HUP0401989A2 - Eljárás 14béta-hidroxi-bakkatin III-1,14-karbonát előállítására - Google Patents
Eljárás 14béta-hidroxi-bakkatin III-1,14-karbonát előállításáraInfo
- Publication number
- HUP0401989A2 HUP0401989A2 HU0401989A HUP0401989A HUP0401989A2 HU P0401989 A2 HUP0401989 A2 HU P0401989A2 HU 0401989 A HU0401989 A HU 0401989A HU P0401989 A HUP0401989 A HU P0401989A HU P0401989 A2 HUP0401989 A2 HU P0401989A2
- Authority
- HU
- Hungary
- Prior art keywords
- iii
- carbonate
- hydroxy
- triethylsilyl
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgya eljárás 14b-hidroxi-bakkatin III-1,14-karbonátelőállítására. A találmány értelmében úgy járnak el, hogy i) az (I)képletű 7-trietilszilil-13-oxobakkatin III vegyületet alkalmasbázisokkal és oxidálószerekkel kezelik, majd ii) az így kapott (II)képletű 7-trietilszilil-13-oxo-l4-hidroxi-bakkatin III vegyület és 14helyzetű hidroxilcsoportjait karbonálásnak vetik alá, majd iii) az ígykapott (III) képletű 14b-hidroxi-7-trietilszilil-13-oxo- -bakkatinIII-1,14-karbonát 13-helyzetű oxocsoportját redukálják és a 7-helyzetűvédőcsoportot lehasítják. A találmány szerinti eljárással előállított14b-hidroxi-bakkatin III-1,14-karbonát tumor elleni hatású újtaxánszármazékok előállítására hasznosítható. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI002186A ITMI20012186A1 (it) | 2001-10-19 | 2001-10-19 | Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato |
| PCT/EP2002/008005 WO2003035633A1 (en) | 2001-10-19 | 2002-07-18 | A process for the preparation of the 14beta-hydroxy-baccatin iii-1,14-carbonate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401989A2 true HUP0401989A2 (hu) | 2005-01-28 |
| HUP0401989A3 HUP0401989A3 (en) | 2007-05-29 |
Family
ID=11448529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401989A HUP0401989A3 (en) | 2001-10-19 | 2002-07-18 | A process for the preparation of the 14 beta-hydroxy-baccatin iii-1,14-carbonate |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7078432B2 (hu) |
| EP (1) | EP1436277B1 (hu) |
| JP (1) | JP4454310B2 (hu) |
| KR (1) | KR100896542B1 (hu) |
| CN (1) | CN1271061C (hu) |
| AT (1) | ATE537160T1 (hu) |
| AU (1) | AU2002328918B2 (hu) |
| BR (1) | BR0213360B1 (hu) |
| CA (1) | CA2463915C (hu) |
| DK (1) | DK1436277T3 (hu) |
| ES (1) | ES2376162T3 (hu) |
| HK (1) | HK1069170A1 (hu) |
| HU (1) | HUP0401989A3 (hu) |
| IL (1) | IL161443A0 (hu) |
| IT (1) | ITMI20012186A1 (hu) |
| MX (1) | MXPA04003519A (hu) |
| NO (1) | NO328562B1 (hu) |
| PL (1) | PL368122A1 (hu) |
| RU (1) | RU2291866C2 (hu) |
| WO (1) | WO2003035633A1 (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20012185A1 (it) * | 2001-10-19 | 2003-04-19 | Indena Spa | Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato |
| ITMI20021921A1 (it) * | 2002-09-10 | 2004-03-11 | Indena Spa | Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali. |
| ES2389518T3 (es) | 2008-01-18 | 2012-10-26 | Indena S.P.A. | Formas sólidas de ortataxel |
| CN103450118A (zh) * | 2013-09-18 | 2013-12-18 | 江苏红豆杉药业有限公司 | 一种半合成法制备紫杉醇的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1254517B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
| US5475011A (en) | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| IT1275936B1 (it) * | 1995-03-17 | 1997-10-24 | Indena Spa | Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni |
| FR2732341A1 (fr) * | 1995-03-27 | 1996-10-04 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| IT1275435B (it) | 1995-05-19 | 1997-08-07 | Indena Spa | Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono |
| IT1283633B1 (it) * | 1996-05-10 | 1998-04-23 | Indena Spa | Derivati tassanici loro sintesi e formulazioni che li contengono |
| US5811452A (en) * | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| IT1318678B1 (it) | 2000-08-10 | 2003-08-27 | Indena Spa | Procedimento per la preparazione di derivati della baccatina iii. |
| IT1320107B1 (it) * | 2000-11-28 | 2003-11-18 | Indena Spa | Procedimento per la preparazione di derivati tassanici. |
| ITMI20012185A1 (it) * | 2001-10-19 | 2003-04-19 | Indena Spa | Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato |
-
2001
- 2001-10-19 IT IT2001MI002186A patent/ITMI20012186A1/it unknown
-
2002
- 2002-07-18 CN CNB028205227A patent/CN1271061C/zh not_active Expired - Fee Related
- 2002-07-18 HU HU0401989A patent/HUP0401989A3/hu unknown
- 2002-07-18 AU AU2002328918A patent/AU2002328918B2/en not_active Ceased
- 2002-07-18 PL PL02368122A patent/PL368122A1/xx not_active Application Discontinuation
- 2002-07-18 WO PCT/EP2002/008005 patent/WO2003035633A1/en active Application Filing
- 2002-07-18 RU RU2004111669/04A patent/RU2291866C2/ru active
- 2002-07-18 EP EP02764721A patent/EP1436277B1/en not_active Expired - Lifetime
- 2002-07-18 IL IL16144302A patent/IL161443A0/xx active IP Right Grant
- 2002-07-18 JP JP2003538149A patent/JP4454310B2/ja not_active Expired - Fee Related
- 2002-07-18 AT AT02764721T patent/ATE537160T1/de active
- 2002-07-18 US US10/492,986 patent/US7078432B2/en not_active Expired - Lifetime
- 2002-07-18 MX MXPA04003519A patent/MXPA04003519A/es active IP Right Grant
- 2002-07-18 KR KR1020047004621A patent/KR100896542B1/ko active IP Right Grant
- 2002-07-18 DK DK02764721.3T patent/DK1436277T3/da active
- 2002-07-18 ES ES02764721T patent/ES2376162T3/es not_active Expired - Lifetime
- 2002-07-18 BR BRPI0213360-1B1A patent/BR0213360B1/pt not_active IP Right Cessation
- 2002-07-18 CA CA002463915A patent/CA2463915C/en not_active Expired - Lifetime
-
2004
- 2004-04-15 NO NO20041537A patent/NO328562B1/no not_active IP Right Cessation
-
2005
- 2005-02-28 HK HK05101660A patent/HK1069170A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2291866C2 (ru) | 2007-01-20 |
| NO328562B1 (no) | 2010-03-22 |
| WO2003035633A1 (en) | 2003-05-01 |
| JP2005512977A (ja) | 2005-05-12 |
| EP1436277A1 (en) | 2004-07-14 |
| DK1436277T3 (da) | 2012-01-23 |
| JP4454310B2 (ja) | 2010-04-21 |
| MXPA04003519A (es) | 2004-07-23 |
| ES2376162T3 (es) | 2012-03-09 |
| CN1271061C (zh) | 2006-08-23 |
| CA2463915C (en) | 2009-11-24 |
| HUP0401989A3 (en) | 2007-05-29 |
| ATE537160T1 (de) | 2011-12-15 |
| US20040266859A1 (en) | 2004-12-30 |
| KR100896542B1 (ko) | 2009-05-07 |
| ITMI20012186A1 (it) | 2003-04-19 |
| IL161443A0 (en) | 2004-09-27 |
| BR0213360B1 (pt) | 2014-04-15 |
| RU2004111669A (ru) | 2005-04-20 |
| NO20041537L (no) | 2004-04-15 |
| HK1069170A1 (en) | 2005-05-13 |
| CA2463915A1 (en) | 2003-05-01 |
| EP1436277B1 (en) | 2011-12-14 |
| CN1571779A (zh) | 2005-01-26 |
| PL368122A1 (en) | 2005-03-21 |
| US7078432B2 (en) | 2006-07-18 |
| AU2002328918B2 (en) | 2008-09-04 |
| KR20040045023A (ko) | 2004-05-31 |
| BR0213360A (pt) | 2004-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |