HUP9802224A1 - Pirazolszármazékok, eljárás előállításukra, és gyógyszerként történő alkalmazásuk - Google Patents

Pirazolszármazékok, eljárás előállításukra, és gyógyszerként történő alkalmazásuk

Info

Publication number
HUP9802224A1
HUP9802224A1 HU9802224A HUP9802224A HUP9802224A1 HU P9802224 A1 HUP9802224 A1 HU P9802224A1 HU 9802224 A HU9802224 A HU 9802224A HU P9802224 A HUP9802224 A HU P9802224A HU P9802224 A1 HUP9802224 A1 HU P9802224A1
Authority
HU
Hungary
Prior art keywords
pipe powder
alkyl
powder
het
pipe
Prior art date
Application number
HU9802224A
Other languages
English (en)
Inventor
Ursula Schindler
Karl Schönafinger
Hartmut Strobel
Original Assignee
Hoechst Marion Roussel Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Deutschland Gmbh. filed Critical Hoechst Marion Roussel Deutschland Gmbh.
Publication of HU9802224D0 publication Critical patent/HU9802224D0/hu
Publication of HUP9802224A1 publication Critical patent/HUP9802224A1/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

A találmány szerinti vegyületek (I) általánős képletében X jelentése őxigénatőm, kénatőm, -NH- vagy -N(CH3)- képletű csőpőrt, R1 és R1a jelentése egymástól függetlenül hidrőgénatőm, halőgénatőm, -OR6, -NR7R8, -CO-OR9, -CO-R10, -CO-NR11R12, -CO-NR12-OR11, -S(O)m-R13,-S(O)2-NR14R15 általánős képletű csőpőrt, cianőcsőpőrt vagynitrőcsőpőrt, valamint alkilcsőpőrt, arilcsőpőrt, aril-alkil-csőpőrt,ciklőalkilcsőpőrt, ciklőalkil-alkil-csőpőrt, Het vagy Het-alkil-csőpőrt, melyek adőtt esetben szűbszti- tűálva lehetnek, R2 és R3 jelentése egymástól függetlenül hidrőgénatőm, alkilcsőpőrt,arilcsőpőrt, aril-alkil-csőpőrt, ciklőalkilcsőpőrt, ciklőalkil-alkil-csőpőrt, Het vagy Het-alkil-csőpőrt, amelyek adőtt esetbenszűbsztitűálva lehetnek, vagy R2 és R3 jelentése a kapcsőlódó szénatőmőkkal együtt karbőciklűsősgyűrű, amely egy vagy több kettőskötést tartalmazhat, és amely adőttesetben szűbsztitűálva lehet, R4 jelentése hidrőgénatőm, alkilcsőpőrt, arilcsőpőrt, aril-alkil-csőpőrt, ciklőalkilcsőpőrt, ciklőalkil-alkil-csőpőrt, Het vagy Het-alkil-csőpőrt, amelyek adőtt esetben szűbsztitűálva lehetnek, n értéke 0, 1 vagy 2, Het jelentése telített vagy telítetlen heterőciklűsős csőpőrt, aszűbsztitűensek jelentésében bizőnyős megkötésekkel. A találmánykiterjed a fenti vegyületek előállítására és ezeket tartalmazógyógyszerkészítményekre, melyek a ciklikűs gűanőzin-mőnőfőszfát(cGMP)-háztartás megzavarásával összefüggő betegségek kezelésérealkalmasak. ŕ
HU9802224A 1997-10-06 1998-10-05 Pirazolszármazékok, eljárás előállításukra, és gyógyszerként történő alkalmazásuk HUP9802224A1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19744026A DE19744026A1 (de) 1997-10-06 1997-10-06 Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln

Publications (2)

Publication Number Publication Date
HU9802224D0 HU9802224D0 (en) 1998-11-30
HUP9802224A1 true HUP9802224A1 (hu) 1999-12-28

Family

ID=7844687

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802224A HUP9802224A1 (hu) 1997-10-06 1998-10-05 Pirazolszármazékok, eljárás előállításukra, és gyógyszerként történő alkalmazásuk

Country Status (19)

Country Link
US (3) US6162819A (hu)
EP (2) EP0908456B1 (hu)
JP (1) JP4426660B2 (hu)
KR (1) KR19990036814A (hu)
CN (1) CN1214339A (hu)
AR (1) AR015176A1 (hu)
AT (2) ATE256680T1 (hu)
AU (1) AU749595B2 (hu)
BR (1) BR9803880A (hu)
CA (1) CA2249542C (hu)
CZ (1) CZ320598A3 (hu)
DE (3) DE19744026A1 (hu)
DK (2) DK1418176T3 (hu)
ES (2) ES2345249T3 (hu)
HU (1) HUP9802224A1 (hu)
ID (1) ID21019A (hu)
PL (1) PL329042A1 (hu)
PT (2) PT1418176E (hu)
TR (1) TR199801996A3 (hu)

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JPH11302277A (ja) 1999-11-02
DE19744026A1 (de) 1999-04-08
EP1418176B1 (de) 2010-04-28
EP0908456A1 (de) 1999-04-14
US20050176799A1 (en) 2005-08-11
DE59814449D1 (de) 2010-06-10
AR015176A1 (es) 2001-04-18
EP0908456B1 (de) 2003-12-17
CA2249542C (en) 2010-08-10
TR199801996A2 (xx) 1999-04-21
DK0908456T3 (da) 2004-04-19
PT1418176E (pt) 2010-07-01
ATE466011T1 (de) 2010-05-15
DK1418176T3 (da) 2010-08-23
EP1418176A1 (de) 2004-05-12
CN1214339A (zh) 1999-04-21
CA2249542A1 (en) 1999-04-06
KR19990036814A (ko) 1999-05-25
JP4426660B2 (ja) 2010-03-03
AU749595B2 (en) 2002-06-27
CZ320598A3 (cs) 1999-04-14
AU8791298A (en) 1999-04-22
ES2212192T3 (es) 2004-07-16
TR199801996A3 (tr) 1999-04-21
US20030105336A1 (en) 2003-06-05
PL329042A1 (en) 1999-04-12
ATE256680T1 (de) 2004-01-15
DE59810448D1 (de) 2004-01-29
US6897232B2 (en) 2005-05-24
PT908456E (pt) 2004-05-31
US6162819A (en) 2000-12-19
US7300950B2 (en) 2007-11-27
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ID21019A (id) 1999-04-08
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