- vagy COO-alkil helyettesítőt hőrdőzó alkilcsőpőrt) és hidrátjaik vagy szőlvátjaik és gyógyászatilag alkalmas sóik az Xa, IXakőagűlációs faktőrnak és trőmbinnak VIIa faktőr és szövetfaktőr általindűkált képződése inhibitőraként, különösen trőmbózis, apőplexia,szívinfarktűs, gyűlladás és arteriőszklerózis kezelésére és/ vagymegelőzésére szőlgáló gyógyszerként vagy tűmőrellenes szerkéntalkalmazhatók. ŕ
HU9802808A 1997-12-04 1998-12-04 N-(4-carbamido-phenyl)-phenylglycin-amid derivatives, process for preparing them, pharmaceuticals containing them and intermediates HUP9802808A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97121285 1997-12-04
EP98121374 1998-11-10

Publications (3)

Publication Number Publication Date
HU9802808D0 HU9802808D0 (en) 1999-02-01
HUP9802808A2 true HUP9802808A2 (hu) 1999-06-28
HUP9802808A3 HUP9802808A3 (en) 2000-03-28

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HU9802808A HUP9802808A3 (en) 1997-12-04 1998-12-04 N-(4-carbamido-phenyl)-phenylglycin-amid derivatives, process for preparing them, pharmaceuticals containing them and intermediates

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US (1) US6140353A (hu)
EP (1) EP0921116B1 (hu)
JP (1) JP3236267B2 (hu)
KR (1) KR100330610B1 (hu)
CN (1) CN1115330C (hu)
AT (1) ATE243192T1 (hu)
AU (1) AU739769B2 (hu)
CA (1) CA2255180A1 (hu)
CZ (1) CZ295105B6 (hu)
DE (1) DE59808751D1 (hu)
DK (1) DK0921116T3 (hu)
ES (1) ES2201396T3 (hu)
HK (1) HK1020941A1 (hu)
HU (1) HUP9802808A3 (hu)
IL (1) IL127361A (hu)
MA (1) MA26572A1 (hu)
MY (1) MY133897A (hu)
NO (1) NO985646L (hu)
NZ (1) NZ333126A (hu)
PT (1) PT921116E (hu)
SI (1) SI0921116T1 (hu)
TW (1) TW544446B (hu)

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WO2000035858A1 (en) 1998-12-14 2000-06-22 F. Hoffmann-La Roche Ag Phenylglycine derivatives
DE10041402A1 (de) * 2000-08-23 2002-03-14 Morphochem Ag Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
US6548694B2 (en) 2000-05-23 2003-04-15 Hoffman-La Roche Inc. N-(4-carbamimidoyl-phenyl)-glycine derivatives
EP1364960A4 (en) 2001-02-02 2005-05-18 Chugai Pharmaceutical Co Ltd PEPTIDE DERIVATIVES
CA2437114A1 (en) * 2001-02-23 2002-09-06 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Diamides which inhibit tryptase and factor xa activity
DE10204072A1 (de) * 2002-01-31 2003-08-14 Morphochem Ag Komb Chemie Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
DE10300049A1 (de) * 2003-01-03 2004-07-15 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Faktor VIIa inhibieren
ATE377017T1 (de) * 2002-01-31 2007-11-15 Morphochem Ag Komb Chemie Verbindungen, die faktor xa-aktiv t inhibieren
TW200410921A (en) * 2002-11-25 2004-07-01 Hoffmann La Roche Mandelic acid derivatives
WO2004072102A2 (en) * 2003-02-11 2004-08-26 Bristol-Myers Squibb Company Benzene acetamide compounds useful as serine protease inhibitors
WO2004072101A2 (en) * 2003-02-11 2004-08-26 Bristol-Myers Squibb Company Phenylglycine derivatives useful as serine protease inhibitors
JP2007500221A (ja) * 2003-05-20 2007-01-11 ジェネンテック・インコーポレーテッド 第ＶＩＩａ因子のベンゾフラン阻害剤
CA2525854C (en) * 2003-05-20 2009-12-15 Genentech, Inc. Acylsulfamide inhibitors of factor viia
US7056932B2 (en) 2003-12-19 2006-06-06 Hoffman-La Roche Inc. Heterocyclyl substituted 1-alkoxy acetic acid amides
ES2310861T3 (es) * 2004-12-08 2009-01-16 Bristol-Myers Squibb Company Compuestos heterociclicos como inhibidores del factor viia.
DE602006016566D1 (de) * 2005-01-10 2010-10-14 Bristol Myers Squibb Co Als antikoagulanzien verwendbare phenylglycinamid-derivate
ES2337831T3 (es) * 2005-06-24 2010-04-29 Bristol-Myers Squibb Company Derivados de fenilglicinamida y piridilclicinamida utiles como agentes anticoagulantes.
WO2007103996A1 (en) * 2006-03-09 2007-09-13 Bristol-Myers Squibb Company 2-(aryloxy)acetamide factor viia inhibitors useful as anticoagulants
US7855194B2 (en) 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives
JP2009539873A (ja) 2006-06-08 2009-11-19 ブリストル−マイヤーズ スクイブ カンパニー 抗凝固剤として有用な第ＶＩＩａ因子インヒビターとしての２−アミノカルボニルフェニルアミノ−２−フェニルアセトアミド類
WO2008079759A1 (en) * 2006-12-20 2008-07-03 Bristol-Myers Squibb Company Bicyclic lactam factor viia inhibitors useful as anticoagulants
EP1967522A1 (en) * 2007-03-07 2008-09-10 Novo Nordisk A/S New blood coagulation factor inhibitors
US8217064B2 (en) * 2007-12-20 2012-07-10 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
CN102653980B (zh) * 2012-03-05 2014-03-19 胡文超 一种发光玻璃地面砖
CN104370813A (zh) * 2014-10-22 2015-02-25 上海大学 异喹啉-6-甲醛的制备方法
CN112939895B (zh) * 2021-02-08 2022-11-04 桂林医学院 一种甘氨酰胺类衍生物及其制备方法和应用

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US5625093A (en) * 1991-10-15 1997-04-29 G. D. Searle & Co. Substituted β-amino acid derivatives useful as platelet aggregation inhibitors
KR0173034B1 (ko) * 1995-04-28 1999-03-30 성재갑 선택적 트롬빈 억제제
DK0892780T3 (da) * 1996-02-22 2003-03-03 Bristol Myers Squibb Pharma Co m-Amidinophenylanaloger som faktor Xa-inhibitorer

Also Published As

Publication number Publication date
JP3236267B2 (ja) 2001-12-10
EP0921116A1 (de) 1999-06-09
SI0921116T1 (en) 2003-10-31
EP0921116B1 (de) 2003-06-18
KR100330610B1 (ko) 2002-11-23
PT921116E (pt) 2003-11-28
US6140353A (en) 2000-10-31
IL127361A0 (en) 1999-10-28
ATE243192T1 (de) 2003-07-15
CZ396998A3 (cs) 1999-11-17
MY133897A (en) 2007-11-30
HK1020941A1 (en) 2000-05-26
DE59808751D1 (de) 2003-07-24
AU9521098A (en) 1999-06-24
HU9802808D0 (en) 1999-02-01
TW544446B (en) 2003-08-01
CN1115330C (zh) 2003-07-23
JPH11246507A (ja) 1999-09-14
ES2201396T3 (es) 2004-03-16
KR19990062766A (ko) 1999-07-26
CA2255180A1 (en) 1999-06-04
NZ333126A (en) 2000-06-23
AU739769B2 (en) 2001-10-18
CN1224714A (zh) 1999-08-04
IL127361A (en) 2002-09-12
NO985646D0 (no) 1998-12-03
CZ295105B6 (cs) 2005-05-18
MA26572A1 (fr) 2004-12-20
NO985646L (no) 1999-06-07
HUP9802808A3 (en) 2000-03-28
DK0921116T3 (da) 2003-10-06

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