HUP9702411A2 - Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények - Google Patents

Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények

Info

Publication number
HUP9702411A2
HUP9702411A2 HU9702411A HUP9702411A HUP9702411A2 HU P9702411 A2 HUP9702411 A2 HU P9702411A2 HU 9702411 A HU9702411 A HU 9702411A HU P9702411 A HUP9702411 A HU P9702411A HU P9702411 A2 HUP9702411 A2 HU P9702411A2
Authority
HU
Hungary
Prior art keywords
atom
hydrogen atom
antiarrythmic
same
pharmaceutical compositions
Prior art date
Application number
HU9702411A
Other languages
English (en)
Hungarian (hu)
Inventor
Gyula Papp
András Varró
Péter Mátyus
Ildikó Varga
Tivadar Rettegi
Alice Druga
Antal Simay
Imre Moravcsik
Pál Berzsenyi
Daniela Barlocco
Giorgio Cignarella
Márta Pátfalusi
Original Assignee
Gyógyszerkutató Intézet Kft.
Szent-Györgyi Albert Orvostudományi Egyetem Farmakológiai és Farmakoterápiai Intézete
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyógyszerkutató Intézet Kft., Szent-Györgyi Albert Orvostudományi Egyetem Farmakológiai és Farmakoterápiai Intézete filed Critical Gyógyszerkutató Intézet Kft.
Priority to HU9702411A priority Critical patent/HUP9702411A2/hu
Publication of HU9702411D0 publication Critical patent/HU9702411D0/hu
Priority to UA2000063362A priority patent/UA61979C2/uk
Priority to CNB988135779A priority patent/CN1140498C/zh
Priority to HK01104636.1A priority patent/HK1033937B/xx
Priority to US09/555,602 priority patent/US6265445B1/en
Priority to BR9814270-4A priority patent/BR9814270A/pt
Priority to DE69806411T priority patent/DE69806411T2/de
Priority to PT98961331T priority patent/PT1037871E/pt
Priority to RU2000118325/04A priority patent/RU2193024C2/ru
Priority to DK98961331T priority patent/DK1037871T3/da
Priority to JP2000524252A priority patent/JP2001525388A/ja
Priority to IL13665998A priority patent/IL136659A/en
Priority to PL341107A priority patent/PL190788B1/pl
Priority to SK879-2000A priority patent/SK284284B6/sk
Priority to EP98961331A priority patent/EP1037871B1/en
Priority to NZ504982A priority patent/NZ504982A/en
Priority to KR1020007006348A priority patent/KR100576905B1/ko
Priority to ES98961331T priority patent/ES2179547T3/es
Priority to CA002313191A priority patent/CA2313191A1/en
Priority to AT98961331T priority patent/ATE220058T1/de
Priority to AU16789/99A priority patent/AU738672B2/en
Priority to PCT/HU1998/000101 priority patent/WO1999029655A1/en
Publication of HUP9702411A2 publication Critical patent/HUP9702411A2/hu
Priority to NO20002946A priority patent/NO20002946L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
HU9702411A 1997-12-11 1997-12-11 Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények HUP9702411A2 (hu)

Priority Applications (23)

Application Number Priority Date Filing Date Title
HU9702411A HUP9702411A2 (hu) 1997-12-11 1997-12-11 Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények
UA2000063362A UA61979C2 (en) 1997-12-11 1998-10-12 Phenoxy alkylamine derivatives, a pharmaceutical composition and a method for treatment of mammals' diseases being accompanied by arrythmia
PCT/HU1998/000101 WO1999029655A1 (en) 1997-12-11 1998-12-10 Novel antiarrhythmic compounds
JP2000524252A JP2001525388A (ja) 1997-12-11 1998-12-10 新規な抗−不整脈化合物
SK879-2000A SK284284B6 (sk) 1997-12-11 1998-12-10 Deriváty fenoxyalkylamínu, farmaceutické kompozície, ktoré obsahujú tieto zlúčeniny, a použitie týchto zlúčenín na výrobu liečiva vhodného na liečenie srdcovej arytmie
US09/555,602 US6265445B1 (en) 1997-12-11 1998-12-10 Antiarrhythmic compounds
BR9814270-4A BR9814270A (pt) 1997-12-11 1998-12-10 Compostos antiarrìtmicos
DE69806411T DE69806411T2 (de) 1997-12-11 1998-12-10 Neue antiarrythmische verbindungen
PT98961331T PT1037871E (pt) 1997-12-11 1998-12-10 Novos compostos antiarritmicos
RU2000118325/04A RU2193024C2 (ru) 1997-12-11 1998-12-10 Новые антиаритмические соединения
DK98961331T DK1037871T3 (da) 1997-12-11 1998-12-10 Nye antiarytmiske forbindelser
CNB988135779A CN1140498C (zh) 1997-12-11 1998-12-10 新的抗心律失常化合物
IL13665998A IL136659A (en) 1997-12-11 1998-12-10 New antiarrhythmic compounds and pharmaceuticals containing them
PL341107A PL190788B1 (pl) 1997-12-11 1998-12-10 Pochodne fenoksyalkiloaminy, kompozycja farmaceutyczna i zastosowanie
HK01104636.1A HK1033937B (en) 1997-12-11 1998-12-10 Novel antiarrhythmic compounds
EP98961331A EP1037871B1 (en) 1997-12-11 1998-12-10 Novel antiarrhythmic compounds
NZ504982A NZ504982A (en) 1997-12-11 1998-12-10 Antiarrhythmic phenoxyalkylamine derivatives
KR1020007006348A KR100576905B1 (ko) 1997-12-11 1998-12-10 신규한 항부정맥 화합물
ES98961331T ES2179547T3 (es) 1997-12-11 1998-12-10 Nuevos derivados de fenoxi-alquil-amina con actividad antiarritmica.
CA002313191A CA2313191A1 (en) 1997-12-11 1998-12-10 Novel antiarrhythmic compounds
AT98961331T ATE220058T1 (de) 1997-12-11 1998-12-10 Neue antiarrythmische verbindungen
AU16789/99A AU738672B2 (en) 1997-12-11 1998-12-10 Novel antiarrhythmic compounds
NO20002946A NO20002946L (no) 1997-12-11 2000-06-08 Nye antiarytmiske forbindelser

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9702411A HUP9702411A2 (hu) 1997-12-11 1997-12-11 Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények

Publications (2)

Publication Number Publication Date
HU9702411D0 HU9702411D0 (en) 1998-03-02
HUP9702411A2 true HUP9702411A2 (hu) 2000-03-28

Family

ID=89995855

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702411A HUP9702411A2 (hu) 1997-12-11 1997-12-11 Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények

Country Status (22)

Country Link
US (1) US6265445B1 (https=)
EP (1) EP1037871B1 (https=)
JP (1) JP2001525388A (https=)
KR (1) KR100576905B1 (https=)
CN (1) CN1140498C (https=)
AT (1) ATE220058T1 (https=)
AU (1) AU738672B2 (https=)
BR (1) BR9814270A (https=)
CA (1) CA2313191A1 (https=)
DE (1) DE69806411T2 (https=)
DK (1) DK1037871T3 (https=)
ES (1) ES2179547T3 (https=)
HU (1) HUP9702411A2 (https=)
IL (1) IL136659A (https=)
NO (1) NO20002946L (https=)
NZ (1) NZ504982A (https=)
PL (1) PL190788B1 (https=)
PT (1) PT1037871E (https=)
RU (1) RU2193024C2 (https=)
SK (1) SK284284B6 (https=)
UA (1) UA61979C2 (https=)
WO (1) WO1999029655A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956786A1 (de) * 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
US20030119406A1 (en) 2001-12-20 2003-06-26 Abuto Francis Paul Targeted on-line stabilized absorbent structures
AU2002357560A1 (en) * 2002-04-26 2003-11-10 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Sulfamidophenylalkylamines and their production and use
CN102603543B (zh) * 2012-04-09 2014-07-02 佛山普正医药科技有限公司 一种盐酸美西律的生产方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD146749A3 (de) * 1977-12-01 1981-03-04 Dieter Lehmann Verfahren zur herstellung von phenoxyalkanolamin-derivaten
EG18188A (en) * 1986-05-01 1992-09-30 Pfizer Ltd Process for preparation anti-arhythmia agents
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
JPH06107614A (ja) * 1992-09-26 1994-04-19 Arakusu:Kk アリールスルホン酸アミド類またはアリールカルボン酸アミド類及びそれらの薬剤として許容される酸付加塩及びその製造法並びにそれを有効成分とする抗消化性潰瘍剤

Also Published As

Publication number Publication date
IL136659A0 (en) 2001-06-14
CN1284941A (zh) 2001-02-21
KR100576905B1 (ko) 2006-05-03
CA2313191A1 (en) 1999-06-17
SK8792000A3 (en) 2001-02-12
IL136659A (en) 2004-08-31
HU9702411D0 (en) 1998-03-02
NO20002946L (no) 2000-08-07
HK1033937A1 (en) 2001-10-05
AU738672B2 (en) 2001-09-20
US6265445B1 (en) 2001-07-24
ES2179547T3 (es) 2003-01-16
JP2001525388A (ja) 2001-12-11
DE69806411T2 (de) 2003-03-20
PT1037871E (pt) 2002-11-29
NO20002946D0 (no) 2000-06-08
WO1999029655A1 (en) 1999-06-17
DE69806411D1 (de) 2002-08-08
PL190788B1 (pl) 2006-01-31
BR9814270A (pt) 2001-10-16
RU2193024C2 (ru) 2002-11-20
NZ504982A (en) 2002-07-26
ATE220058T1 (de) 2002-07-15
CN1140498C (zh) 2004-03-03
KR20010032996A (ko) 2001-04-25
PL341107A1 (en) 2001-03-26
EP1037871B1 (en) 2002-07-03
DK1037871T3 (da) 2002-10-14
EP1037871A1 (en) 2000-09-27
AU1678999A (en) 1999-06-28
SK284284B6 (sk) 2005-01-03
UA61979C2 (en) 2003-12-15

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished