HUP0500125A2 - Új boronát-észterek és eljárás előállításukra - Google Patents

Új boronát-észterek és eljárás előállításukra

Info

Publication number
HUP0500125A2
HUP0500125A2 HU0500125A HUP0500125A HUP0500125A2 HU P0500125 A2 HUP0500125 A2 HU P0500125A2 HU 0500125 A HU0500125 A HU 0500125A HU P0500125 A HUP0500125 A HU P0500125A HU P0500125 A2 HUP0500125 A2 HU P0500125A2
Authority
HU
Hungary
Prior art keywords
preparation
boronate esters
aryl
formula
novel boronate
Prior art date
Application number
HU0500125A
Other languages
English (en)
Inventor
Tom Thomas Puthiaprampil
Sumithra Srinath
Madhavan Sridharan
Sambasivam Ganesh
Original Assignee
Biocon Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Limited filed Critical Biocon Limited
Publication of HUP0500125A2 publication Critical patent/HUP0500125A2/hu
Publication of HUP0500125A3 publication Critical patent/HUP0500125A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány optikailag aktív (IIa) általános képletű dihidroxi-hexanoátszármazékokra vonatkozik, amelyek a HMG-CoA enzim inhibitorok,így az atorvasztatin; cerivasztatin, roszuvasztatin, pitavasztatin,fluvasztatin szintézise során közbenső termékként használhatók fel. Aképletben Ar jelentése helyettesítetlen vagy helyettesített aril- vagyheteroarilcsoport; R3 jelentése 1-8 szénatomos alkilcsoport, aril-vagy aralkilcsoport; R4 jelentése oxigénatom, hidroxi-, cianocsoportvagy halogénatom és a jelentése egyes vagy kettős kötés. A találmánytárgyát képezi a vegyületek előállítási eljárása is. Ó
HU0500125A 2002-02-25 2002-02-25 Novel boronate esters and process for their preparation HUP0500125A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2002/000032 WO2003070733A1 (en) 2002-02-25 2002-02-25 Novel boronate esters

Publications (2)

Publication Number Publication Date
HUP0500125A2 true HUP0500125A2 (hu) 2005-04-28
HUP0500125A3 HUP0500125A3 (en) 2008-03-28

Family

ID=27742233

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500125A HUP0500125A3 (en) 2002-02-25 2002-02-25 Novel boronate esters and process for their preparation

Country Status (21)

Country Link
US (2) US7301046B2 (hu)
EP (1) EP1478650B1 (hu)
JP (1) JP4139334B2 (hu)
KR (1) KR100598079B1 (hu)
AT (1) ATE444299T1 (hu)
AU (1) AU2002241235B2 (hu)
BR (1) BR0215602A (hu)
CA (1) CA2475586C (hu)
CZ (1) CZ2004863A3 (hu)
DE (1) DE60233899D1 (hu)
DK (1) DK1478650T3 (hu)
ES (1) ES2332881T3 (hu)
HR (1) HRP20040888B1 (hu)
HU (1) HUP0500125A3 (hu)
IL (1) IL163333A (hu)
NO (1) NO20043223L (hu)
NZ (1) NZ534688A (hu)
PT (1) PT1478650E (hu)
RO (1) RO122095B1 (hu)
SK (1) SK288093B6 (hu)
WO (1) WO2003070733A1 (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) * 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
EP1323717A1 (en) * 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
DK1478650T3 (da) 2002-02-25 2010-01-25 Biocon Ltd Nye boronatestere
CN101512004A (zh) * 2006-07-19 2009-08-19 密歇根州州立大学托管委员会 D-1,2,4-丁三醇的微生物合成
EP2066788B1 (en) 2006-10-02 2014-07-23 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
KR100933172B1 (ko) 2007-11-30 2009-12-21 씨제이제일제당 (주) 아토르바스타틴 칼슘염의 개선된 제조방법
KR101339648B1 (ko) * 2012-05-10 2013-12-09 (주) 에프엔지리서치 신규한 아토바스타틴 중간체 및 이를 이용한 아토바스타틴의 제조 방법
KR101292743B1 (ko) * 2012-05-17 2013-08-02 (주) 에프엔지리서치 신규한 스타틴 중간체 및 이를 이용한 피타바스타틴, 로수바스타틴, 세리바스타틴 및 플루바스타틴의 제조 방법
KR101528359B1 (ko) * 2013-04-24 2015-06-15 (주) 성운파마코피아 스타틴 화합물 제조를 위한 신규한 보로네이트 에테르 화합물, 그 제조방법 및 상기 보로네이트 에테르 화합물을 이용한 스타틴 화합물 제조방법
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474034A (en) 1982-09-23 1984-10-02 Avery Jr Richard J Refrigerant accumulator and charging apparatus and method for vapor-compression refrigeration system
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
EP0579370B1 (en) 1992-06-10 2000-08-16 Chisso Corporation An optically active 1,5-disubstituted-2,4-0-isoproylidene-2,4-dihydroxypentane and a process for producing the same
ATE158579T1 (de) 1992-07-02 1997-10-15 Hoechst Ag Verfahren zur herstellung von (3r,5s)6-hydroxy- 3,5-0-isopropyliden-3,5-dihydroxy-hexansäure- tert.-butylester
US5481009A (en) * 1993-08-09 1996-01-02 Fujirebio Inc. Methods of producing carboxylic acid ester derivatives and intermediates for use in the methods
US5998633A (en) * 1996-07-29 1999-12-07 Warner-Lambert Company Process for the synthesis of protected esters of (S)-3,4-dihydroxybutyric acid
JPH11171850A (ja) * 1997-12-12 1999-06-29 Kanegafuchi Chem Ind Co Ltd 酪酸エステル誘導体の製造方法
AU2000254249A1 (en) 2000-03-28 2001-10-08 Biocon India Limited Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
DK1478650T3 (da) * 2002-02-25 2010-01-25 Biocon Ltd Nye boronatestere

