AU738672B2 - Novel antiarrhythmic compounds - Google Patents

Novel antiarrhythmic compounds Download PDF

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Publication number
AU738672B2
AU738672B2 AU16789/99A AU1678999A AU738672B2 AU 738672 B2 AU738672 B2 AU 738672B2 AU 16789/99 A AU16789/99 A AU 16789/99A AU 1678999 A AU1678999 A AU 1678999A AU 738672 B2 AU738672 B2 AU 738672B2
Authority
AU
Australia
Prior art keywords
methyl
ethyl
compounds
group
dimethylphenoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU16789/99A
Other languages
English (en)
Other versions
AU1678999A (en
Inventor
Daniella Barlocco
Pal Berzsenyi
Giorgio Cignarella
Alice Druga
Peter Matyus
Imre Moravcsik
Gyula Papp
Marta Patfalusi
Tivadar Rettegi
Antal Simay
Ildiko Varga
Andras Varro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Szent-Gyorgyi Albert Orvostudomanyi Egyetem
Teva Hungary Pharmaceutical Marketing PLC
Original Assignee
Institute for Drugs Research Ltd
Szent-Gyorgyi Albert Orvostudomanyi Egyetem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute for Drugs Research Ltd, Szent-Gyorgyi Albert Orvostudomanyi Egyetem filed Critical Institute for Drugs Research Ltd
Publication of AU1678999A publication Critical patent/AU1678999A/en
Application granted granted Critical
Publication of AU738672B2 publication Critical patent/AU738672B2/en
Assigned to IVAX Drug Research Institute Limited Liability Company, SZENT-GYORGYI ALBERT ORVOSTUDOMANYI EGYETEM reassignment IVAX Drug Research Institute Limited Liability Company Request to Amend Deed and Register Assignors: GYOGYSZERKUTATO INTEZET KFT, SZENT-GYORGYI ALBERT ORVOSTUDOMANYI EGYETEM
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
AU16789/99A 1997-12-11 1998-12-10 Novel antiarrhythmic compounds Ceased AU738672B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP9702411 1997-12-11
HU9702411A HUP9702411A2 (hu) 1997-12-11 1997-12-11 Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények
PCT/HU1998/000101 WO1999029655A1 (en) 1997-12-11 1998-12-10 Novel antiarrhythmic compounds

Publications (2)

Publication Number Publication Date
AU1678999A AU1678999A (en) 1999-06-28
AU738672B2 true AU738672B2 (en) 2001-09-20

Family

ID=89995855

Family Applications (1)

Application Number Title Priority Date Filing Date
AU16789/99A Ceased AU738672B2 (en) 1997-12-11 1998-12-10 Novel antiarrhythmic compounds

Country Status (22)

Country Link
US (1) US6265445B1 (https=)
EP (1) EP1037871B1 (https=)
JP (1) JP2001525388A (https=)
KR (1) KR100576905B1 (https=)
CN (1) CN1140498C (https=)
AT (1) ATE220058T1 (https=)
AU (1) AU738672B2 (https=)
BR (1) BR9814270A (https=)
CA (1) CA2313191A1 (https=)
DE (1) DE69806411T2 (https=)
DK (1) DK1037871T3 (https=)
ES (1) ES2179547T3 (https=)
HU (1) HUP9702411A2 (https=)
IL (1) IL136659A (https=)
NO (1) NO20002946L (https=)
NZ (1) NZ504982A (https=)
PL (1) PL190788B1 (https=)
PT (1) PT1037871E (https=)
RU (1) RU2193024C2 (https=)
SK (1) SK284284B6 (https=)
UA (1) UA61979C2 (https=)
WO (1) WO1999029655A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956786A1 (de) * 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
US20030119406A1 (en) 2001-12-20 2003-06-26 Abuto Francis Paul Targeted on-line stabilized absorbent structures
AU2002357560A1 (en) * 2002-04-26 2003-11-10 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Sulfamidophenylalkylamines and their production and use
CN102603543B (zh) * 2012-04-09 2014-07-02 佛山普正医药科技有限公司 一种盐酸美西律的生产方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD146749A3 (de) * 1977-12-01 1981-03-04 Dieter Lehmann Verfahren zur herstellung von phenoxyalkanolamin-derivaten
EG18188A (en) * 1986-05-01 1992-09-30 Pfizer Ltd Process for preparation anti-arhythmia agents
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
JPH06107614A (ja) * 1992-09-26 1994-04-19 Arakusu:Kk アリールスルホン酸アミド類またはアリールカルボン酸アミド類及びそれらの薬剤として許容される酸付加塩及びその製造法並びにそれを有効成分とする抗消化性潰瘍剤

Also Published As

Publication number Publication date
IL136659A0 (en) 2001-06-14
CN1284941A (zh) 2001-02-21
KR100576905B1 (ko) 2006-05-03
CA2313191A1 (en) 1999-06-17
SK8792000A3 (en) 2001-02-12
IL136659A (en) 2004-08-31
HU9702411D0 (en) 1998-03-02
NO20002946L (no) 2000-08-07
HK1033937A1 (en) 2001-10-05
US6265445B1 (en) 2001-07-24
ES2179547T3 (es) 2003-01-16
JP2001525388A (ja) 2001-12-11
DE69806411T2 (de) 2003-03-20
PT1037871E (pt) 2002-11-29
NO20002946D0 (no) 2000-06-08
WO1999029655A1 (en) 1999-06-17
DE69806411D1 (de) 2002-08-08
PL190788B1 (pl) 2006-01-31
BR9814270A (pt) 2001-10-16
RU2193024C2 (ru) 2002-11-20
NZ504982A (en) 2002-07-26
ATE220058T1 (de) 2002-07-15
CN1140498C (zh) 2004-03-03
KR20010032996A (ko) 2001-04-25
PL341107A1 (en) 2001-03-26
HUP9702411A2 (hu) 2000-03-28
EP1037871B1 (en) 2002-07-03
DK1037871T3 (da) 2002-10-14
EP1037871A1 (en) 2000-09-27
AU1678999A (en) 1999-06-28
SK284284B6 (sk) 2005-01-03
UA61979C2 (en) 2003-12-15

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: SZENT-GYORGYI ALBERT ORVOSTUDOMANYI EGYETEM, IVAX

Free format text: FORMER NAME WAS: GYOGYSZERKUTATO INTEZET KFT., SZENT-GYORGYI ALBERT ORVOSTUDOMANYI EGYETEM