Also Published As

Publication number Publication date
CA2475586C (en) 2011-07-05
NO20043223L (no) 2004-09-28
AU2002241235A1 (en) 2003-09-09
PT1478650E (pt) 2010-01-04
JP2005518427A (ja) 2005-06-23
US20050154213A1 (en) 2005-07-14
DE60233899D1 (de) 2009-11-12
DK1478650T3 (da) 2010-01-25
US7238826B2 (en) 2007-07-03
ES2332881T3 (es) 2010-02-15
BR0215602A (pt) 2004-12-07
HRP20040888A2 (en) 2005-04-30
CA2475586A1 (en) 2003-08-28
ATE444299T1 (de) 2009-10-15
CZ2004863A3 (cs) 2004-12-15
NZ534688A (en) 2005-04-29
IL163333A (en) 2009-05-04
EP1478650A4 (en) 2008-02-13
HRP20040888B1 (en) 2012-12-31
US20060040898A1 (en) 2006-02-23
US7301046B2 (en) 2007-11-27
RO122095B1 (ro) 2008-12-30
KR100598079B1 (ko) 2006-07-07
JP4139334B2 (ja) 2008-08-27
HUP0500125A3 (en) 2008-03-28
EP1478650A1 (en) 2004-11-24
SK288093B6 (sk) 2013-07-02
SK3052004A3 (sk) 2005-02-04
KR20040084915A (ko) 2004-10-06
AU2002241235B2 (en) 2009-04-23
EP1478650B1 (en) 2009-09-30
WO2003070733A1 (en) 2003-08-28

Similar Documents

Publication Publication Date Title
HUP0500125A2 (hu) Új boronát-észterek és eljárás előállításukra
IS5891A (is) Ný sölt HMG-CoA redúktasatálma
MXPA03011681A (es) Uso de inhibidores de epoxido hidrolasa soluble, para tratar enfermedades relacionadas con la enfermedad cardiovascular.
DE69912581D1 (de) Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
IL173802A0 (en) Adamantane and azabicyclo-octane and nonane derivatives, process of their preparation and their use as dpp-iv inhibitors
ATE287389T1 (de) Kristalle des natriumsalzes von pravastatin
WO2004046122A3 (en) Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors
RU2004139029A (ru) Применение замещенных цианопирролидинов и содержащих их комбинированных препаратов для лечения гиперлипидемии и ассоциированных заболеваний
MA32929B1 (fr) Lactames en tant qu'inhibiteurs de bêta-sécrétase
EA200601678A1 (ru) Новые имидазолы
WO2003106450A8 (de) Phenylaminopyrimidine und ihre verwendung als rho-kinase inhibitoren
ATE409693T1 (de) Verfahren zur herstellung von 2-(4- chlorbenzoylamino-3- 2(1h)-chinolinon-4-yl propionsäure
TR199900401T2 (xx) Bidentat metaloproteaz inhibit�rleri.
MA29943B1 (fr) Derives de pyrazolo[4,3-d] pyrimidine-5-yle utilises comme inhibiteurs de pde5
PT1102765E (pt) Processo para a sintese de derivados de (1h)-benzo¬c|quinolizin-3-onas
EA200600551A1 (ru) Соединения пиперазина, способ их получения и фармацевтические композиции, которые их содержат
EA201000180A1 (ru) Способ получения производных пиримидина
IL169191A0 (en) Novel process for preparing a 5 - hydroxy - 3 - oxo - hexanoic acid derivative
HUP0103702A2 (hu) 1-Pirrol-származékok polimorf kristályformái és eljárás az előállításukra
MXPA05012110A (es) Procedimiento para sintetizar intermediarios inhibidores de beta-lactamasa.
DE60334627D1 (de) Verfahren zur herstellung eines 3,5-dihydroxy-6-heptenoats
WO2011031964A3 (en) Inhibitors of biofilm formation
NO20020561L (no) Fremgangsmåte for fremstilling av syrer via alfa-klorepoksi- estere
CO5611117A2 (es) Combinacion de compuestos organicos
GR1006173B (el) Χημικη συνθεση του (3r, 5r) - διυδροξυ - 7 - [2-(4-φθοροφαινυλ) - 5 - σοπροπυλ - 3 - φαινυλ - 4 - φαινυλκαρβαμοϋλο - πυρρολυλο - τριενυδρο - επτανοϊκου ασβεστιου, εφαρμογη φαρμακευτικου σκευασματος και παραγωγικη διαδικασια

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished